2021 MLB Season
2,429 regular-season games · 10 playoff teams · 100,000 simulations
Champion
Atlanta Braves
4th Title
Last Title: 1995
Runner-Up
Houston Astros
4th Appearance
Last Appearance: 2019
Biggest Overachiever
San Francisco Giants
15.92 wins above expected
107 wins · 91.08 expected wins
Biggest Disappointment
Arizona Diamondbacks
13.79 wins below expected
52 wins · 65.79 expected wins
Final Standings
Regular-season records by division. The vsSim column shows actual wins minus the simulation's mean wins — positive means the team overachieved, negative means they underperformed.
| # | Team | W | L | Pct | GB | RS | RA | RD | SimW | vsSim |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Chicago White Sox Division | 93 | 69 | .574 | — | 796 | 636 | +160 | 91.18 | +1.82 |
| 2 | Cleveland Indians | 80 | 82 | .494 | 13 | 717 | 727 | -10 | 82.48 | -2.48 |
| 3 | Detroit Tigers | 77 | 85 | .475 | 16 | 697 | 756 | -59 | 70.45 | +6.55 |
| 4 | Kansas City Royals | 74 | 88 | .457 | 19 | 686 | 788 | -102 | 73.01 | +0.99 |
| 5 | Minnesota Twins | 73 | 89 | .451 | 20 | 729 | 834 | -105 | 76.92 | -3.92 |
| # | Team | W | L | Pct | GB | RS | RA | RD | SimW | vsSim |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Tampa Bay Rays Division | 100 | 62 | .617 | — | 857 | 651 | +206 | 95.35 | +4.65 |
| 2 | New York Yankees Playoffs | 92 | 70 | .568 | 8 | 711 | 669 | +42 | 86.83 | +5.17 |
| 3 | Boston Red Sox Playoffs | 92 | 70 | .568 | 8 | 829 | 749 | +80 | 85.17 | +6.83 |
| 4 | Toronto Blue Jays | 92 | 70 | .568 | 8 | 849 | 660 | +189 | 87.18 | +4.82 |
| 5 | Baltimore Orioles | 52 | 110 | .321 | 48 | 659 | 956 | -297 | 62.92 | -10.92 |
| # | Team | W | L | Pct | GB | RS | RA | RD | SimW | vsSim |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Houston Astros Division | 95 | 67 | .586 | — | 863 | 658 | +205 | 95.64 | -0.64 |
| 2 | Seattle Mariners | 90 | 72 | .556 | 5 | 697 | 748 | -51 | 77.66 | +12.34 |
| 3 | Oakland Athletics | 86 | 76 | .531 | 9 | 743 | 687 | +56 | 87.55 | -1.55 |
| 4 | Los Angeles Angels | 76 | 86 | .469 | 19 | 720 | 807 | -87 | 75.62 | +0.38 |
| 5 | Texas Rangers | 60 | 102 | .370 | 35 | 625 | 815 | -190 | 67.01 | -7.01 |
| # | Team | W | L | Pct | GB | RS | RA | RD | SimW | vsSim |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Milwaukee Brewers Division | 95 | 67 | .586 | — | 738 | 623 | +115 | 88.34 | +6.66 |
| 2 | St. Louis Cardinals Playoffs | 90 | 72 | .556 | 5 | 706 | 672 | +34 | 83.01 | +6.99 |
| 3 | Cincinnati Reds | 83 | 79 | .512 | 12 | 786 | 760 | +26 | 82.86 | +0.14 |
| 4 | Chicago Cubs | 71 | 91 | .438 | 24 | 705 | 839 | -134 | 78.63 | -7.63 |
| 5 | Pittsburgh Pirates | 61 | 101 | .377 | 34 | 609 | 833 | -224 | 66.20 | -5.20 |
| # | Team | W | L | Pct | GB | RS | RA | RD | SimW | vsSim |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Atlanta Braves Division | 88 | 73 | .547 | — | 790 | 656 | +134 | 86.90 | +1.10 |
| 2 | Philadelphia Phillies | 82 | 80 | .506 | 6.5 | 734 | 745 | -11 | 80.28 | +1.72 |
| 3 | New York Mets | 77 | 85 | .475 | 11.5 | 636 | 668 | -32 | 80.19 | -3.19 |
| 4 | Miami Marlins | 67 | 95 | .414 | 21.5 | 623 | 701 | -78 | 74.91 | -7.91 |
| 5 | Washington Nationals | 65 | 97 | .401 | 23.5 | 724 | 820 | -96 | 77.19 | -12.19 |
| # | Team | W | L | Pct | GB | RS | RA | RD | SimW | vsSim |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | San Francisco Giants Division | 107 | 55 | .660 | — | 804 | 594 | +210 | 91.08 | +15.92 |
| 2 | Los Angeles Dodgers Playoffs | 106 | 56 | .654 | 1 | 830 | 561 | +269 | 101.99 | +4.01 |
| 3 | San Diego Padres | 79 | 83 | .488 | 28 | 729 | 708 | +21 | 84.65 | -5.65 |
| 4 | Colorado Rockies | 74 | 87 | .460 | 32.5 | 739 | 796 | -57 | 71.98 | +2.02 |
| 5 | Arizona Diamondbacks | 52 | 110 | .321 | 55 | 679 | 893 | -214 | 65.79 | -13.79 |
Playoff Bracket
The path each team took through the postseason — reconstructed from actual playoff games, not the simulation.
American League
Wild Card
National League
Wild Card
World Series
Season Summary
Every team's regular-season finish compared against 100,000 simulations. Click any column header to sort; use the dropdown to filter by League or Division. Luck is the team's actual outcome minus the sim's mean — positive means the team beat the model. Percentile is where the actual result fell in the team's sim distribution (e.g. 90% = the team did this well or better in only 10% of sims).
| Team | League | Division | Elo | Actual | Avg. Wins | Luck | Percentile | Min | 5th | Q1 | Median | Q3 | 95th | Max |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Los Angeles Dodgers | National | NL West | 1627 | 106 | 101.99 | +4.01 | 76.83% | 74 | 92 | 98 | 102 | 106 | 112 | 125 |
| Tampa Bay Rays | American | AL East | 1596 | 100 | 95.35 | +4.65 | 80.05% | 72 | 85 | 91 | 95 | 99 | 105 | 117 |
| San Francisco Giants | National | NL West | 1596 | 107 | 91.08 | +15.92 | 99.63% | 69 | 81 | 87 | 91 | 95 | 101 | 115 |
| Toronto Blue Jays | American | AL East | 1566 | 92 | 87.18 | +4.82 | 80.21% | 64 | 77 | 83 | 87 | 91 | 97 | 113 |
| Atlanta Braves | National | NL East | 1566 | 88 | 87.40 | +0.60 | 56.84% | 64 | 77 | 83 | 87 | 92 | 98 | 109 |
| Houston Astros | American | AL West | 1564 | 95 | 95.64 | -0.64 | 49.06% | 70 | 85 | 91 | 96 | 100 | 106 | 118 |
| Chicago White Sox | American | AL Central | 1544 | 93 | 91.18 | +1.82 | 64.62% | 69 | 81 | 87 | 91 | 95 | 102 | 114 |
| Milwaukee Brewers | National | NL Central | 1544 | 95 | 88.34 | +6.66 | 87.49% | 66 | 78 | 84 | 88 | 93 | 99 | 118 |
| New York Yankees | American | AL East | 1541 | 92 | 86.83 | +5.17 | 81.80% | 64 | 77 | 83 | 87 | 91 | 97 | 108 |
| St. Louis Cardinals | National | NL Central | 1537 | 90 | 83.01 | +6.99 | 88.78% | 58 | 73 | 79 | 83 | 87 | 93 | 107 |
| Boston Red Sox | American | AL East | 1526 | 92 | 85.17 | +6.83 | 88.54% | 62 | 75 | 81 | 85 | 89 | 95 | 109 |
| Oakland Athletics | American | AL West | 1520 | 86 | 87.55 | -1.55 | 43.56% | 65 | 77 | 83 | 87 | 92 | 98 | 112 |
| Seattle Mariners | American | AL West | 1510 | 90 | 77.66 | +12.34 | 97.84% | 52 | 67 | 73 | 78 | 82 | 88 | 105 |
| Cincinnati Reds | National | NL Central | 1497 | 83 | 82.86 | +0.14 | 53.86% | 59 | 72 | 79 | 83 | 87 | 93 | 106 |
| Cleveland Indians | American | AL Central | 1495 | 80 | 82.48 | -2.48 | 38.07% | 60 | 72 | 78 | 82 | 87 | 93 | 111 |
| Philadelphia Phillies | National | NL East | 1493 | 82 | 80.28 | +1.72 | 63.80% | 56 | 70 | 76 | 80 | 85 | 90 | 103 |
| San Diego Padres | National | NL West | 1482 | 79 | 84.65 | -5.65 | 20.68% | 62 | 74 | 80 | 85 | 89 | 95 | 107 |
| Colorado Rockies | National | NL West | 1480 | 74 | 72.48 | +1.52 | 62.99% | 51 | 62 | 68 | 72 | 77 | 83 | 95 |
| New York Mets | National | NL East | 1478 | 77 | 80.19 | -3.19 | 33.92% | 54 | 70 | 76 | 80 | 85 | 91 | 103 |
| Detroit Tigers | American | AL Central | 1475 | 77 | 70.45 | +6.55 | 87.10% | 47 | 60 | 66 | 70 | 75 | 81 | 94 |
| Minnesota Twins | American | AL Central | 1475 | 73 | 76.92 | -3.92 | 29.51% | 54 | 67 | 73 | 77 | 81 | 87 | 104 |
| Los Angeles Angels | American | AL West | 1465 | 76 | 75.62 | +0.38 | 55.48% | 54 | 65 | 71 | 76 | 80 | 86 | 100 |
| Kansas City Royals | American | AL Central | 1458 | 74 | 73.01 | +0.99 | 59.73% | 50 | 63 | 69 | 73 | 77 | 83 | 98 |
| Washington Nationals | National | NL East | 1445 | 65 | 77.19 | -12.19 | 3.24% | 54 | 67 | 73 | 77 | 81 | 88 | 99 |
| Miami Marlins | National | NL East | 1443 | 67 | 74.91 | -7.91 | 11.42% | 51 | 65 | 71 | 75 | 79 | 85 | 96 |
| Chicago Cubs | National | NL Central | 1441 | 71 | 78.63 | -7.63 | 12.24% | 55 | 68 | 74 | 79 | 83 | 89 | 102 |
| Texas Rangers | American | AL West | 1417 | 60 | 67.01 | -7.01 | 14.35% | 45 | 57 | 63 | 67 | 71 | 77 | 93 |
| Arizona Diamondbacks | National | NL West | 1417 | 52 | 65.79 | -13.79 | 1.45% | 44 | 56 | 62 | 66 | 70 | 76 | 89 |
| Pittsburgh Pirates | National | NL Central | 1412 | 61 | 66.20 | -5.20 | 22.83% | 43 | 56 | 62 | 66 | 71 | 76 | 89 |
| Baltimore Orioles | American | AL East | 1389 | 52 | 62.92 | -10.92 | 4.34% | 40 | 53 | 59 | 63 | 67 | 73 | 87 |
Head-to-Head
Each cell shows a team's record (row vs column) and below it the expected number of wins the model predicted based on each individual game's win probability. Navy-tinted cells mean the team beat the model's expectations by more than half a win in that matchup; gold-tinted cells mean they fell short by the same margin. The first matrix for each division covers within-division games; the second (when shown) covers games against teams outside that division — aggregated by division when there are many opponents, broken out team-by-team when there are few.
Within AL Central
| Team | Sox | Indians | Tigers | Royals | Twins |
|---|---|---|---|---|---|
| Chicago White Sox | — |
10-9
(10.2 exp.)
|
12-7
(11.7 exp.)
|
9-10
(11.5 exp.)
|
13-6
(11.2 exp.)
|
| Cleveland Indians |
9-10
(8.8 exp.)
|
— |
12-7
(10.7 exp.)
|
14-5
(10.4 exp.)
|
8-11
(10.1 exp.)
|
| Detroit Tigers |
7-12
(7.3 exp.)
|
7-12
(8.3 exp.)
|
— |
8-11
(9.2 exp.)
|
8-11
(8.7 exp.)
|
| Kansas City Royals |
10-9
(7.5 exp.)
|
5-14
(8.6 exp.)
|
11-8
(9.8 exp.)
|
— |
10-9
(9.2 exp.)
|
| Minnesota Twins |
6-13
(7.8 exp.)
|
11-8
(8.9 exp.)
|
11-8
(10.3 exp.)
|
9-10
(9.8 exp.)
|
— |
AL Central vs. Other Divisions
| Team | AL East | AL West | NL Central | NL East | NL West |
|---|---|---|---|---|---|
| Chicago White Sox |
19-14
(17.3 exp.)
|
16-17
(17.7 exp.)
|
14-6
(11.6 exp.)
|
—
|
—
|
| Cleveland Indians |
13-21
(16.2 exp.)
|
15-17
(16.1 exp.)
|
9-11
(10.2 exp.)
|
—
|
—
|
| Detroit Tigers |
18-14
(13.2 exp.)
|
18-16
(14.8 exp.)
|
11-9
(9.0 exp.)
|
—
|
—
|
| Kansas City Royals |
12-21
(14.4 exp.)
|
14-19
(14.3 exp.)
|
12-8
(9.1 exp.)
|
—
|
—
|
| Minnesota Twins |
13-20
(14.4 exp.)
|
13-20
(16.0 exp.)
|
10-10
(9.7 exp.)
|
—
|
—
|
Within AL East
| Team | Orioles | Sox | Yankees | Rays | Jays |
|---|---|---|---|---|---|
| Baltimore Orioles | — |
6-13
(7.7 exp.)
|
8-11
(7.3 exp.)
|
1-18
(5.9 exp.)
|
5-14
(6.2 exp.)
|
| Boston Red Sox |
13-6
(11.3 exp.)
|
— |
10-9
(9.7 exp.)
|
8-11
(8.0 exp.)
|
10-9
(9.5 exp.)
|
| New York Yankees |
11-8
(11.7 exp.)
|
9-10
(9.3 exp.)
|
— |
8-11
(9.0 exp.)
|
8-11
(9.8 exp.)
|
| Tampa Bay Rays |
18-1
(13.1 exp.)
|
11-8
(11.0 exp.)
|
11-8
(10.0 exp.)
|
— |
11-8
(10.3 exp.)
|
| Toronto Blue Jays |
14-5
(12.8 exp.)
|
9-10
(9.5 exp.)
|
11-8
(9.2 exp.)
|
8-11
(8.7 exp.)
|
— |
AL East vs. Other Divisions
| Team | AL Central | AL West | NL Central | NL East | NL West |
|---|---|---|---|---|---|
| Baltimore Orioles |
10-24
(14.1 exp.)
|
15-17
(13.7 exp.)
|
—
|
7-13
(8.1 exp.)
|
—
|
| Boston Red Sox |
20-13
(18.1 exp.)
|
15-18
(17.5 exp.)
|
—
|
16-4
(11.0 exp.)
|
—
|
| New York Yankees |
22-10
(18.1 exp.)
|
22-12
(18.5 exp.)
|
—
|
12-8
(10.5 exp.)
|
—
|
| Tampa Bay Rays |
19-13
(19.6 exp.)
|
15-19
(19.5 exp.)
|
—
|
15-5
(11.9 exp.)
|
—
|
| Toronto Blue Jays |
19-15
(19.5 exp.)
|
17-15
(17.1 exp.)
|
—
|
14-6
(10.3 exp.)
|
—
|
Within AL West
| Team | Astros | Angels | Athletics | Mariners | Rangers |
|---|---|---|---|---|---|
| Houston Astros | — |
13-6
(11.6 exp.)
|
11-8
(10.4 exp.)
|
11-8
(11.2 exp.)
|
14-5
(12.5 exp.)
|
| Los Angeles Angels |
6-13
(7.4 exp.)
|
— |
4-15
(8.2 exp.)
|
8-11
(9.2 exp.)
|
11-8
(10.5 exp.)
|
| Oakland Athletics |
8-11
(8.6 exp.)
|
15-4
(10.8 exp.)
|
— |
4-15
(10.6 exp.)
|
10-9
(12.2 exp.)
|
| Seattle Mariners |
8-11
(7.8 exp.)
|
11-8
(9.8 exp.)
|
15-4
(8.4 exp.)
|
— |
13-6
(10.7 exp.)
|
| Texas Rangers |
5-14
(6.5 exp.)
|
8-11
(8.5 exp.)
|
9-10
(6.8 exp.)
|
6-13
(8.3 exp.)
|
— |
AL West vs. Other Divisions
| Team | AL Central | AL East | NL Central | NL East | NL West |
|---|---|---|---|---|---|
| Houston Astros |
19-16
(21.7 exp.)
|
18-13
(17.3 exp.)
|
—
|
—
|
9-11
(11.1 exp.)
|
| Los Angeles Angels |
21-12
(16.3 exp.)
|
15-18
(15.1 exp.)
|
—
|
—
|
11-9
(8.9 exp.)
|
| Oakland Athletics |
23-10
(18.3 exp.)
|
15-18
(16.9 exp.)
|
—
|
—
|
11-9
(10.1 exp.)
|
| Seattle Mariners |
15-17
(15.8 exp.)
|
19-15
(15.1 exp.)
|
—
|
—
|
9-11
(10.0 exp.)
|
| Texas Rangers |
11-21
(14.0 exp.)
|
14-20
(14.3 exp.)
|
—
|
—
|
7-13
(8.6 exp.)
|
Within NL Central
| Team | Cubs | Reds | Brewers | Pirates | Cardinals |
|---|---|---|---|---|---|
| Chicago Cubs | — |
8-11
(9.2 exp.)
|
4-15
(8.6 exp.)
|
14-5
(10.7 exp.)
|
9-10
(8.7 exp.)
|
| Cincinnati Reds |
11-8
(9.8 exp.)
|
— |
9-10
(8.8 exp.)
|
13-6
(11.5 exp.)
|
10-9
(9.4 exp.)
|
| Milwaukee Brewers |
15-4
(10.4 exp.)
|
10-9
(10.2 exp.)
|
— |
14-5
(12.1 exp.)
|
8-11
(10.1 exp.)
|
| Pittsburgh Pirates |
5-14
(8.3 exp.)
|
6-13
(7.5 exp.)
|
5-14
(6.9 exp.)
|
— |
7-12
(7.8 exp.)
|
| St. Louis Cardinals |
10-9
(10.3 exp.)
|
9-10
(9.6 exp.)
|
11-8
(8.9 exp.)
|
12-7
(11.2 exp.)
|
— |
NL Central vs. Other Divisions
| Team | AL Central | AL East | AL West | NL East | NL West |
|---|---|---|---|---|---|
| Chicago Cubs |
6-14
(9.5 exp.)
|
—
|
—
|
13-21
(16.8 exp.)
|
17-15
(15.1 exp.)
|
| Cincinnati Reds |
9-11
(10.5 exp.)
|
—
|
—
|
20-13
(17.2 exp.)
|
11-22
(15.6 exp.)
|
| Milwaukee Brewers |
8-12
(11.3 exp.)
|
—
|
—
|
17-14
(16.6 exp.)
|
23-12
(17.6 exp.)
|
| Pittsburgh Pirates |
10-10
(8.6 exp.)
|
—
|
—
|
17-17
(13.8 exp.)
|
11-21
(13.3 exp.)
|
| St. Louis Cardinals |
11-9
(10.6 exp.)
|
—
|
—
|
17-16
(16.8 exp.)
|
20-13
(15.8 exp.)
|
Within NL East
| Team | Braves | Marlins | Mets | Phillies | Nationals |
|---|---|---|---|---|---|
| Atlanta Braves | — |
11-8
(10.8 exp.)
|
10-9
(9.9 exp.)
|
10-9
(10.2 exp.)
|
14-5
(10.6 exp.)
|
| Miami Marlins |
8-11
(8.2 exp.)
|
— |
9-10
(8.9 exp.)
|
10-9
(9.0 exp.)
|
8-11
(9.3 exp.)
|
| New York Mets |
9-10
(9.1 exp.)
|
10-9
(10.1 exp.)
|
— |
9-10
(9.6 exp.)
|
11-8
(9.9 exp.)
|
| Philadelphia Phillies |
9-10
(8.8 exp.)
|
9-10
(10.0 exp.)
|
10-9
(9.4 exp.)
|
— |
13-6
(9.6 exp.)
|
| Washington Nationals |
5-14
(8.4 exp.)
|
11-8
(9.7 exp.)
|
8-11
(9.1 exp.)
|
6-13
(9.4 exp.)
|
— |
NL East vs. Other Divisions
| Team | AL Central | AL East | AL West | NL Central | NL West |
|---|---|---|---|---|---|
| Atlanta Braves |
—
|
6-14
(10.6 exp.)
|
—
|
22-12
(18.4 exp.)
|
15-16
(16.2 exp.)
|
| Miami Marlins |
—
|
3-17
(8.9 exp.)
|
—
|
12-20
(15.4 exp.)
|
17-17
(15.2 exp.)
|
| New York Mets |
—
|
9-11
(9.7 exp.)
|
—
|
13-20
(16.7 exp.)
|
16-17
(15.0 exp.)
|
| Philadelphia Phillies |
—
|
8-12
(9.6 exp.)
|
—
|
20-14
(17.4 exp.)
|
13-19
(15.6 exp.)
|
| Washington Nationals |
—
|
10-10
(9.4 exp.)
|
—
|
14-18
(15.9 exp.)
|
11-23
(15.4 exp.)
|
Within NL West
| Team | Diamondbacks | Rockies | Dodgers | Padres | Giants |
|---|---|---|---|---|---|
| Arizona Diamondbacks | — |
9-10
(9.1 exp.)
|
3-16
(5.4 exp.)
|
8-11
(7.4 exp.)
|
2-17
(6.3 exp.)
|
| Colorado Rockies |
10-9
(9.9 exp.)
|
— |
6-13
(6.5 exp.)
|
11-8
(7.7 exp.)
|
4-15
(7.8 exp.)
|
| Los Angeles Dodgers |
16-3
(13.6 exp.)
|
13-6
(12.5 exp.)
|
— |
12-7
(11.8 exp.)
|
9-10
(10.7 exp.)
|
| San Diego Padres |
11-8
(11.6 exp.)
|
8-11
(11.3 exp.)
|
7-12
(7.2 exp.)
|
— |
8-11
(8.3 exp.)
|
| San Francisco Giants |
17-2
(12.7 exp.)
|
15-4
(11.2 exp.)
|
10-9
(8.3 exp.)
|
11-8
(10.7 exp.)
|
— |
NL West vs. Other Divisions
| Team | AL Central | AL East | AL West | NL Central | NL East |
|---|---|---|---|---|---|
| Arizona Diamondbacks |
—
|
—
|
4-16
(8.3 exp.)
|
13-19
(14.1 exp.)
|
13-21
(15.1 exp.)
|
| Colorado Rockies |
—
|
—
|
10-10
(9.4 exp.)
|
14-19
(15.7 exp.)
|
19-13
(15.1 exp.)
|
| Los Angeles Dodgers |
—
|
—
|
12-8
(12.3 exp.)
|
20-13
(20.8 exp.)
|
24-9
(20.5 exp.)
|
| San Diego Padres |
—
|
—
|
14-6
(10.6 exp.)
|
16-17
(17.8 exp.)
|
15-18
(17.9 exp.)
|
| San Francisco Giants |
—
|
—
|
13-7
(10.8 exp.)
|
20-14
(19.3 exp.)
|
21-11
(17.9 exp.)
|
Scoring Distribution
Histograms of runs scored and allowed, a home-vs-away score scatter (marker size grows with how often that exact score happened), and summary stats — all driven by the team filter below. Default view is league-wide.
Summary Statistics
| Mean scored | — |
| Mean allowed | — |
| StdDev scored | — |
| StdDev allowed | — |
| Correlation (home vs away score) | — |
| Sample size (games) | — |
Actual vs. Run Differential
How runs translated into wins. Teams above the cluster overperformed their runs differential (often called Pythagorean luck), while teams below underperformed. Hover for exact values.
Top Overachievers & Disappointments
The teams furthest from where the simulation said they'd land — a fast read of the Luck column on top of the main season summary above.
Top Overachievers
| # | Team | Actual | Sim | Luck |
|---|---|---|---|---|
| 1 | San Francisco Giants | 107 | 91.08 | +15.92 |
| 2 | Seattle Mariners | 90 | 77.66 | +12.34 |
| 3 | St. Louis Cardinals | 90 | 83.01 | +6.99 |
| 4 | Boston Red Sox | 92 | 85.17 | +6.83 |
| 5 | Milwaukee Brewers | 95 | 88.34 | +6.66 |
Biggest Disappointments
| # | Team | Actual | Sim | Luck |
|---|---|---|---|---|
| 1 | Arizona Diamondbacks | 52 | 65.79 | -13.79 |
| 2 | Washington Nationals | 65 | 77.19 | -12.19 |
| 3 | Baltimore Orioles | 52 | 62.92 | -10.92 |
| 4 | Miami Marlins | 67 | 74.91 | -7.91 |
| 5 | Chicago Cubs | 71 | 78.63 | -7.63 |
Top Streaks
Ranked by model unlikelihood — the product of pregame W/L probabilities over the games in each team's streak. A short streak by a poor team can outrank a longer one by a strong team since the poor team's per-game probabilities were lower going in.
Longest Winning Streaks
| # | Team | Games | Dates | Probability |
|---|---|---|---|---|
| 1 | St. Louis Cardinals | 17 | Sep 11 – Sep 28 | 1 in 118,336 |
| 2 | New York Yankees | 13 | Aug 14 – Aug 27 | 1 in 3,931 |
| 3 | Oakland Athletics | 13 | Apr 9 – Apr 24 | 1 in 3,829 |
| 4 | Boston Red Sox | 9 | Apr 5 – Apr 14 | 1 in 923 |
| 5 | Tampa Bay Rays | 11 | May 13 – May 24 | 1 in 587 |
Longest Losing Streaks
| # | Team | Games | Dates | Probability |
|---|---|---|---|---|
| 1 | Arizona Diamondbacks | 17 | Jun 2 – Jun 20 | 1 in 3,648 |
| 2 | Baltimore Orioles | 19 | Aug 3 – Aug 24 | 1 in 3,032 |
| 3 | Kansas City Royals | 11 | May 2 – May 13 | 1 in 1,524 |
| 4 | Chicago Cubs | 12 | Aug 5 – Aug 16 | 1 in 879 |
| 5 | New York Yankees | 7 | Sep 4 – Sep 10 | 1 in 551 |
Home-Field Advantage Edge
The simulation applies the same home-field boost to every game across the league, so the per-game home win probabilities bake in the model's idea of HFA. For each team, we add up those probabilities over home games and compare to actual home wins — and do the same on the road. The bar height is (home wins above expected) minus (road wins above expected). A tall positive bar means the team's home/road split exceeded what the model predicted — a real Coors-style edge. A tall negative bar means the reverse: they played worse at home or better on the road than expected.
Finish Position Heatmaps
Each cell is the probability — across 100,000 simulations — that the team (row) finished at that position (column). Use the buttons to switch between divisions, leagues, and the overall MLB view. Rows are sorted by the simulation's average finish (best at top).
| Team | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|
| Chicago White Sox | 77.69% | 17.52% | 3.79% | 0.88% | 0.12% |
| Cleveland Indians | 16.33% | 47.78% | 22.84% | 9.70% | 3.35% |
| Minnesota Twins | 3.99% | 20.81% | 36.44% | 24.86% | 13.90% |
| Kansas City Royals | 1.41% | 9.06% | 22.94% | 34.44% | 32.15% |
| Detroit Tigers | 0.58% | 4.83% | 13.99% | 30.12% | 50.48% |
| Team | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|
| Tampa Bay Rays | 65.94% | 21.51% | 8.77% | 3.77% | 0.01% |
| Toronto Blue Jays | 13.41% | 28.98% | 29.94% | 27.29% | 0.38% |
| New York Yankees | 12.44% | 28.23% | 30.45% | 28.43% | 0.45% |
| Boston Red Sox | 8.21% | 21.28% | 30.70% | 38.98% | 0.83% |
| Baltimore Orioles | — | — | 0.14% | 1.53% | 98.33% |
| Team | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|
| Houston Astros | 79.59% | 17.93% | 2.20% | 0.28% | — |
| Oakland Athletics | 18.14% | 61.63% | 15.75% | 4.04% | 0.44% |
| Seattle Mariners | 1.51% | 12.39% | 43.94% | 32.91% | 9.25% |
| Los Angeles Angels | 0.73% | 7.46% | 32.69% | 43.79% | 15.33% |
| Texas Rangers | 0.03% | 0.59% | 5.42% | 18.98% | 74.98% |
| Team | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|
| Milwaukee Brewers | 54.53% | 25.98% | 13.53% | 5.50% | 0.46% |
| St. Louis Cardinals | 19.23% | 29.60% | 29.04% | 19.42% | 2.71% |
| Cincinnati Reds | 19.18% | 28.64% | 28.83% | 20.71% | 2.64% |
| Chicago Cubs | 6.89% | 15.30% | 26.61% | 43.01% | 8.19% |
| Pittsburgh Pirates | 0.17% | 0.48% | 1.99% | 11.36% | 86.00% |
| Team | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|
| Atlanta Braves | 59.11% | 22.07% | 11.55% | 5.17% | 2.10% |
| Philadelphia Phillies | 14.82% | 26.25% | 24.99% | 19.94% | 14.00% |
| New York Mets | 14.85% | 25.64% | 24.27% | 20.46% | 14.78% |
| Washington Nationals | 7.34% | 15.92% | 21.80% | 28.00% | 26.94% |
| Miami Marlins | 3.88% | 10.12% | 17.39% | 26.43% | 42.18% |
| Team | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|
| Los Angeles Dodgers | 86.49% | 11.96% | 1.51% | 0.03% | 0.01% |
| San Francisco Giants | 11.44% | 63.89% | 22.90% | 1.65% | 0.12% |
| San Diego Padres | 2.06% | 23.00% | 64.79% | 9.27% | 0.88% |
| Colorado Rockies | 0.01% | 1.03% | 9.35% | 65.97% | 23.64% |
| Arizona Diamondbacks | — | 0.12% | 1.45% | 23.08% | 75.35% |
| Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Houston Astros | 35.28% | 24.35% | 15.96% | 10.63% | 5.97% | 3.68% | 2.16% | 1.07% | 0.54% | 0.24% | 0.08% | 0.03% | 0.01% | — | — |
| Tampa Bay Rays | 34.28% | 24.00% | 16.32% | 10.23% | 6.12% | 3.90% | 2.60% | 1.35% | 0.78% | 0.27% | 0.11% | 0.03% | 0.01% | — | — |
| Chicago White Sox | 12.99% | 16.73% | 17.88% | 15.58% | 12.68% | 9.02% | 6.35% | 4.13% | 2.37% | 1.30% | 0.69% | 0.19% | 0.07% | 0.01% | 0.01% |
| Oakland Athletics | 4.76% | 9.13% | 11.60% | 13.82% | 14.78% | 14.25% | 11.23% | 8.34% | 5.62% | 3.32% | 1.84% | 0.90% | 0.32% | 0.07% | 0.02% |
| Toronto Blue Jays | 4.62% | 8.38% | 11.62% | 13.90% | 14.28% | 13.17% | 11.10% | 9.14% | 6.29% | 3.96% | 2.10% | 0.84% | 0.44% | 0.13% | 0.03% |
| New York Yankees | 4.14% | 8.34% | 11.11% | 12.94% | 13.24% | 13.59% | 12.56% | 9.56% | 6.73% | 3.61% | 2.41% | 1.15% | 0.47% | 0.14% | 0.01% |
| Boston Red Sox | 2.71% | 5.48% | 7.81% | 10.44% | 13.27% | 13.89% | 13.73% | 11.23% | 8.74% | 6.24% | 3.48% | 1.86% | 0.89% | 0.19% | 0.04% |
| Cleveland Indians | 0.93% | 2.38% | 4.69% | 6.93% | 9.56% | 11.88% | 13.21% | 14.23% | 12.11% | 9.63% | 6.59% | 4.56% | 2.35% | 0.74% | 0.21% |
| Seattle Mariners | 0.11% | 0.55% | 1.31% | 2.14% | 3.56% | 5.58% | 8.34% | 11.51% | 14.19% | 15.28% | 14.14% | 10.36% | 7.33% | 4.21% | 1.39% |
| Minnesota Twins | 0.08% | 0.31% | 0.84% | 1.57% | 3.08% | 4.53% | 7.80% | 10.59% | 13.61% | 15.59% | 14.76% | 12.30% | 8.77% | 4.48% | 1.69% |
| Los Angeles Angels | 0.09% | 0.23% | 0.53% | 1.06% | 1.92% | 3.80% | 5.68% | 8.73% | 12.46% | 14.58% | 16.22% | 14.43% | 10.98% | 6.54% | 2.75% |
| Kansas City Royals | 0.01% | 0.10% | 0.21% | 0.55% | 1.03% | 1.67% | 3.20% | 5.46% | 8.54% | 12.11% | 15.24% | 18.41% | 16.21% | 11.86% | 5.40% |
| Detroit Tigers | — | 0.01% | 0.08% | 0.14% | 0.42% | 0.81% | 1.52% | 3.29% | 5.36% | 8.07% | 12.52% | 17.33% | 20.79% | 19.08% | 10.58% |
| Texas Rangers | — | 0.01% | 0.04% | 0.07% | 0.08% | 0.19% | 0.42% | 1.04% | 2.10% | 4.49% | 7.23% | 11.76% | 20.19% | 28.30% | 24.08% |
| Baltimore Orioles | — | — | — | — | 0.01% | 0.04% | 0.10% | 0.33% | 0.56% | 1.31% | 2.59% | 5.85% | 11.17% | 24.25% | 53.79% |
| Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Los Angeles Dodgers | 79.88% | 13.01% | 4.08% | 1.70% | 0.70% | 0.33% | 0.14% | 0.07% | 0.04% | 0.02% | 0.01% | 0.01% | — | 0.01% | — |
| San Francisco Giants | 9.59% | 29.12% | 19.95% | 14.00% | 9.21% | 6.19% | 4.65% | 3.16% | 2.07% | 1.11% | 0.54% | 0.20% | 0.17% | 0.04% | — |
| Milwaukee Brewers | 4.03% | 17.92% | 17.90% | 15.81% | 12.69% | 9.79% | 7.05% | 5.36% | 3.81% | 2.44% | 1.70% | 0.90% | 0.39% | 0.17% | 0.04% |
| Atlanta Braves | 2.79% | 14.87% | 17.16% | 14.85% | 12.82% | 10.15% | 8.15% | 6.34% | 4.82% | 3.65% | 2.16% | 1.39% | 0.62% | 0.20% | 0.03% |
| San Diego Padres | 1.54% | 8.02% | 10.70% | 11.95% | 12.66% | 11.68% | 11.32% | 9.09% | 8.00% | 6.10% | 4.19% | 2.57% | 1.52% | 0.56% | 0.10% |
| St. Louis Cardinals | 0.73% | 5.04% | 8.05% | 9.80% | 11.39% | 11.91% | 11.27% | 10.39% | 9.30% | 8.03% | 5.99% | 4.27% | 2.24% | 1.19% | 0.40% |
| Cincinnati Reds | 0.77% | 5.02% | 7.86% | 9.60% | 11.06% | 11.23% | 11.39% | 10.51% | 10.08% | 7.65% | 6.44% | 4.14% | 2.77% | 1.10% | 0.38% |
| Philadelphia Phillies | 0.28% | 2.19% | 4.30% | 6.16% | 7.73% | 9.71% | 10.18% | 11.47% | 11.27% | 10.95% | 9.67% | 7.65% | 5.25% | 2.33% | 0.86% |
| New York Mets | 0.20% | 2.06% | 4.06% | 6.69% | 7.70% | 9.50% | 10.14% | 10.86% | 10.81% | 10.88% | 9.82% | 8.04% | 5.69% | 2.65% | 0.90% |
| Chicago Cubs | 0.10% | 1.44% | 2.95% | 4.03% | 5.67% | 7.41% | 9.29% | 10.27% | 11.74% | 11.50% | 11.43% | 11.26% | 7.29% | 4.13% | 1.49% |
| Washington Nationals | 0.09% | 0.83% | 1.87% | 3.05% | 4.31% | 5.95% | 7.73% | 9.16% | 10.49% | 12.51% | 12.93% | 12.32% | 10.36% | 6.00% | 2.40% |
| Miami Marlins | — | 0.34% | 0.71% | 1.61% | 2.57% | 3.77% | 4.94% | 7.40% | 8.49% | 11.89% | 13.42% | 15.26% | 14.98% | 9.67% | 4.95% |
| Colorado Rockies | — | 0.13% | 0.35% | 0.68% | 1.32% | 1.95% | 2.96% | 4.53% | 6.27% | 8.38% | 12.49% | 16.13% | 19.20% | 16.12% | 9.49% |
| Pittsburgh Pirates | — | 0.01% | 0.05% | 0.05% | 0.11% | 0.26% | 0.41% | 0.72% | 1.46% | 2.55% | 4.75% | 8.34% | 15.01% | 28.97% | 37.31% |
| Arizona Diamondbacks | — | — | 0.01% | 0.02% | 0.06% | 0.17% | 0.38% | 0.67% | 1.35% | 2.34% | 4.46% | 7.52% | 14.51% | 26.86% | 41.65% |
| Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Los Angeles Dodgers | 55.67% | 20.36% | 9.93% | 5.10% | 3.07% | 2.21% | 1.21% | 0.80% | 0.51% | 0.41% | 0.26% | 0.14% | 0.09% | 0.07% | 0.05% | 0.02% | 0.06% | — | 0.01% | 0.01% | — | 0.01% | 0.01% | — | — | — | — | — | — | — |
| Houston Astros | 14.63% | 20.14% | 15.96% | 11.67% | 9.68% | 7.08% | 5.57% | 3.69% | 3.09% | 2.39% | 1.61% | 1.23% | 0.86% | 0.64% | 0.62% | 0.41% | 0.26% | 0.18% | 0.12% | 0.06% | 0.04% | 0.04% | 0.02% | — | 0.01% | — | — | — | — | — |
| Tampa Bay Rays | 13.07% | 19.81% | 15.97% | 12.88% | 8.91% | 7.07% | 5.76% | 4.01% | 2.91% | 2.37% | 1.80% | 1.42% | 1.13% | 0.84% | 0.64% | 0.49% | 0.33% | 0.22% | 0.18% | 0.07% | 0.04% | 0.03% | 0.01% | 0.01% | 0.02% | 0.01% | — | — | — | — |
| Chicago White Sox | 3.99% | 8.89% | 10.56% | 10.34% | 9.72% | 8.67% | 8.72% | 7.37% | 5.85% | 4.99% | 3.97% | 3.78% | 3.03% | 2.40% | 1.92% | 1.62% | 1.15% | 0.90% | 0.74% | 0.55% | 0.34% | 0.24% | 0.13% | 0.07% | 0.02% | 0.03% | 0.01% | — | — | — |
| San Francisco Giants | 4.58% | 8.05% | 10.04% | 10.73% | 10.40% | 8.84% | 8.11% | 7.17% | 6.11% | 5.19% | 4.14% | 3.34% | 2.80% | 2.47% | 2.20% | 1.69% | 1.31% | 0.87% | 0.71% | 0.44% | 0.30% | 0.19% | 0.13% | 0.09% | 0.05% | 0.05% | — | — | — | — |
| Milwaukee Brewers | 1.58% | 4.05% | 6.26% | 7.10% | 7.88% | 7.91% | 7.94% | 7.61% | 7.18% | 6.71% | 5.95% | 5.59% | 4.42% | 4.05% | 3.55% | 2.66% | 2.43% | 1.77% | 1.37% | 1.19% | 0.95% | 0.59% | 0.48% | 0.29% | 0.25% | 0.15% | 0.06% | 0.03% | — | — |
| Oakland Athletics | 1.35% | 3.41% | 5.23% | 6.10% | 7.03% | 7.63% | 7.17% | 7.00% | 7.24% | 6.78% | 6.58% | 5.68% | 5.02% | 4.97% | 3.94% | 3.24% | 2.77% | 2.19% | 1.75% | 1.51% | 1.13% | 0.80% | 0.65% | 0.36% | 0.21% | 0.15% | 0.08% | 0.01% | 0.02% | — |
| Atlanta Braves | 1.23% | 3.29% | 5.18% | 6.41% | 6.76% | 7.34% | 7.21% | 7.52% | 7.12% | 6.58% | 5.80% | 5.44% | 5.12% | 4.42% | 4.16% | 3.42% | 2.98% | 2.63% | 1.96% | 1.49% | 1.24% | 1.05% | 0.61% | 0.41% | 0.32% | 0.20% | 0.07% | 0.03% | 0.01% | — |
| Toronto Blue Jays | 1.15% | 3.36% | 4.59% | 6.04% | 6.81% | 7.18% | 7.14% | 7.16% | 6.79% | 6.64% | 6.17% | 5.63% | 5.51% | 4.71% | 3.95% | 3.72% | 3.40% | 2.68% | 2.05% | 1.61% | 1.08% | 0.93% | 0.50% | 0.57% | 0.20% | 0.22% | 0.09% | 0.06% | 0.06% | — |
| New York Yankees | 0.93% | 2.62% | 4.96% | 5.77% | 6.47% | 7.14% | 6.52% | 6.68% | 6.87% | 6.54% | 6.03% | 6.07% | 5.84% | 5.25% | 4.23% | 3.95% | 3.23% | 2.74% | 1.95% | 1.72% | 1.41% | 1.10% | 0.74% | 0.52% | 0.29% | 0.23% | 0.12% | 0.07% | 0.01% | — |
| Boston Red Sox | 0.56% | 1.61% | 2.85% | 4.00% | 4.74% | 5.30% | 5.64% | 6.43% | 6.47% | 6.94% | 6.33% | 6.49% | 6.09% | 5.34% | 5.78% | 4.67% | 4.14% | 3.58% | 2.96% | 2.71% | 2.19% | 1.71% | 1.26% | 0.84% | 0.65% | 0.45% | 0.16% | 0.03% | 0.06% | 0.02% |
| San Diego Padres | 0.55% | 1.43% | 2.40% | 3.39% | 4.53% | 4.44% | 5.53% | 5.81% | 6.14% | 6.36% | 6.67% | 6.09% | 6.45% | 5.92% | 5.32% | 5.16% | 4.89% | 4.10% | 3.44% | 3.06% | 2.27% | 1.91% | 1.42% | 1.03% | 0.67% | 0.57% | 0.28% | 0.13% | 0.03% | 0.01% |
| St. Louis Cardinals | 0.19% | 0.77% | 1.34% | 2.15% | 2.77% | 3.75% | 4.41% | 4.78% | 5.40% | 5.83% | 6.18% | 6.12% | 6.04% | 6.35% | 6.27% | 5.65% | 5.15% | 5.04% | 4.78% | 3.71% | 3.59% | 2.65% | 2.36% | 1.55% | 1.23% | 0.84% | 0.49% | 0.38% | 0.19% | 0.04% |
| Cincinnati Reds | 0.19% | 0.79% | 1.43% | 2.36% | 2.71% | 3.46% | 4.14% | 4.94% | 5.06% | 5.59% | 5.71% | 6.05% | 6.27% | 6.13% | 6.24% | 5.83% | 5.51% | 5.19% | 4.51% | 3.81% | 3.39% | 2.87% | 2.31% | 2.23% | 1.36% | 0.82% | 0.56% | 0.38% | 0.11% | 0.05% |
| Cleveland Indians | 0.18% | 0.60% | 1.31% | 2.03% | 2.58% | 3.24% | 3.90% | 4.29% | 5.26% | 5.38% | 5.70% | 5.63% | 5.91% | 6.12% | 6.02% | 5.98% | 5.58% | 5.47% | 4.93% | 4.43% | 3.77% | 3.17% | 2.79% | 1.99% | 1.50% | 1.00% | 0.63% | 0.38% | 0.18% | 0.05% |
| Philadelphia Phillies | 0.02% | 0.28% | 0.52% | 0.93% | 1.27% | 1.90% | 2.55% | 2.93% | 3.60% | 3.92% | 4.89% | 5.08% | 5.40% | 5.82% | 5.82% | 5.72% | 6.15% | 6.35% | 5.97% | 5.80% | 5.54% | 4.73% | 4.14% | 3.34% | 2.76% | 2.15% | 1.16% | 0.73% | 0.40% | 0.13% |
| New York Mets | 0.07% | 0.19% | 0.54% | 0.91% | 1.34% | 2.04% | 2.33% | 3.18% | 3.53% | 3.83% | 4.59% | 5.19% | 5.49% | 5.16% | 5.81% | 5.58% | 6.52% | 6.29% | 5.93% | 5.68% | 5.36% | 4.63% | 4.33% | 3.54% | 2.99% | 2.13% | 1.31% | 0.87% | 0.46% | 0.18% |
| Chicago Cubs | 0.01% | 0.13% | 0.24% | 0.62% | 0.87% | 1.36% | 1.49% | 2.18% | 2.31% | 3.06% | 3.45% | 4.00% | 4.36% | 5.05% | 5.40% | 5.97% | 5.96% | 6.48% | 6.69% | 6.47% | 6.02% | 6.31% | 5.45% | 4.59% | 3.79% | 3.10% | 1.99% | 1.56% | 0.80% | 0.29% |
| Seattle Mariners | 0.02% | 0.05% | 0.16% | 0.52% | 0.73% | 0.80% | 1.12% | 1.52% | 1.83% | 2.44% | 2.88% | 3.31% | 3.63% | 4.54% | 4.83% | 5.99% | 5.70% | 6.42% | 6.79% | 7.07% | 6.82% | 6.50% | 5.83% | 5.51% | 4.61% | 4.01% | 2.87% | 1.90% | 1.05% | 0.55% |
| Washington Nationals | — | 0.07% | 0.18% | 0.27% | 0.59% | 0.82% | 1.06% | 1.38% | 1.89% | 2.03% | 2.89% | 3.10% | 3.92% | 3.93% | 4.51% | 5.36% | 6.08% | 6.00% | 6.64% | 6.87% | 6.78% | 6.27% | 6.56% | 6.33% | 5.14% | 4.05% | 3.28% | 2.14% | 1.31% | 0.55% |
| Minnesota Twins | 0.01% | 0.03% | 0.17% | 0.30% | 0.44% | 0.68% | 0.83% | 1.14% | 1.60% | 1.97% | 2.63% | 3.11% | 3.32% | 4.31% | 4.54% | 5.24% | 5.49% | 5.98% | 6.84% | 7.04% | 6.85% | 7.05% | 6.76% | 5.88% | 5.75% | 4.52% | 3.28% | 2.33% | 1.31% | 0.60% |
| Los Angeles Angels | 0.02% | 0.05% | 0.07% | 0.18% | 0.26% | 0.45% | 0.64% | 0.78% | 1.10% | 1.38% | 1.62% | 2.42% | 2.68% | 3.09% | 4.06% | 4.69% | 5.07% | 5.66% | 6.44% | 6.67% | 7.57% | 7.40% | 7.17% | 7.18% | 6.52% | 5.66% | 4.76% | 3.05% | 2.28% | 1.08% |
| Miami Marlins | — | 0.01% | 0.06% | 0.11% | 0.22% | 0.35% | 0.38% | 0.75% | 0.94% | 1.11% | 1.63% | 2.08% | 2.45% | 2.98% | 3.37% | 3.91% | 4.66% | 5.42% | 5.81% | 6.80% | 7.04% | 7.66% | 7.71% | 7.92% | 7.20% | 6.46% | 4.90% | 4.04% | 2.73% | 1.30% |
| Kansas City Royals | — | 0.01% | 0.03% | 0.04% | 0.11% | 0.19% | 0.28% | 0.39% | 0.53% | 0.58% | 0.99% | 1.07% | 1.44% | 2.00% | 2.16% | 3.25% | 3.55% | 4.03% | 5.01% | 5.60% | 6.28% | 7.72% | 8.28% | 8.59% | 9.03% | 8.19% | 7.62% | 5.96% | 4.60% | 2.47% |
| Colorado Rockies | — | — | 0.02% | 0.05% | 0.07% | 0.06% | 0.18% | 0.31% | 0.45% | 0.57% | 0.93% | 1.09% | 1.45% | 1.67% | 2.15% | 2.52% | 3.37% | 3.85% | 4.43% | 5.12% | 6.28% | 7.50% | 8.10% | 8.42% | 8.63% | 9.43% | 8.22% | 7.07% | 4.91% | 3.15% |
| Detroit Tigers | — | — | — | — | 0.03% | 0.05% | 0.10% | 0.11% | 0.16% | 0.25% | 0.40% | 0.55% | 0.80% | 1.01% | 1.35% | 1.77% | 2.09% | 2.59% | 3.46% | 4.33% | 5.06% | 6.09% | 7.19% | 8.43% | 9.82% | 10.14% | 10.49% | 9.72% | 8.54% | 5.47% |
| Texas Rangers | — | — | — | — | 0.01% | 0.03% | 0.05% | 0.03% | 0.01% | 0.07% | 0.08% | 0.13% | 0.19% | 0.28% | 0.37% | 0.57% | 0.74% | 1.32% | 1.44% | 2.31% | 2.74% | 3.39% | 4.79% | 6.55% | 8.19% | 10.59% | 13.03% | 14.74% | 14.26% | 14.09% |
| Pittsburgh Pirates | — | — | — | — | — | 0.01% | 0.01% | 0.03% | 0.04% | 0.04% | 0.06% | 0.09% | 0.15% | 0.26% | 0.30% | 0.38% | 0.70% | 0.87% | 1.31% | 1.72% | 2.63% | 3.14% | 4.31% | 5.66% | 7.81% | 8.99% | 12.69% | 15.46% | 16.61% | 16.73% |
| Arizona Diamondbacks | — | — | — | — | — | — | 0.01% | 0.01% | — | 0.05% | 0.04% | 0.05% | 0.12% | 0.20% | 0.29% | 0.43% | 0.48% | 0.89% | 1.29% | 1.55% | 2.14% | 2.99% | 3.80% | 5.18% | 6.95% | 9.47% | 12.27% | 14.98% | 18.79% | 18.02% |
| Baltimore Orioles | — | — | — | — | — | — | — | — | 0.01% | — | 0.02% | 0.03% | 0.02% | 0.02% | 0.15% | 0.11% | 0.25% | 0.29% | 0.49% | 0.60% | 1.15% | 1.33% | 2.16% | 2.92% | 4.03% | 6.39% | 9.58% | 13.95% | 21.28% | 35.22% |
Win Totals in Context
How did each team's actual results compare to their simulated results, Elo rating, average opponent Elo, and percentile within simulated outcomes? Use the buttons to switch between views. In each chart, dashed crosshairs at the league means split the plot into four quadrants: pastel green (team did well, model agreed), pastel red (team did poorly, model agreed), and pastel yellow (model and reality disagreed). Click a division in the legend to toggle it.
Playoff Seed Probabilities
Across the 10,000 regular-season simulations, the probability that each team finished as each playoff seed (or missed the playoffs entirely). Rows sorted by likelihood of earning the top seed; teams that more often missed the playoffs sit toward the bottom.
| Team | 1 Seed | 2 Seed | 3 Seed | 4 Seed | 5 Seed | Missed Playoffs |
|---|---|---|---|---|---|---|
| Houston Astros | 35.28% | 29.12% | 15.19% | 7.72% | 5.04% | 7.65% |
| Tampa Bay Rays | 34.29% | 22.94% | 8.71% | 15.63% | 8.53% | 9.90% |
| Chicago White Sox | 12.99% | 20.53% | 44.17% | 2.12% | 3.37% | 16.82% |
| Oakland Athletics | 4.76% | 8.06% | 5.32% | 17.42% | 16.41% | 48.03% |
| Toronto Blue Jays | 4.61% | 5.59% | 3.21% | 18.52% | 17.92% | 50.15% |
| New York Yankees | 4.13% | 5.54% | 2.77% | 18.26% | 16.70% | 52.60% |
| Boston Red Sox | 2.72% | 3.60% | 1.89% | 12.63% | 16.17% | 62.99% |
| Cleveland Indians | 0.93% | 3.04% | 12.36% | 3.89% | 6.96% | 72.82% |
| Seattle Mariners | 0.11% | 0.59% | 0.81% | 1.88% | 3.55% | 93.06% |
| Los Angeles Angels | 0.09% | 0.25% | 0.39% | 0.76% | 2.00% | 96.51% |
| Minnesota Twins | 0.08% | 0.56% | 3.35% | 0.78% | 2.35% | 92.88% |
| Kansas City Royals | 0.01% | 0.16% | 1.24% | 0.25% | 0.65% | 97.69% |
| Detroit Tigers | — | 0.02% | 0.56% | 0.05% | 0.28% | 99.09% |
| Texas Rangers | — | — | 0.03% | 0.09% | 0.06% | 99.82% |
| Baltimore Orioles | — | — | — | — | 0.01% | 99.99% |
| Team | 1 Seed | 2 Seed | 3 Seed | 4 Seed | 5 Seed | Missed Playoffs |
|---|---|---|---|---|---|---|
| Los Angeles Dodgers | 79.88% | 5.84% | 0.77% | 11.07% | 1.67% | 0.77% |
| San Francisco Giants | 9.59% | 1.61% | 0.24% | 52.21% | 16.54% | 19.81% |
| Milwaukee Brewers | 4.03% | 31.02% | 19.48% | 3.96% | 9.94% | 31.57% |
| Atlanta Braves | 2.79% | 26.17% | 30.15% | 1.90% | 5.87% | 33.12% |
| San Diego Padres | 1.54% | 0.40% | 0.12% | 17.28% | 22.09% | 58.57% |
| Cincinnati Reds | 0.77% | 9.70% | 8.71% | 3.60% | 10.30% | 66.92% |
| St. Louis Cardinals | 0.73% | 9.92% | 8.58% | 3.64% | 10.60% | 66.53% |
| Philadelphia Phillies | 0.28% | 4.82% | 9.72% | 1.64% | 5.66% | 77.88% |
| New York Mets | 0.20% | 4.50% | 10.15% | 1.66% | 6.09% | 77.40% |
| Chicago Cubs | 0.10% | 3.22% | 3.57% | 1.43% | 4.86% | 86.82% |
| Washington Nationals | 0.09% | 1.93% | 5.32% | 0.76% | 3.14% | 88.76% |
| Miami Marlins | — | 0.81% | 3.07% | 0.36% | 1.71% | 94.05% |
| Colorado Rockies | — | 0.01% | — | 0.45% | 1.41% | 98.13% |
| Pittsburgh Pirates | — | 0.05% | 0.12% | 0.02% | 0.07% | 99.74% |
| Arizona Diamondbacks | — | — | — | 0.02% | 0.05% | 99.93% |
Wins Required to Achieve Each Seed
Empirical cumulative distribution: for each seed in each league, the probability that a team holding that seed finished the regular season with at most a given number of wins. The point where each line passes through 50% is roughly the median wins for that seed.
Season Trends
How each metric evolved across the season — Elo rating, actual wins, simulated final wins, playoff probability, and division-title probability — day by day. Pick a division to see all five charts for its teams.
Elo Through the Playoffs
How each playoff team's Elo rating evolved as the postseason unfolded. Elo Progression traces every team's game-by-game Elo trajectory through their playoff run — teams eliminated early have short lines, deeper runs extend further right; click a team in the legend to isolate it. Net Elo Change summarizes the same data as one bar per team from first playoff game to last, sorted biggest gain to biggest loss.
Stochastic Playoff Outcomes
Across 10,000 simulations starting from preseason Elo, every team had a chance to make the playoffs based on how the regular-season Monte Carlo played out. The default view sums those simulations up: what fraction of them had each team making the playoffs, advancing each round, and winning the title. The round buttons switch to heatmaps showing how often every pair of teams faced off in each round across all sims.
| Team | Made Playoffs | Advanced to LDS | Advanced to LCS | Advanced to World Series | Won World Series |
|---|---|---|---|---|---|
| Los Angeles Dodgers | 95.05% | 95.05% | 64.88% | 48.39% | 32.35% |
| Tampa Bay Rays | 80.48% | 80.48% | 51.94% | 33.06% | 16.74% |
| Houston Astros | 86.37% | 86.37% | 47.41% | 24.33% | 10.20% |
| San Francisco Giants | 68.75% | 55.82% | 25.35% | 16.54% | 9.60% |
| Atlanta Braves | 63.05% | 63.05% | 36.80% | 14.37% | 7.04% |
| Chicago White Sox | 80.24% | 80.24% | 36.27% | 15.24% | 5.72% |
| Milwaukee Brewers | 60.95% | 60.95% | 30.43% | 9.94% | 4.58% |
| Toronto Blue Jays | 36.44% | 33.04% | 16.87% | 9.11% | 4.16% |
| New York Yankees | 34.96% | 30.11% | 13.26% | 6.26% | 2.18% |
| St. Louis Cardinals | 25.49% | 25.49% | 11.85% | 3.90% | 1.76% |
| Oakland Athletics | 33.96% | 33.96% | 14.03% | 5.26% | 1.70% |
| Boston Red Sox | 28.80% | 21.74% | 9.33% | 3.66% | 0.99% |
| Cincinnati Reds | 24.72% | 24.72% | 9.41% | 2.34% | 0.79% |
| Cleveland Indians | 20.72% | 20.72% | 6.79% | 2.03% | 0.62% |
| Philadelphia Phillies | 17.78% | 17.78% | 6.52% | 1.47% | 0.55% |
| San Diego Padres | 39.37% | 16.51% | 3.46% | 1.20% | 0.35% |
| New York Mets | 17.56% | 17.56% | 5.55% | 0.94% | 0.23% |
| Seattle Mariners | 5.43% | 3.79% | 1.48% | 0.55% | 0.17% |
| Minnesota Twins | 5.19% | 5.19% | 1.54% | 0.35% | 0.09% |
| Washington Nationals | 8.69% | 8.69% | 2.01% | 0.31% | 0.07% |
| Miami Marlins | 4.57% | 4.57% | 1.28% | 0.23% | 0.03% |
| Chicago Cubs | 8.82% | 8.82% | 2.23% | 0.33% | 0.03% |
| Detroit Tigers | 0.77% | 0.77% | 0.20% | 0.05% | 0.02% |
| Los Angeles Angels | 2.76% | 1.82% | 0.44% | 0.04% | 0.01% |
| Kansas City Royals | 1.68% | 1.68% | 0.42% | 0.06% | 0.01% |
| Colorado Rockies | 1.86% | 0.75% | 0.17% | 0.04% | 0.01% |
| Pittsburgh Pirates | 0.20% | 0.20% | 0.06% | — | — |
| Texas Rangers | 0.15% | 0.09% | 0.02% | — | — |
| Baltimore Orioles | 0.01% | — | — | — | — |
| Arizona Diamondbacks | 0.07% | 0.04% | — | — | — |
Loser → ↓ Winner | Baltimore Orioles | Boston Red Sox | Chicago White Sox | Cleveland Indians | Detroit Tigers | Houston Astros | Kansas City Royals | Los Angeles Angels | Minnesota Twins | New York Yankees | Oakland Athletics | Seattle Mariners | Tampa Bay Rays | Texas Rangers | Toronto Blue Jays |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Boston Red Sox | 0.39% | 0.84% | 0.02% | 0.93% | 0.06% | 0.24% | 0.22% | 2.90% | 3.07% | 0.41% | 1.52% | 0.02% | 2.91% | ||
| Chicago White Sox | 0.32% | 0.02% | 0.16% | 0.02% | 0.05% | 0.04% | 0.52% | 0.49% | 0.09% | 0.34% | 0.50% | ||||
| Cleveland Indians | 0.90% | 0.02% | 0.01% | 0.27% | 0.02% | 0.08% | 0.04% | 0.83% | 0.77% | 0.15% | 0.55% | 0.75% | |||
| Detroit Tigers | 0.02% | 0.01% | 0.02% | 0.01% | 0.05% | 0.02% | 0.01% | 0.03% | 0.02% | ||||||
| Houston Astros | 1.19% | 0.22% | 0.57% | 0.05% | 0.11% | 0.15% | 1.49% | 0.12% | 0.22% | 1.04% | 1.62% | ||||
| Kansas City Royals | 0.02% | 0.02% | 0.02% | 0.04% | 0.06% | 0.02% | 0.04% | 0.05% | |||||||
| Los Angeles Angels | 0.18% | 0.03% | 0.09% | 0.06% | 0.13% | 0.21% | 0.03% | 0.13% | 0.01% | 0.22% | |||||
| Minnesota Twins | 0.21% | 0.02% | 0.05% | 0.12% | 0.01% | 0.02% | 0.22% | 0.17% | 0.09% | 0.01% | 0.28% | ||||
| New York Yankees | 3.24% | 0.56% | 1.11% | 0.06% | 1.19% | 0.19% | 0.31% | 0.39% | 4.01% | 0.59% | 1.55% | 0.02% | 4.45% | ||
| Oakland Athletics | 3.21% | 0.49% | 1.17% | 0.05% | 0.06% | 0.24% | 0.29% | 3.92% | 0.50% | 2.39% | 3.50% | ||||
| Seattle Mariners | 0.35% | 0.04% | 0.15% | 0.14% | 0.01% | 0.02% | 0.05% | 0.42% | 0.39% | 0.36% | 0.35% | ||||
| Tampa Bay Rays | 0.01% | 2.05% | 0.55% | 0.99% | 1.31% | 0.12% | 0.24% | 0.29% | 2.37% | 3.98% | 0.46% | 0.01% | 2.16% | ||
| Texas Rangers | 0.03% | 0.01% | 0.02% | ||||||||||||
| Toronto Blue Jays | 3.55% | 0.61% | 1.43% | 0.05% | 1.73% | 0.09% | 0.35% | 0.46% | 4.39% | 4.70% | 0.67% | 1.58% | 0.02% |
Loser → ↓ Winner | Arizona Diamondbacks | Atlanta Braves | Chicago Cubs | Cincinnati Reds | Colorado Rockies | Los Angeles Dodgers | Miami Marlins | Milwaukee Brewers | New York Mets | Philadelphia Phillies | Pittsburgh Pirates | San Diego Padres | San Francisco Giants | St. Louis Cardinals | Washington Nationals |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arizona Diamondbacks | 0.01% | 0.01% | 0.01% | 0.01% | |||||||||||
| Atlanta Braves | 0.01% | 0.09% | 0.10% | 0.04% | 0.36% | 0.01% | 0.12% | 0.09% | 0.05% | 0.75% | 2.10% | 0.16% | 0.06% | ||
| Chicago Cubs | 0.02% | 0.12% | 0.01% | 0.17% | 0.01% | 0.10% | 0.07% | 0.11% | 0.30% | 0.87% | 0.13% | 0.02% | |||
| Cincinnati Reds | 0.17% | 0.17% | 0.07% | 0.31% | 0.06% | 0.17% | 0.23% | 0.11% | 1.16% | 2.68% | 0.30% | 0.11% | |||
| Colorado Rockies | 0.03% | 0.03% | 0.06% | 0.03% | 0.01% | 0.02% | 0.01% | 0.02% | 0.10% | 0.42% | 0.01% | ||||
| Los Angeles Dodgers | 0.44% | 0.40% | 0.96% | 0.12% | 0.13% | 0.94% | 0.48% | 0.52% | 0.01% | 2.58% | 0.75% | 0.97% | 0.26% | ||
| Miami Marlins | 0.03% | 0.02% | 0.06% | 0.02% | 0.03% | 0.03% | 0.14% | 0.31% | 0.03% | 0.02% | |||||
| Milwaukee Brewers | 0.01% | 0.13% | 0.22% | 0.25% | 0.04% | 0.47% | 0.03% | 0.21% | 0.15% | 1.35% | 3.30% | 0.22% | 0.04% | ||
| New York Mets | 0.08% | 0.05% | 0.17% | 0.02% | 0.19% | 0.01% | 0.15% | 0.06% | 0.48% | 1.31% | 0.11% | 0.08% | |||
| Philadelphia Phillies | 0.06% | 0.09% | 0.19% | 0.02% | 0.28% | 0.02% | 0.13% | 0.08% | 0.53% | 1.42% | 0.11% | 0.03% | |||
| Pittsburgh Pirates | 0.01% | 0.01% | 0.01% | ||||||||||||
| San Diego Padres | 0.39% | 0.50% | 0.99% | 0.12% | 1.20% | 0.18% | 1.06% | 0.62% | 0.47% | 0.01% | 7.54% | 1.01% | 0.36% | ||
| San Francisco Giants | 0.01% | 2.34% | 2.47% | 5.12% | 0.62% | 0.50% | 0.89% | 4.47% | 2.98% | 2.61% | 0.04% | 16.03% | 4.85% | 1.45% | |
| St. Louis Cardinals | 0.10% | 0.29% | 0.36% | 0.05% | 0.50% | 0.03% | 0.20% | 0.21% | 0.20% | 1.24% | 2.97% | 0.11% | |||
| Washington Nationals | 0.03% | 0.02% | 0.04% | 0.01% | 0.11% | 0.09% | 0.02% | 0.01% | 0.25% | 0.68% | 0.09% |
Loser → ↓ Winner | Boston Red Sox | Chicago White Sox | Cleveland Indians | Detroit Tigers | Houston Astros | Kansas City Royals | Los Angeles Angels | Minnesota Twins | New York Yankees | Oakland Athletics | Seattle Mariners | Tampa Bay Rays | Texas Rangers | Toronto Blue Jays |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Boston Red Sox | 2.26% | 0.61% | 0.02% | 2.26% | 0.07% | 0.05% | 0.15% | 0.49% | 0.58% | 0.02% | 2.42% | 0.40% | ||
| Chicago White Sox | 2.31% | 0.76% | 0.01% | 12.60% | 0.05% | 0.39% | 0.14% | 3.35% | 5.34% | 0.59% | 7.28% | 3.45% | ||
| Cleveland Indians | 0.38% | 0.55% | 2.52% | 0.04% | 0.02% | 0.61% | 0.86% | 0.10% | 1.29% | 0.01% | 0.41% | |||
| Detroit Tigers | 0.05% | 0.09% | 0.01% | 0.02% | 0.03% | |||||||||
| Houston Astros | 3.41% | 15.34% | 5.00% | 0.23% | 0.48% | 0.32% | 1.54% | 3.97% | 6.03% | 0.59% | 6.23% | 0.02% | 4.25% | |
| Kansas City Royals | 0.04% | 0.01% | 0.16% | 0.04% | 0.05% | 0.01% | 0.05% | 0.06% | ||||||
| Los Angeles Angels | 0.02% | 0.13% | 0.02% | 0.10% | 0.03% | 0.02% | 0.12% | |||||||
| Minnesota Twins | 0.05% | 0.05% | 0.60% | 0.02% | 0.08% | 0.25% | 0.03% | 0.36% | 0.10% | |||||
| New York Yankees | 0.46% | 3.26% | 0.95% | 0.01% | 3.53% | 0.09% | 0.04% | 0.12% | 0.69% | 0.05% | 3.40% | 0.01% | 0.65% | |
| Oakland Athletics | 0.43% | 3.89% | 1.37% | 0.06% | 3.89% | 0.11% | 0.04% | 0.36% | 0.71% | 0.08% | 2.41% | 0.68% | ||
| Seattle Mariners | 0.03% | 0.56% | 0.09% | 0.01% | 0.36% | 0.06% | 0.03% | 0.03% | 0.26% | 0.05% | ||||
| Tampa Bay Rays | 4.60% | 13.78% | 4.19% | 0.18% | 8.82% | 0.35% | 0.46% | 0.97% | 6.64% | 5.05% | 0.75% | 0.03% | 6.12% | |
| Texas Rangers | 0.01% | 0.01% | ||||||||||||
| Toronto Blue Jays | 0.63% | 4.13% | 0.94% | 0.05% | 4.02% | 0.11% | 0.02% | 0.29% | 0.89% | 1.01% | 0.09% | 4.69% |
Loser → ↓ Winner | Arizona Diamondbacks | Atlanta Braves | Chicago Cubs | Cincinnati Reds | Colorado Rockies | Los Angeles Dodgers | Miami Marlins | Milwaukee Brewers | New York Mets | Philadelphia Phillies | Pittsburgh Pirates | San Diego Padres | San Francisco Giants | St. Louis Cardinals | Washington Nationals |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Atlanta Braves | 2.89% | 6.82% | 0.01% | 2.19% | 0.05% | 17.03% | 0.10% | 0.11% | 0.09% | 0.40% | 0.88% | 6.13% | 0.10% | ||
| Chicago Cubs | 0.85% | 0.03% | 0.13% | 0.14% | 0.05% | 0.37% | 0.35% | 0.03% | 0.03% | 0.25% | |||||
| Cincinnati Reds | 3.35% | 0.03% | 1.19% | 0.53% | 0.19% | 1.46% | 1.45% | 0.07% | 0.16% | 0.04% | 0.94% | ||||
| Colorado Rockies | 0.01% | 0.12% | 0.02% | 0.01% | 0.01% | ||||||||||
| Los Angeles Dodgers | 0.04% | 3.83% | 1.58% | 4.25% | 0.49% | 0.77% | 5.13% | 2.48% | 2.53% | 0.02% | 10.66% | 27.67% | 4.08% | 1.35% | |
| Miami Marlins | 0.16% | 0.29% | 0.07% | 0.52% | 0.01% | 0.02% | 0.02% | 0.19% | |||||||
| Milwaukee Brewers | 12.32% | 0.12% | 0.38% | 0.05% | 2.02% | 1.31% | 5.37% | 4.67% | 0.48% | 0.75% | 0.25% | 2.71% | |||
| New York Mets | 0.04% | 0.63% | 1.21% | 0.35% | 2.40% | 0.03% | 0.07% | 0.81% | 0.01% | ||||||
| Philadelphia Phillies | 0.04% | 0.68% | 1.30% | 0.64% | 2.54% | 0.01% | 0.01% | 0.05% | 0.12% | 1.12% | 0.01% | ||||
| Pittsburgh Pirates | 0.01% | 0.03% | 0.01% | 0.01% | |||||||||||
| San Diego Padres | 0.14% | 0.03% | 0.06% | 0.01% | 2.33% | 0.19% | 0.05% | 0.06% | 0.42% | 0.11% | 0.06% | ||||
| San Francisco Giants | 1.13% | 0.20% | 0.48% | 0.02% | 19.44% | 0.08% | 1.35% | 0.39% | 0.38% | 1.21% | 0.55% | 0.12% | |||
| St. Louis Cardinals | 4.51% | 0.05% | 0.07% | 1.53% | 0.38% | 0.29% | 1.78% | 1.71% | 0.09% | 0.33% | 1.11% | ||||
| Washington Nationals | 0.02% | 0.22% | 0.42% | 0.16% | 0.80% | 0.01% | 0.01% | 0.01% | 0.36% |
Loser → ↓ Winner | Boston Red Sox | Chicago White Sox | Cleveland Indians | Detroit Tigers | Houston Astros | Kansas City Royals | Los Angeles Angels | Minnesota Twins | New York Yankees | Oakland Athletics | Seattle Mariners | Tampa Bay Rays | Texas Rangers | Toronto Blue Jays |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Boston Red Sox | 0.86% | 0.19% | 1.20% | 0.04% | 0.04% | 0.08% | 0.39% | 0.03% | 0.64% | 0.19% | ||||
| Chicago White Sox | 1.24% | 0.41% | 0.02% | 3.74% | 0.03% | 0.09% | 0.11% | 1.57% | 1.56% | 0.12% | 4.62% | 0.01% | 1.72% | |
| Cleveland Indians | 0.19% | 0.28% | 0.39% | 0.01% | 0.19% | 0.19% | 0.01% | 0.58% | 0.19% | |||||
| Detroit Tigers | 0.02% | 0.02% | 0.01% | |||||||||||
| Houston Astros | 2.03% | 5.47% | 1.23% | 0.04% | 0.08% | 0.07% | 0.22% | 2.33% | 1.55% | 0.22% | 8.60% | 0.01% | 2.48% | |
| Kansas City Royals | 0.01% | 0.02% | 0.02% | 0.01% | ||||||||||
| Los Angeles Angels | 0.02% | 0.01% | 0.01% | |||||||||||
| Minnesota Twins | 0.04% | 0.05% | 0.06% | 0.07% | 0.09% | 0.04% | ||||||||
| New York Yankees | 0.27% | 1.70% | 0.29% | 1.87% | 0.02% | 0.02% | 0.09% | 0.47% | 0.05% | 1.17% | 0.31% | |||
| Oakland Athletics | 0.29% | 1.26% | 0.23% | 0.02% | 0.89% | 0.02% | 0.01% | 0.09% | 0.39% | 0.04% | 1.47% | 0.55% | ||
| Seattle Mariners | 0.04% | 0.14% | 0.03% | 0.10% | 0.01% | 0.04% | 0.03% | 0.11% | 0.05% | |||||
| Tampa Bay Rays | 1.33% | 8.81% | 1.92% | 0.07% | 11.97% | 0.14% | 0.16% | 0.44% | 1.96% | 3.69% | 0.35% | 2.22% | ||
| Toronto Blue Jays | 0.24% | 2.43% | 0.46% | 2.81% | 0.03% | 0.03% | 0.20% | 0.37% | 0.87% | 0.11% | 1.56% |
Loser → ↓ Winner | Atlanta Braves | Chicago Cubs | Cincinnati Reds | Colorado Rockies | Los Angeles Dodgers | Miami Marlins | Milwaukee Brewers | New York Mets | Philadelphia Phillies | Pittsburgh Pirates | San Diego Padres | San Francisco Giants | St. Louis Cardinals | Washington Nationals |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Atlanta Braves | 0.17% | 0.44% | 0.07% | 7.16% | 0.03% | 1.12% | 0.23% | 0.36% | 0.02% | 0.68% | 3.45% | 0.52% | 0.12% | |
| Chicago Cubs | 0.03% | 0.01% | 0.12% | 0.05% | 0.01% | 0.01% | 0.02% | 0.08% | ||||||
| Cincinnati Reds | 0.24% | 0.86% | 0.01% | 0.25% | 0.05% | 0.04% | 0.19% | 0.48% | 0.15% | 0.07% | ||||
| Colorado Rockies | 0.02% | 0.01% | 0.01% | |||||||||||
| Los Angeles Dodgers | 15.27% | 1.13% | 4.41% | 0.03% | 0.61% | 13.89% | 2.83% | 3.19% | 0.02% | 0.19% | 1.11% | 4.77% | 0.94% | |
| Miami Marlins | 0.02% | 0.02% | 0.09% | 0.01% | 0.01% | 0.01% | 0.02% | 0.05% | ||||||
| Milwaukee Brewers | 0.80% | 0.08% | 0.40% | 0.01% | 4.70% | 0.05% | 0.13% | 0.28% | 0.61% | 2.35% | 0.47% | 0.06% | ||
| New York Mets | 0.04% | 0.01% | 0.03% | 0.01% | 0.55% | 0.06% | 0.01% | 0.07% | 0.13% | 0.03% | ||||
| Philadelphia Phillies | 0.12% | 0.01% | 0.07% | 0.52% | 0.14% | 0.02% | 0.16% | 0.34% | 0.09% | |||||
| San Diego Padres | 0.30% | 0.02% | 0.08% | 0.07% | 0.05% | 0.31% | 0.09% | 0.07% | 0.02% | 0.15% | 0.04% | |||
| San Francisco Giants | 5.21% | 0.45% | 1.44% | 0.72% | 0.26% | 4.11% | 1.12% | 0.98% | 0.02% | 0.05% | 1.75% | 0.43% | ||
| St. Louis Cardinals | 0.36% | 0.02% | 0.14% | 0.01% | 1.57% | 0.04% | 0.53% | 0.12% | 0.10% | 0.23% | 0.74% | 0.04% | ||
| Washington Nationals | 0.02% | 0.03% | 0.13% | 0.01% | 0.04% | 0.06% | 0.02% |
Loser → ↓ Winner | Atlanta Braves | Boston Red Sox | Chicago Cubs | Chicago White Sox | Cincinnati Reds | Cleveland Indians | Colorado Rockies | Detroit Tigers | Houston Astros | Kansas City Royals | Los Angeles Angels | Los Angeles Dodgers | Miami Marlins | Milwaukee Brewers | Minnesota Twins | New York Mets | New York Yankees | Oakland Athletics | Philadelphia Phillies | San Diego Padres | San Francisco Giants | Seattle Mariners | St. Louis Cardinals | Tampa Bay Rays | Toronto Blue Jays | Washington Nationals |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Atlanta Braves | 0.39% | 1.06% | 0.15% | 1.76% | 0.02% | 0.02% | 0.50% | 0.55% | 0.05% | 1.91% | 0.63% | |||||||||||||||
| Boston Red Sox | 0.17% | 0.04% | 0.37% | 0.01% | 0.09% | 0.04% | 0.02% | 0.21% | 0.04% | |||||||||||||||||
| Chicago Cubs | 0.01% | 0.01% | 0.01% | |||||||||||||||||||||||
| Chicago White Sox | 1.13% | 0.04% | 0.26% | 2.05% | 0.04% | 0.72% | 0.11% | 0.11% | 0.12% | 0.83% | 0.26% | 0.05% | ||||||||||||||
| Cincinnati Reds | 0.01% | 0.17% | 0.03% | 0.15% | 0.11% | 0.06% | 0.01% | 0.17% | 0.08% | |||||||||||||||||
| Cleveland Indians | 0.17% | 0.01% | 0.02% | 0.20% | 0.07% | 0.03% | 0.09% | 0.03% | ||||||||||||||||||
| Colorado Rockies | 0.01% | |||||||||||||||||||||||||
| Detroit Tigers | 0.01% | 0.01% | ||||||||||||||||||||||||
| Houston Astros | 1.58% | 0.05% | 0.38% | 0.01% | 3.85% | 0.06% | 1.26% | 0.22% | 0.24% | 0.24% | 1.71% | 0.53% | 0.07% | |||||||||||||
| Kansas City Royals | 0.01% | |||||||||||||||||||||||||
| Los Angeles Angels | 0.01% | |||||||||||||||||||||||||
| Los Angeles Dodgers | 1.42% | 5.16% | 0.77% | 0.02% | 7.95% | 0.01% | 0.02% | 0.17% | 2.34% | 2.00% | 0.20% | 9.39% | 2.90% | |||||||||||||
| Miami Marlins | 0.03% | |||||||||||||||||||||||||
| Milwaukee Brewers | 0.21% | 0.82% | 0.18% | 0.01% | 1.17% | 0.02% | 0.31% | 0.29% | 0.03% | 1.12% | 0.42% | |||||||||||||||
| Minnesota Twins | 0.01% | 0.04% | 0.01% | 0.02% | 0.01% | |||||||||||||||||||||
| New York Mets | 0.01% | 0.04% | 0.08% | 0.04% | 0.06% | |||||||||||||||||||||
| New York Yankees | 0.41% | 0.03% | 0.08% | 0.76% | 0.29% | 0.04% | 0.04% | 0.03% | 0.38% | 0.11% | 0.01% | |||||||||||||||
| Oakland Athletics | 0.29% | 0.02% | 0.06% | 0.62% | 0.01% | 0.28% | 0.04% | 0.04% | 0.26% | 0.08% | ||||||||||||||||
| Philadelphia Phillies | 0.02% | 0.06% | 0.11% | 0.01% | 0.06% | 0.03% | 0.17% | 0.09% | ||||||||||||||||||
| San Diego Padres | 0.01% | 0.08% | 0.01% | 0.06% | 0.03% | 0.01% | 0.11% | 0.04% | ||||||||||||||||||
| San Francisco Giants | 0.50% | 1.71% | 0.22% | 2.42% | 0.01% | 0.04% | 0.58% | 0.53% | 0.08% | 2.87% | 0.64% | |||||||||||||||
| Seattle Mariners | 0.01% | 0.02% | 0.05% | 0.01% | 0.02% | 0.02% | 0.02% | 0.02% | ||||||||||||||||||
| St. Louis Cardinals | 0.09% | 0.37% | 0.05% | 0.39% | 0.01% | 0.01% | 0.10% | 0.10% | 0.51% | 0.13% | ||||||||||||||||
| Tampa Bay Rays | 2.86% | 0.12% | 0.49% | 0.01% | 6.53% | 0.06% | 2.09% | 0.22% | 0.37% | 0.32% | 2.68% | 0.90% | 0.09% | |||||||||||||
| Toronto Blue Jays | 0.69% | 0.03% | 0.20% | 0.01% | 1.55% | 0.01% | 0.54% | 0.04% | 0.08% | 0.10% | 0.73% | 0.16% | 0.02% | |||||||||||||
| Washington Nationals | 0.01% | 0.01% | 0.04% | 0.01% |
Actual Bracket Simulation
With the actual playoff bracket fixed in place, this second simulation re-runs each matchup 10,000 times and tallies how often each team advanced past each round and won the title. The right-most column shows what actually happened. Round buttons switch to matchup heatmaps for that round.
| Team | Advanced to LDS | Advanced to LCS | Advanced to World Series | Won World Series | Actual Outcome |
|---|---|---|---|---|---|
| Tampa Bay Rays | 100.00% | 66.40% | 41.23% | 21.18% | Eliminated in Wild Card |
| San Francisco Giants | 100.00% | 49.79% | 31.67% | 18.59% | Eliminated in Wild Card |
| Los Angeles Dodgers | 67.56% | 38.70% | 26.79% | 18.13% | Eliminated in LDS |
| Houston Astros | 100.00% | 56.86% | 26.25% | 11.12% | Eliminated in World Series |
| Atlanta Braves | 100.00% | 55.06% | 21.33% | 9.91% | Won World Series |
| Milwaukee Brewers | 100.00% | 44.94% | 15.08% | 6.69% | Eliminated in Wild Card |
| Chicago White Sox | 100.00% | 43.14% | 17.58% | 6.63% | Eliminated in Wild Card |
| New York Yankees | 49.56% | 17.71% | 8.40% | 3.51% | Eliminated in Wild Card |
| St. Louis Cardinals | 32.44% | 11.51% | 5.13% | 2.17% | Eliminated in Wild Card |
| Boston Red Sox | 50.44% | 15.89% | 6.54% | 2.07% | Eliminated in LDS |
Loser → ↓ Winner | Boston Red Sox | New York Yankees |
|---|---|---|
| Boston Red Sox | 50.44% | |
| New York Yankees | 49.56% |
Loser → ↓ Winner | Los Angeles Dodgers | St. Louis Cardinals |
|---|---|---|
| Los Angeles Dodgers | 67.56% | |
| St. Louis Cardinals | 32.44% |
Loser → ↓ Winner | Boston Red Sox | Chicago White Sox | Houston Astros | New York Yankees | Tampa Bay Rays |
|---|---|---|---|---|---|
| Boston Red Sox | 15.89% | ||||
| Chicago White Sox | 43.14% | ||||
| Houston Astros | 56.86% | ||||
| New York Yankees | 17.71% | ||||
| Tampa Bay Rays | 34.55% | 31.85% |
Loser → ↓ Winner | Atlanta Braves | Los Angeles Dodgers | Milwaukee Brewers | San Francisco Giants | St. Louis Cardinals |
|---|---|---|---|---|---|
| Atlanta Braves | 55.06% | ||||
| Los Angeles Dodgers | 38.70% | ||||
| Milwaukee Brewers | 44.94% | ||||
| San Francisco Giants | 28.86% | 20.93% | |||
| St. Louis Cardinals | 11.51% |
Loser → ↓ Winner | Boston Red Sox | Chicago White Sox | Houston Astros | New York Yankees | Tampa Bay Rays |
|---|---|---|---|---|---|
| Boston Red Sox | 2.82% | 3.72% | |||
| Chicago White Sox | 3.77% | 3.75% | 10.06% | ||
| Houston Astros | 5.58% | 5.56% | 15.11% | ||
| New York Yankees | 3.92% | 4.48% | |||
| Tampa Bay Rays | 18.82% | 22.41% |
Loser → ↓ Winner | Atlanta Braves | Los Angeles Dodgers | Milwaukee Brewers | San Francisco Giants | St. Louis Cardinals |
|---|---|---|---|---|---|
| Atlanta Braves | 6.72% | 10.78% | 3.83% | ||
| Los Angeles Dodgers | 14.59% | 12.20% | |||
| Milwaukee Brewers | 5.19% | 7.34% | 2.55% | ||
| San Francisco Giants | 16.41% | 15.26% | |||
| St. Louis Cardinals | 2.73% | 2.40% |
Loser → ↓ Winner | Atlanta Braves | Boston Red Sox | Chicago White Sox | Houston Astros | Los Angeles Dodgers | Milwaukee Brewers | New York Yankees | San Francisco Giants | St. Louis Cardinals | Tampa Bay Rays |
|---|---|---|---|---|---|---|---|---|---|---|
| Atlanta Braves | 0.80% | 2.00% | 2.53% | 0.92% | 3.66% | |||||
| Boston Red Sox | 0.50% | 0.37% | 0.43% | 0.63% | 0.14% | |||||
| Chicago White Sox | 1.69% | 1.31% | 1.28% | 1.92% | 0.43% | |||||
| Houston Astros | 2.98% | 1.88% | 2.13% | 3.33% | 0.80% | |||||
| Los Angeles Dodgers | 1.43% | 3.54% | 4.97% | 1.48% | 6.71% | |||||
| Milwaukee Brewers | 0.56% | 1.56% | 1.83% | 0.68% | 2.06% | |||||
| New York Yankees | 0.87% | 0.70% | 0.72% | 1.03% | 0.19% | |||||
| San Francisco Giants | 1.52% | 3.30% | 5.22% | 1.62% | 6.93% | |||||
| St. Louis Cardinals | 0.16% | 0.55% | 0.58% | 0.19% | 0.69% | |||||
| Tampa Bay Rays | 5.38% | 4.40% | 3.83% | 6.17% | 1.40% |
Most-Likely Championship Paths
For each playoff team, the opponent they most often faced and defeated at each round across all bracket simulations. Each step shows two numbers: Matchup % is the fraction of this team's wins in this round that came against this opponent; Win % is the head-to-head probability they beat this opponent when the two meet. Note: fixed early-round matchups against bracket-determined opponents will show 100% Matchup — that's because those pairings are decided by the bracket.
Regular Season Games
Every regular-season game from each team's perspective. Pick a team from the dropdown — it filters every table on this tab. Sort any column by clicking its header. @ before an opponent name indicates an away game.
| Date | Opponent | Score | Pre Elo | Opp Elo | Win % | Loss % | Elo Δ | Record |
|---|---|---|---|---|---|---|---|---|
| 2021-04-01 | @ San Diego Padres | L 7-8 | 1495.41 | 1506.32 | 44.60% | 55.40% | -1.48 | 0-1 |
| 2021-04-02 | @ San Diego Padres | L 2-4 | 1493.93 | 1507.80 | 44.18% | 55.82% | -2.07 | 0-2 |
| 2021-04-03 | @ San Diego Padres | L 0-7 | 1491.86 | 1509.87 | 43.59% | 56.41% | -3.83 | 0-3 |
| 2021-04-04 | @ San Diego Padres | W 3-1 | 1488.03 | 1513.70 | 42.51% | 57.49% | +2.70 | 1-3 |
| 2021-04-06 | @ Colorado Rockies | W 10-8 | 1490.73 | 1473.69 | 48.60% | 51.40% | +1.71 | 2-3 |
| 2021-04-07 | @ Colorado Rockies | L 0-8 | 1492.44 | 1471.98 | 49.09% | 50.91% | -4.61 | 2-4 |
| 2021-04-08 | @ Colorado Rockies | L 3-7 | 1487.83 | 1476.59 | 47.76% | 52.24% | -3.18 | 2-5 |
| 2021-04-09 | Cincinnati Reds | L 5-6 | 1484.65 | 1511.47 | 50.00% | 50.00% | -1.17 | 2-6 |
| 2021-04-10 | Cincinnati Reds | W 8-3 | 1483.48 | 1512.64 | 49.66% | 50.34% | +3.74 | 3-6 |
| 2021-04-11 | Cincinnati Reds | W 7-0 | 1487.22 | 1508.90 | 50.73% | 49.27% | +4.33 | 4-6 |
| 2021-04-12 | Oakland Athletics | L 5-9 | 1491.55 | 1503.05 | 52.20% | 47.80% | -3.47 | 4-7 |
| 2021-04-13 | Oakland Athletics | L 5-7 | 1488.08 | 1506.52 | 51.20% | 48.80% | -2.40 | 4-8 |
| 2021-04-15 | @ Washington Nationals | W 11-6 | 1485.68 | 1504.06 | 43.54% | 56.46% | +4.19 | 5-8 |
| 2021-04-16 | @ Washington Nationals | L 0-1 | 1489.87 | 1499.87 | 44.73% | 55.27% | -1.49 | 5-9 |
| 2021-04-17 | @ Washington Nationals | L 2-6 | 1488.38 | 1501.35 | 44.30% | 55.70% | -2.94 | 5-10 |
| 2021-04-18 | @ Washington Nationals | W 5-2 | 1485.44 | 1504.30 | 43.47% | 56.53% | +3.25 | 6-10 |
| 2021-04-20 | @ Cincinnati Reds | W 5-4 | 1488.69 | 1505.51 | 43.76% | 56.24% | +1.87 | 7-10 |
| 2021-04-21 | @ Cincinnati Reds | W 8-5 | 1490.56 | 1503.65 | 44.29% | 55.71% | +2.26 | 8-10 |
| 2021-04-22 | @ Cincinnati Reds | W 14-11 | 1492.82 | 1501.38 | 44.93% | 55.07% | +2.24 | 9-10 |
| 2021-04-23 | @ Atlanta Braves | L 4-5 | 1495.06 | 1521.20 | 42.44% | 57.56% | -1.41 | 9-11 |
| 2021-04-25 | @ Atlanta Braves | W 5-0 | 1493.65 | 1522.61 | 42.05% | 57.95% | +4.31 | 10-11 |
| 2021-04-25 | @ Atlanta Braves | W 7-0 | 1497.96 | 1518.31 | 43.26% | 56.74% | +4.98 | 11-11 |
| 2021-04-27 | San Diego Padres | W 5-1 | 1502.94 | 1513.35 | 52.35% | 47.65% | +3.16 | 12-11 |
| 2021-04-28 | San Diego Padres | L 3-12 | 1506.10 | 1510.19 | 53.26% | 46.74% | -5.30 | 12-12 |
| 2021-04-29 | Colorado Rockies | W 5-3 | 1500.80 | 1473.38 | 57.74% | 42.26% | +1.98 | 13-12 |
| 2021-04-30 | Colorado Rockies | W 7-2 | 1502.78 | 1471.40 | 58.29% | 41.71% | +3.10 | 14-12 |
| 2021-05-01 | Colorado Rockies | L 6-14 | 1505.88 | 1468.30 | 59.16% | 40.84% | -5.55 | 14-13 |
| 2021-05-02 | Colorado Rockies | W 8-4 | 1500.33 | 1473.85 | 57.60% | 42.40% | +2.81 | 15-13 |
| 2021-05-04 | @ Miami Marlins | L 3-9 | 1503.14 | 1481.41 | 49.27% | 50.73% | -4.01 | 15-14 |
| 2021-05-05 | @ Miami Marlins | L 0-8 | 1499.13 | 1485.42 | 48.12% | 51.88% | -4.52 | 15-15 |
| 2021-05-06 | @ Miami Marlins | L 1-3 | 1494.61 | 1489.94 | 46.82% | 53.18% | -2.19 | 15-16 |
| 2021-05-07 | @ New York Mets | L 4-5 | 1492.42 | 1497.95 | 45.36% | 54.64% | -1.07 | 15-17 |
| 2021-05-08 | @ New York Mets | L 2-4 | 1491.35 | 1499.02 | 45.06% | 54.94% | -2.11 | 15-18 |
| 2021-05-09 | @ New York Mets | L 2-4 | 1489.24 | 1501.13 | 44.46% | 55.54% | -2.09 | 15-19 |
| 2021-05-10 | Miami Marlins | W 5-2 | 1487.15 | 1490.85 | 53.32% | 46.68% | +2.68 | 16-19 |
| 2021-05-11 | Miami Marlins | W 11-3 | 1489.83 | 1488.17 | 54.08% | 45.92% | +4.31 | 17-19 |
| 2021-05-12 | Miami Marlins | L 2-3 | 1494.14 | 1483.85 | 55.31% | 44.69% | -1.83 | 17-20 |
| 2021-05-13 | Miami Marlins | L 1-5 | 1492.31 | 1485.69 | 54.79% | 45.21% | -3.64 | 17-21 |
| 2021-05-14 | Washington Nationals | L 2-17 | 1488.67 | 1496.15 | 52.77% | 47.23% | -6.79 | 17-22 |
| 2021-05-15 | Washington Nationals | W 11-4 | 1481.88 | 1502.94 | 50.82% | 49.18% | +4.32 | 18-22 |
| 2021-05-16 | Washington Nationals | L 0-3 | 1486.20 | 1498.62 | 52.07% | 47.93% | -2.99 | 18-23 |
| 2021-05-17 | @ Los Angeles Dodgers | L 1-3 | 1483.21 | 1567.93 | 34.48% | 65.52% | -1.62 | 18-24 |
| 2021-05-18 | @ Los Angeles Dodgers | L 1-9 | 1481.59 | 1569.55 | 34.06% | 65.94% | -3.20 | 18-25 |
| 2021-05-19 | @ Los Angeles Dodgers | L 2-4 | 1478.39 | 1572.75 | 33.24% | 66.76% | -1.56 | 18-26 |
| 2021-05-20 | @ Los Angeles Dodgers | L 2-3 | 1476.83 | 1574.31 | 32.84% | 67.16% | -1.09 | 18-27 |
| 2021-05-21 | @ Colorado Rockies | L 1-7 | 1475.74 | 1457.51 | 48.77% | 51.23% | -3.97 | 18-28 |
| 2021-05-22 | @ Colorado Rockies | L 6-7 | 1471.77 | 1461.48 | 47.63% | 52.37% | -1.58 | 18-29 |
| 2021-05-23 | @ Colorado Rockies | L 3-4 | 1470.19 | 1463.06 | 47.18% | 52.82% | -1.56 | 18-30 |
| 2021-05-25 | San Francisco Giants | L 0-8 | 1468.63 | 1522.41 | 46.12% | 53.88% | -4.33 | 18-31 |
| 2021-05-26 | San Francisco Giants | L 4-5 | 1464.30 | 1526.74 | 44.89% | 55.11% | -1.49 | 18-32 |
| 2021-05-27 | St. Louis Cardinals | L 4-5 | 1462.81 | 1512.03 | 46.77% | 53.23% | -1.10 | 18-33 |
| 2021-05-28 | St. Louis Cardinals | L 6-8 | 1461.71 | 1513.13 | 46.46% | 53.54% | -2.18 | 18-34 |
| 2021-05-29 | St. Louis Cardinals | L 4-7 | 1459.53 | 1515.31 | 45.84% | 54.16% | -2.64 | 18-35 |
| 2021-05-30 | St. Louis Cardinals | W 9-2 | 1456.89 | 1517.94 | 45.08% | 54.92% | +4.82 | 19-35 |
| 2021-05-31 | New York Mets | L 2-6 | 1461.71 | 1506.80 | 47.37% | 52.63% | -3.14 | 19-36 |
| 2021-06-01 | New York Mets | W 6-5 | 1458.57 | 1509.94 | 46.47% | 53.53% | +1.26 | 20-36 |
| 2021-06-02 | New York Mets | L 6-7 | 1459.83 | 1508.69 | 46.83% | 53.17% | -1.56 | 20-37 |
| 2021-06-03 | @ Milwaukee Brewers | L 4-7 | 1458.27 | 1497.89 | 40.56% | 59.44% | -2.33 | 20-38 |
| 2021-06-04 | @ Milwaukee Brewers | L 1-5 | 1455.94 | 1500.22 | 39.91% | 60.09% | -2.65 | 20-39 |
| 2021-06-05 | @ Milwaukee Brewers | L 5-7 | 1453.29 | 1502.87 | 39.18% | 60.82% | -1.84 | 20-40 |
| 2021-06-06 | @ Milwaukee Brewers | L 0-2 | 1451.45 | 1504.71 | 38.68% | 61.32% | -1.82 | 20-41 |
| 2021-06-08 | @ Oakland Athletics | L 2-5 | 1449.63 | 1525.94 | 35.59% | 64.41% | -2.04 | 20-42 |
| 2021-06-09 | @ Oakland Athletics | L 0-4 | 1447.59 | 1527.99 | 35.05% | 64.95% | -2.33 | 20-43 |
| 2021-06-11 | Los Angeles Angels | L 5-6 | 1445.26 | 1484.16 | 48.26% | 51.74% | -1.13 | 20-44 |
| 2021-06-12 | Los Angeles Angels | L 7-8 | 1444.13 | 1485.29 | 47.93% | 52.07% | -1.59 | 20-45 |
| 2021-06-13 | Los Angeles Angels | L 3-10 | 1442.54 | 1486.88 | 47.47% | 52.53% | -4.17 | 20-46 |
| 2021-06-14 | @ San Francisco Giants | L 2-5 | 1438.37 | 1536.44 | 32.77% | 67.23% | -1.89 | 20-47 |
| 2021-06-15 | @ San Francisco Giants | L 8-9 | 1436.48 | 1538.33 | 32.29% | 67.71% | -1.07 | 20-48 |
| 2021-06-16 | @ San Francisco Giants | L 7-13 | 1435.41 | 1539.40 | 32.02% | 67.98% | -2.61 | 20-49 |
| 2021-06-17 | @ San Francisco Giants | L 3-10 | 1432.80 | 1542.00 | 31.37% | 68.63% | -2.75 | 20-50 |
| 2021-06-18 | Los Angeles Dodgers | L 0-3 | 1430.05 | 1579.67 | 33.02% | 66.98% | -1.90 | 20-51 |
| 2021-06-19 | Los Angeles Dodgers | L 3-9 | 1428.15 | 1581.57 | 32.54% | 67.46% | -2.65 | 20-52 |
| 2021-06-20 | Los Angeles Dodgers | L 8-9 | 1425.50 | 1584.22 | 31.88% | 68.12% | -1.05 | 20-53 |
| 2021-06-21 | Milwaukee Brewers | W 5-1 | 1424.45 | 1506.24 | 42.15% | 57.85% | +3.84 | 21-53 |
| 2021-06-22 | Milwaukee Brewers | L 0-5 | 1428.29 | 1502.40 | 43.23% | 56.77% | -3.21 | 21-54 |
| 2021-06-23 | Milwaukee Brewers | L 2-3 | 1425.08 | 1505.61 | 42.33% | 57.67% | -1.41 | 21-55 |
| 2021-06-25 | @ San Diego Padres | L 5-11 | 1423.67 | 1540.76 | 30.40% | 69.60% | -2.47 | 21-56 |
| 2021-06-26 | @ San Diego Padres | W 10-1 | 1421.20 | 1543.24 | 29.80% | 70.20% | +6.99 | 22-56 |
| 2021-06-27 | @ San Diego Padres | L 4-5 | 1428.19 | 1536.25 | 31.51% | 68.49% | -1.04 | 22-57 |
| 2021-06-28 | @ St. Louis Cardinals | L 1-7 | 1427.15 | 1473.84 | 39.58% | 60.42% | -3.22 | 22-58 |
| 2021-06-29 | @ St. Louis Cardinals | L 2-3 | 1423.93 | 1477.06 | 38.70% | 61.30% | -1.29 | 22-59 |
| 2021-06-30 | @ St. Louis Cardinals | L 4-7 | 1422.64 | 1478.35 | 38.35% | 61.65% | -2.20 | 22-60 |
| 2021-07-01 | San Francisco Giants | W 5-3 | 1420.44 | 1547.23 | 35.99% | 64.01% | +3.00 | 23-60 |
| 2021-07-02 | San Francisco Giants | L 4-11 | 1423.44 | 1544.22 | 36.79% | 63.21% | -3.23 | 23-61 |
| 2021-07-03 | San Francisco Giants | L 5-6 | 1420.21 | 1547.45 | 35.93% | 64.07% | -1.19 | 23-62 |
| 2021-07-04 | San Francisco Giants | L 2-5 | 1419.02 | 1548.64 | 35.62% | 64.38% | -2.05 | 23-63 |
| 2021-07-06 | Colorado Rockies | W 4-3 | 1416.97 | 1461.75 | 47.41% | 52.59% | +1.74 | 24-63 |
| 2021-07-07 | Colorado Rockies | W 6-4 | 1418.71 | 1460.01 | 47.91% | 52.09% | +2.45 | 25-63 |
| 2021-07-08 | Colorado Rockies | L 3-9 | 1421.16 | 1457.56 | 48.62% | 51.38% | -3.95 | 25-64 |
| 2021-07-09 | @ Los Angeles Dodgers | W 5-2 | 1417.21 | 1590.74 | 23.99% | 76.01% | +4.37 | 26-64 |
| 2021-07-10 | @ Los Angeles Dodgers | L 1-22 | 1421.58 | 1586.37 | 24.92% | 75.08% | -3.79 | 26-65 |
| 2021-07-11 | @ Los Angeles Dodgers | L 4-7 | 1417.79 | 1590.16 | 24.11% | 75.89% | -1.39 | 26-66 |
| 2021-07-16 | Chicago Cubs | L 1-5 | 1416.40 | 1490.79 | 43.19% | 56.81% | -2.87 | 26-67 |
| 2021-07-17 | Chicago Cubs | L 2-4 | 1413.53 | 1493.65 | 42.38% | 57.62% | -1.99 | 26-68 |
| 2021-07-18 | Chicago Cubs | W 6-4 | 1411.54 | 1495.64 | 41.82% | 58.18% | +2.73 | 27-68 |
| 2021-07-19 | Pittsburgh Pirates | W 4-2 | 1414.27 | 1434.55 | 50.94% | 49.06% | +2.31 | 28-68 |
| 2021-07-20 | Pittsburgh Pirates | W 11-6 | 1416.58 | 1432.24 | 51.60% | 48.40% | +3.59 | 29-68 |
| 2021-07-21 | Pittsburgh Pirates | W 6-4 | 1420.17 | 1428.65 | 52.63% | 47.37% | +2.22 | 30-68 |
| 2021-07-23 | @ Chicago Cubs | L 3-8 | 1422.39 | 1488.50 | 36.94% | 63.06% | -2.74 | 30-69 |
| 2021-07-24 | @ Chicago Cubs | W 7-3 | 1419.65 | 1491.24 | 36.21% | 63.79% | +4.24 | 31-69 |
| 2021-07-25 | @ Chicago Cubs | L 1-5 | 1423.89 | 1487.01 | 37.34% | 62.66% | -2.48 | 31-70 |
| 2021-07-27 | @ Texas Rangers | L 4-5 | 1421.41 | 1424.59 | 45.70% | 54.30% | -1.52 | 31-71 |
| 2021-07-28 | @ Texas Rangers | W 3-2 | 1419.89 | 1426.11 | 45.26% | 54.74% | +1.82 | 32-71 |
| 2021-07-30 | Los Angeles Dodgers | W 6-5 | 1421.71 | 1586.28 | 31.15% | 68.85% | +1.61 | 33-71 |
| 2021-07-31 | Los Angeles Dodgers | L 3-8 | 1423.32 | 1584.66 | 31.55% | 68.45% | -2.34 | 33-72 |
| 2021-08-01 | Los Angeles Dodgers | L 0-13 | 1420.98 | 1587.00 | 30.97% | 69.03% | -3.71 | 33-73 |
| 2021-08-02 | San Francisco Giants | L 8-11 | 1417.27 | 1556.28 | 34.39% | 65.61% | -1.39 | 33-74 |
| 2021-08-03 | San Francisco Giants | W 3-1 | 1415.88 | 1557.68 | 34.03% | 65.97% | +3.09 | 34-74 |
| 2021-08-04 | San Francisco Giants | L 1-7 | 1418.97 | 1554.58 | 34.83% | 65.17% | -2.83 | 34-75 |
| 2021-08-05 | San Francisco Giants | L 4-5 | 1416.14 | 1557.42 | 34.09% | 65.91% | -0.80 | 34-76 |
| 2021-08-06 | @ San Diego Padres | W 8-5 | 1415.34 | 1538.00 | 29.73% | 70.27% | +4.04 | 35-76 |
| 2021-08-07 | @ San Diego Padres | L 2-6 | 1419.38 | 1533.96 | 30.71% | 69.29% | -2.04 | 35-77 |
| 2021-08-08 | @ San Diego Padres | L 0-2 | 1417.34 | 1535.99 | 30.21% | 69.79% | -1.42 | 35-78 |
| 2021-08-10 | @ San Francisco Giants | L 7-8 | 1415.92 | 1560.95 | 27.11% | 72.89% | -0.90 | 35-79 |
| 2021-08-11 | @ San Francisco Giants | L 2-7 | 1415.02 | 1561.85 | 26.91% | 73.09% | -1.99 | 35-80 |
| 2021-08-12 | San Diego Padres | W 12-3 | 1413.03 | 1535.69 | 36.54% | 63.46% | +6.32 | 36-80 |
| 2021-08-13 | San Diego Padres | W 3-2 | 1419.35 | 1529.37 | 38.24% | 61.76% | +2.05 | 37-80 |
| 2021-08-14 | San Diego Padres | W 7-0 | 1421.40 | 1527.32 | 38.80% | 61.20% | +5.37 | 38-80 |
| 2021-08-15 | San Diego Padres | L 2-8 | 1426.77 | 1521.95 | 40.28% | 59.72% | -3.27 | 38-81 |
| 2021-08-17 | Philadelphia Phillies | W 3-2 | 1423.50 | 1501.06 | 42.74% | 57.26% | +1.90 | 39-81 |
| 2021-08-18 | Philadelphia Phillies | W 4-2 | 1425.40 | 1499.16 | 43.28% | 56.72% | +2.66 | 40-81 |
| 2021-08-19 | Philadelphia Phillies | W 6-2 | 1428.06 | 1496.50 | 44.03% | 55.97% | +3.72 | 41-81 |
| 2021-08-20 | @ Colorado Rockies | L 4-9 | 1431.78 | 1483.46 | 38.90% | 61.10% | -2.89 | 41-82 |
| 2021-08-21 | @ Colorado Rockies | L 2-5 | 1428.89 | 1486.34 | 38.11% | 61.89% | -2.19 | 41-83 |
| 2021-08-22 | @ Colorado Rockies | W 8-4 | 1426.70 | 1488.54 | 37.52% | 62.48% | +4.15 | 42-83 |
| 2021-08-23 | @ Pittsburgh Pirates | L 5-6 | 1430.85 | 1411.79 | 48.89% | 51.11% | -1.63 | 42-84 |
| 2021-08-24 | @ Pittsburgh Pirates | L 2-4 | 1429.22 | 1413.42 | 48.42% | 51.58% | -2.27 | 42-85 |
| 2021-08-25 | @ Pittsburgh Pirates | W 5-2 | 1426.95 | 1415.69 | 47.77% | 52.23% | +3.00 | 43-85 |
| 2021-08-26 | @ Philadelphia Phillies | W 8-7 | 1429.95 | 1492.63 | 37.40% | 62.60% | +2.08 | 44-85 |
| 2021-08-27 | @ Philadelphia Phillies | L 6-7 | 1432.03 | 1490.55 | 37.96% | 62.04% | -0.89 | 44-86 |
| 2021-08-28 | @ Philadelphia Phillies | L 0-7 | 1431.14 | 1491.45 | 37.72% | 62.28% | -3.31 | 44-87 |
| 2021-08-29 | @ Philadelphia Phillies | L 4-7 | 1427.83 | 1494.76 | 36.83% | 63.17% | -2.12 | 44-88 |
| 2021-08-30 | San Diego Padres | L 5-7 | 1425.71 | 1505.64 | 42.41% | 57.59% | -1.99 | 44-89 |
| 2021-08-31 | San Diego Padres | L 0-3 | 1423.72 | 1507.64 | 41.85% | 58.15% | -2.41 | 44-90 |
| 2021-09-01 | San Diego Padres | W 8-3 | 1421.31 | 1510.04 | 41.18% | 58.82% | +4.37 | 45-90 |
| 2021-09-03 | Seattle Mariners | L 5-6 | 1425.68 | 1497.74 | 43.52% | 56.48% | -1.02 | 45-91 |
| 2021-09-04 | Seattle Mariners | L 5-8 | 1424.66 | 1498.76 | 43.23% | 56.77% | -2.49 | 45-92 |
| 2021-09-05 | Seattle Mariners | L 4-10 | 1422.17 | 1501.24 | 42.53% | 57.47% | -2.45 | 45-93 |
| 2021-09-07 | Texas Rangers | L 1-3 | 1419.72 | 1422.74 | 53.41% | 46.59% | -2.50 | 45-94 |
| 2021-09-08 | Texas Rangers | L 5-8 | 1417.22 | 1425.25 | 52.70% | 47.30% | -3.03 | 45-95 |
| 2021-09-10 | @ Seattle Mariners | L 4-5 | 1414.19 | 1502.62 | 34.00% | 66.00% | -1.13 | 45-96 |
| 2021-09-11 | @ Seattle Mariners | W 7-3 | 1413.06 | 1503.74 | 33.71% | 66.29% | +4.40 | 46-96 |
| 2021-09-12 | @ Seattle Mariners | W 5-4 | 1417.46 | 1499.34 | 34.85% | 65.15% | +2.16 | 47-96 |
| 2021-09-13 | @ Los Angeles Dodgers | L 1-5 | 1419.62 | 1615.16 | 21.76% | 78.24% | -1.44 | 47-97 |
| 2021-09-14 | @ Los Angeles Dodgers | L 4-8 | 1418.18 | 1616.60 | 21.48% | 78.52% | -1.43 | 47-98 |
| 2021-09-15 | @ Los Angeles Dodgers | L 3-5 | 1416.75 | 1618.03 | 21.20% | 78.80% | -0.99 | 47-99 |
| 2021-09-17 | @ Houston Astros | L 3-4 | 1415.76 | 1566.73 | 26.44% | 73.56% | -0.63 | 47-100 |
| 2021-09-18 | @ Houston Astros | W 6-4 | 1415.13 | 1567.35 | 26.30% | 73.70% | +2.45 | 48-100 |
| 2021-09-19 | @ Houston Astros | L 6-7 | 1417.58 | 1564.90 | 26.85% | 73.15% | -0.89 | 48-101 |
| 2021-09-20 | Atlanta Braves | L 4-11 | 1416.69 | 1547.47 | 35.47% | 64.53% | -3.11 | 48-102 |
| 2021-09-21 | Atlanta Braves | L 1-6 | 1413.58 | 1550.58 | 34.65% | 65.35% | -2.58 | 48-103 |
| 2021-09-22 | Atlanta Braves | L 2-9 | 1411.00 | 1553.15 | 33.98% | 66.02% | -2.98 | 48-104 |
| 2021-09-23 | Atlanta Braves | W 6-4 | 1408.02 | 1556.14 | 33.21% | 66.79% | +3.13 | 49-104 |
| 2021-09-24 | Los Angeles Dodgers | L 2-4 | 1411.15 | 1618.04 | 26.18% | 73.82% | -1.23 | 49-105 |
| 2021-09-25 | Los Angeles Dodgers | W 7-2 | 1409.92 | 1619.27 | 25.90% | 74.10% | +5.51 | 50-105 |
| 2021-09-26 | Los Angeles Dodgers | L 0-3 | 1415.43 | 1613.77 | 27.14% | 72.86% | -1.57 | 50-106 |
| 2021-09-28 | @ San Francisco Giants | L 4-6 | 1413.86 | 1590.06 | 23.71% | 76.29% | -1.11 | 50-107 |
| 2021-09-29 | @ San Francisco Giants | L 0-1 | 1412.75 | 1591.17 | 23.48% | 76.52% | -0.78 | 50-108 |
| 2021-09-30 | @ San Francisco Giants | L 4-5 | 1411.97 | 1591.95 | 23.32% | 76.68% | -0.77 | 50-109 |
| 2021-10-01 | Colorado Rockies | L 7-9 | 1411.20 | 1485.34 | 43.23% | 56.77% | -2.03 | 50-110 |
| 2021-10-02 | Colorado Rockies | W 11-2 | 1409.17 | 1487.37 | 42.65% | 57.35% | +5.71 | 51-110 |
| 2021-10-03 | Colorado Rockies | W 5-4 | 1414.88 | 1481.65 | 44.27% | 55.73% | +1.85 | 52-110 |
| 2021-04-01 | @ Philadelphia Phillies | L 2-3 | 1525.35 | 1494.34 | 50.61% | 49.39% | -1.18 | 0-1 |
| 2021-04-03 | @ Philadelphia Phillies | L 0-4 | 1524.17 | 1495.52 | 50.27% | 49.73% | -3.34 | 0-2 |
| 2021-04-04 | @ Philadelphia Phillies | L 1-2 | 1520.83 | 1498.86 | 49.31% | 50.69% | -1.64 | 0-3 |
| 2021-04-06 | @ Washington Nationals | L 5-6 | 1519.19 | 1509.96 | 47.48% | 52.52% | -1.57 | 0-4 |
| 2021-04-07 | @ Washington Nationals | W 7-6 | 1517.62 | 1511.54 | 47.02% | 52.98% | +1.75 | 1-4 |
| 2021-04-07 | @ Washington Nationals | W 2-0 | 1519.37 | 1509.78 | 47.53% | 52.47% | +2.47 | 2-4 |
| 2021-04-09 | Philadelphia Phillies | W 8-1 | 1521.84 | 1502.80 | 56.56% | 43.44% | +3.81 | 3-4 |
| 2021-04-10 | Philadelphia Phillies | W 5-4 | 1525.65 | 1498.99 | 57.63% | 42.37% | +1.41 | 4-4 |
| 2021-04-11 | Philadelphia Phillies | L 6-7 | 1527.06 | 1497.58 | 58.03% | 41.97% | -1.93 | 4-5 |
| 2021-04-12 | Miami Marlins | L 3-5 | 1525.13 | 1472.32 | 61.26% | 38.74% | -2.87 | 4-6 |
| 2021-04-13 | Miami Marlins | L 8-14 | 1522.26 | 1475.20 | 60.47% | 39.53% | -4.92 | 4-7 |
| 2021-04-14 | Miami Marlins | L 5-6 | 1517.34 | 1480.12 | 59.11% | 40.89% | -1.39 | 4-8 |
| 2021-04-15 | Miami Marlins | W 7-6 | 1515.95 | 1481.50 | 58.72% | 41.28% | +1.37 | 5-8 |
| 2021-04-16 | @ Chicago Cubs | W 5-2 | 1517.32 | 1494.82 | 49.39% | 50.61% | +2.91 | 6-8 |
| 2021-04-17 | @ Chicago Cubs | L 4-13 | 1520.23 | 1491.91 | 50.22% | 49.78% | -5.00 | 6-9 |
| 2021-04-18 | @ Chicago Cubs | W 13-4 | 1515.23 | 1496.91 | 48.78% | 51.22% | +5.10 | 7-9 |
| 2021-04-20 | @ New York Yankees | L 1-3 | 1520.33 | 1514.06 | 47.05% | 52.95% | -2.21 | 7-10 |
| 2021-04-21 | @ New York Yankees | W 4-1 | 1518.12 | 1516.27 | 46.42% | 53.58% | +3.08 | 8-10 |
| 2021-04-23 | Arizona Diamondbacks | W 5-4 | 1521.20 | 1495.06 | 57.56% | 42.44% | +1.41 | 9-10 |
| 2021-04-25 | Arizona Diamondbacks | L 0-5 | 1522.61 | 1493.65 | 57.95% | 42.05% | -4.30 | 9-11 |
| 2021-04-25 | Arizona Diamondbacks | L 0-7 | 1518.31 | 1497.96 | 56.74% | 43.26% | -4.98 | 9-12 |
| 2021-04-26 | Chicago Cubs | W 8-7 | 1513.33 | 1500.19 | 55.72% | 44.28% | +1.47 | 10-12 |
| 2021-04-27 | Chicago Cubs | W 5-0 | 1514.80 | 1498.72 | 56.14% | 43.86% | +3.25 | 11-12 |
| 2021-04-28 | Chicago Cubs | W 10-0 | 1518.05 | 1495.46 | 57.06% | 42.94% | +4.51 | 12-12 |
| 2021-04-29 | Chicago Cubs | L 3-9 | 1522.56 | 1490.95 | 58.32% | 41.68% | -4.74 | 12-13 |
| 2021-04-30 | @ Toronto Blue Jays | L 5-13 | 1517.82 | 1498.75 | 52.74% | 47.26% | -4.95 | 12-14 |
| 2021-05-01 | @ Toronto Blue Jays | L 5-6 | 1512.87 | 1503.70 | 51.32% | 48.68% | -1.21 | 12-15 |
| 2021-05-02 | @ Toronto Blue Jays | L 2-7 | 1511.66 | 1504.91 | 50.97% | 49.03% | -3.78 | 12-16 |
| 2021-05-04 | @ Washington Nationals | W 6-1 | 1507.88 | 1504.18 | 46.68% | 53.32% | +3.96 | 13-16 |
| 2021-05-05 | @ Washington Nationals | W 5-3 | 1511.84 | 1500.23 | 47.82% | 52.18% | +2.45 | 14-16 |
| 2021-05-06 | @ Washington Nationals | W 3-2 | 1514.29 | 1497.78 | 48.52% | 51.48% | +1.70 | 15-16 |
| 2021-05-07 | Philadelphia Phillies | L 2-12 | 1515.99 | 1492.81 | 57.14% | 42.86% | -5.99 | 15-17 |
| 2021-05-08 | Philadelphia Phillies | W 8-7 | 1510.00 | 1498.80 | 55.44% | 44.56% | +1.04 | 16-17 |
| 2021-05-09 | Philadelphia Phillies | W 6-1 | 1511.04 | 1497.76 | 55.74% | 44.26% | +3.29 | 17-17 |
| 2021-05-11 | Toronto Blue Jays | L 3-5 | 1514.33 | 1511.13 | 54.30% | 45.70% | -2.55 | 17-18 |
| 2021-05-12 | Toronto Blue Jays | L 1-4 | 1511.78 | 1513.68 | 53.57% | 46.43% | -3.08 | 17-19 |
| 2021-05-13 | Toronto Blue Jays | L 4-8 | 1508.70 | 1516.76 | 52.69% | 47.31% | -3.50 | 17-20 |
| 2021-05-14 | @ Milwaukee Brewers | W 6-3 | 1505.20 | 1499.36 | 46.99% | 53.01% | +3.05 | 18-20 |
| 2021-05-15 | @ Milwaukee Brewers | W 5-1 | 1508.25 | 1496.31 | 47.87% | 52.13% | +3.46 | 19-20 |
| 2021-05-16 | @ Milwaukee Brewers | L 9-10 | 1511.71 | 1492.85 | 48.86% | 51.14% | -1.62 | 19-21 |
| 2021-05-17 | New York Mets | L 1-3 | 1510.09 | 1499.48 | 55.36% | 44.64% | -2.60 | 19-22 |
| 2021-05-18 | New York Mets | L 3-4 | 1507.49 | 1502.08 | 54.62% | 45.38% | -1.82 | 19-23 |
| 2021-05-19 | New York Mets | W 5-4 | 1505.67 | 1503.89 | 54.10% | 45.90% | +1.53 | 20-23 |
| 2021-05-20 | Pittsburgh Pirates | L 4-6 | 1507.20 | 1451.62 | 61.63% | 38.37% | -2.05 | 20-24 |
| 2021-05-21 | Pittsburgh Pirates | W 20-1 | 1505.15 | 1453.67 | 61.08% | 38.92% | +5.63 | 21-24 |
| 2021-05-22 | Pittsburgh Pirates | W 6-1 | 1510.78 | 1448.04 | 62.61% | 37.39% | +2.78 | 22-24 |
| 2021-05-23 | Pittsburgh Pirates | W 7-1 | 1513.56 | 1445.26 | 63.35% | 36.65% | +2.98 | 23-24 |
| 2021-05-25 | @ Boston Red Sox | W 3-1 | 1516.54 | 1521.40 | 45.46% | 54.54% | +2.56 | 24-24 |
| 2021-05-26 | @ Boston Red Sox | L 5-9 | 1519.10 | 1518.84 | 46.19% | 53.81% | -3.07 | 24-25 |
| 2021-05-29 | @ New York Mets | L 2-13 | 1516.03 | 1501.49 | 48.24% | 51.76% | -5.31 | 24-26 |
| 2021-05-31 | Washington Nationals | W 5-3 | 1510.72 | 1487.85 | 57.10% | 42.90% | +2.02 | 25-26 |
| 2021-06-01 | Washington Nationals | L 6-11 | 1512.74 | 1485.84 | 57.66% | 42.34% | -4.28 | 25-27 |
| 2021-06-02 | Washington Nationals | L 3-5 | 1508.46 | 1490.12 | 56.46% | 43.54% | -2.65 | 25-28 |
| 2021-06-03 | Washington Nationals | W 5-1 | 1505.81 | 1492.77 | 55.71% | 44.29% | +2.94 | 26-28 |
| 2021-06-04 | Los Angeles Dodgers | L 5-9 | 1508.75 | 1581.52 | 43.42% | 56.58% | -2.89 | 26-29 |
| 2021-06-05 | Los Angeles Dodgers | W 6-4 | 1505.86 | 1584.40 | 42.61% | 57.39% | +2.70 | 27-29 |
| 2021-06-06 | Los Angeles Dodgers | W 4-2 | 1508.56 | 1581.71 | 43.37% | 56.63% | +2.66 | 28-29 |
| 2021-06-08 | @ Philadelphia Phillies | W 9-5 | 1511.22 | 1490.75 | 49.09% | 50.91% | +3.38 | 29-29 |
| 2021-06-09 | @ Philadelphia Phillies | L 1-2 | 1514.60 | 1487.37 | 50.06% | 49.94% | -1.66 | 29-30 |
| 2021-06-10 | @ Philadelphia Phillies | L 3-4 | 1512.94 | 1489.03 | 49.59% | 50.41% | -1.17 | 29-31 |
| 2021-06-11 | @ Miami Marlins | L 3-4 | 1511.77 | 1483.11 | 50.27% | 49.73% | -1.67 | 29-32 |
| 2021-06-12 | @ Miami Marlins | L 2-4 | 1510.10 | 1484.78 | 49.79% | 50.21% | -2.34 | 29-33 |
| 2021-06-13 | @ Miami Marlins | W 6-4 | 1507.76 | 1487.12 | 49.12% | 50.88% | +2.39 | 30-33 |
| 2021-06-15 | Boston Red Sox | L 8-10 | 1510.15 | 1518.97 | 52.58% | 47.42% | -2.47 | 30-34 |
| 2021-06-16 | Boston Red Sox | L 8-10 | 1507.68 | 1521.44 | 51.87% | 48.13% | -2.43 | 30-35 |
| 2021-06-17 | St. Louis Cardinals | W 4-0 | 1505.25 | 1494.22 | 55.42% | 44.58% | +2.96 | 31-35 |
| 2021-06-18 | St. Louis Cardinals | W 9-1 | 1508.21 | 1491.26 | 56.26% | 43.74% | +4.11 | 32-35 |
| 2021-06-20 | St. Louis Cardinals | L 1-9 | 1512.32 | 1487.15 | 57.42% | 42.58% | -5.40 | 32-36 |
| 2021-06-20 | St. Louis Cardinals | W 1-0 | 1506.92 | 1492.55 | 55.90% | 44.10% | +1.47 | 33-36 |
| 2021-06-21 | @ New York Mets | L 2-4 | 1508.39 | 1516.45 | 45.00% | 55.00% | -2.11 | 33-37 |
| 2021-06-21 | @ New York Mets | W 1-0 | 1506.28 | 1518.57 | 44.40% | 55.60% | +1.84 | 34-37 |
| 2021-06-22 | @ New York Mets | W 3-0 | 1508.12 | 1516.72 | 44.93% | 55.07% | +3.17 | 35-37 |
| 2021-06-23 | @ New York Mets | L 3-7 | 1511.29 | 1513.56 | 45.83% | 54.17% | -3.04 | 35-38 |
| 2021-06-24 | @ Cincinnati Reds | L 3-5 | 1508.25 | 1492.95 | 48.35% | 51.65% | -2.27 | 35-39 |
| 2021-06-25 | @ Cincinnati Reds | W 3-2 | 1505.98 | 1495.22 | 47.70% | 52.30% | +1.73 | 36-39 |
| 2021-06-26 | @ Cincinnati Reds | L 1-4 | 1507.71 | 1493.48 | 48.19% | 51.81% | -2.77 | 36-40 |
| 2021-06-27 | @ Cincinnati Reds | W 4-0 | 1504.94 | 1496.26 | 47.40% | 52.60% | +3.49 | 37-40 |
| 2021-06-29 | New York Mets | L 3-4 | 1508.43 | 1511.79 | 53.37% | 46.63% | -1.77 | 37-41 |
| 2021-06-30 | New York Mets | W 20-2 | 1506.66 | 1513.56 | 52.86% | 47.14% | +6.64 | 38-41 |
| 2021-07-01 | New York Mets | W 4-3 | 1513.30 | 1506.92 | 54.76% | 45.24% | +1.50 | 39-41 |
| 2021-07-02 | Miami Marlins | W 1-0 | 1514.80 | 1487.97 | 57.65% | 42.35% | +1.41 | 40-41 |
| 2021-07-03 | Miami Marlins | L 2-3 | 1516.21 | 1486.57 | 58.05% | 41.95% | -1.93 | 40-42 |
| 2021-07-04 | Miami Marlins | W 8-7 | 1514.28 | 1488.49 | 57.51% | 42.49% | +1.00 | 41-42 |
| 2021-07-05 | @ Pittsburgh Pirates | L 1-11 | 1515.28 | 1425.27 | 59.00% | 41.00% | -6.19 | 41-43 |
| 2021-07-06 | @ Pittsburgh Pirates | L 1-2 | 1509.09 | 1431.47 | 57.26% | 42.74% | -1.91 | 41-44 |
| 2021-07-07 | @ Pittsburgh Pirates | W 14-3 | 1507.18 | 1433.37 | 56.73% | 43.27% | +4.77 | 42-44 |
| 2021-07-09 | @ Miami Marlins | W 5-0 | 1511.95 | 1491.43 | 49.10% | 50.90% | +3.78 | 43-44 |
| 2021-07-10 | @ Miami Marlins | W 5-4 | 1515.73 | 1487.65 | 50.19% | 49.81% | +1.65 | 44-44 |
| 2021-07-11 | @ Miami Marlins | L 4-7 | 1517.38 | 1485.99 | 50.66% | 49.34% | -2.91 | 44-45 |
| 2021-07-16 | Tampa Bay Rays | L 6-7 | 1514.47 | 1563.52 | 46.80% | 53.20% | -1.10 | 44-46 |
| 2021-07-17 | Tampa Bay Rays | W 9-0 | 1513.37 | 1564.62 | 46.48% | 53.52% | +5.33 | 45-46 |
| 2021-07-18 | Tampa Bay Rays | L 5-7 | 1518.70 | 1559.29 | 48.01% | 51.99% | -2.25 | 45-47 |
| 2021-07-20 | San Diego Padres | W 2-1 | 1516.45 | 1539.14 | 50.59% | 49.41% | +1.64 | 46-47 |
| 2021-07-21 | San Diego Padres | L 2-3 | 1518.09 | 1537.50 | 51.06% | 48.94% | -1.70 | 46-48 |
| 2021-07-21 | San Diego Padres | L 5-6 | 1516.39 | 1539.19 | 50.57% | 49.43% | -1.68 | 46-49 |
| 2021-07-22 | @ Philadelphia Phillies | W 7-2 | 1514.71 | 1500.11 | 48.25% | 51.75% | +3.84 | 47-49 |
| 2021-07-23 | @ Philadelphia Phillies | L 1-5 | 1518.55 | 1496.27 | 49.35% | 50.65% | -3.27 | 47-50 |
| 2021-07-24 | @ Philadelphia Phillies | W 15-3 | 1515.28 | 1499.55 | 48.41% | 51.59% | +5.93 | 48-50 |
| 2021-07-25 | @ Philadelphia Phillies | L 1-2 | 1521.21 | 1493.62 | 50.12% | 49.88% | -1.66 | 48-51 |
| 2021-07-26 | @ New York Mets | W 2-0 | 1519.55 | 1510.36 | 47.47% | 52.53% | +2.46 | 49-51 |
| 2021-07-26 | @ New York Mets | L 0-1 | 1522.01 | 1507.90 | 48.18% | 51.82% | -1.60 | 49-52 |
| 2021-07-27 | @ New York Mets | W 12-5 | 1520.41 | 1509.50 | 47.72% | 52.28% | +4.60 | 50-52 |
| 2021-07-28 | @ New York Mets | L 1-2 | 1525.01 | 1504.91 | 49.04% | 50.96% | -1.63 | 50-53 |
| 2021-07-29 | @ New York Mets | W 6-3 | 1523.38 | 1506.53 | 48.57% | 51.43% | +2.96 | 51-53 |
| 2021-07-30 | Milwaukee Brewers | L 5-9 | 1526.34 | 1545.10 | 51.15% | 48.85% | -3.40 | 51-54 |
| 2021-07-31 | Milwaukee Brewers | W 8-1 | 1522.94 | 1548.49 | 50.18% | 49.82% | +4.37 | 52-54 |
| 2021-08-01 | Milwaukee Brewers | L 1-2 | 1527.31 | 1544.12 | 51.44% | 48.56% | -1.70 | 52-55 |
| 2021-08-03 | @ St. Louis Cardinals | W 6-1 | 1525.61 | 1487.21 | 51.67% | 48.33% | +3.59 | 53-55 |
| 2021-08-04 | @ St. Louis Cardinals | W 7-4 | 1529.20 | 1483.63 | 52.70% | 47.30% | +2.72 | 54-55 |
| 2021-08-05 | @ St. Louis Cardinals | W 8-4 | 1531.92 | 1480.91 | 53.48% | 46.52% | +3.08 | 55-55 |
| 2021-08-06 | Washington Nationals | W 8-4 | 1535.00 | 1482.50 | 61.22% | 38.78% | +2.58 | 56-55 |
| 2021-08-07 | Washington Nationals | L 2-3 | 1537.58 | 1479.92 | 61.92% | 38.08% | -2.06 | 56-56 |
| 2021-08-08 | Washington Nationals | W 5-4 | 1535.52 | 1481.98 | 61.36% | 38.64% | +1.29 | 57-56 |
| 2021-08-10 | Cincinnati Reds | W 3-2 | 1536.81 | 1512.68 | 57.27% | 42.73% | +1.41 | 58-56 |
| 2021-08-11 | Cincinnati Reds | W 8-6 | 1538.22 | 1511.26 | 57.67% | 42.33% | +1.41 | 59-56 |
| 2021-08-12 | Cincinnati Reds | L 3-12 | 1539.63 | 1509.86 | 58.07% | 41.93% | -5.78 | 59-57 |
| 2021-08-13 | @ Washington Nationals | W 4-2 | 1533.85 | 1475.13 | 54.58% | 45.42% | +2.13 | 60-57 |
| 2021-08-14 | @ Washington Nationals | W 12-2 | 1535.98 | 1473.00 | 55.19% | 44.81% | +4.70 | 61-57 |
| 2021-08-15 | @ Washington Nationals | W 6-5 | 1540.68 | 1468.29 | 56.53% | 43.47% | +1.45 | 62-57 |
| 2021-08-16 | @ Miami Marlins | W 12-2 | 1542.13 | 1478.51 | 55.28% | 44.72% | +4.69 | 63-57 |
| 2021-08-17 | @ Miami Marlins | W 2-0 | 1546.82 | 1473.81 | 56.61% | 43.39% | +2.04 | 64-57 |
| 2021-08-18 | @ Miami Marlins | W 11-9 | 1548.86 | 1471.78 | 57.19% | 42.81% | +2.01 | 65-57 |
| 2021-08-20 | @ Baltimore Orioles | W 3-0 | 1550.87 | 1399.75 | 67.17% | 32.83% | +1.89 | 66-57 |
| 2021-08-21 | @ Baltimore Orioles | W 5-4 | 1552.76 | 1397.86 | 67.64% | 32.36% | +1.07 | 67-57 |
| 2021-08-22 | @ Baltimore Orioles | W 3-1 | 1553.83 | 1396.79 | 67.91% | 32.09% | +1.51 | 68-57 |
| 2021-08-23 | New York Yankees | L 1-5 | 1555.34 | 1546.61 | 55.09% | 44.91% | -3.66 | 68-58 |
| 2021-08-24 | New York Yankees | L 4-5 | 1551.68 | 1550.27 | 54.05% | 45.95% | -1.80 | 68-59 |
| 2021-08-27 | San Francisco Giants | W 6-5 | 1549.88 | 1573.07 | 50.52% | 49.48% | +1.65 | 69-59 |
| 2021-08-28 | San Francisco Giants | L 0-5 | 1551.53 | 1571.42 | 50.99% | 49.01% | -3.79 | 69-60 |
| 2021-08-29 | San Francisco Giants | W 9-0 | 1547.74 | 1575.21 | 49.90% | 50.10% | +4.99 | 70-60 |
| 2021-08-30 | @ Los Angeles Dodgers | L 3-5 | 1552.73 | 1603.96 | 38.96% | 61.04% | -1.83 | 70-61 |
| 2021-08-31 | @ Los Angeles Dodgers | L 2-3 | 1550.90 | 1605.79 | 38.46% | 61.54% | -1.27 | 70-62 |
| 2021-09-01 | @ Los Angeles Dodgers | L 3-4 | 1549.63 | 1607.07 | 38.11% | 61.89% | -1.27 | 70-63 |
| 2021-09-02 | @ Colorado Rockies | W 6-5 | 1548.36 | 1487.09 | 54.95% | 45.05% | +1.50 | 71-63 |
| 2021-09-03 | @ Colorado Rockies | L 3-4 | 1549.86 | 1485.59 | 55.37% | 44.63% | -1.84 | 71-64 |
| 2021-09-04 | @ Colorado Rockies | L 6-7 | 1548.02 | 1487.43 | 54.85% | 45.15% | -1.82 | 71-65 |
| 2021-09-05 | @ Colorado Rockies | W 9-2 | 1546.20 | 1489.25 | 54.33% | 45.67% | +4.01 | 72-65 |
| 2021-09-07 | Washington Nationals | W 8-5 | 1550.21 | 1457.18 | 66.59% | 33.41% | +1.92 | 73-65 |
| 2021-09-08 | Washington Nationals | L 2-4 | 1552.13 | 1455.26 | 67.08% | 32.92% | -3.15 | 73-66 |
| 2021-09-09 | Washington Nationals | W 7-6 | 1548.98 | 1458.41 | 66.27% | 33.73% | +0.79 | 74-66 |
| 2021-09-10 | Miami Marlins | W 6-2 | 1549.77 | 1462.93 | 65.79% | 34.21% | +2.27 | 75-66 |
| 2021-09-11 | Miami Marlins | L 4-6 | 1552.04 | 1460.66 | 66.38% | 33.62% | -3.11 | 75-67 |
| 2021-09-12 | Miami Marlins | W 5-3 | 1548.93 | 1463.77 | 65.57% | 34.43% | +1.61 | 76-67 |
| 2021-09-14 | Colorado Rockies | L 4-5 | 1550.54 | 1481.75 | 63.42% | 36.58% | -2.10 | 76-68 |
| 2021-09-15 | Colorado Rockies | L 2-3 | 1548.44 | 1483.85 | 62.85% | 37.15% | -1.48 | 76-69 |
| 2021-09-17 | @ San Francisco Giants | L 5-6 | 1546.96 | 1579.97 | 41.48% | 58.52% | -0.97 | 76-70 |
| 2021-09-18 | @ San Francisco Giants | L 0-2 | 1545.99 | 1580.94 | 41.21% | 58.79% | -1.94 | 76-71 |
| 2021-09-19 | @ San Francisco Giants | W 3-0 | 1544.05 | 1582.88 | 40.67% | 59.33% | +3.42 | 77-71 |
| 2021-09-20 | @ Arizona Diamondbacks | W 11-4 | 1547.47 | 1416.69 | 64.53% | 35.47% | +3.11 | 78-71 |
| 2021-09-21 | @ Arizona Diamondbacks | W 6-1 | 1550.58 | 1413.58 | 65.35% | 34.65% | +2.57 | 79-71 |
| 2021-09-22 | @ Arizona Diamondbacks | W 9-2 | 1553.15 | 1411.00 | 66.02% | 33.98% | +2.99 | 80-71 |
| 2021-09-23 | @ Arizona Diamondbacks | L 4-6 | 1556.14 | 1408.02 | 66.79% | 33.21% | -3.14 | 80-72 |
| 2021-09-24 | @ San Diego Padres | W 4-0 | 1553.00 | 1495.60 | 54.40% | 45.60% | +3.03 | 81-72 |
| 2021-09-25 | @ San Diego Padres | W 10-8 | 1556.03 | 1492.57 | 55.26% | 44.74% | +1.49 | 82-72 |
| 2021-09-26 | @ San Diego Padres | W 4-3 | 1557.52 | 1491.09 | 55.68% | 44.32% | +1.47 | 83-72 |
| 2021-09-28 | Philadelphia Phillies | W 2-1 | 1558.99 | 1499.57 | 62.16% | 37.84% | +1.25 | 84-72 |
| 2021-09-29 | Philadelphia Phillies | W 7-2 | 1560.24 | 1498.31 | 62.50% | 37.50% | +2.79 | 85-72 |
| 2021-09-30 | Philadelphia Phillies | W 5-3 | 1563.03 | 1495.53 | 63.24% | 36.76% | +1.72 | 86-72 |
| 2021-10-01 | New York Mets | L 3-4 | 1564.75 | 1480.06 | 65.51% | 34.49% | -2.17 | 86-73 |
| 2021-10-02 | New York Mets | W 6-5 | 1562.58 | 1482.24 | 64.95% | 35.05% | +1.16 | 87-73 |
| 2021-10-03 | New York Mets | W 5-0 | 1563.74 | 1481.08 | 65.25% | 34.75% | +2.58 | 88-73 |
| 2021-04-02 | @ Boston Red Sox | W 3-0 | 1477.07 | 1495.50 | 43.53% | 56.47% | +3.25 | 1-0 |
| 2021-04-03 | @ Boston Red Sox | W 4-2 | 1480.32 | 1492.25 | 44.45% | 55.55% | +2.60 | 2-0 |
| 2021-04-04 | @ Boston Red Sox | W 11-3 | 1482.92 | 1489.64 | 45.19% | 54.81% | +5.15 | 3-0 |
| 2021-04-05 | @ New York Yankees | L 0-7 | 1488.07 | 1526.55 | 40.72% | 59.28% | -3.58 | 3-1 |
| 2021-04-06 | @ New York Yankees | L 2-7 | 1484.49 | 1530.13 | 39.73% | 60.27% | -2.95 | 3-2 |
| 2021-04-07 | @ New York Yankees | W 4-3 | 1481.54 | 1533.08 | 38.92% | 61.08% | +1.44 | 4-2 |
| 2021-04-08 | Boston Red Sox | L 3-7 | 1482.98 | 1495.41 | 52.06% | 47.94% | -3.46 | 4-3 |
| 2021-04-10 | Boston Red Sox | L 4-6 | 1479.52 | 1498.87 | 51.07% | 48.93% | -1.69 | 4-4 |
| 2021-04-11 | Boston Red Sox | L 9-14 | 1477.83 | 1500.56 | 50.58% | 49.42% | -3.76 | 4-5 |
| 2021-04-13 | Seattle Mariners | L 3-4 | 1474.07 | 1482.55 | 52.63% | 47.37% | -1.23 | 4-6 |
| 2021-04-13 | Seattle Mariners | W 7-6 | 1472.84 | 1483.78 | 52.28% | 47.72% | +1.58 | 5-6 |
| 2021-04-15 | Seattle Mariners | L 2-4 | 1474.42 | 1482.20 | 52.73% | 47.27% | -2.48 | 5-7 |
| 2021-04-15 | Seattle Mariners | L 1-2 | 1471.94 | 1484.67 | 52.02% | 47.98% | -1.72 | 5-8 |
| 2021-04-16 | @ Texas Rangers | W 5-2 | 1470.22 | 1472.45 | 45.83% | 54.17% | +3.11 | 6-8 |
| 2021-04-17 | @ Texas Rangers | W 6-1 | 1473.33 | 1469.34 | 46.73% | 53.27% | +3.96 | 7-8 |
| 2021-04-18 | @ Texas Rangers | L 0-1 | 1477.29 | 1465.38 | 47.86% | 52.14% | -1.13 | 7-9 |
| 2021-04-20 | @ Miami Marlins | W 7-5 | 1476.16 | 1482.37 | 45.27% | 54.73% | +2.57 | 8-9 |
| 2021-04-21 | @ Miami Marlins | L 0-3 | 1478.73 | 1479.80 | 46.00% | 54.00% | -2.64 | 8-10 |
| 2021-04-23 | Oakland Athletics | L 1-3 | 1476.09 | 1524.72 | 46.86% | 53.14% | -2.20 | 8-11 |
| 2021-04-24 | Oakland Athletics | L 2-7 | 1473.89 | 1526.92 | 46.23% | 53.77% | -3.43 | 8-12 |
| 2021-04-25 | Oakland Athletics | W 8-1 | 1470.46 | 1530.35 | 45.25% | 54.75% | +4.80 | 9-12 |
| 2021-04-26 | New York Yankees | W 4-2 | 1475.26 | 1517.17 | 47.83% | 52.17% | +2.45 | 10-12 |
| 2021-04-27 | New York Yankees | L 1-5 | 1477.71 | 1514.72 | 48.53% | 51.47% | -3.22 | 10-13 |
| 2021-04-28 | New York Yankees | L 0-7 | 1474.49 | 1517.94 | 47.60% | 52.40% | -4.18 | 10-14 |
| 2021-04-29 | New York Yankees | W 4-3 | 1470.31 | 1522.12 | 46.40% | 53.60% | +1.26 | 11-14 |
| 2021-04-30 | @ Oakland Athletics | W 3-2 | 1471.57 | 1525.43 | 38.60% | 61.40% | +2.04 | 12-14 |
| 2021-05-01 | @ Oakland Athletics | W 8-4 | 1473.61 | 1523.39 | 39.16% | 60.84% | +4.04 | 13-14 |
| 2021-05-02 | @ Oakland Athletics | L 5-7 | 1477.65 | 1519.35 | 40.27% | 59.73% | -1.89 | 13-15 |
| 2021-05-03 | @ Seattle Mariners | W 5-3 | 1475.76 | 1490.95 | 43.99% | 56.01% | +2.63 | 14-15 |
| 2021-05-04 | @ Seattle Mariners | L 2-5 | 1478.39 | 1488.32 | 44.74% | 55.26% | -2.58 | 14-16 |
| 2021-05-05 | @ Seattle Mariners | W 6-0 | 1475.81 | 1490.89 | 44.00% | 56.00% | +4.56 | 15-16 |
| 2021-05-07 | Boston Red Sox | L 2-6 | 1480.37 | 1509.94 | 49.60% | 50.40% | -3.30 | 15-17 |
| 2021-05-08 | Boston Red Sox | L 6-11 | 1477.07 | 1513.23 | 48.65% | 51.35% | -3.61 | 15-18 |
| 2021-05-09 | Boston Red Sox | L 3-4 | 1473.46 | 1516.84 | 47.61% | 52.39% | -1.58 | 15-19 |
| 2021-05-10 | Boston Red Sox | W 4-1 | 1471.88 | 1518.42 | 47.16% | 52.84% | +3.04 | 16-19 |
| 2021-05-11 | @ New York Mets | L 2-3 | 1474.92 | 1503.22 | 42.14% | 57.86% | -1.40 | 16-20 |
| 2021-05-12 | @ New York Mets | L 1-7 | 1473.52 | 1504.62 | 41.75% | 58.25% | -3.39 | 16-21 |
| 2021-05-14 | New York Yankees | L 4-5 | 1470.13 | 1527.33 | 45.63% | 54.37% | -1.52 | 16-22 |
| 2021-05-15 | New York Yankees | L 2-8 | 1468.61 | 1528.85 | 45.20% | 54.80% | -3.67 | 16-23 |
| 2021-05-16 | New York Yankees | W 10-6 | 1464.94 | 1532.52 | 44.15% | 55.85% | +3.70 | 17-23 |
| 2021-05-18 | Tampa Bay Rays | L 6-13 | 1468.64 | 1539.07 | 43.75% | 56.25% | -3.84 | 17-24 |
| 2021-05-19 | Tampa Bay Rays | L 7-9 | 1464.80 | 1542.92 | 42.67% | 57.33% | -2.00 | 17-25 |
| 2021-05-20 | Tampa Bay Rays | L 1-10 | 1462.80 | 1544.92 | 42.10% | 57.90% | -4.20 | 17-26 |
| 2021-05-21 | @ Washington Nationals | L 2-4 | 1458.60 | 1495.26 | 40.97% | 59.03% | -1.92 | 17-27 |
| 2021-05-22 | @ Washington Nationals | L 9-12 | 1456.68 | 1497.18 | 40.44% | 59.56% | -2.32 | 17-28 |
| 2021-05-23 | @ Washington Nationals | L 5-6 | 1454.36 | 1499.51 | 39.79% | 60.21% | -1.33 | 17-29 |
| 2021-05-24 | @ Minnesota Twins | L 3-8 | 1453.03 | 1489.82 | 40.95% | 59.05% | -3.04 | 17-30 |
| 2021-05-25 | @ Minnesota Twins | L 4-7 | 1449.99 | 1492.86 | 40.11% | 59.89% | -2.30 | 17-31 |
| 2021-05-26 | @ Minnesota Twins | L 2-3 | 1447.69 | 1495.16 | 39.47% | 60.53% | -1.31 | 17-32 |
| 2021-05-27 | @ Chicago White Sox | L 1-5 | 1446.38 | 1531.36 | 34.45% | 65.55% | -2.29 | 17-33 |
| 2021-05-29 | @ Chicago White Sox | L 4-7 | 1444.09 | 1533.65 | 33.86% | 66.14% | -1.95 | 17-34 |
| 2021-05-29 | @ Chicago White Sox | L 1-3 | 1442.14 | 1535.60 | 33.36% | 66.64% | -1.56 | 17-35 |
| 2021-05-30 | @ Chicago White Sox | L 1-3 | 1440.58 | 1537.16 | 32.96% | 67.04% | -1.55 | 17-36 |
| 2021-05-31 | Minnesota Twins | L 2-3 | 1439.03 | 1490.31 | 46.48% | 53.52% | -1.09 | 17-37 |
| 2021-06-01 | Minnesota Twins | W 7-4 | 1437.94 | 1491.40 | 46.17% | 53.83% | +3.09 | 18-37 |
| 2021-06-02 | Minnesota Twins | W 6-3 | 1441.03 | 1488.30 | 47.05% | 52.95% | +3.05 | 19-37 |
| 2021-06-04 | Cleveland Indians | W 3-1 | 1444.08 | 1507.88 | 44.69% | 55.31% | +2.59 | 20-37 |
| 2021-06-05 | Cleveland Indians | L 4-10 | 1446.67 | 1505.29 | 45.43% | 54.57% | -3.69 | 20-38 |
| 2021-06-06 | Cleveland Indians | W 18-5 | 1442.98 | 1508.98 | 44.38% | 55.62% | +6.66 | 21-38 |
| 2021-06-08 | New York Mets | W 10-3 | 1449.64 | 1514.70 | 44.51% | 55.49% | +4.87 | 22-38 |
| 2021-06-09 | New York Mets | L 1-14 | 1454.51 | 1509.82 | 45.90% | 54.10% | -5.49 | 22-39 |
| 2021-06-11 | @ Tampa Bay Rays | L 2-4 | 1449.02 | 1568.35 | 30.13% | 69.87% | -1.42 | 22-40 |
| 2021-06-12 | @ Tampa Bay Rays | L 4-5 | 1447.60 | 1569.77 | 29.79% | 70.21% | -0.99 | 22-41 |
| 2021-06-13 | @ Tampa Bay Rays | L 1-7 | 1446.61 | 1570.75 | 29.55% | 70.45% | -2.40 | 22-42 |
| 2021-06-14 | @ Cleveland Indians | L 3-4 | 1444.21 | 1504.17 | 37.77% | 62.23% | -1.25 | 22-43 |
| 2021-06-15 | @ Cleveland Indians | L 2-7 | 1442.96 | 1505.42 | 37.43% | 62.57% | -2.78 | 22-44 |
| 2021-06-16 | @ Cleveland Indians | L 7-8 | 1440.18 | 1508.20 | 36.69% | 63.31% | -1.22 | 22-45 |
| 2021-06-17 | @ Cleveland Indians | L 3-10 | 1438.96 | 1509.42 | 36.36% | 63.64% | -3.19 | 22-46 |
| 2021-06-18 | Toronto Blue Jays | W 7-1 | 1435.77 | 1521.14 | 41.65% | 58.35% | +4.74 | 23-46 |
| 2021-06-19 | Toronto Blue Jays | L 7-10 | 1440.51 | 1516.40 | 42.98% | 57.02% | -2.47 | 23-47 |
| 2021-06-20 | Toronto Blue Jays | L 4-7 | 1438.04 | 1518.87 | 42.28% | 57.72% | -2.43 | 23-48 |
| 2021-06-21 | Houston Astros | L 2-10 | 1435.61 | 1572.53 | 34.66% | 65.34% | -3.26 | 23-49 |
| 2021-06-22 | Houston Astros | L 1-3 | 1432.35 | 1575.79 | 33.82% | 66.18% | -1.58 | 23-50 |
| 2021-06-23 | Houston Astros | L 0-13 | 1430.77 | 1577.37 | 33.41% | 66.59% | -4.00 | 23-51 |
| 2021-06-24 | @ Toronto Blue Jays | L 0-9 | 1426.77 | 1525.23 | 32.72% | 67.28% | -3.26 | 23-52 |
| 2021-06-25 | @ Toronto Blue Jays | W 6-5 | 1423.51 | 1528.49 | 31.90% | 68.10% | +1.60 | 24-52 |
| 2021-06-26 | @ Toronto Blue Jays | L 4-12 | 1425.11 | 1526.89 | 32.30% | 67.70% | -3.04 | 24-53 |
| 2021-06-27 | @ Toronto Blue Jays | L 2-5 | 1422.07 | 1529.92 | 31.54% | 68.46% | -1.81 | 24-54 |
| 2021-06-28 | @ Houston Astros | W 9-7 | 1420.26 | 1581.46 | 25.31% | 74.69% | +3.51 | 25-54 |
| 2021-06-29 | @ Houston Astros | W 13-3 | 1423.77 | 1577.95 | 26.08% | 73.92% | +7.76 | 26-54 |
| 2021-06-30 | @ Houston Astros | W 5-2 | 1431.53 | 1570.19 | 27.84% | 72.16% | +4.15 | 27-54 |
| 2021-07-02 | @ Los Angeles Angels | L 7-8 | 1435.68 | 1485.84 | 39.10% | 60.90% | -1.30 | 27-55 |
| 2021-07-03 | @ Los Angeles Angels | L 1-4 | 1434.38 | 1487.14 | 38.75% | 61.25% | -2.23 | 27-56 |
| 2021-07-04 | @ Los Angeles Angels | L 5-6 | 1432.15 | 1489.37 | 38.14% | 61.86% | -1.27 | 27-57 |
| 2021-07-06 | Toronto Blue Jays | W 7-5 | 1430.88 | 1532.96 | 39.33% | 60.67% | +2.85 | 28-57 |
| 2021-07-07 | Toronto Blue Jays | L 2-10 | 1433.73 | 1530.11 | 40.12% | 59.88% | -3.76 | 28-58 |
| 2021-07-09 | Chicago White Sox | L 1-12 | 1429.97 | 1537.76 | 38.55% | 61.45% | -4.25 | 28-59 |
| 2021-07-10 | Chicago White Sox | L 3-8 | 1425.72 | 1542.01 | 37.40% | 62.60% | -2.78 | 28-60 |
| 2021-07-11 | Chicago White Sox | L 5-7 | 1422.94 | 1544.78 | 36.65% | 63.35% | -1.21 | 28-61 |
| 2021-07-16 | @ Kansas City Royals | L 2-9 | 1421.73 | 1430.84 | 44.85% | 55.15% | -3.94 | 28-62 |
| 2021-07-17 | @ Kansas City Royals | W 8-4 | 1417.79 | 1434.78 | 43.73% | 56.27% | +3.73 | 29-62 |
| 2021-07-18 | @ Kansas City Royals | W 5-0 | 1421.52 | 1431.05 | 44.79% | 55.21% | +4.10 | 30-62 |
| 2021-07-19 | @ Tampa Bay Rays | W 6-1 | 1425.62 | 1561.54 | 28.16% | 71.84% | +5.34 | 31-62 |
| 2021-07-20 | @ Tampa Bay Rays | L 3-9 | 1430.96 | 1556.21 | 29.42% | 70.58% | -2.40 | 31-63 |
| 2021-07-21 | @ Tampa Bay Rays | L 4-5 | 1428.56 | 1558.60 | 28.85% | 71.15% | -0.95 | 31-64 |
| 2021-07-23 | Washington Nationals | W 6-1 | 1427.61 | 1499.91 | 43.49% | 56.51% | +4.19 | 32-64 |
| 2021-07-24 | Washington Nationals | W 5-3 | 1431.80 | 1495.71 | 44.68% | 55.32% | +2.60 | 33-64 |
| 2021-07-25 | Washington Nationals | W 5-4 | 1434.40 | 1493.11 | 45.42% | 54.58% | +1.81 | 34-64 |
| 2021-07-27 | Miami Marlins | L 3-7 | 1436.21 | 1482.73 | 47.16% | 52.84% | -3.13 | 34-65 |
| 2021-07-28 | Miami Marlins | W 8-7 | 1433.08 | 1485.86 | 46.26% | 53.74% | +1.78 | 35-65 |
| 2021-07-29 | @ Detroit Tigers | L 2-6 | 1434.86 | 1466.52 | 41.67% | 58.33% | -2.76 | 35-66 |
| 2021-07-30 | @ Detroit Tigers | W 4-3 | 1432.10 | 1469.29 | 40.90% | 59.10% | +1.96 | 36-66 |
| 2021-07-31 | @ Detroit Tigers | W 5-2 | 1434.06 | 1467.33 | 41.44% | 58.56% | +3.37 | 37-66 |
| 2021-08-01 | @ Detroit Tigers | L 2-6 | 1437.43 | 1463.96 | 42.39% | 57.61% | -2.82 | 37-67 |
| 2021-08-02 | @ New York Yankees | W 7-1 | 1434.61 | 1524.51 | 33.81% | 66.19% | +5.38 | 38-67 |
| 2021-08-03 | @ New York Yankees | L 1-13 | 1439.99 | 1519.12 | 35.21% | 64.79% | -4.05 | 38-68 |
| 2021-08-04 | @ New York Yankees | L 3-10 | 1435.94 | 1523.17 | 34.16% | 65.84% | -3.00 | 38-69 |
| 2021-08-06 | Tampa Bay Rays | L 6-10 | 1432.94 | 1566.07 | 35.16% | 64.84% | -2.33 | 38-70 |
| 2021-08-07 | Tampa Bay Rays | L 3-12 | 1430.61 | 1568.40 | 34.55% | 65.45% | -3.44 | 38-71 |
| 2021-08-08 | Tampa Bay Rays | L 6-9 | 1427.17 | 1571.84 | 33.66% | 66.34% | -1.94 | 38-72 |
| 2021-08-10 | Detroit Tigers | L 4-9 | 1425.23 | 1468.03 | 47.70% | 52.30% | -3.54 | 38-73 |
| 2021-08-11 | Detroit Tigers | L 2-5 | 1421.69 | 1471.57 | 46.68% | 53.32% | -2.68 | 38-74 |
| 2021-08-12 | Detroit Tigers | L 4-6 | 1419.01 | 1474.25 | 45.91% | 54.09% | -2.16 | 38-75 |
| 2021-08-13 | @ Boston Red Sox | L 1-8 | 1416.85 | 1516.63 | 32.55% | 67.45% | -2.86 | 38-76 |
| 2021-08-14 | @ Boston Red Sox | L 2-16 | 1413.99 | 1519.49 | 31.83% | 68.17% | -3.95 | 38-77 |
| 2021-08-15 | @ Boston Red Sox | L 2-6 | 1410.04 | 1523.45 | 30.85% | 69.15% | -2.05 | 38-78 |
| 2021-08-16 | @ Tampa Bay Rays | L 2-9 | 1407.99 | 1568.63 | 25.37% | 74.63% | -2.23 | 38-79 |
| 2021-08-17 | @ Tampa Bay Rays | L 0-10 | 1405.76 | 1570.86 | 24.89% | 75.11% | -2.61 | 38-80 |
| 2021-08-18 | @ Tampa Bay Rays | L 4-8 | 1403.15 | 1573.47 | 24.33% | 75.67% | -1.62 | 38-81 |
| 2021-08-19 | @ Tampa Bay Rays | L 2-7 | 1401.53 | 1575.08 | 23.99% | 76.01% | -1.78 | 38-82 |
| 2021-08-20 | Atlanta Braves | L 0-3 | 1399.75 | 1550.87 | 32.83% | 67.17% | -1.89 | 38-83 |
| 2021-08-21 | Atlanta Braves | L 4-5 | 1397.86 | 1552.76 | 32.36% | 67.64% | -1.07 | 38-84 |
| 2021-08-22 | Atlanta Braves | L 1-3 | 1396.79 | 1553.83 | 32.09% | 67.91% | -1.51 | 38-85 |
| 2021-08-24 | Los Angeles Angels | L 8-14 | 1395.28 | 1475.00 | 42.44% | 57.56% | -3.45 | 38-86 |
| 2021-08-25 | Los Angeles Angels | W 10-6 | 1391.83 | 1478.45 | 41.47% | 58.53% | +3.89 | 39-86 |
| 2021-08-26 | Los Angeles Angels | W 13-1 | 1395.72 | 1474.57 | 42.56% | 57.44% | +6.60 | 40-86 |
| 2021-08-27 | Tampa Bay Rays | L 3-6 | 1402.32 | 1586.19 | 28.82% | 71.18% | -1.65 | 40-87 |
| 2021-08-28 | Tampa Bay Rays | L 3-4 | 1400.67 | 1587.84 | 28.43% | 71.57% | -0.95 | 40-88 |
| 2021-08-29 | Tampa Bay Rays | L 8-12 | 1399.72 | 1588.79 | 28.21% | 71.79% | -1.87 | 40-89 |
| 2021-08-30 | @ Toronto Blue Jays | L 3-7 | 1397.85 | 1542.61 | 27.14% | 72.86% | -1.80 | 40-90 |
| 2021-08-31 | @ Toronto Blue Jays | W 4-2 | 1396.05 | 1544.42 | 26.73% | 73.27% | +3.44 | 41-90 |
| 2021-09-01 | @ Toronto Blue Jays | L 4-5 | 1399.49 | 1540.98 | 27.52% | 72.48% | -0.92 | 41-91 |
| 2021-09-03 | @ New York Yankees | L 3-4 | 1398.57 | 1551.69 | 26.20% | 73.80% | -0.61 | 41-92 |
| 2021-09-04 | @ New York Yankees | W 4-3 | 1397.96 | 1552.31 | 26.06% | 73.94% | +2.45 | 42-92 |
| 2021-09-05 | @ New York Yankees | W 8-7 | 1400.41 | 1549.86 | 26.61% | 73.39% | +2.44 | 43-92 |
| 2021-09-06 | Kansas City Royals | L 2-3 | 1402.85 | 1460.35 | 45.59% | 54.41% | -1.51 | 43-93 |
| 2021-09-07 | Kansas City Royals | W 7-3 | 1401.34 | 1461.86 | 45.16% | 54.84% | +3.64 | 44-93 |
| 2021-09-08 | Kansas City Royals | W 9-8 | 1404.98 | 1458.22 | 46.20% | 53.80% | +1.78 | 45-93 |
| 2021-09-09 | Kansas City Royals | L 0-6 | 1406.76 | 1456.43 | 46.71% | 53.29% | -3.79 | 45-94 |
| 2021-09-10 | Toronto Blue Jays | W 6-3 | 1402.97 | 1563.41 | 31.66% | 68.34% | +3.93 | 46-94 |
| 2021-09-11 | Toronto Blue Jays | L 10-11 | 1406.90 | 1559.48 | 32.65% | 67.35% | -1.09 | 46-95 |
| 2021-09-11 | Toronto Blue Jays | L 2-11 | 1405.81 | 1560.56 | 32.37% | 67.63% | -3.22 | 46-96 |
| 2021-09-12 | Toronto Blue Jays | L 7-22 | 1402.59 | 1563.79 | 31.57% | 68.43% | -4.06 | 46-97 |
| 2021-09-14 | New York Yankees | L 2-7 | 1398.53 | 1529.93 | 35.38% | 64.62% | -2.63 | 46-98 |
| 2021-09-15 | New York Yankees | L 3-4 | 1395.90 | 1532.56 | 34.69% | 65.31% | -1.15 | 46-99 |
| 2021-09-16 | New York Yankees | W 3-2 | 1394.75 | 1533.71 | 34.39% | 65.61% | +1.54 | 47-99 |
| 2021-09-17 | @ Boston Red Sox | L 1-7 | 1396.29 | 1521.86 | 29.38% | 70.62% | -2.39 | 47-100 |
| 2021-09-18 | @ Boston Red Sox | L 3-9 | 1393.90 | 1524.25 | 28.81% | 71.19% | -2.34 | 47-101 |
| 2021-09-19 | @ Boston Red Sox | L 6-8 | 1391.56 | 1526.59 | 28.26% | 71.74% | -1.33 | 47-102 |
| 2021-09-20 | @ Philadelphia Phillies | W 2-0 | 1390.23 | 1500.06 | 31.29% | 68.71% | +3.23 | 48-102 |
| 2021-09-21 | @ Philadelphia Phillies | L 2-3 | 1393.46 | 1496.84 | 32.10% | 67.90% | -0.76 | 48-103 |
| 2021-09-22 | @ Philadelphia Phillies | L 3-4 | 1392.70 | 1497.59 | 31.91% | 68.09% | -1.06 | 48-104 |
| 2021-09-23 | Texas Rangers | W 3-0 | 1391.64 | 1415.99 | 50.35% | 49.65% | +2.86 | 49-104 |
| 2021-09-24 | Texas Rangers | L 5-8 | 1394.50 | 1413.14 | 51.17% | 48.83% | -2.94 | 49-105 |
| 2021-09-25 | Texas Rangers | W 3-2 | 1391.56 | 1416.08 | 50.32% | 49.68% | +1.64 | 50-105 |
| 2021-09-26 | Texas Rangers | L 4-7 | 1393.20 | 1414.43 | 50.80% | 49.20% | -2.92 | 50-106 |
| 2021-09-28 | Boston Red Sox | W 4-2 | 1390.28 | 1524.16 | 35.06% | 64.94% | +3.05 | 51-106 |
| 2021-09-29 | Boston Red Sox | L 0-6 | 1393.33 | 1521.11 | 35.86% | 64.14% | -2.91 | 51-107 |
| 2021-09-30 | Boston Red Sox | W 6-2 | 1390.42 | 1524.03 | 35.09% | 64.91% | +4.31 | 52-107 |
| 2021-10-01 | @ Toronto Blue Jays | L 4-6 | 1394.73 | 1560.03 | 24.87% | 75.13% | -1.17 | 52-108 |
| 2021-10-02 | @ Toronto Blue Jays | L 1-10 | 1393.56 | 1561.19 | 24.62% | 75.38% | -2.45 | 52-109 |
| 2021-10-03 | @ Toronto Blue Jays | L 4-12 | 1391.11 | 1563.65 | 24.10% | 75.90% | -2.27 | 52-110 |
| 2021-04-02 | Baltimore Orioles | L 0-3 | 1495.50 | 1477.07 | 56.47% | 43.53% | -3.25 | 0-1 |
| 2021-04-03 | Baltimore Orioles | L 2-4 | 1492.25 | 1480.32 | 55.55% | 44.45% | -2.61 | 0-2 |
| 2021-04-04 | Baltimore Orioles | L 3-11 | 1489.64 | 1482.92 | 54.81% | 45.19% | -5.14 | 0-3 |
| 2021-04-05 | Tampa Bay Rays | W 11-2 | 1484.50 | 1529.96 | 47.31% | 52.69% | +5.24 | 1-3 |
| 2021-04-06 | Tampa Bay Rays | W 6-5 | 1489.74 | 1524.71 | 48.82% | 51.18% | +1.20 | 2-3 |
| 2021-04-07 | Tampa Bay Rays | W 9-2 | 1490.94 | 1523.51 | 49.17% | 50.83% | +4.47 | 3-3 |
| 2021-04-08 | @ Baltimore Orioles | W 7-3 | 1495.41 | 1482.98 | 47.94% | 52.06% | +3.46 | 4-3 |
| 2021-04-10 | @ Baltimore Orioles | W 6-4 | 1498.87 | 1479.52 | 48.93% | 51.07% | +1.69 | 5-3 |
| 2021-04-11 | @ Baltimore Orioles | W 14-9 | 1500.56 | 1477.83 | 49.42% | 50.58% | +3.76 | 6-3 |
| 2021-04-13 | @ Minnesota Twins | W 4-2 | 1504.32 | 1527.79 | 42.82% | 57.18% | +2.68 | 7-3 |
| 2021-04-14 | @ Minnesota Twins | W 3-2 | 1507.00 | 1525.10 | 43.58% | 56.42% | +1.87 | 8-3 |
| 2021-04-14 | @ Minnesota Twins | W 7-1 | 1508.87 | 1523.23 | 44.11% | 55.89% | +4.55 | 9-3 |
| 2021-04-15 | @ Minnesota Twins | L 3-4 | 1513.42 | 1518.69 | 45.40% | 54.60% | -1.51 | 9-4 |
| 2021-04-17 | Chicago White Sox | W 7-4 | 1511.91 | 1507.47 | 54.48% | 45.52% | +2.62 | 10-4 |
| 2021-04-18 | Chicago White Sox | L 2-3 | 1514.53 | 1504.85 | 55.23% | 44.77% | -1.83 | 10-5 |
| 2021-04-18 | Chicago White Sox | L 1-5 | 1512.70 | 1506.69 | 54.70% | 45.30% | -3.64 | 10-6 |
| 2021-04-19 | Chicago White Sox | W 11-4 | 1509.06 | 1510.32 | 53.67% | 46.33% | +4.07 | 11-6 |
| 2021-04-20 | Toronto Blue Jays | W 4-2 | 1513.13 | 1495.73 | 56.32% | 43.68% | +2.06 | 12-6 |
| 2021-04-21 | Toronto Blue Jays | L 3-6 | 1515.19 | 1493.68 | 56.90% | 43.10% | -3.28 | 12-7 |
| 2021-04-22 | Seattle Mariners | L 3-7 | 1511.91 | 1490.96 | 56.83% | 43.17% | -2.67 | 12-8 |
| 2021-04-23 | Seattle Mariners | W 6-5 | 1509.24 | 1493.62 | 56.07% | 43.93% | +1.46 | 13-8 |
| 2021-04-24 | Seattle Mariners | L 2-8 | 1510.70 | 1492.17 | 56.48% | 43.52% | -4.59 | 13-9 |
| 2021-04-25 | Seattle Mariners | W 5-3 | 1506.11 | 1496.76 | 55.18% | 44.82% | +2.10 | 14-9 |
| 2021-04-27 | @ New York Mets | W 2-1 | 1508.21 | 1495.61 | 47.96% | 52.04% | +1.73 | 15-9 |
| 2021-04-28 | @ New York Mets | W 1-0 | 1509.94 | 1493.88 | 48.46% | 51.54% | +1.71 | 16-9 |
| 2021-04-29 | @ Texas Rangers | L 1-4 | 1511.65 | 1461.97 | 53.29% | 46.71% | -3.06 | 16-10 |
| 2021-04-30 | @ Texas Rangers | W 6-1 | 1508.59 | 1465.03 | 52.41% | 47.59% | +3.53 | 17-10 |
| 2021-05-01 | @ Texas Rangers | L 6-8 | 1512.12 | 1461.50 | 53.43% | 46.57% | -2.51 | 17-11 |
| 2021-05-02 | @ Texas Rangers | L 3-5 | 1509.61 | 1464.01 | 52.71% | 47.29% | -2.47 | 17-12 |
| 2021-05-04 | Detroit Tigers | W 11-7 | 1507.14 | 1427.03 | 64.91% | 35.09% | +2.33 | 18-12 |
| 2021-05-05 | Detroit Tigers | L 5-6 | 1509.47 | 1424.70 | 65.52% | 34.48% | -1.54 | 18-13 |
| 2021-05-06 | Detroit Tigers | W 12-9 | 1507.93 | 1426.24 | 65.12% | 34.88% | +2.01 | 19-13 |
| 2021-05-07 | @ Baltimore Orioles | W 6-2 | 1509.94 | 1480.37 | 50.40% | 49.60% | +3.29 | 20-13 |
| 2021-05-08 | @ Baltimore Orioles | W 11-6 | 1513.23 | 1477.07 | 51.35% | 48.65% | +3.61 | 21-13 |
| 2021-05-09 | @ Baltimore Orioles | W 4-3 | 1516.84 | 1473.46 | 52.39% | 47.61% | +1.58 | 22-13 |
| 2021-05-10 | @ Baltimore Orioles | L 1-4 | 1518.42 | 1471.88 | 52.84% | 47.16% | -3.04 | 22-14 |
| 2021-05-11 | Oakland Athletics | L 2-3 | 1515.38 | 1519.13 | 53.31% | 46.69% | -1.77 | 22-15 |
| 2021-05-12 | Oakland Athletics | L 1-4 | 1513.61 | 1520.90 | 52.80% | 47.20% | -3.03 | 22-16 |
| 2021-05-13 | Oakland Athletics | W 8-1 | 1510.58 | 1523.94 | 51.93% | 48.07% | +4.22 | 23-16 |
| 2021-05-14 | Los Angeles Angels | W 4-3 | 1514.80 | 1471.49 | 59.95% | 40.05% | +1.33 | 24-16 |
| 2021-05-15 | Los Angeles Angels | W 9-0 | 1516.13 | 1470.16 | 60.32% | 39.68% | +3.95 | 25-16 |
| 2021-05-16 | Los Angeles Angels | L 5-6 | 1520.08 | 1466.21 | 61.40% | 38.60% | -2.04 | 25-17 |
| 2021-05-18 | @ Toronto Blue Jays | L 0-8 | 1518.04 | 1522.09 | 49.42% | 50.58% | -4.64 | 25-18 |
| 2021-05-19 | @ Toronto Blue Jays | W 7-3 | 1513.40 | 1526.73 | 48.08% | 51.92% | +3.45 | 26-18 |
| 2021-05-20 | @ Toronto Blue Jays | W 8-7 | 1516.85 | 1523.28 | 49.07% | 50.93% | +1.69 | 27-18 |
| 2021-05-21 | @ Philadelphia Phillies | W 11-3 | 1518.54 | 1491.51 | 50.04% | 49.96% | +4.69 | 28-18 |
| 2021-05-22 | @ Philadelphia Phillies | W 4-3 | 1523.23 | 1486.81 | 51.39% | 48.61% | +1.62 | 29-18 |
| 2021-05-23 | @ Philadelphia Phillies | L 2-6 | 1524.85 | 1485.20 | 51.85% | 48.15% | -3.45 | 29-19 |
| 2021-05-25 | Atlanta Braves | L 1-3 | 1521.40 | 1516.54 | 54.54% | 45.46% | -2.56 | 29-20 |
| 2021-05-26 | Atlanta Braves | W 9-5 | 1518.84 | 1519.10 | 53.81% | 46.19% | +3.07 | 30-20 |
| 2021-05-28 | Miami Marlins | W 5-2 | 1521.91 | 1494.67 | 57.71% | 42.29% | +2.43 | 31-20 |
| 2021-05-29 | Miami Marlins | W 3-1 | 1524.34 | 1492.24 | 58.39% | 41.61% | +1.95 | 32-20 |
| 2021-05-31 | @ Houston Astros | L 2-11 | 1526.29 | 1538.90 | 44.36% | 55.64% | -4.41 | 32-21 |
| 2021-06-01 | @ Houston Astros | L 1-5 | 1521.88 | 1543.32 | 43.10% | 56.90% | -2.87 | 32-22 |
| 2021-06-02 | @ Houston Astros | L 1-2 | 1519.01 | 1546.18 | 42.30% | 57.70% | -1.40 | 32-23 |
| 2021-06-03 | @ Houston Astros | W 5-1 | 1517.61 | 1547.58 | 41.90% | 58.10% | +3.86 | 33-23 |
| 2021-06-04 | @ New York Yankees | W 5-2 | 1521.47 | 1522.23 | 46.04% | 53.96% | +3.10 | 34-23 |
| 2021-06-05 | @ New York Yankees | W 7-3 | 1524.57 | 1519.13 | 46.93% | 53.07% | +3.52 | 35-23 |
| 2021-06-06 | @ New York Yankees | W 6-5 | 1528.09 | 1515.61 | 47.94% | 52.06% | +1.23 | 36-23 |
| 2021-06-07 | Miami Marlins | W 5-3 | 1529.32 | 1480.17 | 60.76% | 39.24% | +1.84 | 37-23 |
| 2021-06-08 | Houston Astros | L 1-7 | 1531.16 | 1549.27 | 51.25% | 48.75% | -4.17 | 37-24 |
| 2021-06-09 | Houston Astros | L 3-8 | 1526.99 | 1553.44 | 50.05% | 49.95% | -3.71 | 37-25 |
| 2021-06-10 | Houston Astros | W 12-8 | 1523.28 | 1557.15 | 48.98% | 51.02% | +3.38 | 38-25 |
| 2021-06-11 | Toronto Blue Jays | W 6-5 | 1526.66 | 1520.81 | 54.68% | 45.32% | +1.51 | 39-25 |
| 2021-06-12 | Toronto Blue Jays | L 2-7 | 1528.17 | 1519.31 | 55.11% | 44.89% | -4.09 | 39-26 |
| 2021-06-13 | Toronto Blue Jays | L 4-18 | 1524.08 | 1523.40 | 53.94% | 46.06% | -6.70 | 39-27 |
| 2021-06-14 | Toronto Blue Jays | W 2-1 | 1517.38 | 1530.10 | 52.02% | 47.98% | +1.59 | 40-27 |
| 2021-06-15 | @ Atlanta Braves | W 10-8 | 1518.97 | 1510.15 | 47.42% | 52.58% | +2.47 | 41-27 |
| 2021-06-16 | @ Atlanta Braves | W 10-8 | 1521.44 | 1507.68 | 48.13% | 51.87% | +2.43 | 42-27 |
| 2021-06-18 | @ Kansas City Royals | L 3-5 | 1523.87 | 1458.99 | 55.46% | 44.54% | -2.60 | 42-28 |
| 2021-06-19 | @ Kansas City Royals | W 7-1 | 1521.27 | 1461.59 | 54.72% | 45.28% | +3.68 | 43-28 |
| 2021-06-20 | @ Kansas City Royals | L 3-7 | 1524.95 | 1457.91 | 55.77% | 44.23% | -3.70 | 43-29 |
| 2021-06-22 | @ Tampa Bay Rays | W 9-5 | 1521.25 | 1561.77 | 40.43% | 59.57% | +2.79 | 44-29 |
| 2021-06-23 | @ Tampa Bay Rays | L 2-8 | 1524.04 | 1558.98 | 41.21% | 58.79% | -3.35 | 44-30 |
| 2021-06-24 | @ Tampa Bay Rays | L 0-1 | 1520.69 | 1562.33 | 40.28% | 59.72% | -1.33 | 44-31 |
| 2021-06-25 | New York Yankees | W 5-3 | 1519.36 | 1523.91 | 53.19% | 46.81% | +2.19 | 45-31 |
| 2021-06-26 | New York Yankees | W 4-2 | 1521.55 | 1521.71 | 53.82% | 46.18% | +2.17 | 46-31 |
| 2021-06-27 | New York Yankees | W 9-2 | 1523.72 | 1519.54 | 54.44% | 45.56% | +4.00 | 47-31 |
| 2021-06-28 | Kansas City Royals | W 6-5 | 1527.72 | 1448.22 | 64.83% | 35.17% | +1.17 | 48-31 |
| 2021-06-29 | Kansas City Royals | W 7-6 | 1528.89 | 1447.06 | 65.14% | 34.86% | +1.16 | 49-31 |
| 2021-06-30 | Kansas City Royals | W 6-2 | 1530.05 | 1445.90 | 65.44% | 34.56% | +2.29 | 50-31 |
| 2021-07-01 | Kansas City Royals | W 15-1 | 1532.34 | 1443.61 | 66.04% | 33.96% | +4.22 | 51-31 |
| 2021-07-02 | @ Oakland Athletics | W 3-2 | 1536.56 | 1532.39 | 46.75% | 53.25% | +1.25 | 52-31 |
| 2021-07-03 | @ Oakland Athletics | L 6-7 | 1537.81 | 1531.14 | 47.11% | 52.89% | -1.10 | 52-32 |
| 2021-07-04 | @ Oakland Athletics | W 1-0 | 1536.71 | 1532.24 | 46.79% | 53.21% | +1.76 | 53-32 |
| 2021-07-05 | @ Los Angeles Angels | W 5-4 | 1538.47 | 1490.64 | 53.03% | 46.97% | +1.56 | 54-32 |
| 2021-07-06 | @ Los Angeles Angels | L 3-5 | 1540.03 | 1489.08 | 53.47% | 46.53% | -2.51 | 54-33 |
| 2021-07-07 | @ Los Angeles Angels | L 4-5 | 1537.52 | 1491.59 | 52.75% | 47.25% | -1.75 | 54-34 |
| 2021-07-09 | Philadelphia Phillies | W 11-5 | 1535.77 | 1496.89 | 59.34% | 40.66% | +3.31 | 55-34 |
| 2021-07-10 | Philadelphia Phillies | L 2-11 | 1539.08 | 1493.58 | 60.25% | 39.75% | -6.00 | 55-35 |
| 2021-07-11 | Philadelphia Phillies | L 4-5 | 1533.08 | 1499.59 | 58.59% | 41.41% | -1.95 | 55-36 |
| 2021-07-16 | @ New York Yankees | W 4-0 | 1531.13 | 1515.72 | 48.36% | 51.64% | +3.43 | 56-36 |
| 2021-07-17 | @ New York Yankees | L 1-3 | 1534.56 | 1512.29 | 49.35% | 50.65% | -2.32 | 56-37 |
| 2021-07-18 | @ New York Yankees | L 1-9 | 1532.24 | 1514.61 | 48.68% | 51.32% | -4.57 | 56-38 |
| 2021-07-19 | @ Toronto Blue Jays | W 13-4 | 1527.67 | 1540.18 | 44.37% | 55.63% | +5.54 | 57-38 |
| 2021-07-21 | @ Toronto Blue Jays | W 7-4 | 1533.21 | 1534.64 | 45.95% | 54.05% | +3.11 | 58-38 |
| 2021-07-22 | New York Yankees | W 5-4 | 1536.32 | 1522.26 | 55.85% | 44.15% | +1.04 | 59-38 |
| 2021-07-23 | New York Yankees | W 6-2 | 1537.36 | 1521.22 | 56.14% | 43.86% | +2.91 | 60-38 |
| 2021-07-24 | New York Yankees | L 3-4 | 1540.27 | 1518.31 | 56.97% | 43.03% | -1.89 | 60-39 |
| 2021-07-25 | New York Yankees | W 5-4 | 1538.38 | 1520.20 | 56.43% | 43.57% | +1.44 | 61-39 |
| 2021-07-26 | Toronto Blue Jays | W 5-4 | 1539.82 | 1531.59 | 55.02% | 44.98% | +1.50 | 62-39 |
| 2021-07-28 | Toronto Blue Jays | L 1-4 | 1541.32 | 1530.09 | 55.45% | 44.55% | -3.19 | 62-40 |
| 2021-07-28 | Toronto Blue Jays | W 4-1 | 1538.13 | 1533.28 | 54.54% | 45.46% | +2.61 | 63-40 |
| 2021-07-29 | Toronto Blue Jays | L 1-13 | 1540.74 | 1530.67 | 55.28% | 44.72% | -6.36 | 63-41 |
| 2021-07-30 | @ Tampa Bay Rays | L 3-7 | 1534.38 | 1566.52 | 41.60% | 58.40% | -2.76 | 63-42 |
| 2021-07-31 | @ Tampa Bay Rays | L 5-9 | 1531.62 | 1569.28 | 40.83% | 59.17% | -2.71 | 63-43 |
| 2021-08-01 | @ Tampa Bay Rays | L 2-3 | 1528.91 | 1571.99 | 40.08% | 59.92% | -1.33 | 63-44 |
| 2021-08-03 | @ Detroit Tigers | L 2-4 | 1527.58 | 1466.77 | 54.88% | 45.12% | -2.58 | 63-45 |
| 2021-08-04 | @ Detroit Tigers | W 4-1 | 1525.00 | 1469.35 | 54.15% | 45.85% | +2.64 | 64-45 |
| 2021-08-05 | @ Detroit Tigers | L 1-8 | 1527.64 | 1466.71 | 54.90% | 45.10% | -4.82 | 64-46 |
| 2021-08-06 | @ Toronto Blue Jays | L 4-12 | 1522.82 | 1547.40 | 42.66% | 57.34% | -4.01 | 64-47 |
| 2021-08-07 | @ Toronto Blue Jays | L 0-1 | 1518.81 | 1551.40 | 41.54% | 58.46% | -1.38 | 64-48 |
| 2021-08-07 | @ Toronto Blue Jays | W 2-1 | 1517.43 | 1552.78 | 41.15% | 58.85% | +1.38 | 65-48 |
| 2021-08-08 | @ Toronto Blue Jays | L 8-9 | 1518.81 | 1551.40 | 41.54% | 58.46% | -1.38 | 65-49 |
| 2021-08-10 | Tampa Bay Rays | L 4-8 | 1517.43 | 1573.78 | 45.76% | 54.24% | -3.03 | 65-50 |
| 2021-08-11 | Tampa Bay Rays | W 20-8 | 1514.40 | 1576.82 | 44.89% | 55.11% | +6.33 | 66-50 |
| 2021-08-12 | Tampa Bay Rays | L 1-8 | 1520.73 | 1570.48 | 46.70% | 53.30% | -4.10 | 66-51 |
| 2021-08-13 | Baltimore Orioles | W 8-1 | 1516.63 | 1416.85 | 67.45% | 32.55% | +2.86 | 67-51 |
| 2021-08-14 | Baltimore Orioles | W 16-2 | 1519.49 | 1413.99 | 68.17% | 31.83% | +3.96 | 68-51 |
| 2021-08-15 | Baltimore Orioles | W 6-2 | 1523.45 | 1410.04 | 69.15% | 30.85% | +2.04 | 69-51 |
| 2021-08-17 | @ New York Yankees | L 3-5 | 1525.49 | 1531.72 | 45.26% | 54.74% | -2.12 | 69-52 |
| 2021-08-17 | @ New York Yankees | L 0-2 | 1523.37 | 1533.85 | 44.66% | 55.34% | -2.10 | 69-53 |
| 2021-08-18 | @ New York Yankees | L 2-5 | 1521.27 | 1535.95 | 44.06% | 55.94% | -2.53 | 69-54 |
| 2021-08-20 | Texas Rangers | W 6-0 | 1518.74 | 1410.37 | 68.52% | 31.48% | +2.56 | 70-54 |
| 2021-08-21 | Texas Rangers | L 1-10 | 1521.30 | 1407.81 | 69.16% | 30.84% | -6.89 | 70-55 |
| 2021-08-23 | Texas Rangers | W 8-4 | 1514.41 | 1414.69 | 67.44% | 32.56% | +1.53 | 71-55 |
| 2021-08-24 | Minnesota Twins | W 11-9 | 1515.94 | 1466.99 | 60.73% | 39.27% | +1.84 | 72-55 |
| 2021-08-25 | Minnesota Twins | L 6-9 | 1517.78 | 1465.14 | 61.23% | 38.77% | -2.49 | 72-56 |
| 2021-08-26 | Minnesota Twins | W 12-2 | 1515.29 | 1467.63 | 60.55% | 39.45% | +4.14 | 73-56 |
| 2021-08-27 | @ Cleveland Indians | W 4-3 | 1519.43 | 1497.99 | 49.23% | 50.77% | +1.69 | 74-56 |
| 2021-08-28 | @ Cleveland Indians | W 5-3 | 1521.12 | 1496.31 | 49.72% | 50.28% | +1.67 | 75-56 |
| 2021-08-29 | @ Cleveland Indians | L 5-7 | 1522.79 | 1494.64 | 50.20% | 49.80% | -2.36 | 75-57 |
| 2021-08-30 | @ Tampa Bay Rays | L 1-6 | 1520.43 | 1590.66 | 36.39% | 63.61% | -2.70 | 75-58 |
| 2021-08-31 | @ Tampa Bay Rays | L 5-8 | 1517.73 | 1593.36 | 35.67% | 64.33% | -2.05 | 75-59 |
| 2021-09-01 | @ Tampa Bay Rays | W 3-2 | 1515.68 | 1595.41 | 35.13% | 64.87% | +2.15 | 76-59 |
| 2021-09-02 | @ Tampa Bay Rays | W 4-0 | 1517.83 | 1593.26 | 35.70% | 64.30% | +4.27 | 77-59 |
| 2021-09-03 | Cleveland Indians | W 8-5 | 1522.10 | 1504.40 | 56.37% | 43.63% | +2.51 | 78-59 |
| 2021-09-04 | Cleveland Indians | W 4-3 | 1524.61 | 1501.89 | 57.08% | 42.92% | +1.43 | 79-59 |
| 2021-09-05 | Cleveland Indians | L 5-11 | 1526.04 | 1500.47 | 57.48% | 42.52% | -4.68 | 79-60 |
| 2021-09-06 | Tampa Bay Rays | L 10-11 | 1521.36 | 1590.52 | 43.93% | 56.07% | -1.03 | 79-61 |
| 2021-09-07 | Tampa Bay Rays | L 7-12 | 1520.33 | 1591.55 | 43.64% | 56.36% | -3.24 | 79-62 |
| 2021-09-08 | Tampa Bay Rays | W 2-1 | 1517.09 | 1594.79 | 42.72% | 57.28% | +1.90 | 80-62 |
| 2021-09-10 | @ Chicago White Sox | L 3-4 | 1518.99 | 1536.71 | 43.63% | 56.37% | -1.45 | 80-63 |
| 2021-09-11 | @ Chicago White Sox | W 9-8 | 1517.54 | 1538.16 | 43.22% | 56.78% | +1.34 | 81-63 |
| 2021-09-12 | @ Chicago White Sox | L 1-2 | 1518.88 | 1536.83 | 43.60% | 56.40% | -1.45 | 81-64 |
| 2021-09-13 | @ Seattle Mariners | L 4-5 | 1517.43 | 1497.18 | 49.06% | 50.94% | -1.63 | 81-65 |
| 2021-09-14 | @ Seattle Mariners | W 8-4 | 1515.80 | 1498.81 | 48.59% | 51.41% | +3.41 | 82-65 |
| 2021-09-15 | @ Seattle Mariners | W 9-4 | 1519.21 | 1495.39 | 49.57% | 50.43% | +2.65 | 83-65 |
| 2021-09-17 | Baltimore Orioles | W 7-1 | 1521.86 | 1396.29 | 70.62% | 29.38% | +2.39 | 84-65 |
| 2021-09-18 | Baltimore Orioles | W 9-3 | 1524.25 | 1393.90 | 71.19% | 28.81% | +2.34 | 85-65 |
| 2021-09-19 | Baltimore Orioles | W 8-6 | 1526.59 | 1391.56 | 71.74% | 28.26% | +1.33 | 86-65 |
| 2021-09-21 | New York Mets | W 6-3 | 1527.92 | 1486.25 | 59.72% | 40.28% | +2.32 | 87-65 |
| 2021-09-22 | New York Mets | W 12-5 | 1530.24 | 1483.94 | 60.36% | 39.64% | +3.48 | 88-65 |
| 2021-09-24 | New York Yankees | L 3-8 | 1533.72 | 1529.80 | 54.41% | 45.59% | -4.04 | 88-66 |
| 2021-09-25 | New York Yankees | L 3-5 | 1529.68 | 1533.83 | 53.25% | 46.75% | -2.50 | 88-67 |
| 2021-09-26 | New York Yankees | L 3-6 | 1527.18 | 1536.33 | 52.53% | 47.47% | -3.02 | 88-68 |
| 2021-09-28 | @ Baltimore Orioles | L 2-4 | 1524.16 | 1390.28 | 64.94% | 35.06% | -3.05 | 88-69 |
| 2021-09-29 | @ Baltimore Orioles | W 6-0 | 1521.11 | 1393.33 | 64.14% | 35.86% | +2.92 | 89-69 |
| 2021-09-30 | @ Baltimore Orioles | L 2-6 | 1524.03 | 1390.42 | 64.91% | 35.09% | -4.31 | 89-70 |
| 2021-10-01 | @ Washington Nationals | W 4-2 | 1519.72 | 1450.64 | 56.06% | 43.94% | +2.06 | 90-70 |
| 2021-10-02 | @ Washington Nationals | W 5-3 | 1521.78 | 1448.58 | 56.64% | 43.36% | +2.03 | 91-70 |
| 2021-10-03 | @ Washington Nationals | W 7-5 | 1523.81 | 1446.54 | 57.22% | 42.78% | +2.01 | 92-70 |
| 2021-04-01 | Pittsburgh Pirates | L 3-5 | 1508.27 | 1470.06 | 59.24% | 40.76% | -2.79 | 0-1 |
| 2021-04-03 | Pittsburgh Pirates | W 5-1 | 1505.48 | 1472.85 | 58.47% | 41.53% | +2.76 | 1-1 |
| 2021-04-04 | Pittsburgh Pirates | W 4-3 | 1508.24 | 1470.09 | 59.24% | 40.76% | +1.36 | 2-1 |
| 2021-04-05 | Milwaukee Brewers | W 5-3 | 1509.60 | 1492.84 | 56.23% | 43.77% | +2.05 | 3-1 |
| 2021-04-06 | Milwaukee Brewers | L 0-4 | 1511.65 | 1490.79 | 56.81% | 43.19% | -3.77 | 3-2 |
| 2021-04-07 | Milwaukee Brewers | L 2-4 | 1507.88 | 1494.56 | 55.74% | 44.26% | -1.85 | 3-3 |
| 2021-04-08 | @ Pittsburgh Pirates | W 4-2 | 1506.03 | 1458.39 | 53.00% | 47.00% | +2.20 | 4-3 |
| 2021-04-10 | @ Pittsburgh Pirates | L 2-8 | 1508.23 | 1456.18 | 53.63% | 46.37% | -4.36 | 4-4 |
| 2021-04-11 | @ Pittsburgh Pirates | L 1-7 | 1503.87 | 1460.54 | 52.38% | 47.62% | -4.26 | 4-5 |
| 2021-04-12 | @ Milwaukee Brewers | L 3-6 | 1499.61 | 1502.68 | 45.72% | 54.28% | -2.63 | 4-6 |
| 2021-04-13 | @ Milwaukee Brewers | W 3-2 | 1496.98 | 1505.31 | 44.97% | 55.03% | +1.83 | 5-6 |
| 2021-04-14 | @ Milwaukee Brewers | L 0-7 | 1498.81 | 1503.48 | 45.49% | 54.51% | -3.99 | 5-7 |
| 2021-04-16 | Atlanta Braves | L 2-5 | 1494.82 | 1517.32 | 50.61% | 49.39% | -2.91 | 5-8 |
| 2021-04-17 | Atlanta Braves | W 13-4 | 1491.91 | 1520.23 | 49.78% | 50.22% | +5.00 | 6-8 |
| 2021-04-18 | Atlanta Braves | L 4-13 | 1496.91 | 1515.23 | 51.22% | 48.78% | -5.10 | 6-9 |
| 2021-04-20 | New York Mets | W 3-1 | 1491.81 | 1501.73 | 52.42% | 47.58% | +2.23 | 7-9 |
| 2021-04-21 | New York Mets | W 16-4 | 1494.04 | 1499.50 | 53.06% | 46.94% | +5.40 | 8-9 |
| 2021-04-22 | New York Mets | W 4-3 | 1499.44 | 1494.10 | 54.61% | 45.39% | +1.06 | 9-9 |
| 2021-04-23 | Milwaukee Brewers | W 15-2 | 1500.50 | 1514.56 | 51.83% | 48.17% | +5.77 | 10-9 |
| 2021-04-24 | Milwaukee Brewers | L 3-4 | 1506.27 | 1508.80 | 53.48% | 46.52% | -1.78 | 10-10 |
| 2021-04-25 | Milwaukee Brewers | L 0-6 | 1504.49 | 1510.57 | 52.98% | 47.02% | -4.30 | 10-11 |
| 2021-04-26 | @ Atlanta Braves | L 7-8 | 1500.19 | 1513.33 | 44.28% | 55.72% | -1.47 | 10-12 |
| 2021-04-27 | @ Atlanta Braves | L 0-5 | 1498.72 | 1514.80 | 43.86% | 56.14% | -3.26 | 10-13 |
| 2021-04-28 | @ Atlanta Braves | L 0-10 | 1495.46 | 1518.05 | 42.94% | 57.06% | -4.51 | 10-14 |
| 2021-04-29 | @ Atlanta Braves | W 9-3 | 1490.95 | 1522.56 | 41.68% | 58.32% | +4.74 | 11-14 |
| 2021-04-30 | @ Cincinnati Reds | L 6-8 | 1495.69 | 1493.88 | 46.41% | 53.59% | -2.17 | 11-15 |
| 2021-05-01 | @ Cincinnati Reds | W 3-2 | 1493.52 | 1496.06 | 45.79% | 54.21% | +1.80 | 12-15 |
| 2021-05-02 | @ Cincinnati Reds | L 12-13 | 1495.32 | 1494.26 | 46.30% | 53.70% | -1.09 | 12-16 |
| 2021-05-04 | Los Angeles Dodgers | W 7-1 | 1494.23 | 1573.11 | 42.56% | 57.44% | +4.67 | 13-16 |
| 2021-05-04 | Los Angeles Dodgers | W 4-3 | 1498.90 | 1568.44 | 43.88% | 56.12% | +1.86 | 14-16 |
| 2021-05-05 | Los Angeles Dodgers | W 6-5 | 1500.76 | 1566.58 | 44.41% | 55.59% | +1.31 | 15-16 |
| 2021-05-07 | Pittsburgh Pirates | W 3-2 | 1502.07 | 1461.90 | 59.52% | 40.48% | +1.34 | 16-16 |
| 2021-05-08 | Pittsburgh Pirates | W 3-2 | 1503.41 | 1460.56 | 59.89% | 40.11% | +1.33 | 17-16 |
| 2021-05-09 | Pittsburgh Pirates | L 5-6 | 1504.74 | 1459.23 | 60.26% | 39.74% | -2.00 | 17-17 |
| 2021-05-11 | @ Cleveland Indians | L 2-3 | 1502.74 | 1518.27 | 43.94% | 56.06% | -1.46 | 17-18 |
| 2021-05-12 | @ Cleveland Indians | L 1-2 | 1501.28 | 1519.72 | 43.53% | 56.47% | -1.02 | 17-19 |
| 2021-05-14 | @ Detroit Tigers | W 4-2 | 1500.26 | 1431.04 | 56.08% | 43.92% | +2.06 | 18-19 |
| 2021-05-15 | @ Detroit Tigers | L 8-9 | 1502.32 | 1428.97 | 56.66% | 43.34% | -1.33 | 18-20 |
| 2021-05-16 | @ Detroit Tigers | W 5-1 | 1500.99 | 1430.30 | 56.29% | 43.71% | +2.91 | 19-20 |
| 2021-05-17 | Washington Nationals | W 7-3 | 1503.90 | 1501.61 | 54.17% | 45.83% | +3.04 | 20-20 |
| 2021-05-18 | Washington Nationals | W 6-3 | 1506.94 | 1498.57 | 55.04% | 44.96% | +2.59 | 21-20 |
| 2021-05-19 | Washington Nationals | L 3-4 | 1509.53 | 1495.98 | 55.78% | 44.22% | -1.86 | 21-21 |
| 2021-05-20 | Washington Nationals | W 5-2 | 1507.67 | 1497.83 | 55.25% | 44.75% | +2.58 | 22-21 |
| 2021-05-21 | @ St. Louis Cardinals | W 12-3 | 1510.25 | 1519.56 | 44.82% | 55.18% | +5.49 | 23-21 |
| 2021-05-22 | @ St. Louis Cardinals | L 1-2 | 1515.74 | 1514.06 | 46.39% | 53.61% | -1.54 | 23-22 |
| 2021-05-23 | @ St. Louis Cardinals | W 2-1 | 1514.20 | 1515.60 | 45.95% | 54.05% | +1.27 | 24-22 |
| 2021-05-25 | @ Pittsburgh Pirates | W 4-3 | 1515.47 | 1442.28 | 56.64% | 43.36% | +1.44 | 25-22 |
| 2021-05-26 | @ Pittsburgh Pirates | W 4-1 | 1516.91 | 1440.84 | 57.05% | 42.95% | +2.47 | 26-22 |
| 2021-05-27 | @ Pittsburgh Pirates | W 5-3 | 1519.38 | 1438.37 | 57.74% | 42.26% | +1.98 | 27-22 |
| 2021-05-28 | Cincinnati Reds | W 1-0 | 1521.36 | 1477.95 | 59.97% | 40.03% | +1.33 | 28-22 |
| 2021-05-29 | Cincinnati Reds | W 10-2 | 1522.69 | 1476.62 | 60.33% | 39.67% | +3.73 | 29-22 |
| 2021-05-30 | Cincinnati Reds | L 1-5 | 1526.42 | 1472.89 | 61.36% | 38.64% | -4.08 | 29-23 |
| 2021-05-31 | San Diego Padres | W 7-2 | 1522.34 | 1550.14 | 49.85% | 50.15% | +3.73 | 30-23 |
| 2021-06-01 | San Diego Padres | W 4-3 | 1526.07 | 1546.42 | 50.93% | 49.07% | +1.63 | 31-23 |
| 2021-06-02 | San Diego Padres | W 6-1 | 1527.70 | 1544.79 | 51.39% | 48.61% | +3.60 | 32-23 |
| 2021-06-03 | @ San Francisco Giants | L 2-7 | 1531.30 | 1533.23 | 45.88% | 54.12% | -3.40 | 32-24 |
| 2021-06-04 | @ San Francisco Giants | L 5-8 | 1527.90 | 1536.64 | 44.91% | 55.09% | -2.58 | 32-25 |
| 2021-06-05 | @ San Francisco Giants | L 3-4 | 1525.32 | 1539.22 | 44.17% | 55.83% | -1.47 | 32-26 |
| 2021-06-06 | @ San Francisco Giants | W 4-3 | 1523.85 | 1540.68 | 43.76% | 56.24% | +1.87 | 33-26 |
| 2021-06-07 | @ San Diego Padres | L 4-9 | 1525.72 | 1536.73 | 44.58% | 55.42% | -3.31 | 33-27 |
| 2021-06-08 | @ San Diego Padres | W 7-1 | 1522.41 | 1540.04 | 43.64% | 56.36% | +4.58 | 34-27 |
| 2021-06-09 | @ San Diego Padres | W 3-1 | 1526.99 | 1535.45 | 44.95% | 55.05% | +2.59 | 35-27 |
| 2021-06-11 | St. Louis Cardinals | W 8-5 | 1529.58 | 1496.40 | 58.54% | 41.46% | +2.38 | 36-27 |
| 2021-06-12 | St. Louis Cardinals | W 7-2 | 1531.96 | 1494.02 | 59.21% | 40.79% | +3.03 | 37-27 |
| 2021-06-13 | St. Louis Cardinals | W 2-0 | 1534.99 | 1490.99 | 60.05% | 39.95% | +1.87 | 38-27 |
| 2021-06-14 | @ New York Mets | L 2-5 | 1536.86 | 1516.21 | 49.12% | 50.88% | -2.82 | 38-28 |
| 2021-06-15 | @ New York Mets | L 2-3 | 1534.04 | 1519.04 | 48.31% | 51.69% | -1.60 | 38-29 |
| 2021-06-16 | @ New York Mets | L 3-6 | 1532.44 | 1520.64 | 47.84% | 52.16% | -2.76 | 38-30 |
| 2021-06-17 | @ New York Mets | W 2-0 | 1529.68 | 1523.39 | 47.05% | 52.95% | +2.49 | 39-30 |
| 2021-06-18 | Miami Marlins | L 2-10 | 1532.17 | 1479.62 | 61.22% | 38.78% | -5.75 | 39-31 |
| 2021-06-19 | Miami Marlins | L 1-11 | 1526.42 | 1485.37 | 59.64% | 40.36% | -6.26 | 39-32 |
| 2021-06-20 | Miami Marlins | W 2-0 | 1520.16 | 1491.63 | 57.89% | 42.11% | +1.98 | 40-32 |
| 2021-06-21 | Cleveland Indians | L 0-4 | 1522.14 | 1508.76 | 55.75% | 44.25% | -3.71 | 40-33 |
| 2021-06-22 | Cleveland Indians | W 7-1 | 1518.43 | 1512.46 | 54.70% | 45.30% | +3.69 | 41-33 |
| 2021-06-24 | @ Los Angeles Dodgers | W 4-0 | 1522.12 | 1577.52 | 38.39% | 61.61% | +4.09 | 42-33 |
| 2021-06-25 | @ Los Angeles Dodgers | L 2-6 | 1526.21 | 1573.43 | 39.51% | 60.49% | -2.62 | 42-34 |
| 2021-06-26 | @ Los Angeles Dodgers | L 2-3 | 1523.59 | 1576.05 | 38.79% | 61.21% | -1.29 | 42-35 |
| 2021-06-27 | @ Los Angeles Dodgers | L 1-7 | 1522.30 | 1577.34 | 38.44% | 61.56% | -3.13 | 42-36 |
| 2021-06-28 | @ Milwaukee Brewers | L 4-14 | 1519.17 | 1513.90 | 46.91% | 53.09% | -4.92 | 42-37 |
| 2021-06-29 | @ Milwaukee Brewers | L 1-2 | 1514.25 | 1518.83 | 45.50% | 54.50% | -1.51 | 42-38 |
| 2021-06-30 | @ Milwaukee Brewers | L 7-15 | 1512.74 | 1520.34 | 45.07% | 54.93% | -4.24 | 42-39 |
| 2021-07-02 | @ Cincinnati Reds | L 1-2 | 1508.50 | 1495.03 | 48.09% | 51.91% | -1.59 | 42-40 |
| 2021-07-03 | @ Cincinnati Reds | L 2-3 | 1506.91 | 1496.63 | 47.63% | 52.37% | -1.58 | 42-41 |
| 2021-07-04 | @ Cincinnati Reds | L 2-3 | 1505.33 | 1498.21 | 47.17% | 52.83% | -1.57 | 42-42 |
| 2021-07-05 | Philadelphia Phillies | L 3-13 | 1503.76 | 1485.20 | 56.49% | 43.51% | -5.93 | 42-43 |
| 2021-07-06 | Philadelphia Phillies | L 10-15 | 1497.83 | 1491.14 | 54.80% | 45.20% | -4.07 | 42-44 |
| 2021-07-07 | Philadelphia Phillies | W 8-3 | 1493.76 | 1495.20 | 53.64% | 46.36% | +3.44 | 43-44 |
| 2021-07-08 | Philadelphia Phillies | L 0-8 | 1497.20 | 1491.76 | 54.62% | 45.38% | -5.13 | 43-45 |
| 2021-07-09 | St. Louis Cardinals | W 10-5 | 1492.07 | 1480.38 | 55.51% | 44.49% | +3.31 | 44-45 |
| 2021-07-10 | St. Louis Cardinals | L 0-6 | 1495.38 | 1477.07 | 56.45% | 43.55% | -4.59 | 44-46 |
| 2021-07-16 | @ Arizona Diamondbacks | W 5-1 | 1490.79 | 1416.40 | 56.81% | 43.19% | +2.86 | 45-46 |
| 2021-07-17 | @ Arizona Diamondbacks | W 4-2 | 1493.65 | 1413.53 | 57.62% | 42.38% | +1.99 | 46-46 |
| 2021-07-18 | @ Arizona Diamondbacks | L 4-6 | 1495.64 | 1411.54 | 58.18% | 41.82% | -2.73 | 46-47 |
| 2021-07-19 | @ St. Louis Cardinals | L 3-8 | 1492.91 | 1483.03 | 47.57% | 52.43% | -3.53 | 46-48 |
| 2021-07-20 | @ St. Louis Cardinals | W 7-6 | 1489.38 | 1486.56 | 46.56% | 53.44% | +1.78 | 47-48 |
| 2021-07-21 | @ St. Louis Cardinals | L 2-3 | 1491.16 | 1484.79 | 47.07% | 52.93% | -1.11 | 47-49 |
| 2021-07-22 | @ St. Louis Cardinals | L 2-3 | 1490.05 | 1485.89 | 46.75% | 53.25% | -1.55 | 47-50 |
| 2021-07-23 | Arizona Diamondbacks | W 8-3 | 1488.50 | 1422.39 | 63.06% | 36.94% | +2.74 | 48-50 |
| 2021-07-24 | Arizona Diamondbacks | L 3-7 | 1491.24 | 1419.65 | 63.79% | 36.21% | -4.23 | 48-51 |
| 2021-07-25 | Arizona Diamondbacks | W 5-1 | 1487.01 | 1423.89 | 62.66% | 37.34% | +2.47 | 49-51 |
| 2021-07-26 | Cincinnati Reds | W 6-5 | 1489.48 | 1492.81 | 53.37% | 46.63% | +1.55 | 50-51 |
| 2021-07-27 | Cincinnati Reds | L 4-7 | 1491.03 | 1491.26 | 53.81% | 46.19% | -3.09 | 50-52 |
| 2021-07-28 | Cincinnati Reds | L 2-8 | 1487.94 | 1494.36 | 52.93% | 47.07% | -4.31 | 50-53 |
| 2021-07-29 | Cincinnati Reds | L 4-7 | 1483.63 | 1498.66 | 51.69% | 48.31% | -2.97 | 50-54 |
| 2021-07-30 | @ Washington Nationals | L 3-4 | 1480.66 | 1492.22 | 44.50% | 55.50% | -1.48 | 50-55 |
| 2021-07-31 | @ Washington Nationals | W 6-3 | 1479.18 | 1493.70 | 44.08% | 55.92% | +3.22 | 51-55 |
| 2021-08-01 | @ Washington Nationals | L 5-6 | 1482.40 | 1490.48 | 45.00% | 55.00% | -1.49 | 51-56 |
| 2021-08-03 | @ Colorado Rockies | L 6-13 | 1480.91 | 1467.28 | 48.11% | 51.89% | -4.23 | 51-57 |
| 2021-08-04 | @ Colorado Rockies | W 3-2 | 1476.68 | 1471.50 | 46.90% | 53.10% | +1.76 | 52-57 |
| 2021-08-05 | @ Colorado Rockies | L 5-6 | 1478.44 | 1469.74 | 47.40% | 52.60% | -1.57 | 52-58 |
| 2021-08-06 | Chicago White Sox | L 6-8 | 1476.87 | 1532.14 | 45.91% | 54.09% | -1.53 | 52-59 |
| 2021-08-07 | Chicago White Sox | L 0-4 | 1475.34 | 1533.66 | 45.47% | 54.53% | -3.01 | 52-60 |
| 2021-08-08 | Chicago White Sox | L 3-9 | 1472.33 | 1536.68 | 44.61% | 55.39% | -3.63 | 52-61 |
| 2021-08-10 | Milwaukee Brewers | L 2-4 | 1468.70 | 1543.63 | 43.11% | 56.89% | -2.03 | 52-62 |
| 2021-08-10 | Milwaukee Brewers | L 3-6 | 1466.67 | 1545.66 | 42.54% | 57.46% | -2.44 | 52-63 |
| 2021-08-11 | Milwaukee Brewers | L 0-10 | 1464.23 | 1548.10 | 41.86% | 58.14% | -4.40 | 52-64 |
| 2021-08-12 | Milwaukee Brewers | L 4-17 | 1459.83 | 1552.50 | 40.63% | 59.37% | -4.86 | 52-65 |
| 2021-08-13 | @ Miami Marlins | L 10-14 | 1454.97 | 1471.73 | 43.77% | 56.23% | -2.91 | 52-66 |
| 2021-08-14 | @ Miami Marlins | L 4-5 | 1452.06 | 1474.64 | 42.94% | 57.06% | -1.42 | 52-67 |
| 2021-08-15 | @ Miami Marlins | L 1-4 | 1450.64 | 1476.06 | 42.54% | 57.46% | -2.45 | 52-68 |
| 2021-08-16 | @ Cincinnati Reds | L 5-14 | 1448.19 | 1518.89 | 36.33% | 63.67% | -3.62 | 52-69 |
| 2021-08-17 | @ Cincinnati Reds | W 2-1 | 1444.57 | 1522.51 | 35.37% | 64.63% | +2.15 | 53-69 |
| 2021-08-18 | @ Cincinnati Reds | W 7-1 | 1446.72 | 1520.36 | 35.94% | 64.06% | +5.21 | 54-69 |
| 2021-08-20 | Kansas City Royals | L 2-6 | 1451.93 | 1441.20 | 55.38% | 44.62% | -3.68 | 54-70 |
| 2021-08-21 | Kansas City Royals | L 2-4 | 1448.25 | 1444.87 | 54.33% | 45.67% | -2.55 | 54-71 |
| 2021-08-22 | Kansas City Royals | L 1-9 | 1445.70 | 1447.43 | 53.60% | 46.40% | -5.03 | 54-72 |
| 2021-08-23 | Colorado Rockies | W 6-4 | 1440.67 | 1484.39 | 47.56% | 52.44% | +2.46 | 55-72 |
| 2021-08-25 | Colorado Rockies | W 5-2 | 1443.13 | 1481.92 | 48.27% | 51.73% | +2.97 | 56-72 |
| 2021-08-25 | Colorado Rockies | L 10-13 | 1446.10 | 1478.95 | 49.13% | 50.87% | -1.99 | 56-73 |
| 2021-08-27 | @ Chicago White Sox | L 13-17 | 1444.11 | 1542.92 | 32.67% | 67.33% | -2.17 | 56-74 |
| 2021-08-28 | @ Chicago White Sox | W 7-0 | 1441.94 | 1545.09 | 32.13% | 67.87% | +5.96 | 57-74 |
| 2021-08-29 | @ Chicago White Sox | L 1-13 | 1447.90 | 1539.13 | 33.64% | 66.36% | -3.87 | 57-75 |
| 2021-08-31 | @ Minnesota Twins | W 3-1 | 1444.03 | 1467.99 | 42.75% | 57.25% | +2.69 | 58-75 |
| 2021-09-01 | @ Minnesota Twins | W 3-0 | 1446.72 | 1465.31 | 43.51% | 56.49% | +3.25 | 59-75 |
| 2021-09-02 | Pittsburgh Pirates | W 6-5 | 1449.97 | 1408.86 | 59.65% | 40.35% | +0.94 | 60-75 |
| 2021-09-03 | Pittsburgh Pirates | W 6-5 | 1450.91 | 1407.91 | 59.91% | 40.09% | +1.33 | 61-75 |
| 2021-09-04 | Pittsburgh Pirates | W 7-6 | 1452.24 | 1406.58 | 60.28% | 39.72% | +1.32 | 62-75 |
| 2021-09-05 | Pittsburgh Pirates | W 11-8 | 1453.56 | 1405.26 | 60.64% | 39.36% | +2.27 | 63-75 |
| 2021-09-06 | Cincinnati Reds | W 4-3 | 1455.83 | 1512.91 | 45.65% | 54.35% | +1.80 | 64-75 |
| 2021-09-07 | Cincinnati Reds | L 3-4 | 1457.63 | 1511.11 | 46.17% | 53.83% | -1.53 | 64-76 |
| 2021-09-08 | Cincinnati Reds | W 4-1 | 1456.10 | 1512.64 | 45.73% | 54.27% | +2.20 | 65-76 |
| 2021-09-10 | San Francisco Giants | L 1-6 | 1458.30 | 1573.66 | 37.52% | 62.48% | -2.78 | 65-77 |
| 2021-09-11 | San Francisco Giants | L 4-15 | 1455.52 | 1576.45 | 36.77% | 63.23% | -4.05 | 65-78 |
| 2021-09-12 | San Francisco Giants | L 5-6 | 1451.47 | 1580.50 | 35.70% | 64.30% | -1.19 | 65-79 |
| 2021-09-14 | @ Philadelphia Phillies | W 6-3 | 1450.28 | 1495.58 | 39.77% | 60.23% | +3.47 | 66-79 |
| 2021-09-15 | @ Philadelphia Phillies | L 5-6 | 1453.75 | 1492.11 | 40.73% | 59.27% | -1.35 | 66-80 |
| 2021-09-16 | @ Philadelphia Phillies | L 8-17 | 1452.40 | 1493.47 | 40.36% | 59.64% | -4.02 | 66-81 |
| 2021-09-17 | @ Milwaukee Brewers | L 5-8 | 1448.38 | 1561.09 | 30.94% | 69.06% | -1.78 | 66-82 |
| 2021-09-18 | @ Milwaukee Brewers | L 4-6 | 1446.60 | 1562.87 | 30.50% | 69.50% | -1.44 | 66-83 |
| 2021-09-19 | @ Milwaukee Brewers | W 6-4 | 1445.16 | 1564.30 | 30.15% | 69.85% | +3.28 | 67-83 |
| 2021-09-21 | Minnesota Twins | L 5-9 | 1448.44 | 1463.23 | 51.72% | 48.28% | -3.43 | 67-84 |
| 2021-09-22 | Minnesota Twins | L 4-5 | 1445.01 | 1466.67 | 50.74% | 49.26% | -1.69 | 67-85 |
| 2021-09-24 | St. Louis Cardinals | L 5-8 | 1443.32 | 1528.97 | 41.61% | 58.39% | -2.39 | 67-86 |
| 2021-09-24 | St. Louis Cardinals | L 4-12 | 1440.93 | 1531.36 | 40.94% | 59.06% | -3.84 | 67-87 |
| 2021-09-25 | St. Louis Cardinals | L 5-8 | 1437.09 | 1535.21 | 39.88% | 60.12% | -2.30 | 67-88 |
| 2021-09-26 | St. Louis Cardinals | L 2-4 | 1434.79 | 1537.50 | 39.24% | 60.76% | -1.84 | 67-89 |
| 2021-09-28 | @ Pittsburgh Pirates | L 6-8 | 1432.95 | 1411.25 | 49.27% | 50.73% | -2.31 | 67-90 |
| 2021-09-29 | @ Pittsburgh Pirates | W 3-2 | 1430.64 | 1413.56 | 48.60% | 51.40% | +1.71 | 68-90 |
| 2021-09-30 | @ Pittsburgh Pirates | W 9-0 | 1432.35 | 1411.86 | 49.09% | 50.91% | +5.07 | 69-90 |
| 2021-10-01 | @ St. Louis Cardinals | L 3-4 | 1437.42 | 1540.63 | 32.12% | 67.88% | -1.07 | 69-91 |
| 2021-10-02 | @ St. Louis Cardinals | W 6-5 | 1436.35 | 1541.69 | 31.85% | 68.15% | +2.26 | 70-91 |
| 2021-10-03 | @ St. Louis Cardinals | W 3-2 | 1438.61 | 1539.43 | 32.42% | 67.58% | +2.25 | 71-91 |
| 2021-04-01 | @ Los Angeles Angels | L 3-4 | 1501.76 | 1485.45 | 48.49% | 51.51% | -1.61 | 0-1 |
| 2021-04-02 | @ Los Angeles Angels | W 12-8 | 1500.15 | 1487.06 | 48.03% | 51.97% | +3.45 | 1-1 |
| 2021-04-03 | @ Los Angeles Angels | L 3-5 | 1503.60 | 1483.61 | 49.02% | 50.98% | -2.30 | 1-2 |
| 2021-04-04 | @ Los Angeles Angels | L 4-7 | 1501.30 | 1485.92 | 48.36% | 51.64% | -2.78 | 1-3 |
| 2021-04-05 | @ Seattle Mariners | W 6-0 | 1498.52 | 1487.39 | 47.75% | 52.25% | +4.25 | 2-3 |
| 2021-04-06 | @ Seattle Mariners | W 10-4 | 1502.77 | 1483.14 | 48.97% | 51.03% | +4.15 | 3-3 |
| 2021-04-07 | @ Seattle Mariners | L 4-8 | 1506.92 | 1478.99 | 50.16% | 49.84% | -3.34 | 3-4 |
| 2021-04-08 | Kansas City Royals | W 6-0 | 1503.58 | 1479.79 | 57.23% | 42.77% | +3.48 | 4-4 |
| 2021-04-11 | Kansas City Royals | L 3-4 | 1507.06 | 1476.32 | 58.20% | 41.80% | -1.36 | 4-5 |
| 2021-04-12 | Cleveland Indians | W 4-3 | 1505.70 | 1515.58 | 52.43% | 47.57% | +1.58 | 5-5 |
| 2021-04-13 | Cleveland Indians | L 0-2 | 1507.28 | 1514.00 | 52.88% | 47.12% | -1.76 | 5-6 |
| 2021-04-14 | Cleveland Indians | W 8-0 | 1505.52 | 1515.76 | 52.38% | 47.62% | +4.47 | 6-6 |
| 2021-04-15 | Cleveland Indians | L 2-4 | 1509.99 | 1511.29 | 53.66% | 46.34% | -2.52 | 6-7 |
| 2021-04-17 | @ Boston Red Sox | L 4-7 | 1507.47 | 1511.91 | 45.52% | 54.48% | -2.62 | 6-8 |
| 2021-04-18 | @ Boston Red Sox | W 3-2 | 1504.85 | 1514.53 | 44.77% | 55.23% | +1.84 | 7-8 |
| 2021-04-18 | @ Boston Red Sox | W 5-1 | 1506.69 | 1512.70 | 45.30% | 54.70% | +3.63 | 8-8 |
| 2021-04-19 | @ Boston Red Sox | L 4-11 | 1510.32 | 1509.06 | 46.33% | 53.67% | -4.07 | 8-9 |
| 2021-04-20 | @ Cleveland Indians | W 8-5 | 1506.25 | 1511.63 | 45.39% | 54.61% | +3.14 | 9-9 |
| 2021-04-23 | Texas Rangers | W 9-7 | 1509.39 | 1469.63 | 59.46% | 40.54% | +1.90 | 10-9 |
| 2021-04-24 | Texas Rangers | W 2-1 | 1511.29 | 1467.73 | 59.99% | 40.01% | +1.33 | 11-9 |
| 2021-04-25 | Texas Rangers | W 8-4 | 1512.62 | 1466.40 | 60.35% | 39.65% | +2.64 | 12-9 |
| 2021-04-27 | Detroit Tigers | L 2-5 | 1515.26 | 1435.62 | 64.85% | 35.15% | -3.73 | 12-10 |
| 2021-04-29 | Detroit Tigers | W 3-1 | 1511.53 | 1439.35 | 63.87% | 36.13% | +1.69 | 13-10 |
| 2021-04-29 | Detroit Tigers | W 11-0 | 1513.22 | 1437.65 | 64.32% | 35.68% | +3.93 | 14-10 |
| 2021-04-30 | Cleveland Indians | L 3-5 | 1517.15 | 1503.47 | 55.80% | 44.20% | -2.62 | 14-11 |
| 2021-05-01 | Cleveland Indians | W 7-3 | 1514.53 | 1506.09 | 55.05% | 44.95% | +2.99 | 15-11 |
| 2021-05-02 | Cleveland Indians | L 0-5 | 1517.52 | 1503.10 | 55.90% | 44.10% | -4.15 | 15-12 |
| 2021-05-04 | @ Cincinnati Reds | W 9-0 | 1513.37 | 1495.35 | 48.74% | 51.26% | +5.10 | 16-12 |
| 2021-05-05 | @ Cincinnati Reds | L 0-1 | 1518.47 | 1490.24 | 50.21% | 49.79% | -1.18 | 16-13 |
| 2021-05-07 | @ Kansas City Royals | W 3-0 | 1517.29 | 1473.53 | 52.44% | 47.56% | +2.74 | 17-13 |
| 2021-05-08 | @ Kansas City Royals | W 9-1 | 1520.03 | 1470.79 | 53.23% | 46.77% | +4.39 | 18-13 |
| 2021-05-09 | @ Kansas City Royals | W 9-3 | 1524.42 | 1466.40 | 54.48% | 45.52% | +3.70 | 19-13 |
| 2021-05-11 | Minnesota Twins | W 9-3 | 1528.12 | 1501.05 | 57.69% | 42.31% | +3.44 | 20-13 |
| 2021-05-12 | Minnesota Twins | W 13-8 | 1531.56 | 1497.61 | 58.65% | 41.35% | +3.07 | 21-13 |
| 2021-05-13 | Minnesota Twins | W 4-2 | 1534.63 | 1494.54 | 59.51% | 40.49% | +1.90 | 22-13 |
| 2021-05-14 | Kansas City Royals | L 2-6 | 1536.53 | 1456.92 | 64.85% | 35.15% | -4.30 | 22-14 |
| 2021-05-14 | Kansas City Royals | W 3-1 | 1532.23 | 1461.23 | 63.71% | 36.29% | +1.70 | 23-14 |
| 2021-05-15 | Kansas City Royals | L 1-5 | 1533.93 | 1459.52 | 64.16% | 35.84% | -4.26 | 23-15 |
| 2021-05-16 | Kansas City Royals | W 4-3 | 1529.67 | 1463.78 | 63.03% | 36.97% | +1.23 | 24-15 |
| 2021-05-17 | @ Minnesota Twins | W 16-4 | 1530.90 | 1488.99 | 52.18% | 47.82% | +5.50 | 25-15 |
| 2021-05-18 | @ Minnesota Twins | L 4-5 | 1536.40 | 1483.49 | 53.75% | 46.25% | -1.79 | 25-16 |
| 2021-05-19 | @ Minnesota Twins | W 2-1 | 1534.61 | 1485.27 | 53.24% | 46.76% | +1.56 | 26-16 |
| 2021-05-21 | @ New York Yankees | L 1-2 | 1536.17 | 1532.44 | 46.69% | 53.31% | -1.55 | 26-17 |
| 2021-05-22 | @ New York Yankees | L 0-7 | 1534.62 | 1533.99 | 46.24% | 53.76% | -4.07 | 26-18 |
| 2021-05-23 | @ New York Yankees | L 4-5 | 1530.55 | 1538.05 | 45.08% | 54.92% | -1.49 | 26-19 |
| 2021-05-24 | St. Louis Cardinals | W 5-1 | 1529.06 | 1514.33 | 55.94% | 44.06% | +2.92 | 27-19 |
| 2021-05-25 | St. Louis Cardinals | W 8-3 | 1531.98 | 1511.41 | 56.77% | 43.23% | +3.21 | 28-19 |
| 2021-05-26 | St. Louis Cardinals | L 0-4 | 1535.19 | 1508.20 | 57.68% | 42.32% | -3.83 | 28-20 |
| 2021-05-27 | Baltimore Orioles | W 5-1 | 1531.36 | 1446.38 | 65.55% | 34.45% | +2.29 | 29-20 |
| 2021-05-29 | Baltimore Orioles | W 7-4 | 1533.65 | 1444.09 | 66.14% | 33.86% | +1.95 | 30-20 |
| 2021-05-29 | Baltimore Orioles | W 3-1 | 1535.60 | 1442.14 | 66.64% | 33.36% | +1.56 | 31-20 |
| 2021-05-30 | Baltimore Orioles | W 3-1 | 1537.16 | 1440.58 | 67.04% | 32.96% | +1.55 | 32-20 |
| 2021-05-31 | @ Cleveland Indians | W 8-6 | 1538.71 | 1505.41 | 50.94% | 49.06% | +1.63 | 33-20 |
| 2021-05-31 | @ Cleveland Indians | L 1-3 | 1540.34 | 1503.79 | 51.41% | 48.59% | -2.42 | 33-21 |
| 2021-06-01 | @ Cleveland Indians | L 5-6 | 1537.92 | 1506.20 | 50.71% | 49.29% | -1.68 | 33-22 |
| 2021-06-03 | Detroit Tigers | W 4-1 | 1536.24 | 1446.61 | 66.15% | 33.85% | +1.95 | 34-22 |
| 2021-06-04 | Detroit Tigers | W 9-8 | 1538.19 | 1444.66 | 66.65% | 33.35% | +1.10 | 35-22 |
| 2021-06-05 | Detroit Tigers | L 3-4 | 1539.29 | 1443.55 | 66.94% | 33.06% | -2.22 | 35-23 |
| 2021-06-06 | Detroit Tigers | W 3-0 | 1537.07 | 1445.78 | 66.37% | 33.63% | +1.94 | 36-23 |
| 2021-06-08 | Toronto Blue Jays | W 6-1 | 1539.01 | 1522.81 | 56.15% | 43.85% | +3.25 | 37-23 |
| 2021-06-09 | Toronto Blue Jays | L 2-6 | 1542.26 | 1519.56 | 57.07% | 42.93% | -3.79 | 37-24 |
| 2021-06-10 | Toronto Blue Jays | W 5-2 | 1538.47 | 1523.34 | 56.00% | 44.00% | +2.53 | 38-24 |
| 2021-06-11 | @ Detroit Tigers | W 5-4 | 1541.00 | 1447.79 | 59.45% | 40.55% | +0.95 | 39-24 |
| 2021-06-12 | @ Detroit Tigers | W 15-2 | 1541.95 | 1446.84 | 59.71% | 40.29% | +4.83 | 40-24 |
| 2021-06-13 | @ Detroit Tigers | W 4-1 | 1546.78 | 1442.02 | 61.04% | 38.96% | +2.24 | 41-24 |
| 2021-06-14 | Tampa Bay Rays | L 2-5 | 1549.02 | 1573.16 | 50.38% | 49.62% | -2.90 | 41-25 |
| 2021-06-15 | Tampa Bay Rays | W 3-0 | 1546.12 | 1576.06 | 49.55% | 50.45% | +2.90 | 42-25 |
| 2021-06-16 | Tampa Bay Rays | W 8-7 | 1549.02 | 1573.15 | 50.38% | 49.62% | +1.17 | 43-25 |
| 2021-06-17 | @ Houston Astros | L 2-10 | 1550.19 | 1560.60 | 44.67% | 55.33% | -4.20 | 43-26 |
| 2021-06-18 | @ Houston Astros | L 1-2 | 1545.99 | 1564.79 | 43.48% | 56.52% | -1.44 | 43-27 |
| 2021-06-19 | @ Houston Astros | L 3-7 | 1544.55 | 1566.23 | 43.07% | 56.93% | -2.86 | 43-28 |
| 2021-06-20 | @ Houston Astros | L 2-8 | 1541.69 | 1569.09 | 42.26% | 57.74% | -3.44 | 43-29 |
| 2021-06-22 | @ Pittsburgh Pirates | L 3-6 | 1538.25 | 1429.68 | 61.56% | 38.44% | -3.54 | 43-30 |
| 2021-06-23 | @ Pittsburgh Pirates | W 4-3 | 1534.71 | 1433.22 | 60.59% | 39.41% | +1.31 | 44-30 |
| 2021-06-25 | Seattle Mariners | L 3-9 | 1536.02 | 1475.18 | 62.35% | 37.65% | -5.07 | 44-31 |
| 2021-06-26 | Seattle Mariners | L 2-3 | 1530.95 | 1480.25 | 60.97% | 39.03% | -2.02 | 44-32 |
| 2021-06-27 | Seattle Mariners | W 7-5 | 1528.93 | 1482.27 | 60.41% | 39.59% | +1.85 | 45-32 |
| 2021-06-29 | Minnesota Twins | W 7-6 | 1530.78 | 1480.18 | 60.96% | 39.04% | +1.30 | 46-32 |
| 2021-06-30 | Minnesota Twins | W 13-3 | 1532.08 | 1478.89 | 61.31% | 38.69% | +4.06 | 47-32 |
| 2021-07-01 | Minnesota Twins | W 8-5 | 1536.14 | 1474.83 | 62.41% | 37.59% | +2.16 | 48-32 |
| 2021-07-02 | @ Detroit Tigers | W 8-2 | 1538.30 | 1455.69 | 57.97% | 42.03% | +3.42 | 49-32 |
| 2021-07-03 | @ Detroit Tigers | L 5-11 | 1541.72 | 1452.27 | 58.92% | 41.08% | -4.79 | 49-33 |
| 2021-07-04 | @ Detroit Tigers | L 5-6 | 1536.93 | 1457.06 | 57.58% | 42.42% | -1.91 | 49-34 |
| 2021-07-05 | @ Minnesota Twins | L 5-8 | 1535.02 | 1470.22 | 55.45% | 44.55% | -3.19 | 49-35 |
| 2021-07-06 | @ Minnesota Twins | W 4-1 | 1531.83 | 1473.41 | 54.54% | 45.46% | +2.61 | 50-35 |
| 2021-07-07 | @ Minnesota Twins | W 6-1 | 1534.44 | 1470.80 | 55.29% | 44.71% | +3.32 | 51-35 |
| 2021-07-09 | @ Baltimore Orioles | W 12-1 | 1537.76 | 1429.97 | 61.45% | 38.55% | +4.25 | 52-35 |
| 2021-07-10 | @ Baltimore Orioles | W 8-3 | 1542.01 | 1425.72 | 62.60% | 37.40% | +2.77 | 53-35 |
| 2021-07-11 | @ Baltimore Orioles | W 7-5 | 1544.78 | 1422.94 | 63.35% | 36.65% | +1.22 | 54-35 |
| 2021-07-16 | Houston Astros | L 1-7 | 1546.00 | 1570.88 | 50.27% | 49.73% | -4.09 | 54-36 |
| 2021-07-17 | Houston Astros | W 10-1 | 1541.91 | 1574.96 | 49.10% | 50.90% | +5.07 | 55-36 |
| 2021-07-18 | Houston Astros | W 4-0 | 1546.98 | 1569.89 | 50.56% | 49.44% | +3.29 | 56-36 |
| 2021-07-19 | Minnesota Twins | L 2-3 | 1550.27 | 1469.64 | 64.98% | 35.02% | -1.53 | 56-37 |
| 2021-07-19 | Minnesota Twins | W 5-3 | 1548.74 | 1471.16 | 64.58% | 35.42% | +1.66 | 57-37 |
| 2021-07-20 | Minnesota Twins | W 9-5 | 1550.40 | 1469.50 | 65.02% | 34.98% | +2.33 | 58-37 |
| 2021-07-21 | Minnesota Twins | L 2-7 | 1552.73 | 1467.18 | 65.62% | 34.38% | -4.88 | 58-38 |
| 2021-07-23 | @ Milwaukee Brewers | L 1-7 | 1547.85 | 1529.24 | 48.83% | 51.17% | -3.97 | 58-39 |
| 2021-07-24 | @ Milwaukee Brewers | L 1-6 | 1543.88 | 1533.21 | 47.68% | 52.32% | -3.54 | 58-40 |
| 2021-07-25 | @ Milwaukee Brewers | W 3-1 | 1540.34 | 1536.75 | 46.67% | 53.33% | +2.51 | 59-40 |
| 2021-07-26 | @ Kansas City Royals | L 3-4 | 1542.85 | 1442.62 | 60.42% | 39.58% | -2.01 | 59-41 |
| 2021-07-27 | @ Kansas City Royals | W 5-3 | 1540.84 | 1444.62 | 59.86% | 40.14% | +1.89 | 60-41 |
| 2021-07-28 | @ Kansas City Royals | L 2-3 | 1542.73 | 1442.74 | 60.38% | 39.62% | -1.42 | 60-42 |
| 2021-07-29 | @ Kansas City Royals | L 0-5 | 1541.31 | 1444.16 | 59.99% | 40.01% | -4.45 | 60-43 |
| 2021-07-30 | Cleveland Indians | W 6-4 | 1536.86 | 1488.30 | 60.67% | 39.33% | +1.84 | 61-43 |
| 2021-07-31 | Cleveland Indians | L 11-12 | 1538.70 | 1486.45 | 61.18% | 38.82% | -2.03 | 61-44 |
| 2021-08-01 | Cleveland Indians | W 2-1 | 1536.67 | 1488.48 | 60.62% | 39.38% | +1.31 | 62-44 |
| 2021-08-03 | Kansas City Royals | W 7-1 | 1537.98 | 1442.59 | 66.89% | 33.11% | +2.69 | 63-44 |
| 2021-08-04 | Kansas City Royals | L 1-9 | 1540.67 | 1439.90 | 67.57% | 32.43% | -6.35 | 63-45 |
| 2021-08-05 | Kansas City Royals | L 2-3 | 1534.32 | 1446.24 | 65.95% | 34.05% | -2.18 | 63-46 |
| 2021-08-06 | @ Chicago Cubs | W 8-6 | 1532.14 | 1476.87 | 54.09% | 45.91% | +1.52 | 64-46 |
| 2021-08-07 | @ Chicago Cubs | W 4-0 | 1533.66 | 1475.34 | 54.53% | 45.47% | +3.02 | 65-46 |
| 2021-08-08 | @ Chicago Cubs | W 9-3 | 1536.68 | 1472.33 | 55.39% | 44.61% | +3.63 | 66-46 |
| 2021-08-09 | @ Minnesota Twins | W 11-1 | 1540.31 | 1470.17 | 56.21% | 43.79% | +4.59 | 67-46 |
| 2021-08-10 | @ Minnesota Twins | L 3-4 | 1544.90 | 1465.57 | 57.51% | 42.49% | -1.90 | 67-47 |
| 2021-08-11 | @ Minnesota Twins | L 0-1 | 1543.00 | 1467.48 | 56.97% | 43.03% | -1.90 | 67-48 |
| 2021-08-12 | New York Yankees | W 9-8 | 1541.10 | 1527.56 | 51.95% | 48.05% | +1.60 | 68-48 |
| 2021-08-14 | New York Yankees | L 5-7 | 1542.70 | 1525.96 | 56.23% | 43.77% | -1.87 | 68-49 |
| 2021-08-15 | New York Yankees | L 3-5 | 1540.83 | 1527.83 | 55.70% | 44.30% | -2.61 | 68-50 |
| 2021-08-16 | Oakland Athletics | W 5-2 | 1538.22 | 1547.81 | 52.47% | 47.53% | +2.73 | 69-50 |
| 2021-08-17 | Oakland Athletics | W 9-0 | 1540.95 | 1545.08 | 53.25% | 46.75% | +4.66 | 70-50 |
| 2021-08-18 | Oakland Athletics | W 3-2 | 1545.61 | 1540.43 | 54.59% | 45.41% | +1.50 | 71-50 |
| 2021-08-19 | Oakland Athletics | L 4-5 | 1547.11 | 1538.92 | 55.02% | 44.98% | -1.82 | 71-51 |
| 2021-08-20 | @ Tampa Bay Rays | W 7-5 | 1545.29 | 1576.86 | 41.68% | 58.32% | +1.93 | 72-51 |
| 2021-08-21 | @ Tampa Bay Rays | L 4-8 | 1547.22 | 1574.93 | 42.22% | 57.78% | -2.80 | 72-52 |
| 2021-08-22 | @ Tampa Bay Rays | L 0-9 | 1544.42 | 1577.73 | 41.44% | 58.56% | -4.13 | 72-53 |
| 2021-08-23 | @ Toronto Blue Jays | L 1-2 | 1540.29 | 1544.71 | 45.52% | 54.48% | -1.51 | 72-54 |
| 2021-08-24 | @ Toronto Blue Jays | W 5-2 | 1538.78 | 1546.22 | 45.09% | 54.91% | +3.16 | 73-54 |
| 2021-08-25 | @ Toronto Blue Jays | L 1-3 | 1541.94 | 1543.06 | 45.99% | 54.01% | -2.16 | 73-55 |
| 2021-08-26 | @ Toronto Blue Jays | W 10-7 | 1539.78 | 1545.22 | 45.38% | 54.62% | +3.14 | 74-55 |
| 2021-08-27 | Chicago Cubs | W 17-13 | 1542.92 | 1444.11 | 67.33% | 32.67% | +2.17 | 75-55 |
| 2021-08-28 | Chicago Cubs | L 0-7 | 1545.09 | 1441.94 | 67.87% | 32.13% | -5.96 | 75-56 |
| 2021-08-29 | Chicago Cubs | W 13-1 | 1539.13 | 1447.90 | 66.36% | 33.64% | +3.87 | 76-56 |
| 2021-08-31 | Pittsburgh Pirates | W 4-2 | 1543.00 | 1411.84 | 71.28% | 28.72% | +1.35 | 77-56 |
| 2021-09-01 | Pittsburgh Pirates | W 6-3 | 1544.35 | 1410.49 | 71.60% | 28.40% | +1.63 | 78-56 |
| 2021-09-03 | @ Kansas City Royals | L 2-7 | 1545.98 | 1453.57 | 59.33% | 40.67% | -4.41 | 78-57 |
| 2021-09-04 | @ Kansas City Royals | W 10-7 | 1541.57 | 1457.97 | 58.10% | 41.90% | +2.41 | 79-57 |
| 2021-09-05 | @ Kansas City Royals | L 0-6 | 1543.98 | 1455.57 | 58.78% | 41.22% | -4.78 | 79-58 |
| 2021-09-07 | @ Oakland Athletics | W 6-3 | 1539.20 | 1526.81 | 47.93% | 52.07% | +3.00 | 80-58 |
| 2021-09-08 | @ Oakland Athletics | L 1-5 | 1542.20 | 1523.81 | 48.79% | 51.21% | -3.24 | 80-59 |
| 2021-09-09 | @ Oakland Athletics | L 1-3 | 1538.96 | 1527.05 | 47.86% | 52.14% | -2.25 | 80-60 |
| 2021-09-10 | Boston Red Sox | W 4-3 | 1536.71 | 1518.99 | 56.37% | 43.63% | +1.45 | 81-60 |
| 2021-09-11 | Boston Red Sox | L 8-9 | 1538.16 | 1517.54 | 56.78% | 43.22% | -1.33 | 81-61 |
| 2021-09-12 | Boston Red Sox | W 2-1 | 1536.83 | 1518.88 | 56.40% | 43.60% | +1.44 | 82-61 |
| 2021-09-14 | Los Angeles Angels | W 9-3 | 1538.27 | 1467.49 | 63.68% | 36.32% | +2.96 | 83-61 |
| 2021-09-15 | Los Angeles Angels | L 2-3 | 1541.23 | 1464.53 | 64.47% | 35.53% | -2.14 | 83-62 |
| 2021-09-16 | Los Angeles Angels | L 3-9 | 1539.09 | 1466.67 | 63.90% | 36.10% | -5.20 | 83-63 |
| 2021-09-17 | @ Texas Rangers | W 8-0 | 1533.89 | 1426.12 | 61.45% | 38.55% | +3.62 | 84-63 |
| 2021-09-18 | @ Texas Rangers | L 1-2 | 1537.51 | 1422.50 | 62.43% | 37.57% | -2.07 | 84-64 |
| 2021-09-19 | @ Texas Rangers | W 7-2 | 1535.44 | 1424.57 | 61.87% | 38.13% | +2.83 | 85-64 |
| 2021-09-20 | @ Detroit Tigers | L 3-4 | 1538.27 | 1475.84 | 55.11% | 44.89% | -1.83 | 85-65 |
| 2021-09-21 | @ Detroit Tigers | L 3-5 | 1536.44 | 1477.67 | 54.59% | 45.41% | -2.56 | 85-66 |
| 2021-09-23 | @ Cleveland Indians | W 7-2 | 1533.88 | 1494.22 | 51.85% | 48.15% | +3.57 | 86-66 |
| 2021-09-23 | @ Cleveland Indians | L 3-5 | 1537.45 | 1490.64 | 52.88% | 47.12% | -2.48 | 86-67 |
| 2021-09-24 | @ Cleveland Indians | W 1-0 | 1534.97 | 1493.12 | 52.17% | 47.83% | +1.58 | 87-67 |
| 2021-09-25 | @ Cleveland Indians | L 0-6 | 1536.55 | 1491.54 | 52.62% | 47.38% | -4.27 | 87-68 |
| 2021-09-26 | @ Cleveland Indians | W 5-2 | 1532.28 | 1495.82 | 51.39% | 48.61% | +2.79 | 88-68 |
| 2021-09-27 | @ Detroit Tigers | W 8-7 | 1535.07 | 1478.62 | 54.26% | 45.74% | +1.52 | 89-68 |
| 2021-09-28 | Cincinnati Reds | W 7-1 | 1536.59 | 1509.30 | 57.72% | 42.28% | +3.44 | 90-68 |
| 2021-09-29 | Cincinnati Reds | W 6-1 | 1540.03 | 1505.86 | 58.68% | 41.32% | +3.06 | 91-68 |
| 2021-10-01 | Detroit Tigers | W 8-1 | 1543.09 | 1475.96 | 63.20% | 36.80% | +3.24 | 92-68 |
| 2021-10-02 | Detroit Tigers | W 5-4 | 1546.33 | 1472.73 | 64.06% | 35.94% | +1.19 | 93-68 |
| 2021-10-03 | Detroit Tigers | L 2-5 | 1547.52 | 1471.54 | 64.37% | 35.63% | -3.70 | 93-69 |
| 2021-04-01 | St. Louis Cardinals | L 6-11 | 1496.88 | 1508.47 | 52.19% | 47.81% | -3.87 | 0-1 |
| 2021-04-03 | St. Louis Cardinals | W 9-6 | 1493.01 | 1512.34 | 51.07% | 48.93% | +2.81 | 1-1 |
| 2021-04-04 | St. Louis Cardinals | W 12-1 | 1495.82 | 1509.53 | 51.88% | 48.12% | +5.30 | 2-1 |
| 2021-04-05 | Pittsburgh Pirates | W 5-3 | 1501.12 | 1468.74 | 58.43% | 41.57% | +1.95 | 3-1 |
| 2021-04-06 | Pittsburgh Pirates | W 14-1 | 1503.07 | 1466.78 | 58.98% | 41.02% | +4.91 | 4-1 |
| 2021-04-07 | Pittsburgh Pirates | W 11-4 | 1507.98 | 1461.87 | 60.34% | 39.66% | +3.49 | 5-1 |
| 2021-04-09 | @ Arizona Diamondbacks | W 6-5 | 1511.47 | 1484.65 | 50.00% | 50.00% | +1.17 | 6-1 |
| 2021-04-10 | @ Arizona Diamondbacks | L 3-8 | 1512.64 | 1483.48 | 50.34% | 49.66% | -3.74 | 6-2 |
| 2021-04-11 | @ Arizona Diamondbacks | L 0-7 | 1508.90 | 1487.22 | 49.27% | 50.73% | -4.32 | 6-3 |
| 2021-04-12 | @ San Francisco Giants | W 3-0 | 1504.58 | 1499.96 | 46.81% | 53.19% | +3.06 | 7-3 |
| 2021-04-13 | @ San Francisco Giants | L 6-7 | 1507.64 | 1496.90 | 47.69% | 52.31% | -1.59 | 7-4 |
| 2021-04-14 | @ San Francisco Giants | L 0-3 | 1506.05 | 1498.48 | 47.24% | 52.76% | -2.71 | 7-5 |
| 2021-04-16 | Cleveland Indians | W 10-3 | 1503.34 | 1513.81 | 52.35% | 47.65% | +4.18 | 8-5 |
| 2021-04-17 | Cleveland Indians | W 3-2 | 1507.52 | 1509.62 | 53.55% | 46.45% | +1.09 | 9-5 |
| 2021-04-18 | Cleveland Indians | L 3-6 | 1508.61 | 1508.53 | 53.86% | 46.14% | -3.10 | 9-6 |
| 2021-04-20 | Arizona Diamondbacks | L 4-5 | 1505.51 | 1488.69 | 56.24% | 43.76% | -1.86 | 9-7 |
| 2021-04-21 | Arizona Diamondbacks | L 5-8 | 1503.65 | 1490.56 | 55.71% | 44.29% | -2.27 | 9-8 |
| 2021-04-22 | Arizona Diamondbacks | L 11-14 | 1501.38 | 1492.82 | 55.07% | 44.93% | -2.24 | 9-9 |
| 2021-04-23 | @ St. Louis Cardinals | L 4-5 | 1499.14 | 1503.98 | 45.46% | 54.54% | -1.51 | 9-10 |
| 2021-04-24 | @ St. Louis Cardinals | L 0-2 | 1497.63 | 1505.49 | 45.03% | 54.97% | -2.11 | 9-11 |
| 2021-04-25 | @ St. Louis Cardinals | L 2-5 | 1495.52 | 1507.60 | 44.43% | 55.57% | -2.56 | 9-12 |
| 2021-04-26 | @ Los Angeles Dodgers | W 5-3 | 1492.96 | 1574.47 | 34.90% | 65.10% | +2.17 | 10-12 |
| 2021-04-27 | @ Los Angeles Dodgers | W 6-5 | 1495.13 | 1572.30 | 35.47% | 64.53% | +2.14 | 11-12 |
| 2021-04-28 | @ Los Angeles Dodgers | L 0-8 | 1497.27 | 1570.16 | 36.04% | 63.96% | -3.39 | 11-13 |
| 2021-04-30 | Chicago Cubs | W 8-6 | 1493.88 | 1495.69 | 53.59% | 46.41% | +2.18 | 12-13 |
| 2021-05-01 | Chicago Cubs | L 2-3 | 1496.06 | 1493.52 | 54.21% | 45.79% | -1.80 | 12-14 |
| 2021-05-02 | Chicago Cubs | W 13-12 | 1494.26 | 1495.32 | 53.70% | 46.30% | +1.09 | 13-14 |
| 2021-05-04 | Chicago White Sox | L 0-9 | 1495.35 | 1513.37 | 51.26% | 48.74% | -5.11 | 13-15 |
| 2021-05-05 | Chicago White Sox | W 1-0 | 1490.24 | 1518.47 | 49.79% | 50.21% | +1.18 | 14-15 |
| 2021-05-07 | @ Cleveland Indians | W 3-0 | 1491.42 | 1517.77 | 42.41% | 57.59% | +3.31 | 15-15 |
| 2021-05-08 | @ Cleveland Indians | L 2-9 | 1494.73 | 1514.46 | 43.35% | 56.65% | -3.80 | 15-16 |
| 2021-05-10 | @ Pittsburgh Pirates | W 14-1 | 1490.93 | 1461.23 | 50.42% | 49.58% | +5.93 | 16-16 |
| 2021-05-11 | @ Pittsburgh Pirates | L 2-7 | 1496.86 | 1455.29 | 52.13% | 47.87% | -3.87 | 16-17 |
| 2021-05-12 | @ Pittsburgh Pirates | W 5-1 | 1492.99 | 1459.16 | 51.01% | 48.99% | +2.30 | 17-17 |
| 2021-05-13 | @ Colorado Rockies | L 8-13 | 1495.29 | 1459.81 | 51.25% | 48.75% | -3.80 | 17-18 |
| 2021-05-14 | @ Colorado Rockies | L 6-9 | 1491.49 | 1463.62 | 50.16% | 49.84% | -2.89 | 17-19 |
| 2021-05-15 | @ Colorado Rockies | W 6-5 | 1488.60 | 1466.50 | 49.33% | 50.67% | +1.19 | 18-19 |
| 2021-05-16 | @ Colorado Rockies | W 7-6 | 1489.79 | 1465.31 | 49.67% | 50.33% | +1.67 | 19-19 |
| 2021-05-17 | San Francisco Giants | L 3-6 | 1491.46 | 1515.81 | 50.35% | 49.65% | -2.89 | 19-20 |
| 2021-05-18 | San Francisco Giants | L 2-4 | 1488.57 | 1518.71 | 49.52% | 50.48% | -2.33 | 19-21 |
| 2021-05-19 | San Francisco Giants | L 0-4 | 1486.24 | 1521.03 | 48.85% | 51.15% | -3.24 | 19-22 |
| 2021-05-20 | San Francisco Giants | L 4-19 | 1483.00 | 1524.28 | 47.92% | 52.08% | -6.16 | 19-23 |
| 2021-05-21 | Milwaukee Brewers | W 9-4 | 1476.84 | 1489.74 | 52.00% | 48.00% | +3.56 | 20-23 |
| 2021-05-22 | Milwaukee Brewers | L 3-4 | 1480.40 | 1486.17 | 53.02% | 46.98% | -1.76 | 20-24 |
| 2021-05-23 | Milwaukee Brewers | L 4-9 | 1478.64 | 1487.93 | 52.51% | 47.49% | -3.90 | 20-25 |
| 2021-05-25 | @ Washington Nationals | W 2-1 | 1474.74 | 1500.83 | 42.45% | 57.55% | +1.91 | 21-25 |
| 2021-05-26 | @ Washington Nationals | L 3-5 | 1476.65 | 1498.92 | 42.99% | 57.01% | -2.01 | 21-26 |
| 2021-05-27 | @ Washington Nationals | W 3-0 | 1474.64 | 1500.94 | 42.42% | 57.58% | +3.31 | 22-26 |
| 2021-05-28 | @ Chicago Cubs | L 0-1 | 1477.95 | 1521.36 | 40.03% | 59.97% | -1.33 | 22-27 |
| 2021-05-29 | @ Chicago Cubs | L 2-10 | 1476.62 | 1522.69 | 39.67% | 60.33% | -3.73 | 22-28 |
| 2021-05-30 | @ Chicago Cubs | W 5-1 | 1472.89 | 1526.42 | 38.64% | 61.36% | +4.08 | 23-28 |
| 2021-05-31 | Philadelphia Phillies | W 11-1 | 1476.97 | 1484.25 | 52.80% | 47.20% | +4.95 | 24-28 |
| 2021-06-01 | Philadelphia Phillies | L 3-17 | 1481.92 | 1479.29 | 54.22% | 45.78% | -6.73 | 24-29 |
| 2021-06-03 | @ St. Louis Cardinals | W 4-2 | 1475.19 | 1508.37 | 41.45% | 58.55% | +2.75 | 25-29 |
| 2021-06-04 | @ St. Louis Cardinals | W 6-4 | 1477.94 | 1505.63 | 42.22% | 57.78% | +2.71 | 26-29 |
| 2021-06-05 | @ St. Louis Cardinals | W 5-2 | 1480.65 | 1502.91 | 42.99% | 57.01% | +3.28 | 27-29 |
| 2021-06-06 | @ St. Louis Cardinals | W 8-7 | 1483.93 | 1499.63 | 43.92% | 56.08% | +1.86 | 28-29 |
| 2021-06-08 | Milwaukee Brewers | L 1-5 | 1485.79 | 1506.52 | 50.87% | 49.13% | -3.38 | 28-30 |
| 2021-06-09 | Milwaukee Brewers | W 7-3 | 1482.41 | 1509.90 | 49.90% | 50.10% | +3.33 | 29-30 |
| 2021-06-10 | Milwaukee Brewers | L 2-7 | 1485.74 | 1506.58 | 50.86% | 49.14% | -3.78 | 29-31 |
| 2021-06-11 | Colorado Rockies | W 11-5 | 1481.96 | 1454.83 | 57.70% | 42.30% | +3.44 | 30-31 |
| 2021-06-12 | Colorado Rockies | W 10-3 | 1485.40 | 1451.39 | 58.66% | 41.34% | +3.63 | 31-31 |
| 2021-06-13 | Colorado Rockies | W 6-2 | 1489.03 | 1447.76 | 59.67% | 40.33% | +2.68 | 32-31 |
| 2021-06-14 | @ Milwaukee Brewers | W 10-2 | 1491.71 | 1516.49 | 42.63% | 57.37% | +5.39 | 33-31 |
| 2021-06-15 | @ Milwaukee Brewers | W 2-1 | 1497.10 | 1511.11 | 44.16% | 55.84% | +1.31 | 34-31 |
| 2021-06-16 | @ Milwaukee Brewers | W 2-1 | 1498.41 | 1509.79 | 44.53% | 55.47% | +1.84 | 35-31 |
| 2021-06-17 | @ San Diego Padres | L 4-6 | 1500.25 | 1524.28 | 42.74% | 57.26% | -2.01 | 35-32 |
| 2021-06-18 | @ San Diego Padres | L 2-8 | 1498.24 | 1526.29 | 42.17% | 57.83% | -3.43 | 35-33 |
| 2021-06-19 | @ San Diego Padres | L 5-7 | 1494.81 | 1529.72 | 41.21% | 58.79% | -1.93 | 35-34 |
| 2021-06-20 | @ San Diego Padres | L 2-3 | 1492.88 | 1531.66 | 40.68% | 59.32% | -1.35 | 35-35 |
| 2021-06-21 | @ Minnesota Twins | L 5-7 | 1491.53 | 1478.58 | 48.01% | 51.99% | -1.59 | 35-36 |
| 2021-06-22 | @ Minnesota Twins | W 10-7 | 1489.94 | 1480.18 | 47.55% | 52.45% | +3.01 | 36-36 |
| 2021-06-24 | Atlanta Braves | W 5-3 | 1492.95 | 1508.25 | 51.65% | 48.35% | +2.27 | 37-36 |
| 2021-06-25 | Atlanta Braves | L 2-3 | 1495.22 | 1505.98 | 52.30% | 47.70% | -1.74 | 37-37 |
| 2021-06-26 | Atlanta Braves | W 4-1 | 1493.48 | 1507.71 | 51.81% | 48.19% | +2.78 | 38-37 |
| 2021-06-27 | Atlanta Braves | L 0-4 | 1496.26 | 1504.94 | 52.60% | 47.40% | -3.50 | 38-38 |
| 2021-06-28 | Philadelphia Phillies | W 12-4 | 1492.76 | 1493.30 | 53.77% | 46.23% | +4.34 | 39-38 |
| 2021-06-29 | San Diego Padres | L 4-5 | 1497.10 | 1537.29 | 48.07% | 51.93% | -1.59 | 39-39 |
| 2021-06-30 | San Diego Padres | L 5-7 | 1495.51 | 1538.89 | 47.61% | 52.39% | -2.24 | 39-40 |
| 2021-07-01 | San Diego Padres | W 5-4 | 1493.27 | 1541.12 | 46.97% | 53.03% | +1.76 | 40-40 |
| 2021-07-02 | Chicago Cubs | W 2-1 | 1495.03 | 1508.50 | 51.91% | 48.09% | +1.60 | 41-40 |
| 2021-07-03 | Chicago Cubs | W 3-2 | 1496.63 | 1506.91 | 52.37% | 47.63% | +1.58 | 42-40 |
| 2021-07-04 | Chicago Cubs | W 3-2 | 1498.21 | 1505.33 | 52.83% | 47.17% | +1.57 | 43-40 |
| 2021-07-05 | @ Kansas City Royals | W 6-2 | 1499.78 | 1441.83 | 54.47% | 45.53% | +3.02 | 44-40 |
| 2021-07-06 | @ Kansas City Royals | L 6-7 | 1502.80 | 1438.80 | 55.34% | 44.66% | -1.84 | 44-41 |
| 2021-07-07 | @ Kansas City Royals | W 5-2 | 1500.96 | 1440.64 | 54.81% | 45.19% | +2.60 | 45-41 |
| 2021-07-08 | @ Milwaukee Brewers | L 3-5 | 1503.56 | 1531.94 | 42.13% | 57.87% | -1.98 | 45-42 |
| 2021-07-09 | @ Milwaukee Brewers | W 2-0 | 1501.58 | 1533.91 | 41.57% | 58.43% | +2.75 | 46-42 |
| 2021-07-10 | @ Milwaukee Brewers | W 4-3 | 1504.33 | 1531.17 | 42.34% | 57.66% | +1.91 | 47-42 |
| 2021-07-11 | @ Milwaukee Brewers | W 3-1 | 1506.24 | 1529.26 | 42.88% | 57.12% | +2.68 | 48-42 |
| 2021-07-16 | Milwaukee Brewers | L 6-11 | 1508.92 | 1526.57 | 51.31% | 48.69% | -3.81 | 48-43 |
| 2021-07-17 | Milwaukee Brewers | L 4-7 | 1505.11 | 1530.38 | 50.22% | 49.78% | -2.04 | 48-44 |
| 2021-07-18 | Milwaukee Brewers | L 0-8 | 1503.07 | 1532.43 | 49.63% | 50.37% | -4.66 | 48-45 |
| 2021-07-19 | New York Mets | L 11-15 | 1498.41 | 1504.90 | 52.92% | 47.08% | -2.48 | 48-46 |
| 2021-07-20 | New York Mets | W 4-3 | 1495.93 | 1507.38 | 52.20% | 47.80% | +1.58 | 49-46 |
| 2021-07-21 | New York Mets | L 0-7 | 1497.51 | 1505.80 | 52.66% | 47.34% | -4.62 | 49-47 |
| 2021-07-23 | St. Louis Cardinals | W 6-5 | 1492.89 | 1487.44 | 54.62% | 45.38% | +1.50 | 50-47 |
| 2021-07-24 | St. Louis Cardinals | W 5-3 | 1494.39 | 1485.94 | 55.05% | 44.95% | +2.11 | 51-47 |
| 2021-07-25 | St. Louis Cardinals | L 6-10 | 1496.50 | 1483.83 | 55.65% | 44.35% | -3.69 | 51-48 |
| 2021-07-26 | @ Chicago Cubs | L 5-6 | 1492.81 | 1489.48 | 46.63% | 53.37% | -1.55 | 51-49 |
| 2021-07-27 | @ Chicago Cubs | W 7-4 | 1491.26 | 1491.03 | 46.19% | 53.81% | +3.10 | 52-49 |
| 2021-07-28 | @ Chicago Cubs | W 8-2 | 1494.36 | 1487.94 | 47.07% | 52.93% | +4.30 | 53-49 |
| 2021-07-29 | @ Chicago Cubs | W 7-4 | 1498.66 | 1483.63 | 48.31% | 51.69% | +2.97 | 54-49 |
| 2021-07-30 | @ New York Mets | W 6-2 | 1501.63 | 1503.58 | 45.88% | 54.12% | +3.60 | 55-49 |
| 2021-07-31 | @ New York Mets | L 4-5 | 1505.23 | 1499.98 | 46.90% | 53.10% | -1.10 | 55-50 |
| 2021-08-01 | @ New York Mets | W 7-1 | 1504.13 | 1501.08 | 46.59% | 53.41% | +4.34 | 56-50 |
| 2021-08-03 | Minnesota Twins | L 5-7 | 1508.47 | 1462.81 | 60.28% | 39.72% | -2.83 | 56-51 |
| 2021-08-04 | Minnesota Twins | W 6-5 | 1505.64 | 1465.64 | 59.49% | 40.51% | +1.34 | 57-51 |
| 2021-08-05 | Pittsburgh Pirates | W 7-4 | 1506.98 | 1424.54 | 65.22% | 34.78% | +2.00 | 58-51 |
| 2021-08-06 | Pittsburgh Pirates | W 10-0 | 1508.98 | 1422.54 | 65.74% | 34.26% | +3.60 | 59-51 |
| 2021-08-07 | Pittsburgh Pirates | W 11-3 | 1512.58 | 1418.94 | 66.67% | 33.33% | +3.13 | 60-51 |
| 2021-08-08 | Pittsburgh Pirates | W 3-2 | 1515.71 | 1415.81 | 67.46% | 32.54% | +1.08 | 61-51 |
| 2021-08-09 | @ Cleveland Indians | L 3-9 | 1516.79 | 1486.33 | 50.53% | 49.47% | -4.11 | 61-52 |
| 2021-08-10 | @ Atlanta Braves | L 2-3 | 1512.68 | 1536.81 | 42.73% | 57.27% | -1.42 | 61-53 |
| 2021-08-11 | @ Atlanta Braves | L 6-8 | 1511.26 | 1538.22 | 42.33% | 57.67% | -1.40 | 61-54 |
| 2021-08-12 | @ Atlanta Braves | W 12-3 | 1509.86 | 1539.63 | 41.93% | 58.07% | +5.78 | 62-54 |
| 2021-08-13 | @ Philadelphia Phillies | W 6-1 | 1515.64 | 1504.31 | 47.78% | 52.22% | +3.88 | 63-54 |
| 2021-08-14 | @ Philadelphia Phillies | L 1-6 | 1519.52 | 1500.43 | 48.89% | 51.11% | -3.63 | 63-55 |
| 2021-08-15 | @ Philadelphia Phillies | W 7-4 | 1515.89 | 1504.06 | 47.85% | 52.15% | +3.00 | 64-55 |
| 2021-08-16 | Chicago Cubs | W 14-5 | 1518.89 | 1448.19 | 63.67% | 36.33% | +3.62 | 65-55 |
| 2021-08-17 | Chicago Cubs | L 1-2 | 1522.51 | 1444.57 | 64.63% | 35.37% | -2.15 | 65-56 |
| 2021-08-18 | Chicago Cubs | L 1-7 | 1520.36 | 1446.72 | 64.06% | 35.94% | -5.21 | 65-57 |
| 2021-08-19 | Miami Marlins | W 6-1 | 1515.15 | 1469.77 | 60.24% | 39.76% | +2.95 | 66-57 |
| 2021-08-20 | Miami Marlins | W 5-3 | 1518.10 | 1466.82 | 61.05% | 38.95% | +1.83 | 67-57 |
| 2021-08-21 | Miami Marlins | W 7-4 | 1519.93 | 1464.99 | 61.55% | 38.45% | +2.21 | 68-57 |
| 2021-08-22 | Miami Marlins | W 3-1 | 1522.14 | 1462.78 | 62.15% | 37.85% | +1.78 | 69-57 |
| 2021-08-24 | @ Milwaukee Brewers | L 4-7 | 1523.92 | 1554.99 | 41.75% | 58.25% | -2.40 | 69-58 |
| 2021-08-25 | @ Milwaukee Brewers | L 1-4 | 1521.52 | 1557.39 | 41.08% | 58.92% | -2.36 | 69-59 |
| 2021-08-26 | @ Milwaukee Brewers | W 5-1 | 1519.16 | 1559.75 | 40.42% | 59.58% | +3.95 | 70-59 |
| 2021-08-27 | @ Miami Marlins | W 6-0 | 1523.11 | 1460.99 | 55.07% | 44.93% | +3.66 | 71-59 |
| 2021-08-28 | @ Miami Marlins | L 1-6 | 1526.77 | 1457.33 | 56.11% | 43.89% | -4.17 | 71-60 |
| 2021-08-29 | @ Miami Marlins | L 1-2 | 1522.60 | 1461.50 | 54.92% | 45.08% | -1.82 | 71-61 |
| 2021-08-30 | St. Louis Cardinals | L 1-3 | 1520.78 | 1493.28 | 57.75% | 42.25% | -2.71 | 71-62 |
| 2021-09-01 | St. Louis Cardinals | L 4-5 | 1518.07 | 1495.99 | 56.99% | 43.01% | -1.90 | 71-63 |
| 2021-09-01 | St. Louis Cardinals | W 12-2 | 1516.17 | 1497.88 | 56.45% | 43.55% | +4.58 | 72-63 |
| 2021-09-03 | Detroit Tigers | L 5-15 | 1520.75 | 1458.62 | 62.52% | 37.48% | -6.57 | 72-64 |
| 2021-09-04 | Detroit Tigers | W 7-4 | 1514.18 | 1465.19 | 60.74% | 39.26% | +2.26 | 73-64 |
| 2021-09-05 | Detroit Tigers | L 1-4 | 1516.44 | 1462.93 | 61.35% | 38.65% | -3.53 | 73-65 |
| 2021-09-06 | @ Chicago Cubs | L 3-4 | 1512.91 | 1455.83 | 54.35% | 45.65% | -1.80 | 73-66 |
| 2021-09-07 | @ Chicago Cubs | W 4-3 | 1511.11 | 1457.63 | 53.83% | 46.17% | +1.53 | 74-66 |
| 2021-09-08 | @ Chicago Cubs | L 1-4 | 1512.64 | 1456.10 | 54.27% | 45.73% | -2.21 | 74-67 |
| 2021-09-10 | @ St. Louis Cardinals | W 4-2 | 1510.43 | 1495.31 | 48.32% | 51.68% | +2.43 | 75-67 |
| 2021-09-11 | @ St. Louis Cardinals | L 4-6 | 1512.86 | 1492.88 | 49.02% | 50.98% | -2.30 | 75-68 |
| 2021-09-12 | @ St. Louis Cardinals | L 0-2 | 1510.56 | 1495.18 | 48.36% | 51.64% | -2.27 | 75-69 |
| 2021-09-14 | @ Pittsburgh Pirates | L 5-6 | 1508.29 | 1406.59 | 60.62% | 39.38% | -2.02 | 75-70 |
| 2021-09-15 | @ Pittsburgh Pirates | L 4-5 | 1506.27 | 1408.61 | 60.06% | 39.94% | -1.99 | 75-71 |
| 2021-09-16 | @ Pittsburgh Pirates | W 1-0 | 1504.28 | 1410.60 | 59.51% | 40.49% | +1.34 | 76-71 |
| 2021-09-17 | Los Angeles Dodgers | W 3-1 | 1505.62 | 1619.02 | 37.79% | 62.21% | +2.93 | 77-71 |
| 2021-09-18 | Los Angeles Dodgers | L 1-5 | 1508.55 | 1616.10 | 38.58% | 61.42% | -2.57 | 77-72 |
| 2021-09-19 | Los Angeles Dodgers | L 5-8 | 1505.98 | 1618.66 | 37.88% | 62.12% | -2.17 | 77-73 |
| 2021-09-20 | Pittsburgh Pirates | W 9-5 | 1503.81 | 1413.86 | 66.19% | 33.81% | +2.24 | 78-73 |
| 2021-09-21 | Pittsburgh Pirates | L 2-6 | 1506.05 | 1411.62 | 66.77% | 33.23% | -4.43 | 78-74 |
| 2021-09-23 | Washington Nationals | L 2-3 | 1501.62 | 1457.65 | 60.04% | 39.96% | -2.00 | 78-75 |
| 2021-09-24 | Washington Nationals | W 8-7 | 1499.62 | 1459.64 | 59.49% | 40.51% | +0.95 | 79-75 |
| 2021-09-25 | Washington Nationals | W 7-6 | 1500.57 | 1458.69 | 59.76% | 40.24% | +1.34 | 80-75 |
| 2021-09-26 | Washington Nationals | W 9-2 | 1501.91 | 1457.35 | 60.12% | 39.88% | +3.50 | 81-75 |
| 2021-09-27 | Pittsburgh Pirates | W 13-1 | 1505.41 | 1415.13 | 66.24% | 33.76% | +3.89 | 82-75 |
| 2021-09-28 | @ Chicago White Sox | L 1-7 | 1509.30 | 1536.59 | 42.28% | 57.72% | -3.44 | 82-76 |
| 2021-09-29 | @ Chicago White Sox | L 1-6 | 1505.86 | 1540.03 | 41.32% | 58.68% | -3.07 | 82-77 |
| 2021-10-01 | @ Pittsburgh Pirates | L 2-9 | 1502.79 | 1406.79 | 59.83% | 40.17% | -5.26 | 82-78 |
| 2021-10-02 | @ Pittsburgh Pirates | L 6-8 | 1497.53 | 1412.04 | 58.37% | 41.63% | -2.74 | 82-79 |
| 2021-10-03 | @ Pittsburgh Pirates | W 6-3 | 1494.79 | 1414.78 | 57.60% | 42.40% | +2.44 | 83-79 |
| 2021-04-01 | @ Detroit Tigers | L 2-3 | 1510.14 | 1454.17 | 54.19% | 45.81% | -1.80 | 0-1 |
| 2021-04-03 | @ Detroit Tigers | L 2-5 | 1508.34 | 1455.97 | 53.68% | 46.32% | -3.09 | 0-2 |
| 2021-04-04 | @ Detroit Tigers | W 9-3 | 1505.25 | 1459.06 | 52.79% | 47.21% | +3.84 | 1-2 |
| 2021-04-05 | Kansas City Royals | L 0-3 | 1509.09 | 1478.46 | 58.19% | 41.81% | -3.34 | 1-3 |
| 2021-04-07 | Kansas City Royals | W 4-2 | 1505.75 | 1481.80 | 57.25% | 42.75% | +2.00 | 2-3 |
| 2021-04-09 | Detroit Tigers | W 4-1 | 1507.75 | 1450.74 | 61.83% | 38.17% | +2.20 | 3-3 |
| 2021-04-10 | Detroit Tigers | W 11-3 | 1509.95 | 1448.55 | 62.42% | 37.58% | +3.53 | 4-3 |
| 2021-04-11 | Detroit Tigers | W 5-2 | 1513.48 | 1445.02 | 63.37% | 36.63% | +2.10 | 5-3 |
| 2021-04-12 | @ Chicago White Sox | L 3-4 | 1515.58 | 1505.70 | 47.57% | 52.43% | -1.58 | 5-4 |
| 2021-04-13 | @ Chicago White Sox | W 2-0 | 1514.00 | 1507.28 | 47.12% | 52.88% | +1.76 | 6-4 |
| 2021-04-14 | @ Chicago White Sox | L 0-8 | 1515.76 | 1505.52 | 47.62% | 52.38% | -4.47 | 6-5 |
| 2021-04-15 | @ Chicago White Sox | W 4-2 | 1511.29 | 1509.99 | 46.34% | 53.66% | +2.52 | 7-5 |
| 2021-04-16 | @ Cincinnati Reds | L 3-10 | 1513.81 | 1503.34 | 47.65% | 52.35% | -4.19 | 7-6 |
| 2021-04-17 | @ Cincinnati Reds | L 2-3 | 1509.62 | 1507.52 | 46.45% | 53.55% | -1.09 | 7-7 |
| 2021-04-18 | @ Cincinnati Reds | W 6-3 | 1508.53 | 1508.61 | 46.14% | 53.86% | +3.10 | 8-7 |
| 2021-04-20 | Chicago White Sox | L 5-8 | 1511.63 | 1506.25 | 54.61% | 45.39% | -3.14 | 8-8 |
| 2021-04-22 | New York Yankees | L 3-6 | 1508.49 | 1513.19 | 53.17% | 46.83% | -3.06 | 8-9 |
| 2021-04-23 | New York Yankees | L 3-5 | 1505.43 | 1516.24 | 52.30% | 47.70% | -2.46 | 8-10 |
| 2021-04-24 | New York Yankees | L 1-2 | 1502.97 | 1518.70 | 51.59% | 48.41% | -1.71 | 8-11 |
| 2021-04-25 | New York Yankees | W 7-3 | 1501.26 | 1520.41 | 51.10% | 48.90% | +3.25 | 9-11 |
| 2021-04-26 | Minnesota Twins | W 5-3 | 1504.51 | 1503.18 | 54.04% | 45.96% | +1.52 | 10-11 |
| 2021-04-27 | Minnesota Twins | W 7-4 | 1506.03 | 1501.66 | 54.47% | 45.53% | +2.62 | 11-11 |
| 2021-04-28 | Minnesota Twins | L 2-10 | 1508.65 | 1499.04 | 55.22% | 44.78% | -5.18 | 11-12 |
| 2021-04-30 | @ Chicago White Sox | W 5-3 | 1503.47 | 1517.15 | 44.20% | 55.80% | +2.62 | 12-12 |
| 2021-05-01 | @ Chicago White Sox | L 3-7 | 1506.09 | 1514.53 | 44.95% | 55.05% | -2.99 | 12-13 |
| 2021-05-02 | @ Chicago White Sox | W 5-0 | 1503.10 | 1517.52 | 44.10% | 55.90% | +4.15 | 13-13 |
| 2021-05-03 | @ Kansas City Royals | W 8-6 | 1507.25 | 1484.05 | 49.49% | 50.51% | +2.37 | 14-13 |
| 2021-05-04 | @ Kansas City Royals | W 7-3 | 1509.62 | 1481.67 | 50.17% | 49.83% | +3.31 | 15-13 |
| 2021-05-05 | @ Kansas City Royals | W 5-4 | 1512.93 | 1478.37 | 51.12% | 48.88% | +1.62 | 16-13 |
| 2021-05-06 | @ Kansas City Royals | W 4-0 | 1514.55 | 1476.74 | 51.59% | 48.41% | +3.22 | 17-13 |
| 2021-05-07 | Cincinnati Reds | L 0-3 | 1517.77 | 1491.42 | 57.59% | 42.41% | -3.31 | 17-14 |
| 2021-05-08 | Cincinnati Reds | W 9-2 | 1514.46 | 1494.73 | 56.65% | 43.35% | +3.81 | 18-14 |
| 2021-05-11 | Chicago Cubs | W 3-2 | 1518.27 | 1502.74 | 56.06% | 43.94% | +1.45 | 19-14 |
| 2021-05-12 | Chicago Cubs | W 2-1 | 1519.72 | 1501.28 | 56.47% | 43.53% | +1.03 | 20-14 |
| 2021-05-13 | @ Seattle Mariners | W 4-2 | 1520.75 | 1477.42 | 52.38% | 47.62% | +2.23 | 21-14 |
| 2021-05-14 | @ Seattle Mariners | L 3-7 | 1522.98 | 1475.18 | 53.02% | 46.98% | -3.52 | 21-15 |
| 2021-05-15 | @ Seattle Mariners | L 3-7 | 1519.46 | 1478.70 | 52.01% | 47.99% | -3.45 | 21-16 |
| 2021-05-16 | @ Seattle Mariners | L 2-3 | 1516.01 | 1482.15 | 51.02% | 48.98% | -1.70 | 21-17 |
| 2021-05-17 | @ Los Angeles Angels | L 4-7 | 1514.31 | 1468.25 | 52.77% | 47.23% | -3.03 | 21-18 |
| 2021-05-18 | @ Los Angeles Angels | W 6-5 | 1511.28 | 1471.29 | 51.90% | 48.10% | +1.60 | 22-18 |
| 2021-05-19 | @ Los Angeles Angels | W 3-2 | 1512.88 | 1469.69 | 52.36% | 47.64% | +1.58 | 23-18 |
| 2021-05-21 | Minnesota Twins | L 0-10 | 1514.46 | 1482.81 | 58.33% | 41.67% | -6.13 | 23-19 |
| 2021-05-22 | Minnesota Twins | W 5-3 | 1508.33 | 1488.94 | 56.61% | 43.39% | +1.45 | 24-19 |
| 2021-05-23 | Minnesota Twins | L 5-8 | 1509.78 | 1487.50 | 57.01% | 42.99% | -2.32 | 24-20 |
| 2021-05-24 | @ Detroit Tigers | W 6-5 | 1507.46 | 1438.71 | 56.01% | 43.99% | +1.46 | 25-20 |
| 2021-05-25 | @ Detroit Tigers | W 4-1 | 1508.92 | 1437.25 | 56.42% | 43.58% | +2.50 | 26-20 |
| 2021-05-26 | @ Detroit Tigers | L 0-1 | 1511.42 | 1434.74 | 57.13% | 42.87% | -1.89 | 26-21 |
| 2021-05-27 | @ Detroit Tigers | W 5-2 | 1509.53 | 1436.64 | 56.60% | 43.40% | +2.49 | 27-21 |
| 2021-05-28 | Toronto Blue Jays | L 2-11 | 1512.02 | 1517.65 | 53.04% | 46.96% | -5.28 | 27-22 |
| 2021-05-30 | Toronto Blue Jays | L 1-4 | 1506.74 | 1522.93 | 51.52% | 48.48% | -2.96 | 27-23 |
| 2021-05-30 | Toronto Blue Jays | W 6-5 | 1503.78 | 1525.90 | 50.67% | 49.33% | +1.63 | 28-23 |
| 2021-05-31 | Chicago White Sox | L 6-8 | 1505.41 | 1538.71 | 49.06% | 50.94% | -1.62 | 28-24 |
| 2021-05-31 | Chicago White Sox | W 3-1 | 1503.79 | 1540.34 | 48.59% | 51.41% | +2.41 | 29-24 |
| 2021-06-01 | Chicago White Sox | W 6-5 | 1506.20 | 1537.92 | 49.29% | 50.71% | +1.68 | 30-24 |
| 2021-06-04 | @ Baltimore Orioles | L 1-3 | 1507.88 | 1444.08 | 55.31% | 44.69% | -2.59 | 30-25 |
| 2021-06-05 | @ Baltimore Orioles | W 10-4 | 1505.29 | 1446.67 | 54.57% | 45.43% | +3.69 | 31-25 |
| 2021-06-06 | @ Baltimore Orioles | L 5-18 | 1508.98 | 1442.98 | 55.62% | 44.38% | -6.66 | 31-26 |
| 2021-06-08 | @ St. Louis Cardinals | W 10-1 | 1502.32 | 1497.77 | 46.81% | 53.19% | +5.30 | 32-26 |
| 2021-06-09 | @ St. Louis Cardinals | L 2-8 | 1507.62 | 1492.47 | 48.33% | 51.67% | -3.93 | 32-27 |
| 2021-06-11 | Seattle Mariners | W 7-0 | 1503.69 | 1464.79 | 59.34% | 40.66% | +3.57 | 33-27 |
| 2021-06-12 | Seattle Mariners | W 5-4 | 1507.26 | 1461.22 | 60.33% | 39.67% | +0.93 | 34-27 |
| 2021-06-13 | Seattle Mariners | L 2-6 | 1508.19 | 1460.28 | 60.59% | 39.41% | -4.02 | 34-28 |
| 2021-06-14 | Baltimore Orioles | W 4-3 | 1504.17 | 1444.21 | 62.23% | 37.77% | +1.25 | 35-28 |
| 2021-06-15 | Baltimore Orioles | W 7-2 | 1505.42 | 1442.96 | 62.57% | 37.43% | +2.78 | 36-28 |
| 2021-06-16 | Baltimore Orioles | W 8-7 | 1508.20 | 1440.18 | 63.31% | 36.69% | +1.22 | 37-28 |
| 2021-06-17 | Baltimore Orioles | W 10-3 | 1509.42 | 1438.96 | 63.64% | 36.36% | +3.19 | 38-28 |
| 2021-06-18 | @ Pittsburgh Pirates | L 10-11 | 1512.61 | 1425.83 | 58.55% | 41.45% | -1.94 | 38-29 |
| 2021-06-19 | @ Pittsburgh Pirates | L 3-6 | 1510.67 | 1427.77 | 58.01% | 41.99% | -3.33 | 38-30 |
| 2021-06-20 | @ Pittsburgh Pirates | W 2-1 | 1507.34 | 1431.11 | 57.07% | 42.93% | +1.42 | 39-30 |
| 2021-06-21 | @ Chicago Cubs | W 4-0 | 1508.76 | 1522.14 | 44.25% | 55.75% | +3.70 | 40-30 |
| 2021-06-22 | @ Chicago Cubs | L 1-7 | 1512.46 | 1518.43 | 45.30% | 54.70% | -3.68 | 40-31 |
| 2021-06-24 | @ Minnesota Twins | W 4-1 | 1508.78 | 1477.16 | 50.70% | 49.30% | +2.83 | 41-31 |
| 2021-06-25 | @ Minnesota Twins | L 7-8 | 1511.61 | 1474.33 | 51.51% | 48.49% | -1.71 | 41-32 |
| 2021-06-27 | @ Minnesota Twins | L 2-8 | 1509.90 | 1476.04 | 51.02% | 48.98% | -4.15 | 41-33 |
| 2021-06-28 | Detroit Tigers | W 13-5 | 1505.75 | 1449.64 | 61.71% | 38.29% | +3.60 | 42-33 |
| 2021-06-30 | Detroit Tigers | L 4-9 | 1509.35 | 1446.04 | 62.68% | 37.32% | -4.65 | 42-34 |
| 2021-06-30 | Detroit Tigers | L 1-7 | 1504.70 | 1450.70 | 61.42% | 38.58% | -5.00 | 42-35 |
| 2021-07-01 | Houston Astros | L 2-7 | 1499.70 | 1566.04 | 44.33% | 55.67% | -3.29 | 42-36 |
| 2021-07-02 | Houston Astros | L 3-6 | 1496.41 | 1569.33 | 43.40% | 56.60% | -2.49 | 42-37 |
| 2021-07-03 | Houston Astros | L 2-3 | 1493.92 | 1571.83 | 42.69% | 57.31% | -1.42 | 42-38 |
| 2021-07-04 | Houston Astros | L 3-4 | 1492.50 | 1573.24 | 42.30% | 57.70% | -0.99 | 42-39 |
| 2021-07-05 | @ Tampa Bay Rays | L 8-9 | 1491.51 | 1553.56 | 37.49% | 62.51% | -1.25 | 42-40 |
| 2021-07-07 | @ Tampa Bay Rays | L 1-8 | 1490.26 | 1554.80 | 37.15% | 62.85% | -3.26 | 42-41 |
| 2021-07-07 | @ Tampa Bay Rays | L 0-4 | 1487.00 | 1558.07 | 36.28% | 63.72% | -2.41 | 42-42 |
| 2021-07-08 | Kansas City Royals | W 7-4 | 1484.59 | 1438.04 | 60.40% | 39.60% | +2.28 | 43-42 |
| 2021-07-09 | Kansas City Royals | W 2-1 | 1486.87 | 1435.77 | 61.02% | 38.98% | +1.29 | 44-42 |
| 2021-07-10 | Kansas City Royals | W 14-6 | 1488.16 | 1434.47 | 61.38% | 38.62% | +3.63 | 45-42 |
| 2021-07-16 | @ Oakland Athletics | L 4-5 | 1491.79 | 1531.51 | 40.54% | 59.46% | -1.35 | 45-43 |
| 2021-07-17 | @ Oakland Athletics | W 3-2 | 1490.44 | 1532.86 | 40.17% | 59.83% | +1.99 | 46-43 |
| 2021-07-18 | @ Oakland Athletics | W 4-2 | 1492.43 | 1530.87 | 40.72% | 59.28% | +2.78 | 47-43 |
| 2021-07-19 | @ Houston Astros | L 3-4 | 1495.21 | 1566.61 | 36.24% | 63.76% | -1.20 | 47-44 |
| 2021-07-20 | @ Houston Astros | L 3-9 | 1494.01 | 1567.81 | 35.92% | 64.08% | -2.92 | 47-45 |
| 2021-07-21 | @ Houston Astros | W 5-4 | 1491.09 | 1570.73 | 35.15% | 64.85% | +2.15 | 48-45 |
| 2021-07-22 | Tampa Bay Rays | L 4-5 | 1493.24 | 1559.56 | 44.33% | 55.67% | -1.04 | 48-46 |
| 2021-07-23 | Tampa Bay Rays | L 5-10 | 1492.20 | 1560.60 | 44.04% | 55.96% | -3.27 | 48-47 |
| 2021-07-24 | Tampa Bay Rays | L 2-8 | 1488.93 | 1563.87 | 43.11% | 56.89% | -3.51 | 48-48 |
| 2021-07-25 | Tampa Bay Rays | W 3-2 | 1485.42 | 1567.38 | 42.13% | 57.87% | +1.92 | 49-48 |
| 2021-07-27 | St. Louis Cardinals | L 2-4 | 1487.34 | 1487.52 | 53.82% | 46.18% | -2.52 | 49-49 |
| 2021-07-28 | St. Louis Cardinals | W 7-2 | 1484.82 | 1490.05 | 53.10% | 46.90% | +3.48 | 50-49 |
| 2021-07-30 | @ Chicago White Sox | L 4-6 | 1488.30 | 1536.86 | 39.33% | 60.67% | -1.85 | 50-50 |
| 2021-07-31 | @ Chicago White Sox | W 12-11 | 1486.45 | 1538.70 | 38.82% | 61.18% | +2.03 | 51-50 |
| 2021-08-01 | @ Chicago White Sox | L 1-2 | 1488.48 | 1536.67 | 39.38% | 60.62% | -1.30 | 51-51 |
| 2021-08-02 | @ Toronto Blue Jays | W 5-2 | 1487.18 | 1543.04 | 38.33% | 61.67% | +2.50 | 52-51 |
| 2021-08-03 | @ Toronto Blue Jays | L 2-7 | 1489.68 | 1540.54 | 39.01% | 60.99% | -2.89 | 52-52 |
| 2021-08-04 | @ Toronto Blue Jays | L 6-8 | 1486.79 | 1543.43 | 38.22% | 61.78% | -1.80 | 52-53 |
| 2021-08-05 | @ Toronto Blue Jays | L 0-3 | 1484.99 | 1545.23 | 37.73% | 62.27% | -2.17 | 52-54 |
| 2021-08-06 | Detroit Tigers | W 6-1 | 1482.82 | 1471.54 | 55.46% | 44.54% | +3.31 | 53-54 |
| 2021-08-07 | Detroit Tigers | L 1-2 | 1486.13 | 1468.23 | 56.40% | 43.60% | -1.87 | 53-55 |
| 2021-08-08 | Detroit Tigers | W 7-5 | 1484.26 | 1470.10 | 55.86% | 44.14% | +2.07 | 54-55 |
| 2021-08-09 | Cincinnati Reds | W 9-3 | 1486.33 | 1516.79 | 49.47% | 50.53% | +4.11 | 55-55 |
| 2021-08-10 | Oakland Athletics | L 3-4 | 1490.44 | 1542.15 | 46.42% | 53.58% | -1.09 | 55-56 |
| 2021-08-11 | Oakland Athletics | L 3-6 | 1489.35 | 1543.24 | 46.11% | 53.89% | -2.65 | 55-57 |
| 2021-08-12 | Oakland Athletics | L 0-17 | 1486.70 | 1545.89 | 45.35% | 54.65% | -6.21 | 55-58 |
| 2021-08-13 | @ Detroit Tigers | W 7-4 | 1480.49 | 1476.41 | 46.74% | 53.26% | +3.06 | 56-58 |
| 2021-08-14 | @ Detroit Tigers | L 4-6 | 1483.55 | 1473.35 | 47.62% | 52.38% | -2.23 | 56-59 |
| 2021-08-15 | @ Detroit Tigers | W 11-0 | 1481.32 | 1475.58 | 46.98% | 53.02% | +5.84 | 57-59 |
| 2021-08-16 | @ Minnesota Twins | L 4-5 | 1487.16 | 1475.33 | 47.85% | 52.15% | -1.13 | 57-60 |
| 2021-08-17 | @ Minnesota Twins | W 3-1 | 1486.03 | 1476.45 | 47.53% | 52.47% | +2.47 | 58-60 |
| 2021-08-18 | @ Minnesota Twins | L 7-8 | 1488.50 | 1473.99 | 48.24% | 51.76% | -1.13 | 58-61 |
| 2021-08-20 | Los Angeles Angels | W 9-1 | 1487.37 | 1485.00 | 54.18% | 45.82% | +4.30 | 59-61 |
| 2021-08-21 | Los Angeles Angels | W 5-1 | 1491.67 | 1480.70 | 55.41% | 44.59% | +2.96 | 60-61 |
| 2021-08-22 | Los Angeles Angels | W 3-0 | 1494.63 | 1477.74 | 52.43% | 47.57% | +2.73 | 61-61 |
| 2021-08-24 | Texas Rangers | L 3-7 | 1497.36 | 1413.16 | 65.45% | 34.55% | -4.34 | 61-62 |
| 2021-08-25 | Texas Rangers | W 7-2 | 1493.02 | 1417.51 | 64.31% | 35.69% | +2.65 | 62-62 |
| 2021-08-26 | Texas Rangers | W 10-6 | 1495.67 | 1414.86 | 65.01% | 34.99% | +2.32 | 63-62 |
| 2021-08-27 | Boston Red Sox | L 3-4 | 1497.99 | 1519.43 | 50.77% | 49.23% | -1.68 | 63-63 |
| 2021-08-28 | Boston Red Sox | L 3-5 | 1496.31 | 1521.12 | 50.28% | 49.72% | -1.67 | 63-64 |
| 2021-08-29 | Boston Red Sox | W 7-5 | 1494.64 | 1522.79 | 49.80% | 50.20% | +2.35 | 64-64 |
| 2021-08-31 | @ Kansas City Royals | W 7-2 | 1496.99 | 1460.98 | 51.33% | 48.67% | +3.62 | 65-64 |
| 2021-09-01 | @ Kansas City Royals | W 5-3 | 1500.61 | 1457.37 | 52.37% | 47.63% | +1.58 | 66-64 |
| 2021-09-02 | @ Kansas City Royals | W 4-2 | 1502.19 | 1455.79 | 52.82% | 47.18% | +2.21 | 67-64 |
| 2021-09-03 | @ Boston Red Sox | L 5-8 | 1504.40 | 1522.10 | 43.63% | 56.37% | -2.51 | 67-65 |
| 2021-09-04 | @ Boston Red Sox | L 3-4 | 1501.89 | 1524.61 | 42.92% | 57.08% | -1.42 | 67-66 |
| 2021-09-05 | @ Boston Red Sox | W 11-5 | 1500.47 | 1526.04 | 42.52% | 57.48% | +4.67 | 68-66 |
| 2021-09-06 | Minnesota Twins | L 2-5 | 1505.14 | 1460.53 | 60.13% | 39.87% | -3.46 | 68-67 |
| 2021-09-07 | Minnesota Twins | L 0-3 | 1501.68 | 1463.99 | 59.17% | 40.83% | -3.40 | 68-68 |
| 2021-09-08 | Minnesota Twins | L 0-3 | 1498.28 | 1467.39 | 58.22% | 41.78% | -3.35 | 68-69 |
| 2021-09-09 | Minnesota Twins | W 4-1 | 1494.93 | 1470.74 | 57.28% | 42.72% | +2.46 | 69-69 |
| 2021-09-10 | Milwaukee Brewers | L 3-10 | 1497.39 | 1554.77 | 45.61% | 54.39% | -4.01 | 69-70 |
| 2021-09-11 | Milwaukee Brewers | L 0-3 | 1493.38 | 1558.78 | 44.47% | 55.53% | -2.55 | 69-71 |
| 2021-09-12 | Milwaukee Brewers | L 1-11 | 1490.83 | 1561.33 | 43.74% | 56.26% | -4.59 | 69-72 |
| 2021-09-14 | @ Minnesota Twins | W 3-1 | 1486.24 | 1466.96 | 48.92% | 51.08% | +2.39 | 70-72 |
| 2021-09-14 | @ Minnesota Twins | L 3-6 | 1488.63 | 1464.56 | 49.61% | 50.39% | -2.85 | 70-73 |
| 2021-09-15 | @ Minnesota Twins | W 12-3 | 1485.78 | 1467.41 | 48.79% | 51.21% | +5.10 | 71-73 |
| 2021-09-17 | @ New York Yankees | L 0-8 | 1490.88 | 1532.17 | 40.33% | 59.67% | -3.79 | 71-74 |
| 2021-09-18 | @ New York Yankees | W 11-3 | 1487.09 | 1535.96 | 39.28% | 60.72% | +5.71 | 72-74 |
| 2021-09-19 | @ New York Yankees | W 11-1 | 1492.80 | 1530.26 | 40.86% | 59.14% | +6.20 | 73-74 |
| 2021-09-20 | Kansas City Royals | L 2-7 | 1499.00 | 1455.73 | 59.95% | 40.05% | -4.45 | 73-75 |
| 2021-09-20 | Kansas City Royals | L 2-4 | 1494.55 | 1460.18 | 58.71% | 41.29% | -2.75 | 73-76 |
| 2021-09-21 | Kansas City Royals | W 4-1 | 1491.80 | 1462.93 | 57.94% | 42.06% | +2.42 | 74-76 |
| 2021-09-23 | Chicago White Sox | L 2-7 | 1494.22 | 1533.88 | 48.15% | 51.85% | -3.58 | 74-77 |
| 2021-09-23 | Chicago White Sox | W 5-3 | 1490.64 | 1537.45 | 47.12% | 52.88% | +2.48 | 75-77 |
| 2021-09-24 | Chicago White Sox | L 0-1 | 1493.12 | 1534.97 | 47.83% | 52.17% | -1.58 | 75-78 |
| 2021-09-25 | Chicago White Sox | W 6-0 | 1491.54 | 1536.55 | 47.38% | 52.62% | +4.28 | 76-78 |
| 2021-09-26 | Chicago White Sox | L 2-5 | 1495.82 | 1532.28 | 48.61% | 51.39% | -2.80 | 76-79 |
| 2021-09-27 | Kansas City Royals | W 8-3 | 1493.02 | 1462.13 | 58.22% | 41.78% | +3.10 | 77-79 |
| 2021-09-28 | @ Kansas City Royals | L 4-6 | 1496.12 | 1459.03 | 51.48% | 48.52% | -2.41 | 77-80 |
| 2021-09-29 | @ Kansas City Royals | L 5-10 | 1493.71 | 1461.45 | 50.79% | 49.21% | -3.78 | 77-81 |
| 2021-09-30 | @ Kansas City Royals | W 6-1 | 1489.93 | 1465.22 | 49.70% | 50.30% | +3.74 | 78-81 |
| 2021-10-01 | @ Texas Rangers | W 9-6 | 1493.67 | 1418.54 | 56.91% | 43.09% | +2.48 | 79-81 |
| 2021-10-02 | @ Texas Rangers | L 2-7 | 1496.15 | 1416.06 | 57.61% | 42.39% | -4.28 | 79-82 |
| 2021-10-03 | @ Texas Rangers | W 6-0 | 1491.87 | 1420.34 | 56.40% | 43.60% | +3.54 | 80-82 |
| 2021-04-01 | Los Angeles Dodgers | W 8-5 | 1476.86 | 1560.67 | 41.87% | 58.13% | +3.35 | 1-0 |
| 2021-04-02 | Los Angeles Dodgers | L 6-11 | 1480.21 | 1557.33 | 42.81% | 57.19% | -3.18 | 1-1 |
| 2021-04-03 | Los Angeles Dodgers | L 5-6 | 1477.03 | 1560.51 | 41.91% | 58.09% | -1.39 | 1-2 |
| 2021-04-04 | Los Angeles Dodgers | L 2-4 | 1475.64 | 1561.90 | 41.52% | 58.48% | -1.95 | 1-3 |
| 2021-04-06 | Arizona Diamondbacks | L 8-10 | 1473.69 | 1490.73 | 51.40% | 48.60% | -1.71 | 1-4 |
| 2021-04-07 | Arizona Diamondbacks | W 8-0 | 1471.98 | 1492.44 | 50.91% | 49.09% | +4.61 | 2-4 |
| 2021-04-08 | Arizona Diamondbacks | W 7-3 | 1476.59 | 1487.83 | 52.24% | 47.76% | +3.17 | 3-4 |
| 2021-04-09 | @ San Francisco Giants | L 1-3 | 1479.76 | 1493.57 | 44.19% | 55.81% | -2.07 | 3-5 |
| 2021-04-10 | @ San Francisco Giants | L 3-4 | 1477.69 | 1495.64 | 43.60% | 56.40% | -1.45 | 3-6 |
| 2021-04-11 | @ San Francisco Giants | L 0-4 | 1476.24 | 1497.09 | 43.19% | 56.81% | -2.87 | 3-7 |
| 2021-04-13 | @ Los Angeles Dodgers | L 0-7 | 1473.37 | 1575.21 | 32.29% | 67.71% | -2.83 | 3-8 |
| 2021-04-14 | @ Los Angeles Dodgers | L 2-4 | 1470.54 | 1578.05 | 31.58% | 68.42% | -1.49 | 3-9 |
| 2021-04-15 | @ Los Angeles Dodgers | L 5-7 | 1469.05 | 1579.53 | 31.21% | 68.79% | -1.46 | 3-10 |
| 2021-04-17 | New York Mets | L 3-4 | 1467.59 | 1502.30 | 48.86% | 51.14% | -1.62 | 3-11 |
| 2021-04-17 | New York Mets | W 7-2 | 1465.97 | 1503.92 | 48.39% | 51.61% | +3.83 | 4-11 |
| 2021-04-18 | New York Mets | L 1-2 | 1469.80 | 1500.09 | 49.49% | 50.51% | -1.65 | 4-12 |
| 2021-04-20 | Houston Astros | W 6-2 | 1468.15 | 1522.39 | 46.06% | 53.94% | +3.59 | 5-12 |
| 2021-04-21 | Houston Astros | W 6-3 | 1471.74 | 1518.81 | 47.08% | 52.92% | +3.04 | 6-12 |
| 2021-04-23 | Philadelphia Phillies | W 5-4 | 1474.78 | 1490.89 | 51.54% | 48.46% | +1.61 | 7-12 |
| 2021-04-24 | Philadelphia Phillies | L 5-7 | 1476.39 | 1489.28 | 52.00% | 48.00% | -2.44 | 7-13 |
| 2021-04-25 | Philadelphia Phillies | W 12-2 | 1473.95 | 1491.72 | 51.30% | 48.70% | +5.11 | 8-13 |
| 2021-04-26 | @ San Francisco Giants | L 0-12 | 1479.06 | 1505.45 | 42.41% | 57.59% | -4.88 | 8-14 |
| 2021-04-27 | @ San Francisco Giants | W 7-5 | 1474.18 | 1510.33 | 41.04% | 58.96% | +1.96 | 9-14 |
| 2021-04-28 | @ San Francisco Giants | L 3-7 | 1476.14 | 1508.37 | 41.59% | 58.41% | -2.76 | 9-15 |
| 2021-04-29 | @ Arizona Diamondbacks | L 3-5 | 1473.38 | 1500.80 | 42.26% | 57.74% | -1.98 | 9-16 |
| 2021-04-30 | @ Arizona Diamondbacks | L 2-7 | 1471.40 | 1502.78 | 41.71% | 58.29% | -3.10 | 9-17 |
| 2021-05-01 | @ Arizona Diamondbacks | W 14-6 | 1468.30 | 1505.88 | 40.84% | 59.16% | +5.55 | 10-17 |
| 2021-05-02 | @ Arizona Diamondbacks | L 4-8 | 1473.85 | 1500.33 | 42.40% | 57.60% | -2.81 | 10-18 |
| 2021-05-04 | San Francisco Giants | L 4-12 | 1471.04 | 1511.16 | 48.08% | 51.92% | -4.52 | 10-19 |
| 2021-05-04 | San Francisco Giants | W 8-6 | 1466.52 | 1515.68 | 46.78% | 53.22% | +2.50 | 11-19 |
| 2021-05-05 | San Francisco Giants | W 6-5 | 1469.02 | 1513.18 | 47.50% | 52.50% | +1.75 | 12-19 |
| 2021-05-07 | @ St. Louis Cardinals | L 0-5 | 1470.77 | 1515.40 | 39.86% | 60.14% | -2.96 | 12-20 |
| 2021-05-08 | @ St. Louis Cardinals | L 8-9 | 1467.81 | 1518.36 | 39.05% | 60.95% | -1.30 | 12-21 |
| 2021-05-09 | @ St. Louis Cardinals | L 0-2 | 1466.51 | 1519.66 | 38.70% | 61.30% | -1.82 | 12-22 |
| 2021-05-11 | San Diego Padres | L 1-8 | 1464.69 | 1517.46 | 46.27% | 53.73% | -4.06 | 12-23 |
| 2021-05-12 | San Diego Padres | L 3-5 | 1460.63 | 1521.52 | 45.11% | 54.89% | -2.12 | 12-24 |
| 2021-05-12 | San Diego Padres | W 3-2 | 1458.51 | 1523.64 | 44.50% | 55.50% | +1.30 | 13-24 |
| 2021-05-13 | Cincinnati Reds | W 13-8 | 1459.81 | 1495.29 | 48.75% | 51.25% | +3.81 | 14-24 |
| 2021-05-14 | Cincinnati Reds | W 9-6 | 1463.62 | 1491.49 | 49.84% | 50.16% | +2.88 | 15-24 |
| 2021-05-15 | Cincinnati Reds | L 5-6 | 1466.50 | 1488.60 | 50.67% | 49.33% | -1.19 | 15-25 |
| 2021-05-16 | Cincinnati Reds | L 6-7 | 1465.31 | 1489.79 | 50.33% | 49.67% | -1.67 | 15-26 |
| 2021-05-17 | @ San Diego Padres | L 0-7 | 1463.64 | 1530.79 | 36.80% | 63.20% | -3.23 | 15-27 |
| 2021-05-18 | @ San Diego Padres | L 1-2 | 1460.41 | 1534.02 | 35.94% | 64.06% | -0.84 | 15-28 |
| 2021-05-19 | @ San Diego Padres | L 0-3 | 1459.57 | 1534.86 | 35.72% | 64.28% | -2.06 | 15-29 |
| 2021-05-21 | Arizona Diamondbacks | W 7-1 | 1457.51 | 1475.74 | 51.23% | 48.77% | +3.97 | 16-29 |
| 2021-05-22 | Arizona Diamondbacks | W 7-6 | 1461.48 | 1471.77 | 52.37% | 47.63% | +1.58 | 17-29 |
| 2021-05-23 | Arizona Diamondbacks | W 4-3 | 1463.06 | 1470.19 | 52.82% | 47.18% | +1.57 | 18-29 |
| 2021-05-24 | @ New York Mets | W 3-2 | 1464.63 | 1498.16 | 41.41% | 58.59% | +1.94 | 19-29 |
| 2021-05-25 | @ New York Mets | L 1-3 | 1466.57 | 1496.22 | 41.95% | 58.05% | -1.97 | 19-30 |
| 2021-05-27 | @ New York Mets | L 0-1 | 1464.60 | 1498.19 | 41.40% | 58.60% | -1.37 | 19-31 |
| 2021-05-27 | @ New York Mets | L 2-4 | 1463.23 | 1499.56 | 41.02% | 58.98% | -1.93 | 19-32 |
| 2021-05-29 | @ Pittsburgh Pirates | L 0-7 | 1461.30 | 1436.39 | 49.73% | 50.27% | -4.37 | 19-33 |
| 2021-05-29 | @ Pittsburgh Pirates | L 0-4 | 1456.93 | 1440.76 | 48.47% | 51.53% | -3.22 | 19-34 |
| 2021-05-30 | @ Pittsburgh Pirates | W 4-3 | 1453.71 | 1443.97 | 47.55% | 52.45% | +1.75 | 20-34 |
| 2021-06-01 | Texas Rangers | W 3-2 | 1455.46 | 1454.64 | 53.96% | 46.04% | +1.08 | 21-34 |
| 2021-06-02 | Texas Rangers | W 6-3 | 1456.54 | 1453.56 | 54.27% | 45.73% | +2.63 | 22-34 |
| 2021-06-03 | Texas Rangers | W 11-6 | 1459.17 | 1450.93 | 55.02% | 44.98% | +3.33 | 23-34 |
| 2021-06-04 | Oakland Athletics | L 5-9 | 1462.50 | 1523.04 | 45.16% | 54.84% | -2.99 | 23-35 |
| 2021-06-05 | Oakland Athletics | L 3-6 | 1459.51 | 1526.04 | 44.30% | 55.70% | -2.55 | 23-36 |
| 2021-06-06 | Oakland Athletics | W 3-1 | 1456.96 | 1528.59 | 43.58% | 56.42% | +2.65 | 24-36 |
| 2021-06-08 | @ Miami Marlins | L 2-6 | 1459.61 | 1478.33 | 43.49% | 56.51% | -2.89 | 24-37 |
| 2021-06-09 | @ Miami Marlins | W 4-3 | 1456.72 | 1481.22 | 42.67% | 57.33% | +1.90 | 25-37 |
| 2021-06-10 | @ Miami Marlins | L 4-11 | 1458.62 | 1479.32 | 43.21% | 56.79% | -3.79 | 25-38 |
| 2021-06-11 | @ Cincinnati Reds | L 5-11 | 1454.83 | 1481.96 | 42.30% | 57.70% | -3.44 | 25-39 |
| 2021-06-12 | @ Cincinnati Reds | L 3-10 | 1451.39 | 1485.40 | 41.34% | 58.66% | -3.63 | 25-40 |
| 2021-06-13 | @ Cincinnati Reds | L 2-6 | 1447.76 | 1489.03 | 40.33% | 59.67% | -2.68 | 25-41 |
| 2021-06-14 | San Diego Padres | W 3-2 | 1445.08 | 1531.97 | 41.43% | 58.57% | +1.94 | 26-41 |
| 2021-06-15 | San Diego Padres | W 8-4 | 1447.02 | 1530.03 | 41.98% | 58.02% | +3.86 | 27-41 |
| 2021-06-16 | San Diego Padres | W 8-7 | 1450.88 | 1526.17 | 43.06% | 56.94% | +1.89 | 28-41 |
| 2021-06-17 | Milwaukee Brewers | W 7-3 | 1452.77 | 1507.95 | 45.92% | 54.08% | +3.59 | 29-41 |
| 2021-06-18 | Milwaukee Brewers | W 6-5 | 1456.36 | 1504.36 | 46.95% | 53.05% | +1.24 | 30-41 |
| 2021-06-19 | Milwaukee Brewers | L 5-6 | 1457.60 | 1503.12 | 47.31% | 52.69% | -1.57 | 30-42 |
| 2021-06-20 | Milwaukee Brewers | L 6-7 | 1456.03 | 1504.69 | 46.86% | 53.14% | -1.55 | 30-43 |
| 2021-06-22 | @ Seattle Mariners | L 1-2 | 1454.48 | 1477.06 | 42.94% | 57.06% | -1.43 | 30-44 |
| 2021-06-23 | @ Seattle Mariners | W 5-2 | 1453.05 | 1478.48 | 42.54% | 57.46% | +3.30 | 31-44 |
| 2021-06-25 | @ Milwaukee Brewers | L 4-5 | 1456.35 | 1507.02 | 39.04% | 60.96% | -0.91 | 31-45 |
| 2021-06-26 | @ Milwaukee Brewers | L 4-10 | 1455.44 | 1507.93 | 38.79% | 61.21% | -3.16 | 31-46 |
| 2021-06-27 | @ Milwaukee Brewers | L 0-5 | 1452.28 | 1511.09 | 37.93% | 62.07% | -2.81 | 31-47 |
| 2021-06-28 | Pittsburgh Pirates | W 2-0 | 1449.47 | 1441.38 | 55.00% | 45.00% | +2.11 | 32-47 |
| 2021-06-29 | Pittsburgh Pirates | W 8-0 | 1451.58 | 1439.26 | 55.60% | 44.40% | +4.17 | 33-47 |
| 2021-06-30 | Pittsburgh Pirates | W 6-2 | 1455.75 | 1435.09 | 56.78% | 43.22% | +2.87 | 34-47 |
| 2021-07-01 | St. Louis Cardinals | W 5-2 | 1458.62 | 1480.55 | 50.70% | 49.30% | +2.83 | 35-47 |
| 2021-07-02 | St. Louis Cardinals | L 3-9 | 1461.45 | 1477.72 | 51.51% | 48.49% | -2.96 | 35-48 |
| 2021-07-03 | St. Louis Cardinals | W 3-2 | 1458.49 | 1480.68 | 50.66% | 49.34% | +1.64 | 36-48 |
| 2021-07-04 | St. Louis Cardinals | W 3-2 | 1460.13 | 1479.04 | 51.13% | 48.87% | +1.62 | 37-48 |
| 2021-07-06 | @ Arizona Diamondbacks | L 3-4 | 1461.75 | 1416.97 | 52.59% | 47.41% | -1.74 | 37-49 |
| 2021-07-07 | @ Arizona Diamondbacks | L 4-6 | 1460.01 | 1418.71 | 52.09% | 47.91% | -2.45 | 37-50 |
| 2021-07-08 | @ Arizona Diamondbacks | W 9-3 | 1457.56 | 1421.16 | 51.38% | 48.62% | +3.95 | 38-50 |
| 2021-07-09 | @ San Diego Padres | L 2-4 | 1461.51 | 1535.42 | 35.90% | 64.10% | -1.68 | 38-51 |
| 2021-07-10 | @ San Diego Padres | W 3-0 | 1459.83 | 1537.10 | 35.46% | 64.54% | +3.71 | 39-51 |
| 2021-07-11 | @ San Diego Padres | W 3-1 | 1463.54 | 1533.39 | 36.44% | 63.56% | +2.98 | 40-51 |
| 2021-07-16 | Los Angeles Dodgers | L 4-10 | 1466.52 | 1591.54 | 36.23% | 63.77% | -2.94 | 40-52 |
| 2021-07-17 | Los Angeles Dodgers | L 2-9 | 1463.58 | 1594.49 | 35.45% | 64.55% | -3.12 | 40-53 |
| 2021-07-18 | Los Angeles Dodgers | W 6-5 | 1460.46 | 1597.60 | 34.63% | 65.37% | +1.54 | 41-53 |
| 2021-07-20 | Seattle Mariners | L 4-6 | 1462.00 | 1482.47 | 50.91% | 49.09% | -2.39 | 41-54 |
| 2021-07-21 | Seattle Mariners | W 6-3 | 1459.61 | 1484.86 | 50.22% | 49.78% | +2.86 | 42-54 |
| 2021-07-23 | @ Los Angeles Dodgers | W 9-6 | 1462.47 | 1588.05 | 29.38% | 70.62% | +2.87 | 43-54 |
| 2021-07-24 | @ Los Angeles Dodgers | L 0-1 | 1465.34 | 1585.18 | 30.07% | 69.93% | -1.00 | 43-55 |
| 2021-07-25 | @ Los Angeles Dodgers | L 2-3 | 1464.34 | 1586.17 | 29.83% | 70.17% | -0.99 | 43-56 |
| 2021-07-26 | @ Los Angeles Angels | L 2-6 | 1463.35 | 1490.20 | 42.34% | 57.66% | -2.81 | 43-57 |
| 2021-07-27 | @ Los Angeles Angels | W 12-3 | 1460.54 | 1493.01 | 41.55% | 58.45% | +5.82 | 44-57 |
| 2021-07-28 | @ Los Angeles Angels | L 7-8 | 1466.36 | 1487.19 | 43.19% | 56.81% | -1.43 | 44-58 |
| 2021-07-29 | @ San Diego Padres | L 0-3 | 1464.93 | 1536.64 | 36.19% | 63.81% | -2.08 | 44-59 |
| 2021-07-30 | @ San Diego Padres | W 9-4 | 1462.85 | 1538.72 | 35.64% | 64.36% | +4.78 | 45-59 |
| 2021-07-31 | @ San Diego Padres | W 5-3 | 1467.63 | 1533.94 | 36.91% | 63.09% | +2.96 | 46-59 |
| 2021-08-01 | @ San Diego Padres | L 1-8 | 1470.59 | 1530.98 | 37.71% | 62.29% | -3.31 | 46-60 |
| 2021-08-03 | Chicago Cubs | W 13-6 | 1467.28 | 1480.91 | 51.89% | 48.11% | +4.22 | 47-60 |
| 2021-08-04 | Chicago Cubs | L 2-3 | 1471.50 | 1476.68 | 53.10% | 46.90% | -1.76 | 47-61 |
| 2021-08-05 | Chicago Cubs | W 6-5 | 1469.74 | 1478.44 | 52.60% | 47.40% | +1.57 | 48-61 |
| 2021-08-06 | Miami Marlins | W 14-2 | 1471.31 | 1481.50 | 52.39% | 47.61% | +5.48 | 49-61 |
| 2021-08-07 | Miami Marlins | W 7-4 | 1476.79 | 1476.02 | 53.96% | 46.04% | +2.65 | 50-61 |
| 2021-08-08 | Miami Marlins | W 13-8 | 1479.44 | 1473.37 | 54.71% | 45.29% | +3.36 | 51-61 |
| 2021-08-10 | @ Houston Astros | L 0-5 | 1482.80 | 1569.04 | 34.29% | 65.71% | -2.55 | 51-62 |
| 2021-08-11 | @ Houston Astros | L 1-5 | 1480.25 | 1571.58 | 33.63% | 66.37% | -2.23 | 51-63 |
| 2021-08-12 | @ San Francisco Giants | L 0-7 | 1478.02 | 1563.85 | 34.34% | 65.66% | -3.02 | 51-64 |
| 2021-08-13 | @ San Francisco Giants | L 4-5 | 1475.00 | 1566.86 | 33.56% | 66.44% | -1.11 | 51-65 |
| 2021-08-14 | @ San Francisco Giants | W 4-1 | 1473.89 | 1567.98 | 33.28% | 66.72% | +3.84 | 52-65 |
| 2021-08-15 | @ San Francisco Giants | L 2-5 | 1477.73 | 1564.14 | 34.26% | 65.74% | -1.97 | 52-66 |
| 2021-08-16 | San Diego Padres | W 6-5 | 1475.76 | 1525.22 | 46.74% | 53.26% | +1.76 | 53-66 |
| 2021-08-17 | San Diego Padres | W 7-3 | 1477.52 | 1523.46 | 47.25% | 52.75% | +3.51 | 54-66 |
| 2021-08-18 | San Diego Padres | W 7-5 | 1481.03 | 1519.95 | 48.25% | 51.75% | +2.43 | 55-66 |
| 2021-08-20 | Arizona Diamondbacks | W 9-4 | 1483.46 | 1431.78 | 61.10% | 38.90% | +2.88 | 56-66 |
| 2021-08-21 | Arizona Diamondbacks | W 5-2 | 1486.34 | 1428.89 | 61.89% | 38.11% | +2.20 | 57-66 |
| 2021-08-22 | Arizona Diamondbacks | L 4-8 | 1488.54 | 1426.70 | 62.48% | 37.52% | -4.15 | 57-67 |
| 2021-08-23 | @ Chicago Cubs | L 4-6 | 1484.39 | 1440.67 | 52.44% | 47.56% | -2.47 | 57-68 |
| 2021-08-25 | @ Chicago Cubs | L 2-5 | 1481.92 | 1443.13 | 51.73% | 48.27% | -2.97 | 57-69 |
| 2021-08-25 | @ Chicago Cubs | W 13-10 | 1478.95 | 1446.10 | 50.87% | 49.13% | +2.00 | 58-69 |
| 2021-08-27 | @ Los Angeles Dodgers | W 4-2 | 1480.95 | 1610.85 | 28.87% | 71.13% | +3.34 | 59-69 |
| 2021-08-28 | @ Los Angeles Dodgers | L 2-5 | 1484.29 | 1607.51 | 29.66% | 70.34% | -1.71 | 59-70 |
| 2021-08-29 | @ Los Angeles Dodgers | W 5-0 | 1482.58 | 1609.22 | 29.25% | 70.75% | +5.25 | 60-70 |
| 2021-08-30 | @ Texas Rangers | L 3-4 | 1487.83 | 1417.28 | 56.27% | 43.73% | -1.86 | 60-71 |
| 2021-08-31 | @ Texas Rangers | L 3-4 | 1485.97 | 1419.15 | 55.74% | 44.26% | -1.85 | 60-72 |
| 2021-09-01 | @ Texas Rangers | W 9-5 | 1484.12 | 1421.00 | 55.21% | 44.79% | +2.97 | 61-72 |
| 2021-09-02 | Atlanta Braves | L 5-6 | 1487.09 | 1548.36 | 45.05% | 54.95% | -1.50 | 61-73 |
| 2021-09-03 | Atlanta Braves | W 4-3 | 1485.59 | 1549.86 | 44.63% | 55.37% | +1.84 | 62-73 |
| 2021-09-04 | Atlanta Braves | W 7-6 | 1487.43 | 1548.02 | 45.15% | 54.85% | +1.82 | 63-73 |
| 2021-09-05 | Atlanta Braves | L 2-9 | 1489.25 | 1546.20 | 45.67% | 54.33% | -4.01 | 63-74 |
| 2021-09-06 | San Francisco Giants | L 5-10 | 1485.24 | 1564.02 | 42.57% | 57.43% | -3.16 | 63-75 |
| 2021-09-07 | San Francisco Giants | L 3-12 | 1482.08 | 1567.18 | 41.69% | 58.31% | -4.15 | 63-76 |
| 2021-09-08 | San Francisco Giants | L 4-7 | 1477.93 | 1571.33 | 40.53% | 59.47% | -2.33 | 63-77 |
| 2021-09-09 | @ Philadelphia Phillies | W 4-3 | 1475.60 | 1501.73 | 42.44% | 57.56% | +1.91 | 64-77 |
| 2021-09-10 | @ Philadelphia Phillies | W 11-2 | 1477.51 | 1499.82 | 42.98% | 57.02% | +5.68 | 65-77 |
| 2021-09-11 | @ Philadelphia Phillies | L 1-6 | 1483.19 | 1494.14 | 44.59% | 55.41% | -3.31 | 65-78 |
| 2021-09-12 | @ Philadelphia Phillies | W 5-4 | 1479.88 | 1497.45 | 43.65% | 56.35% | +1.87 | 66-78 |
| 2021-09-14 | @ Atlanta Braves | W 5-4 | 1481.75 | 1550.54 | 36.58% | 63.42% | +2.10 | 67-78 |
| 2021-09-15 | @ Atlanta Braves | W 3-2 | 1483.85 | 1548.44 | 37.15% | 62.85% | +1.48 | 68-78 |
| 2021-09-17 | @ Washington Nationals | W 9-8 | 1485.33 | 1454.30 | 50.61% | 49.39% | +1.64 | 69-78 |
| 2021-09-18 | @ Washington Nationals | W 6-0 | 1486.97 | 1452.66 | 51.08% | 48.92% | +3.98 | 70-78 |
| 2021-09-19 | @ Washington Nationals | L 0-3 | 1490.95 | 1448.68 | 52.23% | 47.77% | -3.01 | 70-79 |
| 2021-09-21 | Los Angeles Dodgers | L 4-5 | 1487.94 | 1620.84 | 35.19% | 64.81% | -0.82 | 70-80 |
| 2021-09-22 | Los Angeles Dodgers | W 10-5 | 1487.12 | 1621.67 | 34.97% | 65.03% | +4.83 | 71-80 |
| 2021-09-23 | Los Angeles Dodgers | L 5-7 | 1491.95 | 1616.84 | 36.24% | 63.76% | -1.21 | 71-81 |
| 2021-09-24 | San Francisco Giants | L 2-7 | 1490.74 | 1581.44 | 40.90% | 59.10% | -3.03 | 71-82 |
| 2021-09-25 | San Francisco Giants | L 2-7 | 1487.71 | 1584.48 | 40.06% | 59.94% | -2.98 | 71-83 |
| 2021-09-26 | San Francisco Giants | L 2-6 | 1484.73 | 1587.45 | 39.24% | 60.76% | -2.60 | 71-84 |
| 2021-09-27 | Washington Nationals | L 4-5 | 1482.13 | 1453.85 | 57.86% | 42.14% | -1.92 | 71-85 |
| 2021-09-28 | Washington Nationals | W 3-1 | 1480.21 | 1455.77 | 57.32% | 42.68% | +2.00 | 72-85 |
| 2021-09-29 | Washington Nationals | W 10-5 | 1482.21 | 1453.77 | 57.88% | 42.12% | +3.13 | 73-85 |
| 2021-10-01 | @ Arizona Diamondbacks | W 9-7 | 1485.34 | 1411.20 | 56.77% | 43.23% | +2.03 | 74-85 |
| 2021-10-02 | @ Arizona Diamondbacks | L 2-11 | 1487.37 | 1409.17 | 57.35% | 42.65% | -5.72 | 74-86 |
| 2021-10-03 | @ Arizona Diamondbacks | L 4-5 | 1481.65 | 1414.88 | 55.73% | 44.27% | -1.85 | 74-87 |
| 2021-04-01 | Cleveland Indians | W 3-2 | 1454.17 | 1510.14 | 45.81% | 54.19% | +1.80 | 1-0 |
| 2021-04-03 | Cleveland Indians | W 5-2 | 1455.97 | 1508.34 | 46.32% | 53.68% | +3.09 | 2-0 |
| 2021-04-04 | Cleveland Indians | L 3-9 | 1459.06 | 1505.25 | 47.21% | 52.79% | -3.84 | 2-1 |
| 2021-04-05 | Minnesota Twins | L 6-15 | 1455.22 | 1523.54 | 44.05% | 55.95% | -4.39 | 2-2 |
| 2021-04-06 | Minnesota Twins | W 4-3 | 1450.83 | 1527.92 | 42.81% | 57.19% | +1.34 | 3-2 |
| 2021-04-07 | Minnesota Twins | L 2-3 | 1452.17 | 1526.58 | 43.19% | 56.81% | -1.43 | 3-3 |
| 2021-04-09 | @ Cleveland Indians | L 1-4 | 1450.74 | 1507.75 | 38.17% | 61.83% | -2.19 | 3-4 |
| 2021-04-10 | @ Cleveland Indians | L 3-11 | 1448.55 | 1509.95 | 37.58% | 62.42% | -3.53 | 3-5 |
| 2021-04-11 | @ Cleveland Indians | L 2-5 | 1445.02 | 1513.48 | 36.63% | 63.37% | -2.11 | 3-6 |
| 2021-04-12 | @ Houston Astros | W 6-2 | 1442.91 | 1539.18 | 33.00% | 67.00% | +4.45 | 4-6 |
| 2021-04-13 | @ Houston Astros | W 8-2 | 1447.36 | 1534.73 | 34.14% | 65.86% | +5.36 | 5-6 |
| 2021-04-14 | @ Houston Astros | W 6-4 | 1452.72 | 1529.38 | 35.54% | 64.46% | +3.02 | 6-6 |
| 2021-04-15 | @ Oakland Athletics | L 4-8 | 1455.74 | 1508.92 | 38.69% | 61.31% | -2.57 | 6-7 |
| 2021-04-16 | @ Oakland Athletics | L 0-3 | 1453.17 | 1511.49 | 37.99% | 62.01% | -2.18 | 6-8 |
| 2021-04-17 | @ Oakland Athletics | L 0-7 | 1450.99 | 1513.68 | 37.40% | 62.60% | -3.29 | 6-9 |
| 2021-04-18 | @ Oakland Athletics | L 2-3 | 1447.70 | 1516.96 | 36.52% | 63.48% | -1.21 | 6-10 |
| 2021-04-21 | Pittsburgh Pirates | L 2-3 | 1446.49 | 1467.86 | 50.78% | 49.22% | -1.69 | 6-11 |
| 2021-04-21 | Pittsburgh Pirates | W 5-2 | 1444.80 | 1469.54 | 50.29% | 49.71% | +2.86 | 7-11 |
| 2021-04-22 | Pittsburgh Pirates | L 2-4 | 1447.66 | 1466.68 | 51.12% | 48.88% | -2.40 | 7-12 |
| 2021-04-23 | Kansas City Royals | L 2-6 | 1445.26 | 1476.05 | 49.42% | 50.58% | -3.28 | 7-13 |
| 2021-04-24 | Kansas City Royals | L 1-2 | 1441.98 | 1479.34 | 48.48% | 51.52% | -1.61 | 7-14 |
| 2021-04-25 | Kansas City Royals | L 0-4 | 1440.37 | 1480.95 | 48.02% | 51.98% | -3.19 | 7-15 |
| 2021-04-26 | Kansas City Royals | L 2-3 | 1437.18 | 1484.13 | 47.10% | 52.90% | -1.56 | 7-16 |
| 2021-04-27 | @ Chicago White Sox | W 5-2 | 1435.62 | 1515.26 | 35.15% | 64.85% | +3.73 | 8-16 |
| 2021-04-29 | @ Chicago White Sox | L 1-3 | 1439.35 | 1511.53 | 36.13% | 63.87% | -1.70 | 8-17 |
| 2021-04-29 | @ Chicago White Sox | L 0-11 | 1437.65 | 1513.22 | 35.68% | 64.32% | -3.93 | 8-18 |
| 2021-04-30 | @ New York Yankees | L 0-10 | 1433.72 | 1520.86 | 34.17% | 65.83% | -3.58 | 8-19 |
| 2021-05-01 | @ New York Yankees | L 4-6 | 1430.14 | 1524.45 | 33.25% | 66.75% | -1.56 | 8-20 |
| 2021-05-02 | @ New York Yankees | L 0-2 | 1428.58 | 1526.01 | 32.85% | 67.15% | -1.55 | 8-21 |
| 2021-05-04 | @ Boston Red Sox | L 7-11 | 1427.03 | 1507.14 | 35.09% | 64.91% | -2.33 | 8-22 |
| 2021-05-05 | @ Boston Red Sox | W 6-5 | 1424.70 | 1509.47 | 34.48% | 65.52% | +1.54 | 9-22 |
| 2021-05-06 | @ Boston Red Sox | L 9-12 | 1426.24 | 1507.93 | 34.88% | 65.12% | -2.00 | 9-23 |
| 2021-05-07 | Minnesota Twins | L 3-7 | 1424.24 | 1502.07 | 42.71% | 57.29% | -2.84 | 9-24 |
| 2021-05-08 | Minnesota Twins | W 7-3 | 1421.40 | 1504.91 | 41.91% | 58.09% | +3.86 | 10-24 |
| 2021-05-11 | Kansas City Royals | W 8-7 | 1425.26 | 1462.70 | 48.47% | 51.53% | +1.71 | 11-24 |
| 2021-05-12 | Kansas City Royals | W 4-2 | 1426.97 | 1460.99 | 48.96% | 51.04% | +2.40 | 12-24 |
| 2021-05-13 | Kansas City Royals | W 4-3 | 1429.37 | 1458.59 | 49.65% | 50.35% | +1.67 | 13-24 |
| 2021-05-14 | Chicago Cubs | L 2-4 | 1431.04 | 1500.26 | 43.92% | 56.08% | -2.07 | 13-25 |
| 2021-05-15 | Chicago Cubs | W 9-8 | 1428.97 | 1502.32 | 43.34% | 56.66% | +1.33 | 14-25 |
| 2021-05-16 | Chicago Cubs | L 1-5 | 1430.30 | 1500.99 | 43.71% | 56.29% | -2.90 | 14-26 |
| 2021-05-17 | @ Seattle Mariners | W 4-1 | 1427.40 | 1483.85 | 38.25% | 61.75% | +3.55 | 15-26 |
| 2021-05-18 | @ Seattle Mariners | W 5-0 | 1430.95 | 1480.30 | 39.22% | 60.78% | +4.52 | 16-26 |
| 2021-05-19 | @ Seattle Mariners | W 6-2 | 1435.47 | 1475.79 | 40.46% | 59.54% | +3.95 | 17-26 |
| 2021-05-21 | @ Kansas City Royals | W 7-5 | 1439.42 | 1467.29 | 42.20% | 57.80% | +2.71 | 18-26 |
| 2021-05-22 | @ Kansas City Royals | L 5-7 | 1442.13 | 1464.57 | 42.96% | 57.04% | -2.01 | 18-27 |
| 2021-05-23 | @ Kansas City Royals | L 2-3 | 1440.12 | 1466.59 | 42.40% | 57.60% | -1.41 | 18-28 |
| 2021-05-24 | Cleveland Indians | L 5-6 | 1438.71 | 1507.46 | 43.99% | 56.01% | -1.46 | 18-29 |
| 2021-05-25 | Cleveland Indians | L 1-4 | 1437.25 | 1508.92 | 43.58% | 56.42% | -2.51 | 18-30 |
| 2021-05-26 | Cleveland Indians | W 1-0 | 1434.74 | 1511.42 | 42.87% | 57.13% | +1.90 | 19-30 |
| 2021-05-27 | Cleveland Indians | L 2-5 | 1436.64 | 1509.53 | 43.40% | 56.60% | -2.50 | 19-31 |
| 2021-05-28 | New York Yankees | W 3-2 | 1434.14 | 1535.15 | 39.48% | 60.52% | +1.42 | 20-31 |
| 2021-05-29 | New York Yankees | W 6-1 | 1435.56 | 1533.72 | 39.87% | 60.13% | +4.47 | 21-31 |
| 2021-05-30 | New York Yankees | W 6-2 | 1440.03 | 1529.26 | 41.11% | 58.89% | +3.91 | 22-31 |
| 2021-05-31 | @ Milwaukee Brewers | L 2-3 | 1443.94 | 1500.55 | 38.22% | 61.78% | -0.90 | 22-32 |
| 2021-06-01 | @ Milwaukee Brewers | W 10-7 | 1443.04 | 1501.45 | 37.98% | 62.02% | +3.57 | 23-32 |
| 2021-06-03 | @ Chicago White Sox | L 1-4 | 1446.61 | 1536.24 | 33.85% | 66.15% | -1.95 | 23-33 |
| 2021-06-04 | @ Chicago White Sox | L 8-9 | 1444.66 | 1538.19 | 33.35% | 66.65% | -1.11 | 23-34 |
| 2021-06-05 | @ Chicago White Sox | W 4-3 | 1443.55 | 1539.29 | 33.06% | 66.94% | +2.23 | 24-34 |
| 2021-06-06 | @ Chicago White Sox | L 0-3 | 1445.78 | 1537.07 | 33.63% | 66.37% | -1.94 | 24-35 |
| 2021-06-08 | Seattle Mariners | W 5-3 | 1443.84 | 1468.74 | 50.27% | 49.73% | +2.34 | 25-35 |
| 2021-06-09 | Seattle Mariners | L 6-9 | 1446.18 | 1466.40 | 50.94% | 49.06% | -2.07 | 25-36 |
| 2021-06-10 | Seattle Mariners | W 8-3 | 1444.11 | 1468.47 | 50.35% | 49.65% | +3.68 | 26-36 |
| 2021-06-11 | Chicago White Sox | L 4-5 | 1447.79 | 1541.00 | 40.55% | 59.45% | -0.95 | 26-37 |
| 2021-06-12 | Chicago White Sox | L 2-15 | 1446.84 | 1541.95 | 40.29% | 59.71% | -4.82 | 26-38 |
| 2021-06-13 | Chicago White Sox | L 1-4 | 1442.02 | 1546.78 | 38.96% | 61.04% | -2.24 | 26-39 |
| 2021-06-14 | @ Kansas City Royals | W 10-3 | 1439.78 | 1467.79 | 42.18% | 57.82% | +5.07 | 27-39 |
| 2021-06-15 | @ Kansas City Royals | W 4-3 | 1444.85 | 1462.71 | 43.61% | 56.39% | +1.88 | 28-39 |
| 2021-06-16 | @ Kansas City Royals | W 6-5 | 1446.73 | 1460.84 | 44.14% | 55.86% | +1.85 | 29-39 |
| 2021-06-17 | @ Los Angeles Angels | L 5-7 | 1448.58 | 1484.29 | 41.10% | 58.90% | -1.93 | 29-40 |
| 2021-06-18 | @ Los Angeles Angels | L 3-11 | 1446.65 | 1486.22 | 40.57% | 59.43% | -3.81 | 29-41 |
| 2021-06-19 | @ Los Angeles Angels | L 3-8 | 1442.84 | 1490.03 | 39.51% | 60.49% | -2.93 | 29-42 |
| 2021-06-20 | @ Los Angeles Angels | W 5-3 | 1439.91 | 1492.96 | 38.71% | 61.29% | +2.03 | 30-42 |
| 2021-06-22 | St. Louis Cardinals | W 8-2 | 1441.94 | 1491.08 | 46.79% | 53.21% | +4.33 | 31-42 |
| 2021-06-23 | St. Louis Cardinals | W 6-2 | 1446.27 | 1486.75 | 48.03% | 51.97% | +3.45 | 32-42 |
| 2021-06-24 | Houston Astros | L 3-12 | 1449.72 | 1581.37 | 35.35% | 64.65% | -3.52 | 32-43 |
| 2021-06-26 | Houston Astros | W 3-1 | 1446.20 | 1584.89 | 34.43% | 65.57% | +3.08 | 33-43 |
| 2021-06-26 | Houston Astros | L 2-3 | 1449.28 | 1581.81 | 35.23% | 64.77% | -1.17 | 33-44 |
| 2021-06-27 | Houston Astros | W 2-1 | 1448.11 | 1582.98 | 34.93% | 65.07% | +1.53 | 34-44 |
| 2021-06-28 | @ Cleveland Indians | L 5-13 | 1449.64 | 1505.75 | 38.29% | 61.71% | -3.60 | 34-45 |
| 2021-06-30 | @ Cleveland Indians | W 9-4 | 1446.04 | 1509.35 | 37.32% | 62.68% | +4.66 | 35-45 |
| 2021-06-30 | @ Cleveland Indians | W 7-1 | 1450.70 | 1504.70 | 38.58% | 61.42% | +4.99 | 36-45 |
| 2021-07-02 | Chicago White Sox | L 2-8 | 1455.69 | 1538.30 | 42.03% | 57.97% | -3.42 | 36-46 |
| 2021-07-03 | Chicago White Sox | W 11-5 | 1452.27 | 1541.72 | 41.08% | 58.92% | +4.79 | 37-46 |
| 2021-07-04 | Chicago White Sox | W 6-5 | 1457.06 | 1536.93 | 42.42% | 57.58% | +1.92 | 38-46 |
| 2021-07-05 | @ Texas Rangers | W 7-3 | 1458.98 | 1455.43 | 46.66% | 53.34% | +3.54 | 39-46 |
| 2021-07-06 | @ Texas Rangers | L 5-10 | 1462.52 | 1451.89 | 47.68% | 52.32% | -3.54 | 39-47 |
| 2021-07-07 | @ Texas Rangers | W 5-3 | 1458.98 | 1455.43 | 46.66% | 53.34% | +2.50 | 40-47 |
| 2021-07-08 | @ Minnesota Twins | L 3-5 | 1461.48 | 1467.48 | 45.30% | 54.70% | -2.12 | 40-48 |
| 2021-07-09 | @ Minnesota Twins | L 2-4 | 1459.36 | 1469.61 | 44.69% | 55.31% | -2.10 | 40-49 |
| 2021-07-10 | @ Minnesota Twins | L 4-9 | 1457.26 | 1471.70 | 44.09% | 55.91% | -3.28 | 40-50 |
| 2021-07-11 | @ Minnesota Twins | L 9-12 | 1453.98 | 1474.98 | 43.17% | 56.83% | -1.75 | 40-51 |
| 2021-07-17 | Minnesota Twins | W 1-0 | 1452.23 | 1476.73 | 50.33% | 49.67% | +1.65 | 41-51 |
| 2021-07-17 | Minnesota Twins | W 5-4 | 1453.88 | 1475.08 | 50.80% | 49.20% | +1.15 | 42-51 |
| 2021-07-18 | Minnesota Twins | W 7-0 | 1455.03 | 1473.93 | 51.13% | 48.87% | +4.29 | 43-51 |
| 2021-07-19 | Texas Rangers | W 14-0 | 1459.32 | 1440.96 | 56.46% | 43.54% | +5.41 | 44-51 |
| 2021-07-20 | Texas Rangers | W 4-1 | 1464.73 | 1435.55 | 57.98% | 42.02% | +2.42 | 45-51 |
| 2021-07-21 | Texas Rangers | W 4-2 | 1467.15 | 1433.13 | 58.66% | 41.34% | +1.94 | 46-51 |
| 2021-07-22 | Texas Rangers | W 7-5 | 1469.09 | 1431.19 | 59.20% | 40.80% | +1.92 | 47-51 |
| 2021-07-23 | @ Kansas City Royals | L 3-5 | 1471.01 | 1434.80 | 51.36% | 48.64% | -2.42 | 47-52 |
| 2021-07-24 | @ Kansas City Royals | L 8-9 | 1468.59 | 1437.21 | 50.66% | 49.34% | -1.68 | 47-53 |
| 2021-07-25 | @ Kansas City Royals | L 1-6 | 1466.91 | 1438.89 | 50.18% | 49.82% | -3.72 | 47-54 |
| 2021-07-26 | @ Minnesota Twins | L 5-6 | 1463.19 | 1466.79 | 45.64% | 54.36% | -1.07 | 47-55 |
| 2021-07-27 | @ Minnesota Twins | W 6-5 | 1462.12 | 1467.86 | 45.33% | 54.67% | +1.28 | 48-55 |
| 2021-07-28 | @ Minnesota Twins | W 17-14 | 1463.40 | 1466.58 | 45.70% | 54.30% | +3.12 | 49-55 |
| 2021-07-29 | Baltimore Orioles | W 6-2 | 1466.52 | 1434.86 | 58.33% | 41.67% | +2.77 | 50-55 |
| 2021-07-30 | Baltimore Orioles | L 3-4 | 1469.29 | 1432.10 | 59.10% | 40.90% | -1.96 | 50-56 |
| 2021-07-31 | Baltimore Orioles | L 2-5 | 1467.33 | 1434.06 | 58.56% | 41.44% | -3.37 | 50-57 |
| 2021-08-01 | Baltimore Orioles | W 6-2 | 1463.96 | 1437.43 | 57.61% | 42.39% | +2.81 | 51-57 |
| 2021-08-03 | Boston Red Sox | W 4-2 | 1466.77 | 1527.58 | 45.12% | 54.88% | +2.58 | 52-57 |
| 2021-08-04 | Boston Red Sox | L 1-4 | 1469.35 | 1525.00 | 45.85% | 54.15% | -2.64 | 52-58 |
| 2021-08-05 | Boston Red Sox | W 8-1 | 1466.71 | 1527.64 | 45.10% | 54.90% | +4.83 | 53-58 |
| 2021-08-06 | @ Cleveland Indians | L 1-6 | 1471.54 | 1482.82 | 44.54% | 55.46% | -3.31 | 53-59 |
| 2021-08-07 | @ Cleveland Indians | W 2-1 | 1468.23 | 1486.13 | 43.60% | 56.40% | +1.87 | 54-59 |
| 2021-08-08 | @ Cleveland Indians | L 5-7 | 1470.10 | 1484.26 | 44.14% | 55.86% | -2.07 | 54-60 |
| 2021-08-10 | @ Baltimore Orioles | W 9-4 | 1468.03 | 1425.23 | 52.30% | 47.70% | +3.54 | 55-60 |
| 2021-08-11 | @ Baltimore Orioles | W 5-2 | 1471.57 | 1421.69 | 53.32% | 46.68% | +2.68 | 56-60 |
| 2021-08-12 | @ Baltimore Orioles | W 6-4 | 1474.25 | 1419.01 | 54.09% | 45.91% | +2.16 | 57-60 |
| 2021-08-13 | Cleveland Indians | L 4-7 | 1476.41 | 1480.49 | 53.26% | 46.74% | -3.06 | 57-61 |
| 2021-08-14 | Cleveland Indians | W 6-4 | 1473.35 | 1483.55 | 52.38% | 47.62% | +2.23 | 58-61 |
| 2021-08-15 | Cleveland Indians | L 0-11 | 1475.58 | 1481.32 | 53.02% | 46.98% | -5.84 | 58-62 |
| 2021-08-17 | Los Angeles Angels | L 2-8 | 1469.74 | 1475.32 | 53.05% | 46.95% | -4.31 | 58-63 |
| 2021-08-18 | Los Angeles Angels | L 1-3 | 1465.43 | 1479.63 | 51.81% | 48.19% | -2.43 | 58-64 |
| 2021-08-19 | Los Angeles Angels | L 10-13 | 1463.00 | 1482.06 | 51.11% | 48.89% | -2.94 | 58-65 |
| 2021-08-20 | @ Toronto Blue Jays | W 4-1 | 1460.06 | 1547.57 | 34.12% | 65.88% | +2.68 | 59-65 |
| 2021-08-21 | @ Toronto Blue Jays | L 0-3 | 1462.74 | 1544.89 | 34.82% | 65.18% | -2.01 | 59-66 |
| 2021-08-22 | @ Toronto Blue Jays | W 5-3 | 1460.73 | 1546.89 | 34.30% | 65.70% | +2.19 | 60-66 |
| 2021-08-24 | @ St. Louis Cardinals | W 4-3 | 1462.92 | 1493.37 | 41.84% | 58.16% | +1.93 | 61-66 |
| 2021-08-25 | @ St. Louis Cardinals | L 2-3 | 1464.85 | 1491.44 | 42.38% | 57.62% | -1.00 | 61-67 |
| 2021-08-27 | Toronto Blue Jays | W 2-1 | 1463.85 | 1542.08 | 42.65% | 57.35% | +1.91 | 62-67 |
| 2021-08-28 | Toronto Blue Jays | L 2-3 | 1465.76 | 1540.18 | 43.19% | 56.81% | -1.02 | 62-68 |
| 2021-08-29 | Toronto Blue Jays | L 1-2 | 1464.74 | 1541.19 | 42.90% | 57.10% | -1.42 | 62-69 |
| 2021-08-30 | Minnesota Twins | L 2-3 | 1463.32 | 1466.22 | 53.43% | 46.57% | -1.78 | 62-70 |
| 2021-08-31 | Oakland Athletics | L 3-9 | 1461.54 | 1531.62 | 43.80% | 56.20% | -3.56 | 62-71 |
| 2021-09-01 | Oakland Athletics | W 8-6 | 1457.98 | 1535.18 | 42.79% | 57.21% | +2.69 | 63-71 |
| 2021-09-02 | Oakland Athletics | L 6-8 | 1460.67 | 1532.50 | 43.55% | 56.45% | -2.05 | 63-72 |
| 2021-09-03 | @ Cincinnati Reds | W 15-5 | 1458.62 | 1520.75 | 37.48% | 62.52% | +6.57 | 64-72 |
| 2021-09-04 | @ Cincinnati Reds | L 4-7 | 1465.19 | 1514.18 | 39.26% | 60.74% | -2.26 | 64-73 |
| 2021-09-05 | @ Cincinnati Reds | W 4-1 | 1462.93 | 1516.44 | 38.65% | 61.35% | +3.53 | 65-73 |
| 2021-09-06 | @ Pittsburgh Pirates | L 3-6 | 1466.46 | 1403.00 | 55.26% | 44.74% | -3.18 | 65-74 |
| 2021-09-07 | @ Pittsburgh Pirates | L 2-3 | 1463.28 | 1406.18 | 54.35% | 45.65% | -1.80 | 65-75 |
| 2021-09-08 | @ Pittsburgh Pirates | W 5-1 | 1461.48 | 1407.98 | 53.84% | 46.16% | +3.06 | 66-75 |
| 2021-09-10 | Tampa Bay Rays | W 10-4 | 1464.54 | 1592.89 | 35.79% | 64.21% | +5.22 | 67-75 |
| 2021-09-11 | Tampa Bay Rays | L 2-7 | 1469.76 | 1587.67 | 37.18% | 62.82% | -2.76 | 67-76 |
| 2021-09-12 | Tampa Bay Rays | W 8-7 | 1467.00 | 1590.43 | 36.44% | 63.56% | +1.49 | 68-76 |
| 2021-09-14 | Milwaukee Brewers | W 1-0 | 1468.49 | 1565.93 | 39.97% | 60.03% | +1.41 | 69-76 |
| 2021-09-15 | Milwaukee Brewers | W 4-1 | 1469.90 | 1564.52 | 40.36% | 59.64% | +3.43 | 70-76 |
| 2021-09-16 | @ Tampa Bay Rays | L 2-5 | 1473.33 | 1584.26 | 31.16% | 68.84% | -1.79 | 70-77 |
| 2021-09-17 | @ Tampa Bay Rays | L 4-7 | 1471.54 | 1586.05 | 30.72% | 69.28% | -1.25 | 70-78 |
| 2021-09-18 | @ Tampa Bay Rays | W 4-3 | 1470.29 | 1587.30 | 30.41% | 69.59% | +2.31 | 71-78 |
| 2021-09-19 | @ Tampa Bay Rays | W 2-0 | 1472.60 | 1584.99 | 30.98% | 69.02% | +3.24 | 72-78 |
| 2021-09-20 | Chicago White Sox | W 4-3 | 1475.84 | 1538.27 | 44.89% | 55.11% | +1.83 | 73-78 |
| 2021-09-21 | Chicago White Sox | W 5-3 | 1477.67 | 1536.44 | 45.41% | 54.59% | +2.57 | 74-78 |
| 2021-09-24 | Kansas City Royals | L 1-3 | 1480.24 | 1460.51 | 56.65% | 43.35% | -2.66 | 74-79 |
| 2021-09-25 | Kansas City Royals | W 5-1 | 1477.58 | 1463.17 | 55.90% | 44.10% | +2.92 | 75-79 |
| 2021-09-26 | Kansas City Royals | L 1-2 | 1480.50 | 1460.25 | 56.73% | 43.27% | -1.88 | 75-80 |
| 2021-09-27 | Chicago White Sox | L 7-8 | 1478.62 | 1535.07 | 45.74% | 54.26% | -1.52 | 75-81 |
| 2021-09-28 | @ Minnesota Twins | L 2-3 | 1477.10 | 1470.18 | 47.15% | 52.85% | -1.56 | 75-82 |
| 2021-09-29 | @ Minnesota Twins | L 2-5 | 1475.54 | 1471.75 | 46.70% | 53.30% | -2.69 | 75-83 |
| 2021-09-30 | @ Minnesota Twins | W 10-7 | 1472.85 | 1474.43 | 45.93% | 54.07% | +3.11 | 76-83 |
| 2021-10-01 | @ Chicago White Sox | L 1-8 | 1475.96 | 1543.09 | 36.80% | 63.20% | -3.23 | 76-84 |
| 2021-10-02 | @ Chicago White Sox | L 4-5 | 1472.73 | 1546.33 | 35.94% | 64.06% | -1.19 | 76-85 |
| 2021-10-03 | @ Chicago White Sox | W 5-2 | 1471.54 | 1547.52 | 35.63% | 64.37% | +3.70 | 77-85 |
| 2021-04-01 | @ Oakland Athletics | W 8-1 | 1527.09 | 1520.32 | 47.12% | 52.88% | +4.64 | 1-0 |
| 2021-04-02 | @ Oakland Athletics | W 9-5 | 1531.73 | 1515.67 | 48.46% | 51.54% | +3.43 | 2-0 |
| 2021-04-03 | @ Oakland Athletics | W 9-1 | 1535.16 | 1512.25 | 49.44% | 50.56% | +4.74 | 3-0 |
| 2021-04-04 | @ Oakland Athletics | W 9-2 | 1539.90 | 1507.50 | 50.81% | 49.19% | +4.33 | 4-0 |
| 2021-04-05 | @ Los Angeles Angels | L 6-7 | 1544.23 | 1488.70 | 54.13% | 45.87% | -1.80 | 4-1 |
| 2021-04-06 | @ Los Angeles Angels | W 4-2 | 1542.43 | 1490.49 | 53.61% | 46.39% | +2.18 | 5-1 |
| 2021-04-08 | Oakland Athletics | W 6-2 | 1544.61 | 1497.63 | 60.46% | 39.54% | +2.62 | 6-1 |
| 2021-04-09 | Oakland Athletics | L 2-6 | 1547.23 | 1495.00 | 61.18% | 38.82% | -4.06 | 6-2 |
| 2021-04-10 | Oakland Athletics | L 3-7 | 1543.17 | 1499.06 | 60.06% | 39.94% | -3.99 | 6-3 |
| 2021-04-12 | Detroit Tigers | L 2-6 | 1539.18 | 1442.91 | 67.00% | 33.00% | -4.45 | 6-4 |
| 2021-04-13 | Detroit Tigers | L 2-8 | 1534.73 | 1447.36 | 65.86% | 34.14% | -5.35 | 6-5 |
| 2021-04-14 | Detroit Tigers | L 4-6 | 1529.38 | 1452.72 | 64.46% | 35.54% | -3.03 | 6-6 |
| 2021-04-16 | @ Seattle Mariners | L 5-6 | 1526.35 | 1486.40 | 51.89% | 48.11% | -1.72 | 6-7 |
| 2021-04-17 | @ Seattle Mariners | W 1-0 | 1524.63 | 1488.12 | 51.40% | 48.60% | +1.61 | 7-7 |
| 2021-04-18 | @ Seattle Mariners | L 2-7 | 1526.24 | 1486.51 | 51.86% | 48.14% | -3.85 | 7-8 |
| 2021-04-20 | @ Colorado Rockies | L 2-6 | 1522.39 | 1468.15 | 53.94% | 46.06% | -3.58 | 7-9 |
| 2021-04-21 | @ Colorado Rockies | L 3-6 | 1518.81 | 1471.74 | 52.92% | 47.08% | -3.04 | 7-10 |
| 2021-04-22 | Los Angeles Angels | W 8-2 | 1515.77 | 1488.65 | 57.69% | 42.31% | +3.44 | 8-10 |
| 2021-04-23 | Los Angeles Angels | W 5-4 | 1519.21 | 1485.21 | 58.66% | 41.34% | +0.97 | 9-10 |
| 2021-04-24 | Los Angeles Angels | W 16-2 | 1520.18 | 1484.24 | 58.93% | 41.07% | +5.10 | 10-10 |
| 2021-04-25 | Los Angeles Angels | L 2-4 | 1525.28 | 1479.14 | 60.34% | 39.66% | -2.83 | 10-11 |
| 2021-04-26 | Seattle Mariners | W 5-2 | 1522.45 | 1494.66 | 57.79% | 42.21% | +2.42 | 11-11 |
| 2021-04-27 | Seattle Mariners | W 2-0 | 1524.87 | 1492.23 | 58.47% | 41.53% | +1.95 | 12-11 |
| 2021-04-28 | Seattle Mariners | W 7-5 | 1526.82 | 1490.28 | 59.01% | 40.99% | +1.93 | 13-11 |
| 2021-04-29 | Seattle Mariners | L 0-1 | 1528.75 | 1488.35 | 59.55% | 40.45% | -1.98 | 13-12 |
| 2021-04-30 | @ Tampa Bay Rays | W 9-2 | 1526.77 | 1526.32 | 46.22% | 53.78% | +4.72 | 14-12 |
| 2021-05-01 | @ Tampa Bay Rays | W 3-1 | 1531.49 | 1521.60 | 47.57% | 52.43% | +2.47 | 15-12 |
| 2021-05-02 | @ Tampa Bay Rays | L 4-5 | 1533.96 | 1519.14 | 48.28% | 51.72% | -1.61 | 15-13 |
| 2021-05-04 | @ New York Yankees | L 3-7 | 1532.35 | 1527.55 | 46.84% | 53.16% | -3.11 | 15-14 |
| 2021-05-05 | @ New York Yankees | L 3-6 | 1529.24 | 1530.66 | 45.95% | 54.05% | -2.64 | 15-15 |
| 2021-05-06 | @ New York Yankees | W 7-4 | 1526.60 | 1533.30 | 45.20% | 54.80% | +3.15 | 16-15 |
| 2021-05-07 | Toronto Blue Jays | W 10-4 | 1529.75 | 1513.43 | 56.17% | 43.83% | +3.57 | 17-15 |
| 2021-05-08 | Toronto Blue Jays | L 4-8 | 1533.32 | 1509.86 | 57.18% | 42.82% | -3.80 | 17-16 |
| 2021-05-09 | Toronto Blue Jays | W 7-4 | 1529.52 | 1513.66 | 56.11% | 43.89% | +2.52 | 18-16 |
| 2021-05-10 | Los Angeles Angels | L 4-5 | 1532.04 | 1475.60 | 61.75% | 38.25% | -2.05 | 18-17 |
| 2021-05-11 | Los Angeles Angels | W 5-1 | 1529.99 | 1477.65 | 61.19% | 38.81% | +2.58 | 19-17 |
| 2021-05-12 | Los Angeles Angels | W 9-1 | 1532.57 | 1475.07 | 61.90% | 38.10% | +3.58 | 20-17 |
| 2021-05-13 | Texas Rangers | W 4-3 | 1536.15 | 1472.33 | 62.75% | 37.25% | +0.87 | 21-17 |
| 2021-05-14 | Texas Rangers | W 10-4 | 1537.02 | 1471.45 | 62.99% | 37.01% | +3.01 | 22-17 |
| 2021-05-15 | Texas Rangers | W 6-5 | 1540.03 | 1468.44 | 63.79% | 36.21% | +1.20 | 23-17 |
| 2021-05-16 | Texas Rangers | W 6-2 | 1541.23 | 1467.24 | 64.11% | 35.89% | +2.39 | 24-17 |
| 2021-05-18 | @ Oakland Athletics | L 5-6 | 1543.62 | 1523.37 | 49.06% | 50.94% | -1.63 | 24-18 |
| 2021-05-19 | @ Oakland Athletics | W 8-1 | 1541.99 | 1525.00 | 48.59% | 51.41% | +4.51 | 25-18 |
| 2021-05-20 | @ Oakland Athletics | W 8-4 | 1546.50 | 1520.48 | 49.89% | 50.11% | +3.33 | 26-18 |
| 2021-05-21 | @ Texas Rangers | L 5-7 | 1549.83 | 1461.24 | 58.80% | 41.20% | -1.95 | 26-19 |
| 2021-05-22 | @ Texas Rangers | L 4-8 | 1547.88 | 1463.19 | 58.26% | 41.74% | -3.87 | 26-20 |
| 2021-05-23 | @ Texas Rangers | L 2-3 | 1544.01 | 1467.06 | 57.17% | 42.83% | -1.34 | 26-21 |
| 2021-05-25 | Los Angeles Dodgers | L 2-9 | 1542.67 | 1583.43 | 47.99% | 52.01% | -4.22 | 26-22 |
| 2021-05-26 | Los Angeles Dodgers | W 5-2 | 1538.45 | 1587.64 | 46.78% | 53.22% | +3.06 | 27-22 |
| 2021-05-28 | San Diego Padres | L 3-10 | 1541.51 | 1547.53 | 52.99% | 47.01% | -3.29 | 27-23 |
| 2021-05-29 | San Diego Padres | L 8-11 | 1538.22 | 1550.82 | 52.04% | 47.96% | -2.11 | 27-24 |
| 2021-05-30 | San Diego Padres | W 7-4 | 1536.11 | 1552.93 | 51.43% | 48.57% | +2.79 | 28-24 |
| 2021-05-31 | Boston Red Sox | W 11-2 | 1538.90 | 1526.29 | 55.64% | 44.36% | +4.42 | 29-24 |
| 2021-06-01 | Boston Red Sox | W 5-1 | 1543.32 | 1521.88 | 56.90% | 43.10% | +2.86 | 30-24 |
| 2021-06-02 | Boston Red Sox | W 2-1 | 1546.18 | 1519.01 | 57.70% | 42.30% | +1.40 | 31-24 |
| 2021-06-03 | Boston Red Sox | L 1-5 | 1547.58 | 1517.61 | 58.10% | 41.90% | -3.85 | 31-25 |
| 2021-06-04 | @ Toronto Blue Jays | W 13-1 | 1543.73 | 1528.35 | 48.36% | 51.64% | +5.94 | 32-25 |
| 2021-06-05 | @ Toronto Blue Jays | L 2-6 | 1549.67 | 1522.41 | 50.07% | 49.93% | -3.33 | 32-26 |
| 2021-06-06 | @ Toronto Blue Jays | W 6-3 | 1546.34 | 1525.74 | 49.11% | 50.89% | +2.93 | 33-26 |
| 2021-06-08 | @ Boston Red Sox | W 7-1 | 1549.27 | 1531.16 | 48.75% | 51.25% | +4.17 | 34-26 |
| 2021-06-09 | @ Boston Red Sox | W 8-3 | 1553.44 | 1526.99 | 49.95% | 50.05% | +3.71 | 35-26 |
| 2021-06-10 | @ Boston Red Sox | L 8-12 | 1557.15 | 1523.28 | 51.02% | 48.98% | -3.39 | 35-27 |
| 2021-06-11 | @ Minnesota Twins | W 6-4 | 1553.76 | 1479.07 | 56.85% | 43.15% | +2.03 | 36-27 |
| 2021-06-12 | @ Minnesota Twins | L 2-5 | 1555.79 | 1477.05 | 57.42% | 42.58% | -3.30 | 36-28 |
| 2021-06-13 | @ Minnesota Twins | W 14-3 | 1552.49 | 1480.35 | 56.49% | 43.51% | +4.79 | 37-28 |
| 2021-06-15 | Texas Rangers | W 6-3 | 1557.28 | 1446.56 | 68.82% | 31.18% | +1.27 | 38-28 |
| 2021-06-16 | Texas Rangers | W 8-4 | 1558.55 | 1445.29 | 69.13% | 30.87% | +2.05 | 39-28 |
| 2021-06-17 | Chicago White Sox | W 10-2 | 1560.60 | 1550.19 | 55.33% | 44.67% | +4.19 | 40-28 |
| 2021-06-18 | Chicago White Sox | W 2-1 | 1564.79 | 1545.99 | 56.52% | 43.48% | +1.44 | 41-28 |
| 2021-06-19 | Chicago White Sox | W 7-3 | 1566.23 | 1544.55 | 56.93% | 43.07% | +2.86 | 42-28 |
| 2021-06-20 | Chicago White Sox | W 8-2 | 1569.09 | 1541.69 | 57.74% | 42.26% | +3.44 | 43-28 |
| 2021-06-21 | @ Baltimore Orioles | W 10-2 | 1572.53 | 1435.61 | 65.34% | 34.66% | +3.26 | 44-28 |
| 2021-06-22 | @ Baltimore Orioles | W 3-1 | 1575.79 | 1432.35 | 66.18% | 33.82% | +1.58 | 45-28 |
| 2021-06-23 | @ Baltimore Orioles | W 13-0 | 1577.37 | 1430.77 | 66.59% | 33.41% | +4.00 | 46-28 |
| 2021-06-24 | @ Detroit Tigers | W 12-3 | 1581.37 | 1449.72 | 64.65% | 35.35% | +3.52 | 47-28 |
| 2021-06-26 | @ Detroit Tigers | L 1-3 | 1584.89 | 1446.20 | 65.57% | 34.43% | -3.08 | 47-29 |
| 2021-06-26 | @ Detroit Tigers | W 3-2 | 1581.81 | 1449.28 | 64.77% | 35.23% | +1.17 | 48-29 |
| 2021-06-27 | @ Detroit Tigers | L 1-2 | 1582.98 | 1448.11 | 65.07% | 34.93% | -1.52 | 48-30 |
| 2021-06-28 | Baltimore Orioles | L 7-9 | 1581.46 | 1420.26 | 74.69% | 25.31% | -3.51 | 48-31 |
| 2021-06-29 | Baltimore Orioles | L 3-13 | 1577.95 | 1423.77 | 73.92% | 26.08% | -7.76 | 48-32 |
| 2021-06-30 | Baltimore Orioles | L 2-5 | 1570.19 | 1431.53 | 72.16% | 27.84% | -4.15 | 48-33 |
| 2021-07-01 | @ Cleveland Indians | W 7-2 | 1566.04 | 1499.70 | 55.67% | 44.33% | +3.29 | 49-33 |
| 2021-07-02 | @ Cleveland Indians | W 6-3 | 1569.33 | 1496.41 | 56.60% | 43.40% | +2.50 | 50-33 |
| 2021-07-03 | @ Cleveland Indians | W 3-2 | 1571.83 | 1493.92 | 57.31% | 42.69% | +1.41 | 51-33 |
| 2021-07-04 | @ Cleveland Indians | W 4-3 | 1573.24 | 1492.50 | 57.70% | 42.30% | +1.00 | 52-33 |
| 2021-07-06 | Oakland Athletics | W 9-6 | 1574.24 | 1530.48 | 60.01% | 39.99% | +2.30 | 53-33 |
| 2021-07-07 | Oakland Athletics | W 4-3 | 1576.54 | 1528.18 | 60.65% | 39.35% | +1.30 | 54-33 |
| 2021-07-08 | Oakland Athletics | L 1-2 | 1577.84 | 1526.87 | 61.01% | 38.99% | -2.02 | 54-34 |
| 2021-07-09 | New York Yankees | L 0-4 | 1575.82 | 1510.78 | 62.91% | 37.09% | -4.18 | 54-35 |
| 2021-07-10 | New York Yankees | L 0-1 | 1571.64 | 1514.96 | 61.79% | 38.21% | -2.05 | 54-36 |
| 2021-07-11 | New York Yankees | W 8-7 | 1569.59 | 1517.01 | 61.23% | 38.77% | +1.29 | 55-36 |
| 2021-07-16 | @ Chicago White Sox | W 7-1 | 1570.88 | 1546.00 | 49.73% | 50.27% | +4.08 | 56-36 |
| 2021-07-17 | @ Chicago White Sox | L 1-10 | 1574.96 | 1541.91 | 50.90% | 49.10% | -5.07 | 56-37 |
| 2021-07-18 | @ Chicago White Sox | L 0-4 | 1569.89 | 1546.98 | 49.44% | 50.56% | -3.28 | 56-38 |
| 2021-07-19 | Cleveland Indians | W 4-3 | 1566.61 | 1495.21 | 63.76% | 36.24% | +1.20 | 57-38 |
| 2021-07-20 | Cleveland Indians | W 9-3 | 1567.81 | 1494.01 | 64.08% | 35.92% | +2.92 | 58-38 |
| 2021-07-21 | Cleveland Indians | L 4-5 | 1570.73 | 1491.09 | 64.85% | 35.15% | -2.15 | 58-39 |
| 2021-07-23 | Texas Rangers | W 7-3 | 1568.58 | 1429.28 | 72.23% | 27.77% | +1.85 | 59-39 |
| 2021-07-24 | Texas Rangers | W 4-1 | 1570.43 | 1427.43 | 72.66% | 27.34% | +1.57 | 60-39 |
| 2021-07-25 | Texas Rangers | W 3-1 | 1572.00 | 1425.86 | 73.02% | 26.98% | +1.26 | 61-39 |
| 2021-07-26 | @ Seattle Mariners | L 8-11 | 1573.26 | 1484.69 | 58.80% | 41.20% | -3.38 | 61-40 |
| 2021-07-27 | @ Seattle Mariners | W 8-6 | 1569.88 | 1488.07 | 57.85% | 42.15% | +1.98 | 62-40 |
| 2021-07-28 | @ Seattle Mariners | W 11-4 | 1571.86 | 1486.10 | 58.41% | 41.59% | +3.66 | 63-40 |
| 2021-07-30 | @ San Francisco Giants | W 9-6 | 1575.52 | 1554.54 | 49.16% | 50.84% | +2.92 | 64-40 |
| 2021-07-31 | @ San Francisco Giants | L 6-8 | 1578.44 | 1551.62 | 50.01% | 49.99% | -2.35 | 64-41 |
| 2021-08-01 | @ San Francisco Giants | L 3-5 | 1576.09 | 1553.97 | 49.33% | 50.67% | -2.31 | 64-42 |
| 2021-08-03 | @ Los Angeles Dodgers | W 3-0 | 1573.78 | 1590.71 | 43.74% | 56.26% | +3.23 | 65-42 |
| 2021-08-04 | @ Los Angeles Dodgers | L 5-7 | 1577.01 | 1587.47 | 44.66% | 55.34% | -2.10 | 65-43 |
| 2021-08-05 | Minnesota Twins | L 3-5 | 1574.91 | 1464.29 | 68.80% | 31.20% | -3.23 | 65-44 |
| 2021-08-06 | Minnesota Twins | L 4-5 | 1571.68 | 1467.52 | 68.00% | 32.00% | -1.59 | 65-45 |
| 2021-08-07 | Minnesota Twins | W 4-0 | 1570.09 | 1469.12 | 67.60% | 32.40% | +2.15 | 66-45 |
| 2021-08-08 | Minnesota Twins | L 5-7 | 1572.24 | 1466.97 | 68.14% | 31.86% | -3.20 | 66-46 |
| 2021-08-10 | Colorado Rockies | W 5-0 | 1569.04 | 1482.80 | 65.71% | 34.29% | +2.54 | 67-46 |
| 2021-08-11 | Colorado Rockies | W 5-1 | 1571.58 | 1480.25 | 66.37% | 33.63% | +2.24 | 68-46 |
| 2021-08-13 | @ Los Angeles Angels | W 4-1 | 1573.82 | 1479.28 | 59.63% | 40.37% | +2.32 | 69-46 |
| 2021-08-14 | @ Los Angeles Angels | W 8-2 | 1576.14 | 1476.96 | 60.27% | 39.73% | +3.23 | 70-46 |
| 2021-08-15 | @ Los Angeles Angels | L 1-3 | 1579.37 | 1473.73 | 61.16% | 38.84% | -2.87 | 70-47 |
| 2021-08-16 | @ Kansas City Royals | L 6-7 | 1576.50 | 1435.26 | 65.90% | 34.10% | -2.19 | 70-48 |
| 2021-08-17 | @ Kansas City Royals | L 1-3 | 1574.31 | 1437.45 | 65.33% | 34.67% | -3.07 | 70-49 |
| 2021-08-18 | @ Kansas City Royals | L 2-3 | 1571.24 | 1440.52 | 64.53% | 35.47% | -2.14 | 70-50 |
| 2021-08-19 | @ Kansas City Royals | W 6-3 | 1569.10 | 1442.66 | 63.96% | 36.04% | +1.47 | 71-50 |
| 2021-08-20 | Seattle Mariners | W 12-3 | 1570.57 | 1497.52 | 63.98% | 36.02% | +3.58 | 72-50 |
| 2021-08-21 | Seattle Mariners | W 15-1 | 1574.15 | 1493.93 | 64.93% | 35.07% | +4.36 | 73-50 |
| 2021-08-22 | Seattle Mariners | L 3-6 | 1578.51 | 1489.58 | 66.06% | 33.94% | -2.69 | 73-51 |
| 2021-08-23 | Kansas City Royals | L 1-7 | 1575.82 | 1452.46 | 70.36% | 29.64% | -5.72 | 73-52 |
| 2021-08-24 | Kansas City Royals | W 4-0 | 1570.10 | 1458.18 | 68.96% | 31.04% | +2.06 | 74-52 |
| 2021-08-25 | Kansas City Royals | W 6-5 | 1572.16 | 1456.12 | 69.47% | 30.53% | +0.72 | 75-52 |
| 2021-08-27 | @ Texas Rangers | W 5-4 | 1572.88 | 1412.54 | 68.33% | 31.67% | +1.05 | 76-52 |
| 2021-08-28 | @ Texas Rangers | W 5-2 | 1573.93 | 1411.49 | 68.59% | 31.41% | +1.81 | 77-52 |
| 2021-08-29 | @ Texas Rangers | L 2-13 | 1575.74 | 1409.68 | 69.03% | 30.97% | -7.60 | 77-53 |
| 2021-08-30 | @ Seattle Mariners | W 4-3 | 1568.14 | 1493.50 | 56.84% | 43.16% | +1.43 | 78-53 |
| 2021-08-31 | @ Seattle Mariners | L 0-4 | 1569.57 | 1492.07 | 57.25% | 42.75% | -3.80 | 78-54 |
| 2021-09-01 | @ Seattle Mariners | L 0-1 | 1565.77 | 1495.87 | 56.17% | 43.83% | -1.87 | 78-55 |
| 2021-09-03 | @ San Diego Padres | W 6-3 | 1563.90 | 1505.68 | 54.51% | 45.49% | +2.62 | 79-55 |
| 2021-09-04 | @ San Diego Padres | L 2-10 | 1566.52 | 1503.06 | 55.26% | 44.74% | -5.19 | 79-56 |
| 2021-09-05 | @ San Diego Padres | L 3-4 | 1561.33 | 1508.25 | 53.78% | 46.22% | -1.79 | 79-57 |
| 2021-09-06 | Seattle Mariners | W 11-2 | 1559.54 | 1503.69 | 61.67% | 38.33% | +3.82 | 80-57 |
| 2021-09-07 | Seattle Mariners | W 5-4 | 1563.36 | 1499.87 | 62.71% | 37.29% | +0.88 | 81-57 |
| 2021-09-08 | Seattle Mariners | L 5-8 | 1564.24 | 1499.00 | 62.94% | 37.06% | -3.62 | 81-58 |
| 2021-09-10 | Los Angeles Angels | W 10-5 | 1560.62 | 1468.41 | 66.48% | 33.52% | +2.48 | 82-58 |
| 2021-09-11 | Los Angeles Angels | L 2-4 | 1563.10 | 1465.92 | 67.12% | 32.88% | -3.15 | 82-59 |
| 2021-09-12 | Los Angeles Angels | W 3-1 | 1559.95 | 1469.07 | 66.31% | 33.69% | +1.58 | 83-59 |
| 2021-09-13 | @ Texas Rangers | W 15-1 | 1561.53 | 1431.31 | 64.46% | 35.54% | +4.42 | 84-59 |
| 2021-09-14 | @ Texas Rangers | L 1-8 | 1565.95 | 1426.90 | 65.62% | 34.38% | -5.76 | 84-60 |
| 2021-09-15 | @ Texas Rangers | W 7-2 | 1560.19 | 1432.66 | 64.11% | 35.89% | +2.66 | 85-60 |
| 2021-09-16 | @ Texas Rangers | W 12-1 | 1562.85 | 1430.00 | 64.81% | 35.19% | +3.88 | 86-60 |
| 2021-09-17 | Arizona Diamondbacks | W 4-3 | 1566.73 | 1415.76 | 73.56% | 26.44% | +0.62 | 87-60 |
| 2021-09-18 | Arizona Diamondbacks | L 4-6 | 1567.35 | 1415.13 | 73.70% | 26.30% | -2.45 | 87-61 |
| 2021-09-19 | Arizona Diamondbacks | W 7-6 | 1564.90 | 1417.58 | 73.15% | 26.85% | +0.89 | 88-61 |
| 2021-09-20 | @ Los Angeles Angels | W 10-0 | 1565.79 | 1467.18 | 60.19% | 39.81% | +4.18 | 89-61 |
| 2021-09-21 | @ Los Angeles Angels | W 10-5 | 1569.97 | 1463.00 | 61.34% | 38.66% | +2.87 | 90-61 |
| 2021-09-22 | @ Los Angeles Angels | W 9-5 | 1572.84 | 1460.13 | 62.12% | 37.88% | +1.78 | 91-61 |
| 2021-09-23 | @ Los Angeles Angels | L 2-3 | 1574.62 | 1458.35 | 62.60% | 37.40% | -2.08 | 91-62 |
| 2021-09-24 | @ Oakland Athletics | L 2-14 | 1572.54 | 1521.89 | 53.43% | 46.57% | -6.14 | 91-63 |
| 2021-09-25 | @ Oakland Athletics | L 1-2 | 1566.40 | 1528.04 | 51.67% | 48.33% | -1.72 | 91-64 |
| 2021-09-26 | @ Oakland Athletics | L 3-4 | 1564.68 | 1529.75 | 51.17% | 48.83% | -1.70 | 91-65 |
| 2021-09-28 | Tampa Bay Rays | W 4-3 | 1562.98 | 1590.34 | 49.92% | 50.08% | +1.66 | 92-65 |
| 2021-09-29 | Tampa Bay Rays | L 0-7 | 1564.64 | 1588.68 | 50.40% | 49.60% | -4.42 | 92-66 |
| 2021-09-30 | Tampa Bay Rays | W 3-2 | 1560.22 | 1593.11 | 49.12% | 50.88% | +1.69 | 93-66 |
| 2021-10-01 | Oakland Athletics | L 6-8 | 1561.91 | 1521.95 | 59.49% | 40.51% | -2.80 | 93-67 |
| 2021-10-02 | Oakland Athletics | W 10-4 | 1559.11 | 1524.75 | 58.71% | 41.29% | +3.36 | 94-67 |
| 2021-10-03 | Oakland Athletics | W 7-6 | 1562.47 | 1521.39 | 59.64% | 40.36% | +1.34 | 95-67 |
| 2021-04-01 | Texas Rangers | W 14-10 | 1475.20 | 1472.66 | 54.21% | 45.79% | +3.04 | 1-0 |
| 2021-04-03 | Texas Rangers | W 11-4 | 1478.24 | 1469.62 | 55.08% | 44.92% | +3.95 | 2-0 |
| 2021-04-04 | Texas Rangers | L 3-7 | 1482.19 | 1465.67 | 56.20% | 43.80% | -3.73 | 2-1 |
| 2021-04-05 | @ Cleveland Indians | W 3-0 | 1478.46 | 1509.09 | 41.81% | 58.19% | +3.34 | 3-1 |
| 2021-04-07 | @ Cleveland Indians | L 2-4 | 1481.80 | 1505.75 | 42.75% | 57.25% | -2.01 | 3-2 |
| 2021-04-08 | @ Chicago White Sox | L 0-6 | 1479.79 | 1503.58 | 42.77% | 57.23% | -3.47 | 3-3 |
| 2021-04-11 | @ Chicago White Sox | W 4-3 | 1476.32 | 1507.06 | 41.80% | 58.20% | +1.36 | 4-3 |
| 2021-04-12 | Los Angeles Angels | L 3-10 | 1477.68 | 1487.93 | 52.38% | 47.62% | -4.60 | 4-4 |
| 2021-04-13 | Los Angeles Angels | W 3-2 | 1473.08 | 1492.53 | 51.06% | 48.94% | +1.63 | 5-4 |
| 2021-04-14 | Los Angeles Angels | W 6-1 | 1474.71 | 1490.90 | 51.52% | 48.48% | +3.59 | 6-4 |
| 2021-04-15 | Toronto Blue Jays | W 7-5 | 1478.30 | 1498.54 | 50.94% | 49.06% | +2.31 | 7-4 |
| 2021-04-17 | Toronto Blue Jays | L 1-5 | 1480.61 | 1496.24 | 51.60% | 48.40% | -3.43 | 7-5 |
| 2021-04-17 | Toronto Blue Jays | W 3-2 | 1477.18 | 1499.67 | 50.62% | 49.38% | +1.64 | 8-5 |
| 2021-04-18 | Toronto Blue Jays | W 2-0 | 1478.82 | 1498.03 | 51.09% | 48.91% | +2.30 | 9-5 |
| 2021-04-19 | Tampa Bay Rays | L 1-4 | 1481.12 | 1523.83 | 47.71% | 52.29% | -2.75 | 9-6 |
| 2021-04-20 | Tampa Bay Rays | L 7-14 | 1478.37 | 1526.57 | 46.92% | 53.08% | -4.12 | 9-7 |
| 2021-04-21 | Tampa Bay Rays | W 9-8 | 1474.25 | 1530.69 | 45.74% | 54.26% | +1.80 | 10-7 |
| 2021-04-23 | @ Detroit Tigers | W 6-2 | 1476.05 | 1445.26 | 50.58% | 49.42% | +3.29 | 11-7 |
| 2021-04-24 | @ Detroit Tigers | W 2-1 | 1479.34 | 1441.98 | 51.52% | 48.48% | +1.61 | 12-7 |
| 2021-04-25 | @ Detroit Tigers | W 4-0 | 1480.95 | 1440.37 | 51.98% | 48.02% | +3.18 | 13-7 |
| 2021-04-26 | @ Detroit Tigers | W 3-2 | 1484.13 | 1437.18 | 52.90% | 47.10% | +1.57 | 14-7 |
| 2021-04-27 | @ Pittsburgh Pirates | L 1-2 | 1485.70 | 1475.08 | 47.68% | 52.32% | -1.59 | 14-8 |
| 2021-04-28 | @ Pittsburgh Pirates | W 9-6 | 1484.11 | 1476.66 | 47.22% | 52.78% | +3.04 | 15-8 |
| 2021-04-30 | @ Minnesota Twins | L 1-9 | 1487.15 | 1504.22 | 43.72% | 56.28% | -4.11 | 15-9 |
| 2021-05-01 | @ Minnesota Twins | W 11-3 | 1483.04 | 1508.33 | 42.56% | 57.44% | +5.40 | 16-9 |
| 2021-05-02 | @ Minnesota Twins | L 4-13 | 1488.44 | 1502.94 | 44.09% | 55.91% | -4.39 | 16-10 |
| 2021-05-03 | Cleveland Indians | L 6-8 | 1484.05 | 1507.25 | 50.51% | 49.49% | -2.38 | 16-11 |
| 2021-05-04 | Cleveland Indians | L 3-7 | 1481.67 | 1509.62 | 49.83% | 50.17% | -3.30 | 16-12 |
| 2021-05-05 | Cleveland Indians | L 4-5 | 1478.37 | 1512.93 | 48.88% | 51.12% | -1.63 | 16-13 |
| 2021-05-06 | Cleveland Indians | L 0-4 | 1476.74 | 1514.55 | 48.41% | 51.59% | -3.21 | 16-14 |
| 2021-05-07 | Chicago White Sox | L 0-3 | 1473.53 | 1517.29 | 47.56% | 52.44% | -2.74 | 16-15 |
| 2021-05-08 | Chicago White Sox | L 1-9 | 1470.79 | 1520.03 | 46.77% | 53.23% | -4.39 | 16-16 |
| 2021-05-09 | Chicago White Sox | L 3-9 | 1466.40 | 1524.42 | 45.52% | 54.48% | -3.70 | 16-17 |
| 2021-05-11 | @ Detroit Tigers | L 7-8 | 1462.70 | 1425.26 | 51.53% | 48.47% | -1.71 | 16-18 |
| 2021-05-12 | @ Detroit Tigers | L 2-4 | 1460.99 | 1426.97 | 51.04% | 48.96% | -2.40 | 16-19 |
| 2021-05-13 | @ Detroit Tigers | L 3-4 | 1458.59 | 1429.37 | 50.35% | 49.65% | -1.67 | 16-20 |
| 2021-05-14 | @ Chicago White Sox | W 6-2 | 1456.92 | 1536.53 | 35.15% | 64.85% | +4.31 | 17-20 |
| 2021-05-14 | @ Chicago White Sox | L 1-3 | 1461.23 | 1532.23 | 36.29% | 63.71% | -1.71 | 17-21 |
| 2021-05-15 | @ Chicago White Sox | W 5-1 | 1459.52 | 1533.93 | 35.84% | 64.16% | +4.26 | 18-21 |
| 2021-05-16 | @ Chicago White Sox | L 3-4 | 1463.78 | 1529.67 | 36.97% | 63.03% | -1.22 | 18-22 |
| 2021-05-18 | Milwaukee Brewers | W 2-0 | 1462.56 | 1494.47 | 49.26% | 50.74% | +2.38 | 19-22 |
| 2021-05-19 | Milwaukee Brewers | W 6-4 | 1464.94 | 1492.09 | 49.95% | 50.05% | +2.35 | 20-22 |
| 2021-05-21 | Detroit Tigers | L 5-7 | 1467.29 | 1439.42 | 57.80% | 42.20% | -2.72 | 20-23 |
| 2021-05-22 | Detroit Tigers | W 7-5 | 1464.57 | 1442.13 | 57.04% | 42.96% | +2.02 | 21-23 |
| 2021-05-23 | Detroit Tigers | W 3-2 | 1466.59 | 1440.12 | 57.60% | 42.40% | +1.41 | 22-23 |
| 2021-05-25 | @ Tampa Bay Rays | W 2-1 | 1468.00 | 1557.45 | 33.87% | 66.13% | +2.19 | 23-23 |
| 2021-05-26 | @ Tampa Bay Rays | L 1-2 | 1470.19 | 1555.25 | 34.44% | 65.56% | -0.80 | 23-24 |
| 2021-05-27 | @ Tampa Bay Rays | L 2-7 | 1469.39 | 1556.06 | 34.23% | 65.77% | -2.54 | 23-25 |
| 2021-05-28 | @ Minnesota Twins | W 8-3 | 1466.85 | 1496.47 | 41.95% | 58.05% | +4.30 | 24-25 |
| 2021-05-29 | @ Minnesota Twins | L 5-6 | 1471.15 | 1492.16 | 43.17% | 56.83% | -1.43 | 24-26 |
| 2021-05-30 | @ Minnesota Twins | W 6-3 | 1469.72 | 1493.60 | 42.76% | 57.24% | +3.29 | 25-26 |
| 2021-05-31 | Pittsburgh Pirates | W 7-3 | 1473.01 | 1442.23 | 58.21% | 41.79% | +2.78 | 26-26 |
| 2021-06-01 | Pittsburgh Pirates | W 10-5 | 1475.79 | 1439.46 | 58.98% | 41.02% | +3.04 | 27-26 |
| 2021-06-03 | Minnesota Twins | W 6-5 | 1478.83 | 1485.26 | 52.93% | 47.07% | +1.57 | 28-26 |
| 2021-06-04 | Minnesota Twins | W 14-5 | 1480.40 | 1483.69 | 53.37% | 46.63% | +4.64 | 29-26 |
| 2021-06-05 | Minnesota Twins | L 4-5 | 1485.04 | 1479.05 | 54.70% | 45.30% | -1.82 | 29-27 |
| 2021-06-06 | Minnesota Twins | L 1-2 | 1483.22 | 1480.87 | 54.18% | 45.82% | -1.80 | 29-28 |
| 2021-06-07 | @ Los Angeles Angels | L 3-8 | 1481.42 | 1473.23 | 47.33% | 52.67% | -3.51 | 29-29 |
| 2021-06-08 | @ Los Angeles Angels | L 1-8 | 1477.91 | 1476.74 | 46.32% | 53.68% | -4.07 | 29-30 |
| 2021-06-09 | @ Los Angeles Angels | L 1-6 | 1473.84 | 1480.81 | 45.16% | 54.84% | -3.35 | 29-31 |
| 2021-06-10 | @ Oakland Athletics | W 6-1 | 1470.49 | 1530.31 | 37.79% | 62.21% | +4.62 | 30-31 |
| 2021-06-11 | @ Oakland Athletics | L 3-4 | 1475.11 | 1525.69 | 39.05% | 60.95% | -1.30 | 30-32 |
| 2021-06-12 | @ Oakland Athletics | L 2-11 | 1473.81 | 1526.99 | 38.69% | 61.31% | -3.85 | 30-33 |
| 2021-06-13 | @ Oakland Athletics | L 3-6 | 1469.96 | 1530.84 | 37.64% | 62.36% | -2.17 | 30-34 |
| 2021-06-14 | Detroit Tigers | L 3-10 | 1467.79 | 1439.78 | 57.82% | 42.18% | -5.08 | 30-35 |
| 2021-06-15 | Detroit Tigers | L 3-4 | 1462.71 | 1444.85 | 56.39% | 43.61% | -1.87 | 30-36 |
| 2021-06-16 | Detroit Tigers | L 5-6 | 1460.84 | 1446.73 | 55.86% | 44.14% | -1.85 | 30-37 |
| 2021-06-18 | Boston Red Sox | W 5-3 | 1458.99 | 1523.87 | 44.54% | 55.46% | +2.60 | 31-37 |
| 2021-06-19 | Boston Red Sox | L 1-7 | 1461.59 | 1521.27 | 45.28% | 54.72% | -3.68 | 31-38 |
| 2021-06-20 | Boston Red Sox | W 7-3 | 1457.91 | 1524.95 | 44.23% | 55.77% | +3.70 | 32-38 |
| 2021-06-22 | @ New York Yankees | W 6-5 | 1461.61 | 1521.36 | 37.80% | 62.20% | +2.07 | 33-38 |
| 2021-06-23 | @ New York Yankees | L 5-6 | 1463.68 | 1519.29 | 38.36% | 61.64% | -1.28 | 33-39 |
| 2021-06-24 | @ New York Yankees | L 1-8 | 1462.40 | 1520.57 | 38.01% | 61.99% | -3.34 | 33-40 |
| 2021-06-25 | @ Texas Rangers | L 4-9 | 1459.06 | 1438.72 | 49.07% | 50.93% | -3.64 | 33-41 |
| 2021-06-26 | @ Texas Rangers | L 0-8 | 1455.42 | 1442.36 | 48.03% | 51.97% | -4.51 | 33-42 |
| 2021-06-27 | @ Texas Rangers | L 1-4 | 1450.91 | 1446.87 | 46.73% | 53.27% | -2.69 | 33-43 |
| 2021-06-28 | @ Boston Red Sox | L 5-6 | 1448.22 | 1527.72 | 35.17% | 64.83% | -1.16 | 33-44 |
| 2021-06-29 | @ Boston Red Sox | L 6-7 | 1447.06 | 1528.89 | 34.86% | 65.14% | -1.16 | 33-45 |
| 2021-06-30 | @ Boston Red Sox | L 2-6 | 1445.90 | 1530.05 | 34.56% | 65.44% | -2.29 | 33-46 |
| 2021-07-01 | @ Boston Red Sox | L 1-15 | 1443.61 | 1532.34 | 33.96% | 66.04% | -4.22 | 33-47 |
| 2021-07-02 | Minnesota Twins | W 7-4 | 1439.39 | 1472.67 | 49.06% | 50.94% | +2.93 | 34-47 |
| 2021-07-03 | Minnesota Twins | W 6-3 | 1442.32 | 1469.74 | 49.91% | 50.09% | +2.88 | 35-47 |
| 2021-07-04 | Minnesota Twins | L 2-6 | 1445.20 | 1466.86 | 50.74% | 49.26% | -3.37 | 35-48 |
| 2021-07-05 | Cincinnati Reds | L 2-6 | 1441.83 | 1499.78 | 45.53% | 54.47% | -3.03 | 35-49 |
| 2021-07-06 | Cincinnati Reds | W 7-6 | 1438.80 | 1502.80 | 44.66% | 55.34% | +1.84 | 36-49 |
| 2021-07-07 | Cincinnati Reds | L 2-5 | 1440.64 | 1500.96 | 45.19% | 54.81% | -2.60 | 36-50 |
| 2021-07-08 | @ Cleveland Indians | L 4-7 | 1438.04 | 1484.59 | 39.60% | 60.40% | -2.27 | 36-51 |
| 2021-07-09 | @ Cleveland Indians | L 1-2 | 1435.77 | 1486.87 | 38.98% | 61.02% | -1.30 | 36-52 |
| 2021-07-10 | @ Cleveland Indians | L 6-14 | 1434.47 | 1488.16 | 38.62% | 61.38% | -3.63 | 36-53 |
| 2021-07-16 | Baltimore Orioles | W 9-2 | 1430.84 | 1421.73 | 55.15% | 44.85% | +3.94 | 37-53 |
| 2021-07-17 | Baltimore Orioles | L 4-8 | 1434.78 | 1417.79 | 56.27% | 43.73% | -3.73 | 37-54 |
| 2021-07-18 | Baltimore Orioles | L 0-5 | 1431.05 | 1421.52 | 55.21% | 44.79% | -4.10 | 37-55 |
| 2021-07-20 | @ Milwaukee Brewers | W 5-2 | 1426.95 | 1537.09 | 31.26% | 68.74% | +3.95 | 38-55 |
| 2021-07-21 | @ Milwaukee Brewers | W 6-3 | 1430.90 | 1533.13 | 32.24% | 67.76% | +3.90 | 39-55 |
| 2021-07-23 | Detroit Tigers | W 5-3 | 1434.80 | 1471.01 | 48.64% | 51.36% | +2.41 | 40-55 |
| 2021-07-24 | Detroit Tigers | W 9-8 | 1437.21 | 1468.59 | 49.34% | 50.66% | +1.68 | 41-55 |
| 2021-07-25 | Detroit Tigers | W 6-1 | 1438.89 | 1466.91 | 49.82% | 50.18% | +3.73 | 42-55 |
| 2021-07-26 | Chicago White Sox | W 4-3 | 1442.62 | 1542.85 | 39.58% | 60.42% | +2.00 | 43-55 |
| 2021-07-27 | Chicago White Sox | L 3-5 | 1444.62 | 1540.84 | 40.14% | 59.86% | -1.88 | 43-56 |
| 2021-07-28 | Chicago White Sox | W 3-2 | 1442.74 | 1542.73 | 39.62% | 60.38% | +1.42 | 44-56 |
| 2021-07-29 | Chicago White Sox | W 5-0 | 1444.16 | 1541.31 | 40.01% | 59.99% | +4.45 | 45-56 |
| 2021-07-30 | @ Toronto Blue Jays | L 4-6 | 1448.61 | 1537.02 | 34.00% | 66.00% | -1.60 | 45-57 |
| 2021-07-31 | @ Toronto Blue Jays | L 0-4 | 1447.01 | 1538.62 | 33.59% | 66.41% | -2.23 | 45-58 |
| 2021-08-01 | @ Toronto Blue Jays | L 1-5 | 1444.78 | 1540.85 | 33.02% | 66.98% | -2.19 | 45-59 |
| 2021-08-03 | @ Chicago White Sox | L 1-7 | 1442.59 | 1537.98 | 33.11% | 66.89% | -2.69 | 45-60 |
| 2021-08-04 | @ Chicago White Sox | W 9-1 | 1439.90 | 1540.67 | 32.43% | 67.57% | +6.34 | 46-60 |
| 2021-08-05 | @ Chicago White Sox | W 3-2 | 1446.24 | 1534.32 | 34.05% | 65.95% | +2.19 | 47-60 |
| 2021-08-06 | @ St. Louis Cardinals | L 2-4 | 1448.43 | 1477.82 | 41.99% | 58.01% | -1.97 | 47-61 |
| 2021-08-07 | @ St. Louis Cardinals | L 2-5 | 1446.46 | 1479.79 | 41.44% | 58.56% | -2.38 | 47-62 |
| 2021-08-08 | @ St. Louis Cardinals | W 6-5 | 1444.08 | 1482.17 | 40.77% | 59.23% | +1.97 | 48-62 |
| 2021-08-09 | New York Yankees | L 6-8 | 1446.05 | 1527.55 | 42.19% | 57.81% | -1.41 | 48-63 |
| 2021-08-10 | New York Yankees | W 8-4 | 1444.64 | 1528.96 | 41.80% | 58.20% | +3.87 | 49-63 |
| 2021-08-11 | New York Yankees | L 2-5 | 1448.51 | 1525.09 | 42.88% | 57.12% | -2.47 | 49-64 |
| 2021-08-13 | St. Louis Cardinals | L 0-6 | 1446.04 | 1487.09 | 47.95% | 52.05% | -3.90 | 49-65 |
| 2021-08-14 | St. Louis Cardinals | L 4-9 | 1442.14 | 1490.99 | 46.83% | 53.17% | -3.47 | 49-66 |
| 2021-08-15 | St. Louis Cardinals | L 2-7 | 1438.67 | 1494.47 | 45.83% | 54.17% | -3.41 | 49-67 |
| 2021-08-16 | Houston Astros | W 7-6 | 1435.26 | 1576.50 | 34.10% | 65.90% | +2.19 | 50-67 |
| 2021-08-17 | Houston Astros | W 3-1 | 1437.45 | 1574.31 | 34.67% | 65.33% | +3.07 | 51-67 |
| 2021-08-18 | Houston Astros | W 3-2 | 1440.52 | 1571.24 | 35.47% | 64.53% | +2.14 | 52-67 |
| 2021-08-19 | Houston Astros | L 3-6 | 1442.66 | 1569.10 | 36.04% | 63.96% | -1.46 | 52-68 |
| 2021-08-20 | @ Chicago Cubs | W 6-2 | 1441.20 | 1451.93 | 44.62% | 55.38% | +3.67 | 53-68 |
| 2021-08-21 | @ Chicago Cubs | W 4-2 | 1444.87 | 1448.25 | 45.67% | 54.33% | +2.56 | 54-68 |
| 2021-08-22 | @ Chicago Cubs | W 9-1 | 1447.43 | 1445.70 | 46.40% | 53.60% | +5.03 | 55-68 |
| 2021-08-23 | @ Houston Astros | W 7-1 | 1452.46 | 1575.82 | 29.64% | 70.36% | +5.72 | 56-68 |
| 2021-08-24 | @ Houston Astros | L 0-4 | 1458.18 | 1570.10 | 31.04% | 68.96% | -2.06 | 56-69 |
| 2021-08-25 | @ Houston Astros | L 5-6 | 1456.12 | 1572.16 | 30.53% | 69.47% | -0.72 | 56-70 |
| 2021-08-26 | @ Seattle Mariners | W 6-4 | 1455.40 | 1499.08 | 40.00% | 60.00% | +2.82 | 57-70 |
| 2021-08-27 | @ Seattle Mariners | W 8-7 | 1458.22 | 1496.26 | 40.78% | 59.22% | +1.39 | 58-70 |
| 2021-08-28 | @ Seattle Mariners | W 4-2 | 1459.61 | 1494.87 | 41.17% | 58.83% | +2.76 | 59-70 |
| 2021-08-29 | @ Seattle Mariners | L 3-4 | 1462.37 | 1492.11 | 41.94% | 58.06% | -1.39 | 59-71 |
| 2021-08-31 | Cleveland Indians | L 2-7 | 1460.98 | 1496.99 | 48.67% | 51.33% | -3.61 | 59-72 |
| 2021-09-01 | Cleveland Indians | L 3-5 | 1457.37 | 1500.61 | 47.63% | 52.37% | -1.58 | 59-73 |
| 2021-09-02 | Cleveland Indians | L 2-4 | 1455.79 | 1502.19 | 47.18% | 52.82% | -2.22 | 59-74 |
| 2021-09-03 | Chicago White Sox | W 7-2 | 1453.57 | 1545.98 | 40.67% | 59.33% | +4.40 | 60-74 |
| 2021-09-04 | Chicago White Sox | L 7-10 | 1457.97 | 1541.57 | 41.90% | 58.10% | -2.40 | 60-75 |
| 2021-09-05 | Chicago White Sox | W 6-0 | 1455.57 | 1543.98 | 41.22% | 58.78% | +4.78 | 61-75 |
| 2021-09-06 | @ Baltimore Orioles | W 3-2 | 1460.35 | 1402.85 | 54.41% | 45.59% | +1.51 | 62-75 |
| 2021-09-07 | @ Baltimore Orioles | L 3-7 | 1461.86 | 1401.34 | 54.84% | 45.16% | -3.64 | 62-76 |
| 2021-09-08 | @ Baltimore Orioles | L 8-9 | 1458.22 | 1404.98 | 53.80% | 46.20% | -1.79 | 62-77 |
| 2021-09-09 | @ Baltimore Orioles | W 6-0 | 1456.43 | 1406.76 | 53.29% | 46.71% | +3.80 | 63-77 |
| 2021-09-10 | @ Minnesota Twins | W 6-4 | 1460.23 | 1468.28 | 45.00% | 55.00% | +1.83 | 64-77 |
| 2021-09-11 | @ Minnesota Twins | L 2-9 | 1462.06 | 1466.46 | 45.52% | 54.48% | -4.00 | 64-78 |
| 2021-09-12 | @ Minnesota Twins | W 5-3 | 1458.06 | 1470.45 | 44.39% | 55.61% | +2.61 | 65-78 |
| 2021-09-14 | Oakland Athletics | W 10-7 | 1460.67 | 1526.26 | 44.44% | 55.56% | +3.19 | 66-78 |
| 2021-09-15 | Oakland Athletics | L 10-12 | 1463.86 | 1523.07 | 45.35% | 54.65% | -2.13 | 66-79 |
| 2021-09-16 | Oakland Athletics | L 2-7 | 1461.73 | 1525.20 | 44.74% | 55.26% | -3.32 | 66-80 |
| 2021-09-17 | Seattle Mariners | L 2-6 | 1458.41 | 1492.75 | 48.91% | 51.09% | -3.24 | 66-81 |
| 2021-09-18 | Seattle Mariners | W 8-1 | 1455.17 | 1496.00 | 47.98% | 52.02% | +4.56 | 67-81 |
| 2021-09-19 | Seattle Mariners | L 1-7 | 1459.73 | 1491.43 | 49.29% | 50.71% | -4.00 | 67-82 |
| 2021-09-20 | @ Cleveland Indians | W 7-2 | 1455.73 | 1499.00 | 40.05% | 59.95% | +4.45 | 68-82 |
| 2021-09-20 | @ Cleveland Indians | W 4-2 | 1460.18 | 1494.55 | 41.29% | 58.71% | +2.75 | 69-82 |
| 2021-09-21 | @ Cleveland Indians | L 1-4 | 1462.93 | 1491.80 | 42.06% | 57.94% | -2.42 | 69-83 |
| 2021-09-24 | @ Detroit Tigers | W 3-1 | 1460.51 | 1480.24 | 43.35% | 56.65% | +2.66 | 70-83 |
| 2021-09-25 | @ Detroit Tigers | L 1-5 | 1463.17 | 1477.58 | 44.10% | 55.90% | -2.92 | 70-84 |
| 2021-09-26 | @ Detroit Tigers | W 2-1 | 1460.25 | 1480.50 | 43.27% | 56.73% | +1.88 | 71-84 |
| 2021-09-27 | @ Cleveland Indians | L 3-8 | 1462.13 | 1493.02 | 41.78% | 58.22% | -3.10 | 71-85 |
| 2021-09-28 | Cleveland Indians | W 6-4 | 1459.03 | 1496.12 | 48.52% | 51.48% | +2.42 | 72-85 |
| 2021-09-29 | Cleveland Indians | W 10-5 | 1461.45 | 1493.71 | 49.21% | 50.79% | +3.77 | 73-85 |
| 2021-09-30 | Cleveland Indians | L 1-6 | 1465.22 | 1489.93 | 50.30% | 49.70% | -3.74 | 73-86 |
| 2021-10-01 | Minnesota Twins | W 11-6 | 1461.48 | 1471.32 | 52.44% | 47.56% | +3.53 | 74-86 |
| 2021-10-02 | Minnesota Twins | L 0-4 | 1465.01 | 1467.79 | 53.45% | 46.55% | -3.55 | 74-87 |
| 2021-10-03 | Minnesota Twins | L 3-7 | 1461.46 | 1471.34 | 52.43% | 47.57% | -3.48 | 74-88 |
| 2021-04-01 | Chicago White Sox | W 4-3 | 1485.45 | 1501.76 | 51.51% | 48.49% | +1.61 | 1-0 |
| 2021-04-02 | Chicago White Sox | L 8-12 | 1487.06 | 1500.15 | 51.97% | 48.03% | -3.45 | 1-1 |
| 2021-04-03 | Chicago White Sox | W 5-3 | 1483.61 | 1503.60 | 50.98% | 49.02% | +2.31 | 2-1 |
| 2021-04-04 | Chicago White Sox | W 7-4 | 1485.92 | 1501.30 | 51.64% | 48.36% | +2.78 | 3-1 |
| 2021-04-05 | Houston Astros | W 7-6 | 1488.70 | 1544.23 | 45.87% | 54.13% | +1.79 | 4-1 |
| 2021-04-06 | Houston Astros | L 2-4 | 1490.49 | 1542.43 | 46.39% | 53.61% | -2.17 | 4-2 |
| 2021-04-08 | @ Toronto Blue Jays | W 7-5 | 1488.32 | 1494.82 | 45.23% | 54.77% | +1.81 | 5-2 |
| 2021-04-09 | @ Toronto Blue Jays | W 7-1 | 1490.13 | 1493.00 | 49.59% | 50.41% | +4.10 | 6-2 |
| 2021-04-10 | @ Toronto Blue Jays | L 1-15 | 1494.23 | 1488.90 | 50.77% | 49.23% | -6.30 | 6-3 |
| 2021-04-12 | @ Kansas City Royals | W 10-3 | 1487.93 | 1477.68 | 47.62% | 52.38% | +4.60 | 7-3 |
| 2021-04-13 | @ Kansas City Royals | L 2-3 | 1492.53 | 1473.08 | 48.94% | 51.06% | -1.63 | 7-4 |
| 2021-04-14 | @ Kansas City Royals | L 1-6 | 1490.90 | 1474.71 | 48.48% | 51.52% | -3.60 | 7-5 |
| 2021-04-16 | Minnesota Twins | W 10-3 | 1487.30 | 1520.19 | 49.12% | 50.88% | +4.47 | 8-5 |
| 2021-04-19 | Texas Rangers | L 4-6 | 1491.77 | 1466.51 | 57.43% | 42.57% | -2.69 | 8-6 |
| 2021-04-20 | Texas Rangers | W 6-2 | 1489.08 | 1469.20 | 56.67% | 43.33% | +2.87 | 9-6 |
| 2021-04-21 | Texas Rangers | L 4-7 | 1491.95 | 1466.33 | 57.49% | 42.51% | -3.30 | 9-7 |
| 2021-04-22 | @ Houston Astros | L 2-8 | 1488.65 | 1515.77 | 42.31% | 57.69% | -3.44 | 9-8 |
| 2021-04-23 | @ Houston Astros | L 4-5 | 1485.21 | 1519.21 | 41.34% | 58.66% | -0.97 | 9-9 |
| 2021-04-24 | @ Houston Astros | L 2-16 | 1484.24 | 1520.18 | 41.07% | 58.93% | -5.10 | 9-10 |
| 2021-04-25 | @ Houston Astros | W 4-2 | 1479.14 | 1525.28 | 39.66% | 60.34% | +2.83 | 10-10 |
| 2021-04-26 | @ Texas Rangers | W 9-4 | 1481.97 | 1463.77 | 48.77% | 51.23% | +3.80 | 11-10 |
| 2021-04-27 | @ Texas Rangers | L 1-6 | 1485.77 | 1459.96 | 49.86% | 50.14% | -3.70 | 11-11 |
| 2021-04-28 | @ Texas Rangers | W 4-3 | 1482.07 | 1463.67 | 48.79% | 51.21% | +1.70 | 12-11 |
| 2021-04-30 | @ Seattle Mariners | L 4-7 | 1483.77 | 1490.33 | 45.22% | 54.78% | -2.60 | 12-12 |
| 2021-05-01 | @ Seattle Mariners | W 10-5 | 1481.17 | 1492.93 | 44.48% | 55.52% | +4.12 | 13-12 |
| 2021-05-02 | @ Seattle Mariners | L 0-2 | 1485.29 | 1488.81 | 45.65% | 54.35% | -2.14 | 13-13 |
| 2021-05-03 | Tampa Bay Rays | L 3-7 | 1483.15 | 1520.74 | 48.44% | 51.56% | -3.22 | 13-14 |
| 2021-05-04 | Tampa Bay Rays | L 3-8 | 1479.93 | 1523.96 | 47.52% | 52.48% | -3.53 | 13-15 |
| 2021-05-05 | Tampa Bay Rays | L 1-3 | 1476.40 | 1527.48 | 46.51% | 53.49% | -2.18 | 13-16 |
| 2021-05-06 | Tampa Bay Rays | L 3-8 | 1474.22 | 1529.67 | 45.88% | 54.12% | -3.41 | 13-17 |
| 2021-05-07 | Los Angeles Dodgers | W 9-2 | 1470.81 | 1565.27 | 40.38% | 59.62% | +5.24 | 14-17 |
| 2021-05-08 | Los Angeles Dodgers | L 11-14 | 1476.05 | 1560.03 | 41.84% | 58.16% | -2.40 | 14-18 |
| 2021-05-09 | Los Angeles Dodgers | W 2-1 | 1473.65 | 1562.44 | 41.17% | 58.83% | +1.95 | 15-18 |
| 2021-05-10 | @ Houston Astros | W 5-4 | 1475.60 | 1532.04 | 38.25% | 61.75% | +2.05 | 16-18 |
| 2021-05-11 | @ Houston Astros | L 1-5 | 1477.65 | 1529.99 | 38.81% | 61.19% | -2.58 | 16-19 |
| 2021-05-12 | @ Houston Astros | L 1-9 | 1475.07 | 1532.57 | 38.10% | 61.90% | -3.58 | 16-20 |
| 2021-05-14 | @ Boston Red Sox | L 3-4 | 1471.49 | 1514.80 | 40.05% | 59.95% | -1.33 | 16-21 |
| 2021-05-15 | @ Boston Red Sox | L 0-9 | 1470.16 | 1516.13 | 39.68% | 60.32% | -3.95 | 16-22 |
| 2021-05-16 | @ Boston Red Sox | W 6-5 | 1466.21 | 1520.08 | 38.60% | 61.40% | +2.04 | 17-22 |
| 2021-05-17 | Cleveland Indians | W 7-4 | 1468.25 | 1514.31 | 47.23% | 52.77% | +3.04 | 18-22 |
| 2021-05-18 | Cleveland Indians | L 5-6 | 1471.29 | 1511.28 | 48.10% | 51.90% | -1.60 | 18-23 |
| 2021-05-19 | Cleveland Indians | L 2-3 | 1469.69 | 1512.88 | 47.64% | 52.36% | -1.58 | 18-24 |
| 2021-05-20 | Minnesota Twins | W 7-1 | 1468.11 | 1483.72 | 51.61% | 48.39% | +3.93 | 19-24 |
| 2021-05-20 | Minnesota Twins | L 3-6 | 1472.04 | 1479.78 | 52.74% | 47.26% | -3.03 | 19-25 |
| 2021-05-21 | Oakland Athletics | L 4-8 | 1469.01 | 1517.15 | 46.93% | 53.07% | -3.12 | 19-26 |
| 2021-05-22 | Oakland Athletics | L 2-6 | 1465.89 | 1520.27 | 46.04% | 53.96% | -3.05 | 19-27 |
| 2021-05-23 | Oakland Athletics | W 6-5 | 1462.84 | 1523.33 | 45.16% | 54.84% | +1.82 | 20-27 |
| 2021-05-25 | Texas Rangers | W 11-5 | 1464.66 | 1468.40 | 53.31% | 46.69% | +3.79 | 21-27 |
| 2021-05-26 | Texas Rangers | W 9-8 | 1468.45 | 1464.60 | 54.40% | 45.60% | +1.52 | 22-27 |
| 2021-05-27 | @ Oakland Athletics | L 0-5 | 1469.97 | 1518.81 | 39.29% | 60.71% | -2.92 | 22-28 |
| 2021-05-28 | @ Oakland Athletics | L 1-3 | 1467.05 | 1521.72 | 38.49% | 61.51% | -1.81 | 22-29 |
| 2021-05-29 | @ Oakland Athletics | W 4-0 | 1465.24 | 1523.53 | 38.00% | 62.00% | +4.12 | 23-29 |
| 2021-05-30 | @ Oakland Athletics | W 4-2 | 1469.36 | 1519.41 | 39.12% | 60.88% | +2.86 | 24-29 |
| 2021-05-31 | @ San Francisco Giants | L 1-6 | 1472.22 | 1536.04 | 37.25% | 62.75% | -2.77 | 24-30 |
| 2021-06-01 | @ San Francisco Giants | W 8-1 | 1469.45 | 1538.81 | 36.51% | 63.49% | +5.58 | 25-30 |
| 2021-06-03 | Seattle Mariners | L 2-6 | 1475.03 | 1466.93 | 55.00% | 45.00% | -3.65 | 25-31 |
| 2021-06-04 | Seattle Mariners | W 3-2 | 1471.38 | 1470.58 | 53.96% | 46.04% | +1.53 | 26-31 |
| 2021-06-05 | Seattle Mariners | W 12-5 | 1472.91 | 1469.05 | 54.40% | 45.60% | +4.00 | 27-31 |
| 2021-06-06 | Seattle Mariners | L 5-9 | 1476.91 | 1465.05 | 55.54% | 44.46% | -3.68 | 27-32 |
| 2021-06-07 | Kansas City Royals | W 8-3 | 1473.23 | 1481.42 | 52.67% | 47.33% | +3.51 | 28-32 |
| 2021-06-08 | Kansas City Royals | W 8-1 | 1476.74 | 1477.91 | 53.68% | 46.32% | +4.07 | 29-32 |
| 2021-06-09 | Kansas City Royals | W 6-1 | 1480.81 | 1473.84 | 54.84% | 45.16% | +3.35 | 30-32 |
| 2021-06-11 | @ Arizona Diamondbacks | W 6-5 | 1484.16 | 1445.26 | 51.74% | 48.26% | +1.13 | 31-32 |
| 2021-06-12 | @ Arizona Diamondbacks | W 8-7 | 1485.29 | 1444.13 | 52.07% | 47.93% | +1.59 | 32-32 |
| 2021-06-13 | @ Arizona Diamondbacks | W 10-3 | 1486.88 | 1442.54 | 52.53% | 47.47% | +4.17 | 33-32 |
| 2021-06-14 | @ Oakland Athletics | L 5-8 | 1491.05 | 1533.01 | 40.24% | 59.76% | -2.31 | 33-33 |
| 2021-06-15 | @ Oakland Athletics | L 4-6 | 1488.74 | 1535.32 | 39.60% | 60.40% | -1.86 | 33-34 |
| 2021-06-16 | @ Oakland Athletics | L 4-8 | 1486.88 | 1537.18 | 39.09% | 60.91% | -2.59 | 33-35 |
| 2021-06-17 | Detroit Tigers | W 7-5 | 1484.29 | 1448.58 | 58.90% | 41.10% | +1.93 | 34-35 |
| 2021-06-18 | Detroit Tigers | W 11-3 | 1486.22 | 1446.65 | 59.43% | 40.57% | +3.81 | 35-35 |
| 2021-06-19 | Detroit Tigers | W 8-3 | 1490.03 | 1442.84 | 60.49% | 39.51% | +2.93 | 36-35 |
| 2021-06-20 | Detroit Tigers | L 3-5 | 1492.96 | 1439.91 | 61.29% | 38.71% | -2.04 | 36-36 |
| 2021-06-22 | San Francisco Giants | L 0-5 | 1490.92 | 1545.23 | 46.05% | 53.95% | -3.41 | 36-37 |
| 2021-06-23 | San Francisco Giants | L 3-9 | 1487.51 | 1548.65 | 45.07% | 54.93% | -2.60 | 36-38 |
| 2021-06-25 | @ Tampa Bay Rays | L 3-4 | 1484.91 | 1563.67 | 35.26% | 64.74% | -1.17 | 36-39 |
| 2021-06-26 | @ Tampa Bay Rays | L 3-13 | 1483.74 | 1564.84 | 34.96% | 65.04% | -3.67 | 36-40 |
| 2021-06-27 | @ Tampa Bay Rays | W 6-4 | 1480.07 | 1568.51 | 34.00% | 66.00% | +3.10 | 37-40 |
| 2021-06-28 | @ New York Yankees | W 5-3 | 1483.17 | 1515.54 | 41.57% | 58.43% | +2.75 | 38-40 |
| 2021-06-29 | @ New York Yankees | L 5-11 | 1485.92 | 1512.80 | 42.34% | 57.66% | -3.45 | 38-41 |
| 2021-06-30 | @ New York Yankees | W 11-8 | 1482.47 | 1516.24 | 41.37% | 58.63% | +3.37 | 39-41 |
| 2021-07-02 | Baltimore Orioles | W 8-7 | 1485.84 | 1435.68 | 60.90% | 39.10% | +1.30 | 40-41 |
| 2021-07-03 | Baltimore Orioles | W 4-1 | 1487.14 | 1434.38 | 61.25% | 38.75% | +2.23 | 41-41 |
| 2021-07-04 | Baltimore Orioles | W 6-5 | 1489.37 | 1432.15 | 61.86% | 38.14% | +1.27 | 42-41 |
| 2021-07-05 | Boston Red Sox | L 4-5 | 1490.64 | 1538.47 | 46.97% | 53.03% | -1.56 | 42-42 |
| 2021-07-06 | Boston Red Sox | W 5-3 | 1489.08 | 1540.03 | 46.53% | 53.47% | +2.51 | 43-42 |
| 2021-07-07 | Boston Red Sox | W 5-4 | 1491.59 | 1537.52 | 47.25% | 52.75% | +1.75 | 44-42 |
| 2021-07-09 | @ Seattle Mariners | L 3-7 | 1493.34 | 1479.69 | 48.11% | 51.89% | -3.20 | 44-43 |
| 2021-07-10 | @ Seattle Mariners | L 0-2 | 1490.14 | 1482.89 | 47.19% | 52.81% | -2.21 | 44-44 |
| 2021-07-11 | @ Seattle Mariners | W 7-1 | 1487.93 | 1485.10 | 46.56% | 53.44% | +4.35 | 45-44 |
| 2021-07-16 | Seattle Mariners | L 5-6 | 1492.28 | 1480.76 | 55.49% | 44.51% | -1.85 | 45-45 |
| 2021-07-17 | Seattle Mariners | W 9-4 | 1490.43 | 1482.60 | 54.96% | 45.04% | +3.35 | 46-45 |
| 2021-07-18 | Seattle Mariners | L 4-7 | 1493.78 | 1479.26 | 55.92% | 44.08% | -3.22 | 46-46 |
| 2021-07-19 | @ Oakland Athletics | L 1-4 | 1490.56 | 1528.09 | 40.85% | 59.15% | -2.35 | 46-47 |
| 2021-07-20 | @ Oakland Athletics | L 0-6 | 1488.21 | 1530.44 | 40.20% | 59.80% | -3.27 | 46-48 |
| 2021-07-22 | @ Minnesota Twins | W 3-2 | 1484.94 | 1472.05 | 48.00% | 52.00% | +1.73 | 47-48 |
| 2021-07-23 | @ Minnesota Twins | L 4-5 | 1486.67 | 1470.32 | 48.50% | 51.50% | -1.61 | 47-49 |
| 2021-07-24 | @ Minnesota Twins | W 2-1 | 1485.06 | 1471.93 | 48.04% | 51.96% | +1.72 | 48-49 |
| 2021-07-25 | @ Minnesota Twins | W 6-2 | 1486.78 | 1470.21 | 48.53% | 51.47% | +3.42 | 49-49 |
| 2021-07-26 | Colorado Rockies | W 6-2 | 1490.20 | 1463.35 | 57.66% | 42.34% | +2.81 | 50-49 |
| 2021-07-27 | Colorado Rockies | L 3-12 | 1493.01 | 1460.54 | 58.45% | 41.55% | -5.82 | 50-50 |
| 2021-07-28 | Colorado Rockies | W 8-7 | 1487.19 | 1466.36 | 56.81% | 43.19% | +1.44 | 51-50 |
| 2021-07-29 | Oakland Athletics | L 0-4 | 1488.63 | 1532.95 | 47.48% | 52.52% | -3.16 | 51-51 |
| 2021-07-30 | Oakland Athletics | L 0-2 | 1485.47 | 1536.10 | 46.57% | 53.43% | -2.18 | 51-52 |
| 2021-07-31 | Oakland Athletics | W 1-0 | 1483.29 | 1538.29 | 45.95% | 54.05% | +1.79 | 52-52 |
| 2021-08-01 | Oakland Athletics | L 3-8 | 1485.08 | 1536.50 | 46.46% | 53.54% | -3.45 | 52-53 |
| 2021-08-02 | @ Texas Rangers | L 1-4 | 1481.63 | 1424.40 | 54.37% | 45.63% | -3.12 | 52-54 |
| 2021-08-03 | @ Texas Rangers | W 11-3 | 1478.51 | 1427.52 | 53.48% | 46.52% | +4.36 | 53-54 |
| 2021-08-04 | @ Texas Rangers | W 2-1 | 1482.87 | 1423.16 | 54.73% | 45.27% | +1.51 | 54-54 |
| 2021-08-05 | @ Texas Rangers | W 5-0 | 1484.38 | 1421.65 | 55.15% | 44.85% | +3.33 | 55-54 |
| 2021-08-06 | @ Los Angeles Dodgers | W 4-3 | 1487.71 | 1589.57 | 32.29% | 67.71% | +1.59 | 56-54 |
| 2021-08-07 | @ Los Angeles Dodgers | L 3-5 | 1489.30 | 1587.98 | 32.69% | 67.31% | -1.54 | 56-55 |
| 2021-08-08 | @ Los Angeles Dodgers | L 2-8 | 1487.76 | 1589.52 | 32.30% | 67.70% | -2.63 | 56-56 |
| 2021-08-10 | Toronto Blue Jays | L 3-6 | 1485.13 | 1552.78 | 40.39% | 59.61% | -2.32 | 56-57 |
| 2021-08-10 | Toronto Blue Jays | L 0-4 | 1482.81 | 1555.10 | 43.49% | 56.51% | -2.89 | 56-58 |
| 2021-08-11 | Toronto Blue Jays | L 2-10 | 1479.92 | 1557.99 | 42.67% | 57.33% | -4.00 | 56-59 |
| 2021-08-12 | Toronto Blue Jays | W 6-3 | 1475.92 | 1562.00 | 41.55% | 58.45% | +3.36 | 57-59 |
| 2021-08-13 | Houston Astros | L 1-4 | 1479.28 | 1573.82 | 40.37% | 59.63% | -2.32 | 57-60 |
| 2021-08-14 | Houston Astros | L 2-8 | 1476.96 | 1576.14 | 39.73% | 60.27% | -3.23 | 57-61 |
| 2021-08-15 | Houston Astros | W 3-1 | 1473.73 | 1579.37 | 38.84% | 61.16% | +2.87 | 58-61 |
| 2021-08-16 | @ New York Yankees | L 1-2 | 1476.60 | 1530.44 | 38.60% | 61.40% | -1.28 | 58-62 |
| 2021-08-17 | @ Detroit Tigers | W 8-2 | 1475.32 | 1469.74 | 46.95% | 53.05% | +4.31 | 59-62 |
| 2021-08-18 | @ Detroit Tigers | W 3-1 | 1479.63 | 1465.43 | 48.19% | 51.81% | +2.43 | 60-62 |
| 2021-08-19 | @ Detroit Tigers | W 13-10 | 1482.06 | 1463.00 | 48.89% | 51.11% | +2.94 | 61-62 |
| 2021-08-20 | @ Cleveland Indians | L 1-9 | 1485.00 | 1487.37 | 45.82% | 54.18% | -4.30 | 61-63 |
| 2021-08-21 | @ Cleveland Indians | L 1-5 | 1480.70 | 1491.67 | 44.59% | 55.41% | -2.96 | 61-64 |
| 2021-08-22 | @ Cleveland Indians | L 0-3 | 1477.74 | 1494.63 | 47.57% | 52.43% | -2.74 | 61-65 |
| 2021-08-24 | @ Baltimore Orioles | W 14-8 | 1475.00 | 1395.28 | 57.56% | 42.44% | +3.45 | 62-65 |
| 2021-08-25 | @ Baltimore Orioles | L 6-10 | 1478.45 | 1391.83 | 58.53% | 41.47% | -3.88 | 62-66 |
| 2021-08-26 | @ Baltimore Orioles | L 1-13 | 1474.57 | 1395.72 | 57.44% | 42.56% | -6.61 | 62-67 |
| 2021-08-27 | San Diego Padres | L 0-5 | 1467.96 | 1507.02 | 48.23% | 51.77% | -3.58 | 62-68 |
| 2021-08-28 | San Diego Padres | W 10-2 | 1464.38 | 1510.60 | 47.21% | 52.79% | +4.96 | 63-68 |
| 2021-08-30 | New York Yankees | W 8-7 | 1469.34 | 1553.86 | 41.77% | 58.23% | +1.93 | 64-68 |
| 2021-08-31 | New York Yankees | W 6-4 | 1471.27 | 1551.93 | 42.31% | 57.69% | +2.71 | 65-68 |
| 2021-09-01 | New York Yankees | L 1-4 | 1473.98 | 1549.22 | 43.07% | 56.93% | -2.48 | 65-69 |
| 2021-09-03 | Texas Rangers | W 3-2 | 1471.50 | 1418.03 | 61.35% | 38.65% | +1.29 | 66-69 |
| 2021-09-04 | Texas Rangers | W 4-1 | 1472.79 | 1416.74 | 61.70% | 38.30% | +2.20 | 67-69 |
| 2021-09-05 | Texas Rangers | L 3-7 | 1474.99 | 1414.54 | 62.30% | 37.70% | -4.14 | 67-70 |
| 2021-09-06 | Texas Rangers | L 0-4 | 1470.85 | 1418.68 | 61.17% | 38.83% | -4.06 | 67-71 |
| 2021-09-07 | @ San Diego Padres | W 4-0 | 1466.79 | 1510.03 | 40.06% | 59.94% | +3.98 | 68-71 |
| 2021-09-08 | @ San Diego Padres | L 5-8 | 1470.77 | 1506.05 | 41.16% | 58.84% | -2.36 | 68-72 |
| 2021-09-10 | @ Houston Astros | L 5-10 | 1468.41 | 1560.62 | 33.52% | 66.48% | -2.49 | 68-73 |
| 2021-09-11 | @ Houston Astros | W 4-2 | 1465.92 | 1563.10 | 32.88% | 67.12% | +3.15 | 69-73 |
| 2021-09-12 | @ Houston Astros | L 1-3 | 1469.07 | 1559.95 | 33.69% | 66.31% | -1.58 | 69-74 |
| 2021-09-14 | @ Chicago White Sox | L 3-9 | 1467.49 | 1538.27 | 36.32% | 63.68% | -2.96 | 69-75 |
| 2021-09-15 | @ Chicago White Sox | W 3-2 | 1464.53 | 1541.23 | 35.53% | 64.47% | +2.14 | 70-75 |
| 2021-09-16 | @ Chicago White Sox | W 9-3 | 1466.67 | 1539.09 | 36.10% | 63.90% | +5.20 | 71-75 |
| 2021-09-17 | Oakland Athletics | L 4-5 | 1471.87 | 1528.52 | 45.71% | 54.29% | -1.52 | 71-76 |
| 2021-09-18 | Oakland Athletics | L 1-3 | 1470.35 | 1530.04 | 45.28% | 54.72% | -2.12 | 71-77 |
| 2021-09-19 | Oakland Athletics | L 2-3 | 1468.23 | 1532.16 | 44.67% | 55.33% | -1.05 | 71-78 |
| 2021-09-20 | Houston Astros | L 0-10 | 1467.18 | 1565.79 | 39.81% | 60.19% | -4.18 | 71-79 |
| 2021-09-21 | Houston Astros | L 5-10 | 1463.00 | 1569.97 | 38.66% | 61.34% | -2.87 | 71-80 |
| 2021-09-22 | Houston Astros | L 5-9 | 1460.13 | 1572.84 | 37.88% | 62.12% | -1.78 | 71-81 |
| 2021-09-23 | Houston Astros | W 3-2 | 1458.35 | 1574.62 | 37.40% | 62.60% | +2.08 | 72-81 |
| 2021-09-24 | Seattle Mariners | L 5-6 | 1460.43 | 1506.75 | 47.19% | 52.81% | -1.57 | 72-82 |
| 2021-09-25 | Seattle Mariners | W 14-1 | 1458.86 | 1508.32 | 46.74% | 53.26% | +6.38 | 73-82 |
| 2021-09-26 | Seattle Mariners | L 1-5 | 1465.24 | 1501.95 | 48.57% | 51.43% | -3.23 | 73-83 |
| 2021-09-28 | @ Texas Rangers | L 2-5 | 1462.01 | 1417.35 | 52.57% | 47.43% | -3.02 | 73-84 |
| 2021-09-29 | @ Texas Rangers | W 7-2 | 1458.99 | 1420.38 | 51.70% | 48.30% | +3.58 | 74-84 |
| 2021-09-30 | @ Texas Rangers | L 6-7 | 1462.57 | 1416.79 | 52.73% | 47.27% | -1.75 | 74-85 |
| 2021-10-01 | @ Seattle Mariners | W 2-1 | 1460.82 | 1514.67 | 38.60% | 61.40% | +2.04 | 75-85 |
| 2021-10-02 | @ Seattle Mariners | L 4-6 | 1462.86 | 1512.63 | 39.16% | 60.84% | -1.84 | 75-86 |
| 2021-10-03 | @ Seattle Mariners | W 7-3 | 1461.02 | 1514.47 | 38.66% | 61.34% | +4.08 | 76-86 |
| 2021-04-01 | @ Colorado Rockies | L 5-8 | 1560.67 | 1476.86 | 58.13% | 41.87% | -3.34 | 0-1 |
| 2021-04-02 | @ Colorado Rockies | W 11-6 | 1557.33 | 1480.21 | 57.19% | 42.81% | +3.18 | 1-1 |
| 2021-04-03 | @ Colorado Rockies | W 6-5 | 1560.51 | 1477.03 | 58.09% | 41.91% | +1.39 | 2-1 |
| 2021-04-04 | @ Colorado Rockies | W 4-2 | 1561.90 | 1475.64 | 58.48% | 41.52% | +1.95 | 3-1 |
| 2021-04-05 | @ Oakland Athletics | W 10-3 | 1563.85 | 1503.18 | 54.86% | 45.14% | +3.97 | 4-1 |
| 2021-04-06 | @ Oakland Athletics | W 5-1 | 1567.82 | 1499.22 | 55.99% | 44.01% | +2.92 | 5-1 |
| 2021-04-07 | @ Oakland Athletics | L 3-4 | 1570.74 | 1496.29 | 56.82% | 43.18% | -1.34 | 5-2 |
| 2021-04-09 | Washington Nationals | W 1-0 | 1569.40 | 1507.32 | 62.52% | 37.48% | +1.25 | 6-2 |
| 2021-04-10 | Washington Nationals | W 9-5 | 1570.65 | 1506.07 | 62.85% | 37.15% | +2.46 | 7-2 |
| 2021-04-11 | Washington Nationals | W 3-0 | 1573.11 | 1503.61 | 63.51% | 36.49% | +2.10 | 8-2 |
| 2021-04-13 | Colorado Rockies | W 7-0 | 1575.21 | 1473.37 | 67.71% | 32.29% | +2.84 | 9-2 |
| 2021-04-14 | Colorado Rockies | W 4-2 | 1578.05 | 1470.54 | 68.42% | 31.58% | +1.48 | 10-2 |
| 2021-04-15 | Colorado Rockies | W 7-5 | 1579.53 | 1469.05 | 68.79% | 31.21% | +1.47 | 11-2 |
| 2021-04-16 | @ San Diego Padres | W 11-6 | 1581.00 | 1516.97 | 55.34% | 44.66% | +2.34 | 12-2 |
| 2021-04-17 | @ San Diego Padres | W 2-0 | 1583.34 | 1514.62 | 56.01% | 43.99% | +2.07 | 13-2 |
| 2021-04-18 | @ San Diego Padres | L 2-5 | 1585.41 | 1512.56 | 56.59% | 43.41% | -3.26 | 13-3 |
| 2021-04-19 | @ Seattle Mariners | L 3-4 | 1582.15 | 1490.36 | 59.25% | 40.75% | -1.96 | 13-4 |
| 2021-04-20 | @ Seattle Mariners | W 1-0 | 1580.19 | 1492.33 | 58.70% | 41.30% | +1.37 | 14-4 |
| 2021-04-22 | San Diego Padres | L 2-3 | 1581.56 | 1506.26 | 64.28% | 35.72% | -2.14 | 14-5 |
| 2021-04-23 | San Diego Padres | L 1-6 | 1579.42 | 1508.40 | 63.72% | 36.28% | -4.73 | 14-6 |
| 2021-04-24 | San Diego Padres | W 5-4 | 1574.69 | 1513.13 | 62.45% | 37.55% | +1.25 | 15-6 |
| 2021-04-25 | San Diego Padres | L 7-8 | 1575.94 | 1511.88 | 62.78% | 37.22% | -1.47 | 15-7 |
| 2021-04-26 | Cincinnati Reds | L 3-5 | 1574.47 | 1492.96 | 65.10% | 34.90% | -2.17 | 15-8 |
| 2021-04-27 | Cincinnati Reds | L 5-6 | 1572.30 | 1495.13 | 64.53% | 35.47% | -2.14 | 15-9 |
| 2021-04-28 | Cincinnati Reds | W 8-0 | 1570.16 | 1497.27 | 63.96% | 36.04% | +3.39 | 16-9 |
| 2021-04-29 | @ Milwaukee Brewers | L 1-2 | 1573.55 | 1506.95 | 55.70% | 44.30% | -1.85 | 16-10 |
| 2021-04-30 | @ Milwaukee Brewers | L 1-3 | 1571.70 | 1508.80 | 55.18% | 44.82% | -2.59 | 16-11 |
| 2021-05-01 | @ Milwaukee Brewers | L 5-6 | 1569.11 | 1511.39 | 54.44% | 45.56% | -1.28 | 16-12 |
| 2021-05-02 | @ Milwaukee Brewers | W 16-4 | 1567.83 | 1512.67 | 54.08% | 45.92% | +5.28 | 17-12 |
| 2021-05-04 | @ Chicago Cubs | L 1-7 | 1573.11 | 1494.23 | 57.44% | 42.56% | -4.67 | 17-13 |
| 2021-05-04 | @ Chicago Cubs | L 3-4 | 1568.44 | 1498.90 | 56.12% | 43.88% | -1.86 | 17-14 |
| 2021-05-05 | @ Chicago Cubs | L 5-6 | 1566.58 | 1500.76 | 55.59% | 44.41% | -1.31 | 17-15 |
| 2021-05-07 | @ Los Angeles Angels | L 2-9 | 1565.27 | 1470.81 | 59.62% | 40.38% | -5.24 | 17-16 |
| 2021-05-08 | @ Los Angeles Angels | W 14-11 | 1560.03 | 1476.05 | 58.16% | 41.84% | +2.41 | 18-16 |
| 2021-05-09 | @ Los Angeles Angels | L 1-2 | 1562.44 | 1473.65 | 58.83% | 41.17% | -1.95 | 18-17 |
| 2021-05-11 | Seattle Mariners | W 6-4 | 1560.49 | 1481.91 | 64.71% | 35.29% | +1.65 | 19-17 |
| 2021-05-12 | Seattle Mariners | W 7-1 | 1562.14 | 1480.25 | 65.15% | 34.85% | +2.84 | 20-17 |
| 2021-05-14 | Miami Marlins | W 9-6 | 1564.98 | 1489.33 | 64.33% | 35.67% | +2.05 | 21-17 |
| 2021-05-15 | Miami Marlins | W 7-0 | 1567.03 | 1487.28 | 64.87% | 35.13% | +3.08 | 22-17 |
| 2021-05-16 | Miami Marlins | L 2-3 | 1570.11 | 1484.19 | 65.67% | 34.33% | -2.18 | 22-18 |
| 2021-05-17 | Arizona Diamondbacks | W 3-1 | 1567.93 | 1483.21 | 65.52% | 34.48% | +1.62 | 23-18 |
| 2021-05-18 | Arizona Diamondbacks | W 9-1 | 1569.55 | 1481.59 | 65.94% | 34.06% | +3.20 | 24-18 |
| 2021-05-19 | Arizona Diamondbacks | W 4-2 | 1572.75 | 1478.39 | 66.76% | 33.24% | +1.56 | 25-18 |
| 2021-05-20 | Arizona Diamondbacks | W 3-2 | 1574.31 | 1476.83 | 67.16% | 32.84% | +1.09 | 26-18 |
| 2021-05-21 | @ San Francisco Giants | W 2-1 | 1575.40 | 1530.44 | 52.61% | 47.39% | +1.58 | 27-18 |
| 2021-05-22 | @ San Francisco Giants | W 6-3 | 1576.98 | 1528.86 | 53.07% | 46.93% | +2.69 | 28-18 |
| 2021-05-23 | @ San Francisco Giants | W 11-5 | 1579.67 | 1526.17 | 53.84% | 46.16% | +3.76 | 29-18 |
| 2021-05-25 | @ Houston Astros | W 9-2 | 1583.43 | 1542.67 | 52.01% | 47.99% | +4.21 | 30-18 |
| 2021-05-26 | @ Houston Astros | L 2-5 | 1587.64 | 1538.45 | 53.22% | 46.78% | -3.06 | 30-19 |
| 2021-05-27 | San Francisco Giants | W 4-3 | 1584.58 | 1528.23 | 61.74% | 38.26% | +1.27 | 31-19 |
| 2021-05-28 | San Francisco Giants | L 5-8 | 1585.85 | 1526.96 | 62.09% | 37.91% | -2.52 | 31-20 |
| 2021-05-29 | San Francisco Giants | L 6-11 | 1583.33 | 1529.49 | 61.40% | 38.60% | -4.56 | 31-21 |
| 2021-05-30 | San Francisco Giants | L 4-5 | 1578.77 | 1534.04 | 60.15% | 39.85% | -2.00 | 31-22 |
| 2021-05-31 | St. Louis Cardinals | W 9-4 | 1576.77 | 1513.12 | 62.73% | 37.27% | +2.77 | 32-22 |
| 2021-06-01 | St. Louis Cardinals | L 2-3 | 1579.54 | 1510.35 | 63.47% | 36.53% | -2.11 | 32-23 |
| 2021-06-02 | St. Louis Cardinals | W 14-3 | 1577.43 | 1512.46 | 62.91% | 37.09% | +4.09 | 33-23 |
| 2021-06-04 | @ Atlanta Braves | W 9-5 | 1581.52 | 1508.75 | 56.58% | 43.42% | +2.88 | 34-23 |
| 2021-06-05 | @ Atlanta Braves | L 4-6 | 1584.40 | 1505.86 | 57.39% | 42.61% | -2.69 | 34-24 |
| 2021-06-06 | @ Atlanta Braves | L 2-4 | 1581.71 | 1508.56 | 56.63% | 43.37% | -2.66 | 34-25 |
| 2021-06-08 | @ Pittsburgh Pirates | W 5-3 | 1579.05 | 1442.43 | 65.30% | 34.70% | +1.63 | 35-25 |
| 2021-06-09 | @ Pittsburgh Pirates | W 2-1 | 1580.68 | 1440.80 | 65.72% | 34.28% | +1.14 | 36-25 |
| 2021-06-10 | @ Pittsburgh Pirates | W 6-3 | 1581.82 | 1439.67 | 66.02% | 33.98% | +1.38 | 37-25 |
| 2021-06-11 | Texas Rangers | W 12-1 | 1583.20 | 1442.91 | 72.35% | 27.65% | +3.04 | 38-25 |
| 2021-06-12 | Texas Rangers | L 1-12 | 1586.24 | 1439.87 | 73.04% | 26.96% | -8.04 | 38-26 |
| 2021-06-13 | Texas Rangers | W 5-3 | 1578.20 | 1447.91 | 71.18% | 28.82% | +1.35 | 39-26 |
| 2021-06-14 | Philadelphia Phillies | W 3-1 | 1579.55 | 1495.75 | 65.40% | 34.60% | +1.63 | 40-26 |
| 2021-06-15 | Philadelphia Phillies | W 5-3 | 1581.18 | 1494.12 | 65.82% | 34.18% | +1.60 | 41-26 |
| 2021-06-16 | Philadelphia Phillies | L 0-2 | 1582.78 | 1492.52 | 66.23% | 33.77% | -3.11 | 41-27 |
| 2021-06-18 | @ Arizona Diamondbacks | W 3-0 | 1579.67 | 1430.05 | 66.98% | 33.02% | +1.90 | 42-27 |
| 2021-06-19 | @ Arizona Diamondbacks | W 9-3 | 1581.57 | 1428.15 | 67.46% | 32.54% | +2.65 | 43-27 |
| 2021-06-20 | @ Arizona Diamondbacks | W 9-8 | 1584.22 | 1425.50 | 68.12% | 31.88% | +1.06 | 44-27 |
| 2021-06-21 | @ San Diego Padres | L 2-6 | 1585.28 | 1533.01 | 53.66% | 46.34% | -3.57 | 44-28 |
| 2021-06-22 | @ San Diego Padres | L 2-3 | 1581.71 | 1536.57 | 52.64% | 47.36% | -1.75 | 44-29 |
| 2021-06-23 | @ San Diego Padres | L 3-5 | 1579.96 | 1538.32 | 52.14% | 47.86% | -2.44 | 44-30 |
| 2021-06-24 | Chicago Cubs | L 0-4 | 1577.52 | 1522.12 | 61.61% | 38.39% | -4.09 | 44-31 |
| 2021-06-25 | Chicago Cubs | W 6-2 | 1573.43 | 1526.21 | 60.49% | 39.51% | +2.62 | 45-31 |
| 2021-06-26 | Chicago Cubs | W 3-2 | 1576.05 | 1523.59 | 61.21% | 38.79% | +1.29 | 46-31 |
| 2021-06-27 | Chicago Cubs | W 7-1 | 1577.34 | 1522.30 | 61.56% | 38.44% | +3.12 | 47-31 |
| 2021-06-28 | San Francisco Giants | W 3-2 | 1580.46 | 1550.57 | 58.08% | 41.92% | +1.39 | 48-31 |
| 2021-06-29 | San Francisco Giants | W 3-1 | 1581.85 | 1549.18 | 58.47% | 41.53% | +1.95 | 49-31 |
| 2021-07-01 | @ Washington Nationals | W 6-2 | 1583.80 | 1514.55 | 56.08% | 43.92% | +2.92 | 50-31 |
| 2021-07-02 | @ Washington Nationals | W 10-5 | 1586.72 | 1511.64 | 56.91% | 43.09% | +3.20 | 51-31 |
| 2021-07-03 | @ Washington Nationals | W 5-3 | 1589.92 | 1508.44 | 57.81% | 42.19% | +1.98 | 52-31 |
| 2021-07-04 | @ Washington Nationals | W 5-1 | 1591.90 | 1506.46 | 58.36% | 41.64% | +2.77 | 53-31 |
| 2021-07-05 | @ Miami Marlins | L 4-5 | 1594.67 | 1487.50 | 61.37% | 38.63% | -2.04 | 53-32 |
| 2021-07-06 | @ Miami Marlins | L 1-2 | 1592.63 | 1489.53 | 60.81% | 39.19% | -1.43 | 53-33 |
| 2021-07-07 | @ Miami Marlins | L 6-9 | 1591.20 | 1490.96 | 60.42% | 39.58% | -3.47 | 53-34 |
| 2021-07-08 | @ Miami Marlins | W 6-1 | 1587.73 | 1494.44 | 59.46% | 40.54% | +3.01 | 54-34 |
| 2021-07-09 | Arizona Diamondbacks | L 2-5 | 1590.74 | 1417.21 | 76.01% | 23.99% | -4.37 | 54-35 |
| 2021-07-10 | Arizona Diamondbacks | W 22-1 | 1586.37 | 1421.58 | 75.08% | 24.92% | +3.79 | 55-35 |
| 2021-07-11 | Arizona Diamondbacks | W 7-4 | 1590.16 | 1417.79 | 75.89% | 24.11% | +1.38 | 56-35 |
| 2021-07-16 | @ Colorado Rockies | W 10-4 | 1591.54 | 1466.52 | 63.77% | 36.23% | +2.95 | 57-35 |
| 2021-07-17 | @ Colorado Rockies | W 9-2 | 1594.49 | 1463.58 | 64.55% | 35.45% | +3.11 | 58-35 |
| 2021-07-18 | @ Colorado Rockies | L 5-6 | 1597.60 | 1460.46 | 65.37% | 34.63% | -1.53 | 58-36 |
| 2021-07-19 | San Francisco Giants | L 2-7 | 1596.07 | 1553.39 | 59.87% | 40.13% | -4.45 | 58-37 |
| 2021-07-20 | San Francisco Giants | W 8-6 | 1591.62 | 1557.83 | 58.63% | 41.37% | +1.95 | 59-37 |
| 2021-07-21 | San Francisco Giants | L 2-4 | 1593.57 | 1555.89 | 59.17% | 40.83% | -2.78 | 59-38 |
| 2021-07-22 | San Francisco Giants | L 3-5 | 1590.79 | 1558.67 | 58.40% | 41.60% | -2.74 | 59-39 |
| 2021-07-23 | Colorado Rockies | L 6-9 | 1588.05 | 1462.47 | 70.62% | 29.38% | -2.87 | 59-40 |
| 2021-07-24 | Colorado Rockies | W 1-0 | 1585.18 | 1465.34 | 69.93% | 30.07% | +0.99 | 60-40 |
| 2021-07-25 | Colorado Rockies | W 3-2 | 1586.17 | 1464.34 | 70.17% | 29.83% | +0.99 | 61-40 |
| 2021-07-27 | @ San Francisco Giants | L 1-2 | 1587.16 | 1553.65 | 50.97% | 49.03% | -1.69 | 61-41 |
| 2021-07-28 | @ San Francisco Giants | W 8-0 | 1585.47 | 1555.35 | 50.48% | 49.52% | +4.65 | 62-41 |
| 2021-07-29 | @ San Francisco Giants | L 0-5 | 1590.12 | 1550.70 | 51.82% | 48.18% | -3.84 | 62-42 |
| 2021-07-30 | @ Arizona Diamondbacks | L 5-6 | 1586.28 | 1421.71 | 68.85% | 31.15% | -1.62 | 62-43 |
| 2021-07-31 | @ Arizona Diamondbacks | W 8-3 | 1584.66 | 1423.32 | 68.45% | 31.55% | +2.34 | 63-43 |
| 2021-08-01 | @ Arizona Diamondbacks | W 13-0 | 1587.00 | 1420.98 | 69.03% | 30.97% | +3.71 | 64-43 |
| 2021-08-03 | Houston Astros | L 0-3 | 1590.71 | 1573.78 | 56.26% | 43.74% | -3.24 | 64-44 |
| 2021-08-04 | Houston Astros | W 7-5 | 1587.47 | 1577.01 | 55.34% | 44.66% | +2.10 | 65-44 |
| 2021-08-06 | Los Angeles Angels | L 3-4 | 1589.57 | 1487.71 | 67.71% | 32.29% | -1.59 | 65-45 |
| 2021-08-07 | Los Angeles Angels | W 5-3 | 1587.98 | 1489.30 | 67.31% | 32.69% | +1.54 | 66-45 |
| 2021-08-08 | Los Angeles Angels | W 8-2 | 1589.52 | 1487.76 | 67.70% | 32.30% | +2.62 | 67-45 |
| 2021-08-10 | @ Philadelphia Phillies | W 5-0 | 1592.14 | 1508.77 | 58.07% | 41.93% | +3.11 | 68-45 |
| 2021-08-11 | @ Philadelphia Phillies | W 8-2 | 1595.25 | 1505.66 | 58.94% | 41.06% | +3.34 | 69-45 |
| 2021-08-12 | @ Philadelphia Phillies | L 1-2 | 1598.59 | 1502.32 | 59.87% | 40.13% | -1.98 | 69-46 |
| 2021-08-13 | @ New York Mets | W 6-5 | 1596.61 | 1491.39 | 61.10% | 38.90% | +0.91 | 70-46 |
| 2021-08-14 | @ New York Mets | W 2-1 | 1597.52 | 1490.48 | 61.35% | 38.65% | +0.91 | 71-46 |
| 2021-08-15 | @ New York Mets | W 14-4 | 1598.43 | 1489.57 | 61.60% | 38.40% | +4.03 | 72-46 |
| 2021-08-16 | Pittsburgh Pirates | W 2-1 | 1602.46 | 1410.91 | 77.85% | 22.15% | +0.73 | 73-46 |
| 2021-08-17 | Pittsburgh Pirates | W 4-3 | 1603.19 | 1410.17 | 77.99% | 22.01% | +0.73 | 74-46 |
| 2021-08-18 | Pittsburgh Pirates | W 9-0 | 1603.92 | 1409.44 | 78.14% | 21.86% | +2.18 | 75-46 |
| 2021-08-19 | New York Mets | W 4-1 | 1606.10 | 1485.83 | 69.98% | 30.02% | +1.73 | 76-46 |
| 2021-08-20 | New York Mets | W 3-2 | 1607.83 | 1484.10 | 70.40% | 29.60% | +0.98 | 77-46 |
| 2021-08-21 | New York Mets | W 4-3 | 1608.81 | 1483.12 | 70.63% | 29.37% | +0.98 | 78-46 |
| 2021-08-22 | New York Mets | L 2-7 | 1609.79 | 1482.15 | 70.87% | 29.13% | -5.27 | 78-47 |
| 2021-08-24 | @ San Diego Padres | W 5-2 | 1604.52 | 1513.35 | 59.16% | 40.84% | +2.35 | 79-47 |
| 2021-08-25 | @ San Diego Padres | W 5-3 | 1606.87 | 1511.00 | 59.81% | 40.19% | +1.34 | 80-47 |
| 2021-08-26 | @ San Diego Padres | W 4-0 | 1608.21 | 1509.67 | 60.18% | 39.82% | +2.64 | 81-47 |
| 2021-08-27 | Colorado Rockies | L 2-4 | 1610.85 | 1480.95 | 71.13% | 28.87% | -3.34 | 81-48 |
| 2021-08-28 | Colorado Rockies | W 5-2 | 1607.51 | 1484.29 | 70.34% | 29.66% | +1.71 | 82-48 |
| 2021-08-29 | Colorado Rockies | L 0-5 | 1609.22 | 1482.58 | 70.75% | 29.25% | -5.26 | 82-49 |
| 2021-08-30 | Atlanta Braves | W 5-3 | 1603.96 | 1552.73 | 61.04% | 38.96% | +1.83 | 83-49 |
| 2021-08-31 | Atlanta Braves | W 3-2 | 1605.79 | 1550.90 | 61.54% | 38.46% | +1.28 | 84-49 |
| 2021-09-01 | Atlanta Braves | W 4-3 | 1607.07 | 1549.63 | 61.89% | 38.11% | +1.27 | 85-49 |
| 2021-09-03 | @ San Francisco Giants | L 2-3 | 1608.34 | 1563.84 | 52.55% | 47.45% | -1.24 | 85-50 |
| 2021-09-04 | @ San Francisco Giants | W 6-1 | 1607.10 | 1565.07 | 52.19% | 47.81% | +3.55 | 86-50 |
| 2021-09-05 | @ San Francisco Giants | L 4-6 | 1610.65 | 1561.52 | 53.21% | 46.79% | -2.50 | 86-51 |
| 2021-09-06 | @ St. Louis Cardinals | W 5-1 | 1608.15 | 1496.41 | 61.99% | 38.01% | +2.53 | 87-51 |
| 2021-09-07 | @ St. Louis Cardinals | W 7-2 | 1610.68 | 1493.88 | 62.67% | 37.33% | +2.77 | 88-51 |
| 2021-09-08 | @ St. Louis Cardinals | L 4-5 | 1613.45 | 1491.11 | 63.41% | 36.59% | -2.11 | 88-52 |
| 2021-09-09 | @ St. Louis Cardinals | L 1-2 | 1611.34 | 1493.22 | 62.85% | 37.15% | -2.08 | 88-53 |
| 2021-09-10 | San Diego Padres | W 3-0 | 1609.26 | 1508.42 | 67.58% | 32.42% | +1.86 | 89-53 |
| 2021-09-11 | San Diego Padres | W 5-4 | 1611.12 | 1506.56 | 68.05% | 31.95% | +1.06 | 90-53 |
| 2021-09-12 | San Diego Padres | W 8-0 | 1612.18 | 1505.50 | 68.31% | 31.69% | +2.98 | 91-53 |
| 2021-09-13 | Arizona Diamondbacks | W 5-1 | 1615.16 | 1419.62 | 78.24% | 21.76% | +1.44 | 92-53 |
| 2021-09-14 | Arizona Diamondbacks | W 8-4 | 1616.60 | 1418.18 | 78.52% | 21.48% | +1.43 | 93-53 |
| 2021-09-15 | Arizona Diamondbacks | W 5-3 | 1618.03 | 1416.75 | 78.80% | 21.20% | +0.99 | 94-53 |
| 2021-09-17 | @ Cincinnati Reds | L 1-3 | 1619.02 | 1505.62 | 62.21% | 37.79% | -2.92 | 94-54 |
| 2021-09-18 | @ Cincinnati Reds | W 5-1 | 1616.10 | 1508.55 | 61.42% | 38.58% | +2.56 | 95-54 |
| 2021-09-19 | @ Cincinnati Reds | W 8-5 | 1618.66 | 1505.98 | 62.12% | 37.88% | +2.18 | 96-54 |
| 2021-09-21 | @ Colorado Rockies | W 5-4 | 1620.84 | 1487.94 | 64.81% | 35.19% | +0.83 | 97-54 |
| 2021-09-22 | @ Colorado Rockies | L 5-10 | 1621.67 | 1487.12 | 65.03% | 34.97% | -4.83 | 97-55 |
| 2021-09-23 | @ Colorado Rockies | W 7-5 | 1616.84 | 1491.95 | 63.76% | 36.24% | +1.20 | 98-55 |
| 2021-09-24 | @ Arizona Diamondbacks | W 4-2 | 1618.04 | 1411.15 | 73.82% | 26.18% | +1.23 | 99-55 |
| 2021-09-25 | @ Arizona Diamondbacks | L 2-7 | 1619.27 | 1409.92 | 74.10% | 25.90% | -5.50 | 99-56 |
| 2021-09-26 | @ Arizona Diamondbacks | W 3-0 | 1613.77 | 1415.43 | 72.86% | 27.14% | +1.56 | 100-56 |
| 2021-09-28 | San Diego Padres | W 2-1 | 1615.33 | 1489.62 | 70.64% | 29.36% | +0.98 | 101-56 |
| 2021-09-29 | San Diego Padres | W 11-9 | 1616.31 | 1488.64 | 70.87% | 29.13% | +1.37 | 102-56 |
| 2021-09-30 | San Diego Padres | W 8-3 | 1617.68 | 1487.28 | 71.19% | 28.81% | +2.13 | 103-56 |
| 2021-10-01 | Milwaukee Brewers | W 8-6 | 1619.81 | 1551.51 | 63.35% | 36.65% | +1.72 | 104-56 |
| 2021-10-02 | Milwaukee Brewers | W 8-3 | 1621.53 | 1549.79 | 63.81% | 36.19% | +2.69 | 105-56 |
| 2021-10-03 | Milwaukee Brewers | W 10-3 | 1624.22 | 1547.10 | 64.52% | 35.48% | +3.12 | 106-56 |
| 2021-04-01 | Tampa Bay Rays | L 0-1 | 1479.57 | 1530.30 | 46.56% | 53.44% | -1.55 | 0-1 |
| 2021-04-02 | Tampa Bay Rays | L 4-6 | 1478.02 | 1531.84 | 46.12% | 53.88% | -2.16 | 0-2 |
| 2021-04-03 | Tampa Bay Rays | W 12-7 | 1475.86 | 1534.01 | 45.50% | 54.50% | +4.04 | 1-2 |
| 2021-04-05 | St. Louis Cardinals | L 1-4 | 1479.90 | 1504.23 | 50.35% | 49.65% | -2.89 | 1-3 |
| 2021-04-06 | St. Louis Cardinals | L 2-4 | 1477.01 | 1507.13 | 49.52% | 50.48% | -2.33 | 1-4 |
| 2021-04-07 | St. Louis Cardinals | L 0-7 | 1474.68 | 1509.45 | 48.85% | 51.15% | -4.29 | 1-5 |
| 2021-04-08 | @ New York Mets | L 2-3 | 1470.39 | 1497.02 | 42.37% | 57.63% | -1.40 | 1-6 |
| 2021-04-10 | @ New York Mets | W 3-0 | 1468.99 | 1498.42 | 41.98% | 58.02% | +3.33 | 2-6 |
| 2021-04-12 | @ Atlanta Braves | W 5-3 | 1472.32 | 1525.13 | 38.74% | 61.26% | +2.88 | 3-6 |
| 2021-04-13 | @ Atlanta Braves | W 14-8 | 1475.20 | 1522.26 | 39.53% | 60.47% | +4.92 | 4-6 |
| 2021-04-14 | @ Atlanta Braves | W 6-5 | 1480.12 | 1517.34 | 40.89% | 59.11% | +1.38 | 5-6 |
| 2021-04-15 | @ Atlanta Braves | L 6-7 | 1481.50 | 1515.95 | 41.28% | 58.72% | -1.37 | 5-7 |
| 2021-04-16 | San Francisco Giants | W 4-1 | 1480.13 | 1501.20 | 50.82% | 49.18% | +2.83 | 6-7 |
| 2021-04-17 | San Francisco Giants | W 7-6 | 1482.96 | 1498.37 | 51.64% | 48.36% | +1.14 | 7-7 |
| 2021-04-18 | San Francisco Giants | L 0-1 | 1484.10 | 1497.24 | 51.96% | 48.04% | -1.73 | 7-8 |
| 2021-04-20 | Baltimore Orioles | L 5-7 | 1482.37 | 1476.16 | 54.73% | 45.27% | -2.57 | 7-9 |
| 2021-04-21 | Baltimore Orioles | W 3-0 | 1479.80 | 1478.73 | 54.00% | 46.00% | +2.65 | 8-9 |
| 2021-04-22 | @ San Francisco Giants | L 0-3 | 1482.45 | 1502.88 | 43.25% | 56.75% | -2.49 | 8-10 |
| 2021-04-23 | @ San Francisco Giants | L 3-5 | 1479.96 | 1505.37 | 42.55% | 57.45% | -2.00 | 8-11 |
| 2021-04-24 | @ San Francisco Giants | W 5-2 | 1477.96 | 1507.36 | 41.98% | 58.02% | +3.34 | 9-11 |
| 2021-04-25 | @ San Francisco Giants | L 3-4 | 1481.30 | 1504.03 | 42.92% | 57.08% | -1.43 | 9-12 |
| 2021-04-26 | @ Milwaukee Brewers | W 8-0 | 1479.87 | 1514.88 | 41.20% | 58.80% | +5.53 | 10-12 |
| 2021-04-27 | @ Milwaukee Brewers | L 4-5 | 1485.40 | 1509.36 | 42.75% | 57.25% | -1.42 | 10-13 |
| 2021-04-28 | @ Milwaukee Brewers | W 6-2 | 1483.98 | 1510.78 | 42.35% | 57.65% | +3.82 | 11-13 |
| 2021-04-30 | @ Washington Nationals | L 1-2 | 1487.80 | 1497.79 | 44.73% | 55.27% | -1.05 | 11-14 |
| 2021-05-01 | @ Washington Nationals | L 2-7 | 1486.75 | 1498.84 | 44.43% | 55.57% | -3.29 | 11-15 |
| 2021-05-02 | @ Washington Nationals | L 1-3 | 1483.46 | 1502.14 | 43.49% | 56.51% | -2.05 | 11-16 |
| 2021-05-04 | Arizona Diamondbacks | W 9-3 | 1481.41 | 1503.14 | 50.73% | 49.27% | +4.01 | 12-16 |
| 2021-05-05 | Arizona Diamondbacks | W 8-0 | 1485.42 | 1499.13 | 51.88% | 48.12% | +4.52 | 13-16 |
| 2021-05-06 | Arizona Diamondbacks | W 3-1 | 1489.94 | 1494.61 | 53.18% | 46.82% | +2.20 | 14-16 |
| 2021-05-07 | Milwaukee Brewers | W 6-1 | 1492.14 | 1500.28 | 52.68% | 47.32% | +3.51 | 15-16 |
| 2021-05-08 | Milwaukee Brewers | L 2-6 | 1495.65 | 1496.77 | 53.69% | 46.31% | -3.56 | 15-17 |
| 2021-05-09 | Milwaukee Brewers | L 1-2 | 1492.09 | 1500.33 | 52.66% | 47.34% | -1.24 | 15-18 |
| 2021-05-10 | @ Arizona Diamondbacks | L 2-5 | 1490.85 | 1487.15 | 46.68% | 53.32% | -2.68 | 15-19 |
| 2021-05-11 | @ Arizona Diamondbacks | L 3-11 | 1488.17 | 1489.83 | 45.92% | 54.08% | -4.32 | 15-20 |
| 2021-05-12 | @ Arizona Diamondbacks | W 3-2 | 1483.85 | 1494.14 | 44.69% | 55.31% | +1.84 | 16-20 |
| 2021-05-13 | @ Arizona Diamondbacks | W 5-1 | 1485.69 | 1492.31 | 45.21% | 54.79% | +3.64 | 17-20 |
| 2021-05-14 | @ Los Angeles Dodgers | L 6-9 | 1489.33 | 1564.98 | 35.67% | 64.33% | -2.05 | 17-21 |
| 2021-05-15 | @ Los Angeles Dodgers | L 0-7 | 1487.28 | 1567.03 | 35.13% | 64.87% | -3.09 | 17-22 |
| 2021-05-16 | @ Los Angeles Dodgers | W 3-2 | 1484.19 | 1570.11 | 34.33% | 65.67% | +2.18 | 18-22 |
| 2021-05-18 | @ Philadelphia Phillies | L 3-8 | 1486.37 | 1495.31 | 44.88% | 55.12% | -3.33 | 18-23 |
| 2021-05-19 | @ Philadelphia Phillies | W 3-1 | 1483.04 | 1498.64 | 43.93% | 56.07% | +2.63 | 19-23 |
| 2021-05-20 | @ Philadelphia Phillies | W 6-0 | 1485.67 | 1496.00 | 44.68% | 55.32% | +4.50 | 20-23 |
| 2021-05-21 | New York Mets | L 5-6 | 1490.17 | 1502.37 | 52.10% | 47.90% | -1.22 | 20-24 |
| 2021-05-22 | New York Mets | W 3-1 | 1488.95 | 1503.59 | 51.75% | 48.25% | +2.26 | 21-24 |
| 2021-05-23 | New York Mets | W 5-1 | 1491.21 | 1501.32 | 52.40% | 47.60% | +3.16 | 22-24 |
| 2021-05-24 | Philadelphia Phillies | W 9-6 | 1494.37 | 1488.64 | 54.67% | 45.33% | +2.61 | 23-24 |
| 2021-05-25 | Philadelphia Phillies | L 0-2 | 1496.98 | 1486.04 | 55.41% | 44.59% | -2.60 | 23-25 |
| 2021-05-26 | Philadelphia Phillies | W 4-2 | 1494.38 | 1488.64 | 54.67% | 45.33% | +2.13 | 24-25 |
| 2021-05-27 | Philadelphia Phillies | L 2-3 | 1496.51 | 1486.51 | 55.27% | 44.73% | -1.84 | 24-26 |
| 2021-05-28 | @ Boston Red Sox | L 2-5 | 1494.67 | 1521.91 | 42.29% | 57.71% | -2.43 | 24-27 |
| 2021-05-29 | @ Boston Red Sox | L 1-3 | 1492.24 | 1524.34 | 41.61% | 58.39% | -1.95 | 24-28 |
| 2021-06-01 | @ Toronto Blue Jays | L 1-5 | 1490.29 | 1524.26 | 41.35% | 58.65% | -2.75 | 24-29 |
| 2021-06-02 | @ Toronto Blue Jays | L 5-6 | 1487.54 | 1527.00 | 40.58% | 59.42% | -1.34 | 24-30 |
| 2021-06-03 | @ Pittsburgh Pirates | L 3-5 | 1486.20 | 1436.41 | 53.31% | 46.69% | -2.51 | 24-31 |
| 2021-06-04 | @ Pittsburgh Pirates | L 2-9 | 1483.69 | 1438.92 | 52.59% | 47.41% | -4.62 | 24-32 |
| 2021-06-05 | @ Pittsburgh Pirates | L 7-8 | 1479.07 | 1443.54 | 51.26% | 48.74% | -1.20 | 24-33 |
| 2021-06-06 | @ Pittsburgh Pirates | W 3-1 | 1477.87 | 1444.74 | 50.91% | 49.09% | +2.30 | 25-33 |
| 2021-06-07 | @ Boston Red Sox | L 3-5 | 1480.17 | 1529.32 | 39.24% | 60.76% | -1.84 | 25-34 |
| 2021-06-08 | Colorado Rockies | W 6-2 | 1478.33 | 1459.61 | 56.51% | 43.49% | +2.89 | 26-34 |
| 2021-06-09 | Colorado Rockies | L 3-4 | 1481.22 | 1456.72 | 57.33% | 42.67% | -1.90 | 26-35 |
| 2021-06-10 | Colorado Rockies | W 11-4 | 1479.32 | 1458.62 | 56.79% | 43.21% | +3.79 | 27-35 |
| 2021-06-11 | Atlanta Braves | W 4-3 | 1483.11 | 1511.77 | 49.73% | 50.27% | +1.67 | 28-35 |
| 2021-06-12 | Atlanta Braves | W 4-2 | 1484.78 | 1510.10 | 50.21% | 49.79% | +2.34 | 29-35 |
| 2021-06-13 | Atlanta Braves | L 4-6 | 1487.12 | 1507.76 | 50.88% | 49.12% | -2.39 | 29-36 |
| 2021-06-14 | @ St. Louis Cardinals | L 2-4 | 1484.73 | 1489.12 | 45.53% | 54.47% | -2.14 | 29-37 |
| 2021-06-15 | @ St. Louis Cardinals | L 1-2 | 1482.59 | 1491.25 | 44.92% | 55.08% | -1.49 | 29-38 |
| 2021-06-16 | @ St. Louis Cardinals | L 0-1 | 1481.10 | 1492.75 | 44.49% | 55.51% | -1.48 | 29-39 |
| 2021-06-18 | @ Chicago Cubs | W 10-2 | 1479.62 | 1532.17 | 38.78% | 61.22% | +5.75 | 30-39 |
| 2021-06-19 | @ Chicago Cubs | W 11-1 | 1485.37 | 1526.42 | 40.36% | 59.64% | +6.26 | 31-39 |
| 2021-06-20 | @ Chicago Cubs | L 0-2 | 1491.63 | 1520.16 | 42.11% | 57.89% | -1.97 | 31-40 |
| 2021-06-22 | Toronto Blue Jays | L 1-2 | 1489.66 | 1521.30 | 49.30% | 50.70% | -1.64 | 31-41 |
| 2021-06-23 | Toronto Blue Jays | L 1-3 | 1488.02 | 1522.94 | 48.83% | 51.17% | -2.29 | 31-42 |
| 2021-06-24 | Washington Nationals | L 3-7 | 1485.73 | 1503.90 | 51.24% | 48.76% | -3.40 | 31-43 |
| 2021-06-25 | Washington Nationals | W 11-2 | 1482.33 | 1507.30 | 50.26% | 49.74% | +4.95 | 32-43 |
| 2021-06-26 | Washington Nationals | W 3-2 | 1487.28 | 1502.34 | 51.69% | 48.31% | +1.60 | 33-43 |
| 2021-06-27 | Washington Nationals | L 1-5 | 1488.88 | 1500.74 | 52.15% | 47.85% | -3.46 | 33-44 |
| 2021-06-29 | @ Philadelphia Phillies | L 3-4 | 1485.42 | 1488.96 | 45.65% | 54.35% | -1.51 | 33-45 |
| 2021-06-30 | @ Philadelphia Phillies | W 11-6 | 1483.91 | 1490.47 | 45.22% | 54.78% | +4.06 | 34-45 |
| 2021-07-02 | @ Atlanta Braves | L 0-1 | 1487.97 | 1514.80 | 42.35% | 57.65% | -1.40 | 34-46 |
| 2021-07-03 | @ Atlanta Braves | W 3-2 | 1486.57 | 1516.21 | 41.95% | 58.05% | +1.92 | 35-46 |
| 2021-07-04 | @ Atlanta Braves | L 7-8 | 1488.49 | 1514.28 | 42.49% | 57.51% | -0.99 | 35-47 |
| 2021-07-05 | Los Angeles Dodgers | W 5-4 | 1487.50 | 1594.67 | 38.63% | 61.37% | +2.03 | 36-47 |
| 2021-07-06 | Los Angeles Dodgers | W 2-1 | 1489.53 | 1592.63 | 39.19% | 60.81% | +1.43 | 37-47 |
| 2021-07-07 | Los Angeles Dodgers | W 9-6 | 1490.96 | 1591.20 | 39.58% | 60.42% | +3.48 | 38-47 |
| 2021-07-08 | Los Angeles Dodgers | L 1-6 | 1494.44 | 1587.73 | 40.54% | 59.46% | -3.01 | 38-48 |
| 2021-07-09 | Atlanta Braves | L 0-5 | 1491.43 | 1511.95 | 50.90% | 49.10% | -3.78 | 38-49 |
| 2021-07-10 | Atlanta Braves | L 4-5 | 1487.65 | 1515.73 | 49.81% | 50.19% | -1.66 | 38-50 |
| 2021-07-11 | Atlanta Braves | W 7-4 | 1485.99 | 1517.38 | 49.34% | 50.66% | +2.92 | 39-50 |
| 2021-07-16 | @ Philadelphia Phillies | L 2-5 | 1488.91 | 1501.53 | 44.35% | 55.65% | -2.55 | 39-51 |
| 2021-07-16 | @ Philadelphia Phillies | W 7-0 | 1486.36 | 1504.08 | 43.63% | 56.37% | +4.95 | 40-51 |
| 2021-07-17 | @ Philadelphia Phillies | L 2-4 | 1491.31 | 1499.13 | 45.04% | 54.96% | -1.50 | 40-52 |
| 2021-07-18 | @ Philadelphia Phillies | L 4-7 | 1489.81 | 1500.63 | 44.61% | 55.39% | -2.56 | 40-53 |
| 2021-07-19 | @ Washington Nationals | L 1-18 | 1487.25 | 1493.09 | 45.32% | 54.68% | -6.21 | 40-54 |
| 2021-07-20 | @ Washington Nationals | L 3-6 | 1481.04 | 1499.30 | 43.56% | 56.44% | -2.50 | 40-55 |
| 2021-07-21 | @ Washington Nationals | W 3-1 | 1478.54 | 1501.80 | 42.85% | 57.15% | +1.90 | 41-55 |
| 2021-07-22 | San Diego Padres | L 2-3 | 1480.44 | 1540.87 | 45.17% | 54.83% | -1.50 | 41-56 |
| 2021-07-23 | San Diego Padres | L 2-5 | 1478.94 | 1542.37 | 44.74% | 55.26% | -2.58 | 41-57 |
| 2021-07-24 | San Diego Padres | W 3-2 | 1476.36 | 1544.94 | 44.01% | 55.99% | +1.86 | 42-57 |
| 2021-07-25 | San Diego Padres | W 9-3 | 1478.22 | 1543.08 | 44.54% | 55.46% | +4.51 | 43-57 |
| 2021-07-27 | @ Baltimore Orioles | W 7-3 | 1482.73 | 1436.21 | 52.84% | 47.16% | +3.13 | 44-57 |
| 2021-07-28 | @ Baltimore Orioles | L 7-8 | 1485.86 | 1433.08 | 53.74% | 46.26% | -1.78 | 44-58 |
| 2021-07-30 | New York Yankees | L 1-3 | 1484.08 | 1517.69 | 49.02% | 50.98% | -2.30 | 44-59 |
| 2021-07-31 | New York Yankees | L 2-4 | 1481.78 | 1519.99 | 48.35% | 51.65% | -2.27 | 44-60 |
| 2021-08-01 | New York Yankees | L 1-3 | 1479.51 | 1522.27 | 47.70% | 52.30% | -2.24 | 44-61 |
| 2021-08-02 | New York Mets | W 6-3 | 1477.27 | 1496.74 | 51.05% | 48.95% | +2.81 | 45-61 |
| 2021-08-03 | New York Mets | W 5-4 | 1480.08 | 1493.92 | 51.86% | 48.14% | +1.60 | 46-61 |
| 2021-08-04 | New York Mets | L 3-5 | 1481.68 | 1492.33 | 52.32% | 47.68% | -2.46 | 46-62 |
| 2021-08-05 | New York Mets | W 4-2 | 1479.22 | 1494.78 | 51.61% | 48.39% | +2.28 | 47-62 |
| 2021-08-06 | @ Colorado Rockies | L 2-14 | 1481.50 | 1471.31 | 47.61% | 52.39% | -5.48 | 47-63 |
| 2021-08-07 | @ Colorado Rockies | L 4-7 | 1476.02 | 1476.79 | 46.04% | 53.96% | -2.65 | 47-64 |
| 2021-08-08 | @ Colorado Rockies | L 8-13 | 1473.37 | 1479.44 | 45.29% | 54.71% | -3.36 | 47-65 |
| 2021-08-09 | @ San Diego Padres | L 3-8 | 1470.01 | 1537.41 | 36.77% | 63.23% | -2.73 | 47-66 |
| 2021-08-10 | @ San Diego Padres | L 5-6 | 1467.28 | 1540.14 | 36.04% | 63.96% | -1.20 | 47-67 |
| 2021-08-11 | @ San Diego Padres | W 7-0 | 1466.08 | 1541.34 | 35.72% | 64.28% | +5.65 | 48-67 |
| 2021-08-13 | Chicago Cubs | W 14-10 | 1471.73 | 1454.97 | 56.23% | 43.77% | +2.91 | 49-67 |
| 2021-08-14 | Chicago Cubs | W 5-4 | 1474.64 | 1452.06 | 57.06% | 42.94% | +1.42 | 50-67 |
| 2021-08-15 | Chicago Cubs | W 4-1 | 1476.06 | 1450.64 | 57.46% | 42.54% | +2.45 | 51-67 |
| 2021-08-16 | Atlanta Braves | L 2-12 | 1478.51 | 1542.13 | 44.72% | 55.28% | -4.70 | 51-68 |
| 2021-08-17 | Atlanta Braves | L 0-2 | 1473.81 | 1546.82 | 43.39% | 56.61% | -2.03 | 51-69 |
| 2021-08-18 | Atlanta Braves | L 9-11 | 1471.78 | 1548.86 | 42.81% | 57.19% | -2.01 | 51-70 |
| 2021-08-19 | @ Cincinnati Reds | L 1-6 | 1469.77 | 1515.15 | 39.76% | 60.24% | -2.95 | 51-71 |
| 2021-08-20 | @ Cincinnati Reds | L 3-5 | 1466.82 | 1518.10 | 38.95% | 61.05% | -1.83 | 51-72 |
| 2021-08-21 | @ Cincinnati Reds | L 4-7 | 1464.99 | 1519.93 | 38.45% | 61.55% | -2.21 | 51-73 |
| 2021-08-22 | @ Cincinnati Reds | L 1-3 | 1462.78 | 1522.14 | 37.85% | 62.15% | -1.78 | 51-74 |
| 2021-08-24 | Washington Nationals | L 1-5 | 1461.00 | 1474.22 | 51.95% | 48.05% | -3.45 | 51-75 |
| 2021-08-25 | Washington Nationals | W 4-3 | 1457.55 | 1477.67 | 50.96% | 49.04% | +1.15 | 52-75 |
| 2021-08-26 | Washington Nationals | W 7-5 | 1458.70 | 1476.52 | 51.29% | 48.71% | +2.29 | 53-75 |
| 2021-08-27 | Cincinnati Reds | L 0-6 | 1460.99 | 1523.11 | 44.93% | 55.07% | -3.66 | 53-76 |
| 2021-08-28 | Cincinnati Reds | W 6-1 | 1457.33 | 1526.77 | 43.89% | 56.11% | +4.17 | 54-76 |
| 2021-08-29 | Cincinnati Reds | W 2-1 | 1461.50 | 1522.60 | 45.08% | 54.92% | +1.82 | 55-76 |
| 2021-08-31 | @ New York Mets | L 5-6 | 1463.32 | 1484.35 | 43.16% | 56.84% | -1.43 | 55-77 |
| 2021-08-31 | @ New York Mets | L 1-3 | 1461.89 | 1485.79 | 42.76% | 57.24% | -2.01 | 55-78 |
| 2021-09-02 | @ New York Mets | L 3-4 | 1459.88 | 1487.80 | 42.19% | 57.81% | -1.40 | 55-79 |
| 2021-09-03 | Philadelphia Phillies | W 10-3 | 1458.48 | 1505.36 | 47.11% | 52.89% | +4.65 | 56-79 |
| 2021-09-04 | Philadelphia Phillies | W 3-2 | 1463.13 | 1500.71 | 48.45% | 51.55% | +1.71 | 57-79 |
| 2021-09-05 | Philadelphia Phillies | L 3-4 | 1464.84 | 1499.00 | 48.94% | 51.06% | -1.15 | 57-80 |
| 2021-09-07 | New York Mets | L 4-9 | 1463.69 | 1494.08 | 49.48% | 50.52% | -3.67 | 57-81 |
| 2021-09-08 | New York Mets | W 2-1 | 1460.02 | 1497.76 | 48.42% | 51.58% | +1.21 | 58-81 |
| 2021-09-09 | New York Mets | W 3-2 | 1461.23 | 1496.54 | 48.77% | 51.23% | +1.70 | 59-81 |
| 2021-09-10 | @ Atlanta Braves | L 2-6 | 1462.93 | 1549.77 | 34.21% | 65.79% | -2.27 | 59-82 |
| 2021-09-11 | @ Atlanta Braves | W 6-4 | 1460.66 | 1552.04 | 33.62% | 66.38% | +3.11 | 60-82 |
| 2021-09-12 | @ Atlanta Braves | L 3-5 | 1463.77 | 1548.93 | 34.43% | 65.57% | -1.61 | 60-83 |
| 2021-09-13 | @ Washington Nationals | W 3-0 | 1462.16 | 1455.94 | 47.04% | 52.96% | +3.04 | 61-83 |
| 2021-09-14 | @ Washington Nationals | L 2-8 | 1465.20 | 1452.90 | 47.92% | 52.08% | -3.90 | 61-84 |
| 2021-09-15 | @ Washington Nationals | W 8-6 | 1461.30 | 1456.79 | 46.80% | 53.20% | +2.50 | 62-84 |
| 2021-09-17 | Pittsburgh Pirates | L 1-2 | 1463.80 | 1409.26 | 61.49% | 38.51% | -2.04 | 62-85 |
| 2021-09-18 | Pittsburgh Pirates | L 3-6 | 1461.76 | 1411.30 | 60.94% | 39.06% | -3.50 | 62-86 |
| 2021-09-19 | Pittsburgh Pirates | W 6-5 | 1458.26 | 1414.80 | 59.97% | 40.03% | +0.94 | 63-86 |
| 2021-09-20 | Washington Nationals | W 8-7 | 1459.20 | 1451.68 | 54.92% | 45.08% | +1.05 | 64-86 |
| 2021-09-21 | Washington Nationals | L 1-7 | 1460.25 | 1450.62 | 55.22% | 44.78% | -4.49 | 64-87 |
| 2021-09-22 | Washington Nationals | L 5-7 | 1455.76 | 1455.11 | 53.94% | 46.06% | -2.53 | 64-88 |
| 2021-09-24 | @ Tampa Bay Rays | L 0-8 | 1453.23 | 1584.87 | 28.66% | 71.34% | -2.69 | 64-89 |
| 2021-09-25 | @ Tampa Bay Rays | L 3-7 | 1450.54 | 1587.56 | 28.03% | 71.97% | -1.86 | 64-90 |
| 2021-09-26 | @ Tampa Bay Rays | L 2-3 | 1448.68 | 1589.43 | 27.60% | 72.40% | -0.92 | 64-91 |
| 2021-09-28 | @ New York Mets | L 2-5 | 1447.76 | 1474.42 | 42.37% | 57.63% | -2.43 | 64-92 |
| 2021-09-28 | @ New York Mets | L 1-2 | 1445.33 | 1476.85 | 41.69% | 58.31% | -0.98 | 64-93 |
| 2021-09-29 | @ New York Mets | W 3-2 | 1444.35 | 1477.83 | 41.41% | 58.59% | +1.94 | 65-93 |
| 2021-09-30 | @ New York Mets | L 3-12 | 1446.29 | 1475.89 | 41.96% | 58.04% | -4.18 | 65-94 |
| 2021-10-01 | Philadelphia Phillies | L 0-5 | 1442.11 | 1493.80 | 46.42% | 53.58% | -3.44 | 65-95 |
| 2021-10-02 | Philadelphia Phillies | W 3-1 | 1438.67 | 1497.25 | 45.44% | 54.56% | +2.56 | 66-95 |
| 2021-10-03 | Philadelphia Phillies | W 5-4 | 1441.23 | 1494.69 | 46.17% | 53.83% | +1.79 | 67-95 |
| 2021-04-01 | Minnesota Twins | W 6-5 | 1498.22 | 1518.16 | 50.98% | 49.02% | +1.15 | 1-0 |
| 2021-04-03 | Minnesota Twins | L 0-2 | 1499.37 | 1517.01 | 51.32% | 48.68% | -2.41 | 1-1 |
| 2021-04-04 | Minnesota Twins | L 2-8 | 1496.96 | 1519.42 | 50.62% | 49.38% | -4.12 | 1-2 |
| 2021-04-05 | @ Chicago Cubs | L 3-5 | 1492.84 | 1509.60 | 43.77% | 56.23% | -2.05 | 1-3 |
| 2021-04-06 | @ Chicago Cubs | W 4-0 | 1490.79 | 1511.65 | 43.19% | 56.81% | +3.77 | 2-3 |
| 2021-04-07 | @ Chicago Cubs | W 4-2 | 1494.56 | 1507.88 | 44.26% | 55.74% | +1.85 | 3-3 |
| 2021-04-08 | @ St. Louis Cardinals | L 1-3 | 1496.41 | 1513.74 | 43.69% | 56.31% | -2.05 | 3-4 |
| 2021-04-10 | @ St. Louis Cardinals | W 9-5 | 1494.36 | 1515.80 | 43.11% | 56.89% | +3.78 | 4-4 |
| 2021-04-11 | @ St. Louis Cardinals | W 9-3 | 1498.14 | 1512.02 | 44.18% | 55.82% | +4.54 | 5-4 |
| 2021-04-12 | Chicago Cubs | W 6-3 | 1502.68 | 1499.61 | 54.28% | 45.72% | +2.63 | 6-4 |
| 2021-04-13 | Chicago Cubs | L 2-3 | 1505.31 | 1496.98 | 55.03% | 44.97% | -1.83 | 6-5 |
| 2021-04-14 | Chicago Cubs | W 7-0 | 1503.48 | 1498.81 | 54.51% | 45.49% | +4.00 | 7-5 |
| 2021-04-16 | Pittsburgh Pirates | L 1-6 | 1507.48 | 1465.39 | 59.78% | 40.22% | -4.44 | 7-6 |
| 2021-04-17 | Pittsburgh Pirates | W 7-1 | 1503.04 | 1469.83 | 58.55% | 41.45% | +3.37 | 8-6 |
| 2021-04-18 | Pittsburgh Pirates | L 5-6 | 1506.41 | 1466.46 | 59.49% | 40.51% | -1.40 | 8-7 |
| 2021-04-19 | @ San Diego Padres | W 3-1 | 1505.01 | 1515.81 | 44.61% | 55.39% | +2.60 | 9-7 |
| 2021-04-20 | @ San Diego Padres | W 6-0 | 1507.61 | 1513.21 | 45.35% | 54.65% | +4.45 | 10-7 |
| 2021-04-21 | @ San Diego Padres | W 4-2 | 1512.06 | 1508.77 | 46.62% | 53.38% | +2.50 | 11-7 |
| 2021-04-23 | @ Chicago Cubs | L 2-15 | 1514.56 | 1500.50 | 48.17% | 51.83% | -5.76 | 11-8 |
| 2021-04-24 | @ Chicago Cubs | W 4-3 | 1508.80 | 1506.27 | 46.52% | 53.48% | +1.77 | 12-8 |
| 2021-04-25 | @ Chicago Cubs | W 6-0 | 1510.57 | 1504.49 | 47.02% | 52.98% | +4.31 | 13-8 |
| 2021-04-26 | Miami Marlins | L 0-8 | 1514.88 | 1479.87 | 58.80% | 41.20% | -5.52 | 13-9 |
| 2021-04-27 | Miami Marlins | W 5-4 | 1509.36 | 1485.40 | 57.25% | 42.75% | +1.42 | 14-9 |
| 2021-04-28 | Miami Marlins | L 2-6 | 1510.78 | 1483.98 | 57.65% | 42.35% | -3.83 | 14-10 |
| 2021-04-29 | Los Angeles Dodgers | W 2-1 | 1506.95 | 1573.55 | 44.30% | 55.70% | +1.85 | 15-10 |
| 2021-04-30 | Los Angeles Dodgers | W 3-1 | 1508.80 | 1571.70 | 44.82% | 55.18% | +2.59 | 16-10 |
| 2021-05-01 | Los Angeles Dodgers | W 6-5 | 1511.39 | 1569.11 | 45.56% | 54.44% | +1.28 | 17-10 |
| 2021-05-02 | Los Angeles Dodgers | L 4-16 | 1512.67 | 1567.83 | 45.92% | 54.08% | -5.28 | 17-11 |
| 2021-05-03 | @ Philadelphia Phillies | L 3-4 | 1507.39 | 1485.70 | 49.27% | 50.73% | -1.64 | 17-12 |
| 2021-05-04 | @ Philadelphia Phillies | L 5-6 | 1505.75 | 1487.33 | 48.80% | 51.20% | -1.62 | 17-13 |
| 2021-05-05 | @ Philadelphia Phillies | L 4-5 | 1504.13 | 1488.95 | 48.33% | 51.67% | -1.60 | 17-14 |
| 2021-05-06 | @ Philadelphia Phillies | L 0-2 | 1502.53 | 1490.56 | 47.87% | 52.13% | -2.25 | 17-15 |
| 2021-05-07 | @ Miami Marlins | L 1-6 | 1500.28 | 1492.14 | 47.32% | 52.68% | -3.51 | 17-16 |
| 2021-05-08 | @ Miami Marlins | W 6-2 | 1496.77 | 1495.65 | 46.31% | 53.69% | +3.56 | 18-16 |
| 2021-05-09 | @ Miami Marlins | W 2-1 | 1500.33 | 1492.09 | 47.34% | 52.66% | +1.24 | 19-16 |
| 2021-05-11 | St. Louis Cardinals | L 1-6 | 1501.57 | 1521.47 | 50.99% | 49.01% | -2.68 | 19-17 |
| 2021-05-12 | St. Louis Cardinals | W 4-1 | 1498.89 | 1524.15 | 50.22% | 49.78% | +2.86 | 20-17 |
| 2021-05-13 | St. Louis Cardinals | L 0-2 | 1501.75 | 1521.29 | 51.04% | 48.96% | -2.39 | 20-18 |
| 2021-05-14 | Atlanta Braves | L 3-6 | 1499.36 | 1505.20 | 53.01% | 46.99% | -3.05 | 20-19 |
| 2021-05-15 | Atlanta Braves | L 1-5 | 1496.31 | 1508.25 | 52.13% | 47.87% | -3.46 | 20-20 |
| 2021-05-16 | Atlanta Braves | W 10-9 | 1492.85 | 1511.71 | 51.14% | 48.86% | +1.62 | 21-20 |
| 2021-05-18 | @ Kansas City Royals | L 0-2 | 1494.47 | 1462.56 | 50.74% | 49.26% | -2.38 | 21-21 |
| 2021-05-19 | @ Kansas City Royals | L 4-6 | 1492.09 | 1464.94 | 50.05% | 49.95% | -2.35 | 21-22 |
| 2021-05-21 | @ Cincinnati Reds | L 4-9 | 1489.74 | 1476.84 | 48.00% | 52.00% | -3.57 | 21-23 |
| 2021-05-22 | @ Cincinnati Reds | W 4-3 | 1486.17 | 1480.40 | 46.98% | 53.02% | +1.76 | 22-23 |
| 2021-05-23 | @ Cincinnati Reds | W 9-4 | 1487.93 | 1478.64 | 47.49% | 52.51% | +3.90 | 23-23 |
| 2021-05-24 | San Diego Padres | W 5-3 | 1491.83 | 1546.47 | 46.00% | 54.00% | +2.54 | 24-23 |
| 2021-05-25 | San Diego Padres | L 1-7 | 1494.37 | 1543.94 | 46.72% | 53.28% | -3.80 | 24-24 |
| 2021-05-26 | San Diego Padres | L 1-2 | 1490.57 | 1547.74 | 45.64% | 54.36% | -1.07 | 24-25 |
| 2021-05-27 | San Diego Padres | W 6-5 | 1489.50 | 1548.81 | 45.33% | 54.67% | +1.28 | 25-25 |
| 2021-05-29 | @ Washington Nationals | W 4-1 | 1490.78 | 1497.63 | 45.18% | 54.82% | +3.15 | 26-25 |
| 2021-05-29 | @ Washington Nationals | W 6-2 | 1493.93 | 1494.47 | 46.08% | 53.92% | +3.58 | 27-25 |
| 2021-05-30 | @ Washington Nationals | W 3-0 | 1497.51 | 1490.89 | 47.10% | 52.90% | +3.04 | 28-25 |
| 2021-05-31 | Detroit Tigers | W 3-2 | 1500.55 | 1443.94 | 61.78% | 38.22% | +0.90 | 29-25 |
| 2021-06-01 | Detroit Tigers | L 7-10 | 1501.45 | 1443.04 | 62.02% | 37.98% | -3.56 | 29-26 |
| 2021-06-03 | Arizona Diamondbacks | W 7-4 | 1497.89 | 1458.27 | 59.44% | 40.56% | +2.33 | 30-26 |
| 2021-06-04 | Arizona Diamondbacks | W 5-1 | 1500.22 | 1455.94 | 60.09% | 39.91% | +2.65 | 31-26 |
| 2021-06-05 | Arizona Diamondbacks | W 7-5 | 1502.87 | 1453.29 | 60.82% | 39.18% | +1.84 | 32-26 |
| 2021-06-06 | Arizona Diamondbacks | W 2-0 | 1504.71 | 1451.45 | 61.32% | 38.68% | +1.81 | 33-26 |
| 2021-06-08 | @ Cincinnati Reds | W 5-1 | 1506.52 | 1485.79 | 49.13% | 50.87% | +3.38 | 34-26 |
| 2021-06-09 | @ Cincinnati Reds | L 3-7 | 1509.90 | 1482.41 | 50.10% | 49.90% | -3.32 | 34-27 |
| 2021-06-10 | @ Cincinnati Reds | W 7-2 | 1506.58 | 1485.74 | 49.14% | 50.86% | +3.77 | 35-27 |
| 2021-06-11 | Pittsburgh Pirates | W 7-4 | 1510.35 | 1438.28 | 63.85% | 36.15% | +2.08 | 36-27 |
| 2021-06-12 | Pittsburgh Pirates | W 7-4 | 1512.43 | 1436.21 | 64.40% | 35.60% | +2.05 | 37-27 |
| 2021-06-13 | Pittsburgh Pirates | W 5-2 | 1514.48 | 1434.16 | 64.94% | 35.06% | +2.01 | 38-27 |
| 2021-06-14 | Cincinnati Reds | L 2-10 | 1516.49 | 1491.71 | 57.37% | 42.63% | -5.38 | 38-28 |
| 2021-06-15 | Cincinnati Reds | L 1-2 | 1511.11 | 1497.10 | 55.84% | 44.16% | -1.32 | 38-29 |
| 2021-06-16 | Cincinnati Reds | L 1-2 | 1509.79 | 1498.41 | 55.47% | 44.53% | -1.84 | 38-30 |
| 2021-06-17 | @ Colorado Rockies | L 3-7 | 1507.95 | 1452.77 | 54.08% | 45.92% | -3.59 | 38-31 |
| 2021-06-18 | @ Colorado Rockies | L 5-6 | 1504.36 | 1456.36 | 53.05% | 46.95% | -1.24 | 38-32 |
| 2021-06-19 | @ Colorado Rockies | W 6-5 | 1503.12 | 1457.60 | 52.69% | 47.31% | +1.57 | 39-32 |
| 2021-06-20 | @ Colorado Rockies | W 7-6 | 1504.69 | 1456.03 | 53.14% | 46.86% | +1.55 | 40-32 |
| 2021-06-21 | @ Arizona Diamondbacks | L 1-5 | 1506.24 | 1424.45 | 57.85% | 42.15% | -3.84 | 40-33 |
| 2021-06-22 | @ Arizona Diamondbacks | W 5-0 | 1502.40 | 1428.29 | 56.77% | 43.23% | +3.21 | 41-33 |
| 2021-06-23 | @ Arizona Diamondbacks | W 3-2 | 1505.61 | 1425.08 | 57.67% | 42.33% | +1.41 | 42-33 |
| 2021-06-25 | Colorado Rockies | W 5-4 | 1507.02 | 1456.35 | 60.96% | 39.04% | +0.91 | 43-33 |
| 2021-06-26 | Colorado Rockies | W 10-4 | 1507.93 | 1455.44 | 61.21% | 38.79% | +3.16 | 44-33 |
| 2021-06-27 | Colorado Rockies | W 5-0 | 1511.09 | 1452.28 | 62.07% | 37.93% | +2.81 | 45-33 |
| 2021-06-28 | Chicago Cubs | W 14-4 | 1513.90 | 1519.17 | 53.09% | 46.91% | +4.93 | 46-33 |
| 2021-06-29 | Chicago Cubs | W 2-1 | 1518.83 | 1514.25 | 54.50% | 45.50% | +1.51 | 47-33 |
| 2021-06-30 | Chicago Cubs | W 15-7 | 1520.34 | 1512.74 | 54.93% | 45.07% | +4.23 | 48-33 |
| 2021-07-01 | @ Pittsburgh Pirates | W 7-2 | 1524.57 | 1432.22 | 59.33% | 40.67% | +3.02 | 49-33 |
| 2021-07-02 | @ Pittsburgh Pirates | W 7-2 | 1527.59 | 1429.20 | 60.16% | 39.84% | +2.96 | 50-33 |
| 2021-07-03 | @ Pittsburgh Pirates | W 11-2 | 1530.55 | 1426.25 | 60.97% | 39.03% | +3.88 | 51-33 |
| 2021-07-04 | @ Pittsburgh Pirates | L 0-2 | 1534.43 | 1422.36 | 62.03% | 37.97% | -2.91 | 51-34 |
| 2021-07-05 | @ New York Mets | L 2-4 | 1531.52 | 1511.26 | 49.06% | 50.94% | -2.30 | 51-35 |
| 2021-07-07 | @ New York Mets | L 3-4 | 1529.22 | 1513.56 | 48.40% | 51.60% | -1.14 | 51-36 |
| 2021-07-07 | @ New York Mets | W 5-0 | 1528.08 | 1514.70 | 48.07% | 51.93% | +3.86 | 52-36 |
| 2021-07-08 | Cincinnati Reds | W 5-3 | 1531.94 | 1503.56 | 57.87% | 42.13% | +1.97 | 53-36 |
| 2021-07-09 | Cincinnati Reds | L 0-2 | 1533.91 | 1501.58 | 58.43% | 41.57% | -2.74 | 53-37 |
| 2021-07-10 | Cincinnati Reds | L 3-4 | 1531.17 | 1504.33 | 57.66% | 42.34% | -1.91 | 53-38 |
| 2021-07-11 | Cincinnati Reds | L 1-3 | 1529.26 | 1506.24 | 57.12% | 42.88% | -2.69 | 53-39 |
| 2021-07-16 | @ Cincinnati Reds | W 11-6 | 1526.57 | 1508.92 | 48.69% | 51.31% | +3.81 | 54-39 |
| 2021-07-17 | @ Cincinnati Reds | W 7-4 | 1530.38 | 1505.11 | 49.78% | 50.22% | +2.05 | 55-39 |
| 2021-07-18 | @ Cincinnati Reds | W 8-0 | 1532.43 | 1503.07 | 50.37% | 49.63% | +4.66 | 56-39 |
| 2021-07-20 | Kansas City Royals | L 2-5 | 1537.09 | 1426.95 | 68.74% | 31.26% | -3.96 | 56-40 |
| 2021-07-21 | Kansas City Royals | L 3-6 | 1533.13 | 1430.90 | 67.76% | 32.24% | -3.89 | 56-41 |
| 2021-07-23 | Chicago White Sox | W 7-1 | 1529.24 | 1547.85 | 51.17% | 48.83% | +3.97 | 57-41 |
| 2021-07-24 | Chicago White Sox | W 6-1 | 1533.21 | 1543.88 | 52.32% | 47.68% | +3.54 | 58-41 |
| 2021-07-25 | Chicago White Sox | L 1-3 | 1536.75 | 1540.34 | 53.33% | 46.67% | -2.51 | 58-42 |
| 2021-07-27 | @ Pittsburgh Pirates | W 9-0 | 1534.24 | 1434.18 | 60.39% | 39.61% | +3.95 | 59-42 |
| 2021-07-28 | @ Pittsburgh Pirates | W 7-3 | 1538.19 | 1430.23 | 61.47% | 38.53% | +2.56 | 60-42 |
| 2021-07-29 | @ Pittsburgh Pirates | W 12-0 | 1540.75 | 1427.68 | 62.17% | 37.83% | +4.35 | 61-42 |
| 2021-07-30 | @ Atlanta Braves | W 9-5 | 1545.10 | 1526.34 | 48.85% | 51.15% | +3.39 | 62-42 |
| 2021-07-31 | @ Atlanta Braves | L 1-8 | 1548.49 | 1522.94 | 49.82% | 50.18% | -4.37 | 62-43 |
| 2021-08-01 | @ Atlanta Braves | W 2-1 | 1544.12 | 1527.31 | 48.56% | 51.44% | +1.71 | 63-43 |
| 2021-08-02 | Pittsburgh Pirates | W 6-2 | 1545.83 | 1425.08 | 70.04% | 29.96% | +1.98 | 64-43 |
| 2021-08-03 | Pittsburgh Pirates | L 5-8 | 1547.81 | 1423.09 | 70.52% | 29.48% | -2.86 | 64-44 |
| 2021-08-04 | Pittsburgh Pirates | W 4-2 | 1544.95 | 1425.95 | 69.83% | 30.17% | +1.41 | 65-44 |
| 2021-08-06 | San Francisco Giants | W 2-1 | 1546.36 | 1558.22 | 52.15% | 47.85% | +1.13 | 66-44 |
| 2021-08-07 | San Francisco Giants | L 6-9 | 1547.49 | 1557.09 | 52.47% | 47.53% | -2.14 | 66-45 |
| 2021-08-08 | San Francisco Giants | L 4-5 | 1545.35 | 1559.23 | 51.86% | 48.14% | -1.72 | 66-46 |
| 2021-08-10 | @ Chicago Cubs | W 4-2 | 1543.63 | 1468.70 | 56.89% | 43.11% | +2.03 | 67-46 |
| 2021-08-10 | @ Chicago Cubs | W 6-3 | 1545.66 | 1466.67 | 57.46% | 42.54% | +2.44 | 68-46 |
| 2021-08-11 | @ Chicago Cubs | W 10-0 | 1548.10 | 1464.23 | 58.14% | 41.86% | +4.40 | 69-46 |
| 2021-08-12 | @ Chicago Cubs | W 17-4 | 1552.50 | 1459.83 | 59.37% | 40.63% | +4.86 | 70-46 |
| 2021-08-14 | @ Pittsburgh Pirates | L 4-14 | 1557.36 | 1407.85 | 66.96% | 33.04% | -7.03 | 70-47 |
| 2021-08-14 | @ Pittsburgh Pirates | W 6-0 | 1550.33 | 1414.88 | 65.15% | 34.85% | +2.83 | 71-47 |
| 2021-08-15 | @ Pittsburgh Pirates | W 2-1 | 1553.16 | 1412.04 | 65.89% | 34.11% | +1.14 | 72-47 |
| 2021-08-17 | @ St. Louis Cardinals | W 2-0 | 1554.30 | 1497.87 | 54.26% | 45.74% | +2.15 | 73-47 |
| 2021-08-18 | @ St. Louis Cardinals | W 6-4 | 1556.45 | 1495.72 | 54.87% | 45.13% | +1.49 | 74-47 |
| 2021-08-19 | @ St. Louis Cardinals | L 4-8 | 1557.94 | 1494.22 | 55.30% | 44.70% | -3.67 | 74-48 |
| 2021-08-20 | Washington Nationals | L 1-4 | 1554.27 | 1474.94 | 64.81% | 35.19% | -3.73 | 74-49 |
| 2021-08-21 | Washington Nationals | W 9-6 | 1550.54 | 1478.67 | 63.83% | 36.17% | +2.08 | 75-49 |
| 2021-08-22 | Washington Nationals | W 7-3 | 1552.62 | 1476.59 | 64.38% | 35.62% | +2.37 | 76-49 |
| 2021-08-24 | Cincinnati Reds | W 7-4 | 1554.99 | 1523.92 | 58.25% | 41.75% | +2.40 | 77-49 |
| 2021-08-25 | Cincinnati Reds | W 4-1 | 1557.39 | 1521.52 | 58.92% | 41.08% | +2.36 | 78-49 |
| 2021-08-26 | Cincinnati Reds | L 1-5 | 1559.75 | 1519.16 | 59.58% | 40.42% | -3.95 | 78-50 |
| 2021-08-27 | @ Minnesota Twins | L 0-2 | 1555.80 | 1463.49 | 59.32% | 40.68% | -2.79 | 78-51 |
| 2021-08-28 | @ Minnesota Twins | L 4-6 | 1553.01 | 1466.28 | 58.54% | 41.46% | -2.75 | 78-52 |
| 2021-08-29 | @ Minnesota Twins | W 6-2 | 1550.26 | 1469.02 | 57.77% | 42.23% | +2.81 | 79-52 |
| 2021-08-30 | @ San Francisco Giants | W 3-1 | 1553.07 | 1570.22 | 43.71% | 56.29% | +2.64 | 80-52 |
| 2021-08-31 | @ San Francisco Giants | W 6-2 | 1555.71 | 1567.58 | 44.46% | 55.54% | +3.69 | 81-52 |
| 2021-09-01 | @ San Francisco Giants | W 5-2 | 1559.40 | 1563.89 | 45.51% | 54.49% | +3.13 | 82-52 |
| 2021-09-02 | @ San Francisco Giants | L 1-5 | 1562.53 | 1560.76 | 46.41% | 53.59% | -3.08 | 82-53 |
| 2021-09-03 | St. Louis Cardinals | L 4-15 | 1559.45 | 1493.31 | 63.06% | 36.94% | -6.94 | 82-54 |
| 2021-09-04 | St. Louis Cardinals | W 4-0 | 1552.51 | 1500.25 | 61.18% | 38.82% | +2.57 | 83-54 |
| 2021-09-05 | St. Louis Cardinals | W 6-5 | 1555.08 | 1497.67 | 61.88% | 38.12% | +1.27 | 84-54 |
| 2021-09-06 | Philadelphia Phillies | L 0-12 | 1556.35 | 1500.15 | 61.72% | 38.28% | -7.10 | 84-55 |
| 2021-09-07 | Philadelphia Phillies | W 10-0 | 1549.25 | 1507.25 | 59.77% | 40.23% | +4.22 | 85-55 |
| 2021-09-08 | Philadelphia Phillies | W 4-3 | 1553.47 | 1503.02 | 60.93% | 39.07% | +1.30 | 86-55 |
| 2021-09-10 | @ Cleveland Indians | W 10-3 | 1554.77 | 1497.39 | 54.39% | 45.61% | +4.01 | 87-55 |
| 2021-09-11 | @ Cleveland Indians | W 3-0 | 1558.78 | 1493.38 | 55.53% | 44.47% | +2.55 | 88-55 |
| 2021-09-12 | @ Cleveland Indians | W 11-1 | 1561.33 | 1490.83 | 56.26% | 43.74% | +4.60 | 89-55 |
| 2021-09-14 | @ Detroit Tigers | L 0-1 | 1565.93 | 1468.49 | 60.03% | 39.97% | -1.41 | 89-56 |
| 2021-09-15 | @ Detroit Tigers | L 1-4 | 1564.52 | 1469.90 | 59.64% | 40.36% | -3.43 | 89-57 |
| 2021-09-17 | Chicago Cubs | W 8-5 | 1561.09 | 1448.38 | 69.06% | 30.94% | +1.78 | 90-57 |
| 2021-09-18 | Chicago Cubs | W 6-4 | 1562.87 | 1446.60 | 69.50% | 30.50% | +1.43 | 91-57 |
| 2021-09-19 | Chicago Cubs | L 4-6 | 1564.30 | 1445.16 | 69.85% | 30.15% | -3.28 | 91-58 |
| 2021-09-20 | St. Louis Cardinals | L 2-5 | 1561.02 | 1514.70 | 60.37% | 39.63% | -3.47 | 91-59 |
| 2021-09-21 | St. Louis Cardinals | L 1-2 | 1557.55 | 1518.17 | 59.41% | 40.59% | -1.97 | 91-60 |
| 2021-09-22 | St. Louis Cardinals | L 2-10 | 1555.58 | 1520.15 | 58.86% | 41.14% | -5.53 | 91-61 |
| 2021-09-23 | St. Louis Cardinals | L 5-8 | 1550.05 | 1525.67 | 57.31% | 42.69% | -3.30 | 91-62 |
| 2021-09-24 | New York Mets | W 5-1 | 1546.75 | 1480.46 | 63.08% | 36.92% | +2.45 | 92-62 |
| 2021-09-25 | New York Mets | W 2-1 | 1549.20 | 1478.01 | 63.74% | 36.26% | +1.21 | 93-62 |
| 2021-09-26 | New York Mets | W 8-4 | 1550.41 | 1476.80 | 64.06% | 35.94% | +2.38 | 94-62 |
| 2021-09-28 | @ St. Louis Cardinals | L 2-6 | 1552.79 | 1539.34 | 48.08% | 51.92% | -3.19 | 94-63 |
| 2021-09-29 | @ St. Louis Cardinals | W 4-0 | 1549.60 | 1542.53 | 47.17% | 52.83% | +3.51 | 95-63 |
| 2021-09-30 | @ St. Louis Cardinals | L 3-4 | 1553.11 | 1539.03 | 48.17% | 51.83% | -1.60 | 95-64 |
| 2021-10-01 | @ Los Angeles Dodgers | L 6-8 | 1551.51 | 1619.81 | 36.65% | 63.35% | -1.72 | 95-65 |
| 2021-10-02 | @ Los Angeles Dodgers | L 3-8 | 1549.79 | 1621.53 | 36.19% | 63.81% | -2.69 | 95-66 |
| 2021-10-03 | @ Los Angeles Dodgers | L 3-10 | 1547.10 | 1624.22 | 35.48% | 64.52% | -3.11 | 95-67 |
| 2021-04-01 | @ Milwaukee Brewers | L 5-6 | 1518.16 | 1498.22 | 49.02% | 50.98% | -1.15 | 0-1 |
| 2021-04-03 | @ Milwaukee Brewers | W 2-0 | 1517.01 | 1499.37 | 48.68% | 51.32% | +2.41 | 1-1 |
| 2021-04-04 | @ Milwaukee Brewers | W 8-2 | 1519.42 | 1496.96 | 49.38% | 50.62% | +4.12 | 2-1 |
| 2021-04-05 | @ Detroit Tigers | W 15-6 | 1523.54 | 1455.22 | 55.95% | 44.05% | +4.38 | 3-1 |
| 2021-04-06 | @ Detroit Tigers | L 3-4 | 1527.92 | 1450.83 | 57.19% | 42.81% | -1.34 | 3-2 |
| 2021-04-07 | @ Detroit Tigers | W 3-2 | 1526.58 | 1452.17 | 56.81% | 43.19% | +1.43 | 4-2 |
| 2021-04-08 | Seattle Mariners | W 10-2 | 1528.01 | 1482.32 | 56.54% | 43.46% | +4.09 | 5-2 |
| 2021-04-10 | Seattle Mariners | L 3-4 | 1532.10 | 1478.24 | 61.40% | 38.60% | -1.45 | 5-3 |
| 2021-04-11 | Seattle Mariners | L 6-8 | 1530.65 | 1479.68 | 61.01% | 38.99% | -2.86 | 5-4 |
| 2021-04-13 | Boston Red Sox | L 2-4 | 1527.79 | 1504.32 | 57.18% | 42.82% | -2.69 | 5-5 |
| 2021-04-14 | Boston Red Sox | L 2-3 | 1525.10 | 1507.00 | 56.42% | 43.58% | -1.87 | 5-6 |
| 2021-04-14 | Boston Red Sox | L 1-7 | 1523.23 | 1508.87 | 55.89% | 44.11% | -4.54 | 5-7 |
| 2021-04-15 | Boston Red Sox | W 4-3 | 1518.69 | 1513.42 | 54.60% | 45.40% | +1.50 | 6-7 |
| 2021-04-16 | @ Los Angeles Angels | L 3-10 | 1520.19 | 1487.30 | 50.88% | 49.12% | -4.47 | 6-8 |
| 2021-04-20 | @ Oakland Athletics | L 0-7 | 1515.72 | 1518.17 | 45.80% | 54.20% | -4.02 | 6-9 |
| 2021-04-20 | @ Oakland Athletics | L 0-1 | 1511.70 | 1522.20 | 44.66% | 55.34% | -1.48 | 6-10 |
| 2021-04-21 | @ Oakland Athletics | L 12-13 | 1510.22 | 1523.68 | 44.23% | 55.77% | -1.04 | 6-11 |
| 2021-04-23 | Pittsburgh Pirates | W 2-0 | 1509.18 | 1469.08 | 59.51% | 40.49% | +1.90 | 7-11 |
| 2021-04-24 | Pittsburgh Pirates | L 2-6 | 1511.08 | 1467.18 | 60.03% | 39.97% | -3.99 | 7-12 |
| 2021-04-25 | Pittsburgh Pirates | L 2-6 | 1507.09 | 1471.17 | 58.93% | 41.07% | -3.91 | 7-13 |
| 2021-04-26 | @ Cleveland Indians | L 3-5 | 1503.18 | 1504.51 | 45.96% | 54.04% | -1.52 | 7-14 |
| 2021-04-27 | @ Cleveland Indians | L 4-7 | 1501.66 | 1506.03 | 45.53% | 54.47% | -2.62 | 7-15 |
| 2021-04-28 | @ Cleveland Indians | W 10-2 | 1499.04 | 1508.65 | 44.78% | 55.22% | +5.18 | 8-15 |
| 2021-04-30 | Kansas City Royals | W 9-1 | 1504.22 | 1487.15 | 56.28% | 43.72% | +4.11 | 9-15 |
| 2021-05-01 | Kansas City Royals | L 3-11 | 1508.33 | 1483.04 | 57.44% | 42.56% | -5.39 | 9-16 |
| 2021-05-02 | Kansas City Royals | W 13-4 | 1502.94 | 1488.44 | 55.91% | 44.09% | +4.39 | 10-16 |
| 2021-05-03 | Texas Rangers | W 6-5 | 1507.33 | 1466.48 | 59.61% | 40.39% | +1.34 | 11-16 |
| 2021-05-04 | Texas Rangers | L 3-6 | 1508.67 | 1465.14 | 59.98% | 40.02% | -2.44 | 11-17 |
| 2021-05-05 | Texas Rangers | L 1-3 | 1506.23 | 1467.58 | 59.31% | 40.69% | -2.79 | 11-18 |
| 2021-05-06 | Texas Rangers | L 3-4 | 1503.44 | 1470.36 | 58.53% | 41.47% | -1.37 | 11-19 |
| 2021-05-07 | @ Detroit Tigers | W 7-3 | 1502.07 | 1424.24 | 57.29% | 42.71% | +2.84 | 12-19 |
| 2021-05-08 | @ Detroit Tigers | L 3-7 | 1504.91 | 1421.40 | 58.09% | 41.91% | -3.86 | 12-20 |
| 2021-05-11 | @ Chicago White Sox | L 3-9 | 1501.05 | 1528.12 | 42.31% | 57.69% | -3.44 | 12-21 |
| 2021-05-12 | @ Chicago White Sox | L 8-13 | 1497.61 | 1531.56 | 41.35% | 58.65% | -3.07 | 12-22 |
| 2021-05-13 | @ Chicago White Sox | L 2-4 | 1494.54 | 1534.63 | 40.49% | 59.51% | -1.90 | 12-23 |
| 2021-05-14 | Oakland Athletics | L 1-6 | 1492.64 | 1519.72 | 49.96% | 50.04% | -3.71 | 12-24 |
| 2021-05-15 | Oakland Athletics | W 5-4 | 1488.93 | 1523.42 | 48.89% | 51.11% | +1.69 | 13-24 |
| 2021-05-16 | Oakland Athletics | L 6-7 | 1490.62 | 1521.73 | 49.38% | 50.62% | -1.63 | 13-25 |
| 2021-05-17 | Chicago White Sox | L 4-16 | 1488.99 | 1530.90 | 47.82% | 52.18% | -5.50 | 13-26 |
| 2021-05-18 | Chicago White Sox | W 5-4 | 1483.49 | 1536.40 | 46.25% | 53.75% | +1.78 | 14-26 |
| 2021-05-19 | Chicago White Sox | L 1-2 | 1485.27 | 1534.61 | 46.76% | 53.24% | -1.55 | 14-27 |
| 2021-05-20 | @ Los Angeles Angels | L 1-7 | 1483.72 | 1468.11 | 48.39% | 51.61% | -3.94 | 14-28 |
| 2021-05-20 | @ Los Angeles Angels | W 6-3 | 1479.78 | 1472.04 | 47.26% | 52.74% | +3.03 | 15-28 |
| 2021-05-21 | @ Cleveland Indians | W 10-0 | 1482.81 | 1514.46 | 41.67% | 58.33% | +6.13 | 16-28 |
| 2021-05-22 | @ Cleveland Indians | L 3-5 | 1488.94 | 1508.33 | 43.39% | 56.61% | -1.44 | 16-29 |
| 2021-05-23 | @ Cleveland Indians | W 8-5 | 1487.50 | 1509.78 | 42.99% | 57.01% | +2.32 | 17-29 |
| 2021-05-24 | Baltimore Orioles | W 8-3 | 1489.82 | 1453.03 | 59.05% | 40.95% | +3.04 | 18-29 |
| 2021-05-25 | Baltimore Orioles | W 7-4 | 1492.86 | 1449.99 | 59.89% | 40.11% | +2.30 | 19-29 |
| 2021-05-26 | Baltimore Orioles | W 3-2 | 1495.16 | 1447.69 | 60.53% | 39.47% | +1.31 | 20-29 |
| 2021-05-28 | Kansas City Royals | L 3-8 | 1496.47 | 1466.85 | 58.05% | 41.95% | -4.31 | 20-30 |
| 2021-05-29 | Kansas City Royals | W 6-5 | 1492.16 | 1471.15 | 56.83% | 43.17% | +1.44 | 21-30 |
| 2021-05-30 | Kansas City Royals | L 3-6 | 1493.60 | 1469.72 | 57.24% | 42.76% | -3.29 | 21-31 |
| 2021-05-31 | @ Baltimore Orioles | W 3-2 | 1490.31 | 1439.03 | 53.52% | 46.48% | +1.09 | 22-31 |
| 2021-06-01 | @ Baltimore Orioles | L 4-7 | 1491.40 | 1437.94 | 53.83% | 46.17% | -3.10 | 22-32 |
| 2021-06-02 | @ Baltimore Orioles | L 3-6 | 1488.30 | 1441.03 | 52.95% | 47.05% | -3.04 | 22-33 |
| 2021-06-03 | @ Kansas City Royals | L 5-6 | 1485.26 | 1478.83 | 47.07% | 52.93% | -1.57 | 22-34 |
| 2021-06-04 | @ Kansas City Royals | L 5-14 | 1483.69 | 1480.40 | 46.63% | 53.37% | -4.64 | 22-35 |
| 2021-06-05 | @ Kansas City Royals | W 5-4 | 1479.05 | 1485.04 | 45.30% | 54.70% | +1.82 | 23-35 |
| 2021-06-06 | @ Kansas City Royals | W 2-1 | 1480.87 | 1483.22 | 45.82% | 54.18% | +1.80 | 24-35 |
| 2021-06-08 | New York Yankees | L 4-8 | 1482.67 | 1514.39 | 49.29% | 50.71% | -3.28 | 24-36 |
| 2021-06-09 | New York Yankees | L 6-9 | 1479.39 | 1517.66 | 48.35% | 51.65% | -2.78 | 24-37 |
| 2021-06-10 | New York Yankees | W 7-5 | 1476.61 | 1520.44 | 47.55% | 52.45% | +2.46 | 25-37 |
| 2021-06-11 | Houston Astros | L 4-6 | 1479.07 | 1553.76 | 43.15% | 56.85% | -2.02 | 25-38 |
| 2021-06-12 | Houston Astros | W 5-2 | 1477.05 | 1555.79 | 42.58% | 57.42% | +3.30 | 26-38 |
| 2021-06-13 | Houston Astros | L 3-14 | 1480.35 | 1552.49 | 43.51% | 56.49% | -4.79 | 26-39 |
| 2021-06-14 | @ Seattle Mariners | L 3-4 | 1475.56 | 1464.31 | 47.77% | 52.23% | -1.59 | 26-40 |
| 2021-06-15 | @ Seattle Mariners | L 0-10 | 1473.97 | 1465.89 | 47.31% | 52.69% | -4.96 | 26-41 |
| 2021-06-16 | @ Seattle Mariners | W 7-2 | 1469.01 | 1470.86 | 45.89% | 54.11% | +4.01 | 27-41 |
| 2021-06-18 | @ Texas Rangers | W 7-5 | 1473.02 | 1443.24 | 50.43% | 49.57% | +1.65 | 28-41 |
| 2021-06-19 | @ Texas Rangers | W 3-2 | 1474.67 | 1441.60 | 50.91% | 49.09% | +1.63 | 29-41 |
| 2021-06-20 | @ Texas Rangers | W 4-2 | 1476.30 | 1439.97 | 51.37% | 48.63% | +2.28 | 30-41 |
| 2021-06-21 | Cincinnati Reds | W 7-5 | 1478.58 | 1491.53 | 51.99% | 48.01% | +1.60 | 31-41 |
| 2021-06-22 | Cincinnati Reds | L 7-10 | 1480.18 | 1489.94 | 52.45% | 47.55% | -3.02 | 31-42 |
| 2021-06-24 | Cleveland Indians | L 1-4 | 1477.16 | 1508.78 | 49.30% | 50.70% | -2.83 | 31-43 |
| 2021-06-25 | Cleveland Indians | W 8-7 | 1474.33 | 1511.61 | 48.49% | 51.51% | +1.71 | 32-43 |
| 2021-06-27 | Cleveland Indians | W 8-2 | 1476.04 | 1509.90 | 48.98% | 51.02% | +4.14 | 33-43 |
| 2021-06-29 | @ Chicago White Sox | L 6-7 | 1480.18 | 1530.78 | 39.04% | 60.96% | -1.29 | 33-44 |
| 2021-06-30 | @ Chicago White Sox | L 3-13 | 1478.89 | 1532.08 | 38.69% | 61.31% | -4.06 | 33-45 |
| 2021-07-01 | @ Chicago White Sox | L 5-8 | 1474.83 | 1536.14 | 37.59% | 62.41% | -2.16 | 33-46 |
| 2021-07-02 | @ Kansas City Royals | L 4-7 | 1472.67 | 1439.39 | 50.94% | 49.06% | -2.93 | 33-47 |
| 2021-07-03 | @ Kansas City Royals | L 3-6 | 1469.74 | 1442.32 | 50.09% | 49.91% | -2.88 | 33-48 |
| 2021-07-04 | @ Kansas City Royals | W 6-2 | 1466.86 | 1445.20 | 49.26% | 50.74% | +3.36 | 34-48 |
| 2021-07-05 | Chicago White Sox | W 8-5 | 1470.22 | 1535.02 | 44.55% | 55.45% | +3.19 | 35-48 |
| 2021-07-06 | Chicago White Sox | L 1-4 | 1473.41 | 1531.83 | 45.46% | 54.54% | -2.61 | 35-49 |
| 2021-07-07 | Chicago White Sox | L 1-6 | 1470.80 | 1534.44 | 44.71% | 55.29% | -3.32 | 35-50 |
| 2021-07-08 | Detroit Tigers | W 5-3 | 1467.48 | 1461.48 | 54.70% | 45.30% | +2.13 | 36-50 |
| 2021-07-09 | Detroit Tigers | W 4-2 | 1469.61 | 1459.36 | 55.31% | 44.69% | +2.09 | 37-50 |
| 2021-07-10 | Detroit Tigers | W 9-4 | 1471.70 | 1457.26 | 55.91% | 44.09% | +3.28 | 38-50 |
| 2021-07-11 | Detroit Tigers | W 12-9 | 1474.98 | 1453.98 | 56.83% | 43.17% | +1.75 | 39-50 |
| 2021-07-17 | @ Detroit Tigers | L 0-1 | 1476.73 | 1452.23 | 49.67% | 50.33% | -1.65 | 39-51 |
| 2021-07-17 | @ Detroit Tigers | L 4-5 | 1475.08 | 1453.88 | 49.20% | 50.80% | -1.15 | 39-52 |
| 2021-07-18 | @ Detroit Tigers | L 0-7 | 1473.93 | 1455.03 | 48.87% | 51.13% | -4.29 | 39-53 |
| 2021-07-19 | @ Chicago White Sox | W 3-2 | 1469.64 | 1550.27 | 35.02% | 64.98% | +1.52 | 40-53 |
| 2021-07-19 | @ Chicago White Sox | L 3-5 | 1471.16 | 1548.74 | 35.42% | 64.58% | -1.66 | 40-54 |
| 2021-07-20 | @ Chicago White Sox | L 5-9 | 1469.50 | 1550.40 | 34.98% | 65.02% | -2.32 | 40-55 |
| 2021-07-21 | @ Chicago White Sox | W 7-2 | 1467.18 | 1552.73 | 34.38% | 65.62% | +4.87 | 41-55 |
| 2021-07-22 | Los Angeles Angels | L 2-3 | 1472.05 | 1484.94 | 52.00% | 48.00% | -1.73 | 41-56 |
| 2021-07-23 | Los Angeles Angels | W 5-4 | 1470.32 | 1486.67 | 51.50% | 48.50% | +1.61 | 42-56 |
| 2021-07-24 | Los Angeles Angels | L 1-2 | 1471.93 | 1485.06 | 51.96% | 48.04% | -1.72 | 42-57 |
| 2021-07-25 | Los Angeles Angels | L 2-6 | 1470.21 | 1486.78 | 51.47% | 48.53% | -3.42 | 42-58 |
| 2021-07-26 | Detroit Tigers | W 6-5 | 1466.79 | 1463.19 | 54.36% | 45.64% | +1.07 | 43-58 |
| 2021-07-27 | Detroit Tigers | L 5-6 | 1467.86 | 1462.12 | 54.67% | 45.33% | -1.28 | 43-59 |
| 2021-07-28 | Detroit Tigers | L 14-17 | 1466.58 | 1463.40 | 54.30% | 45.70% | -3.12 | 43-60 |
| 2021-07-30 | @ St. Louis Cardinals | L 1-5 | 1463.46 | 1486.57 | 42.87% | 57.13% | -2.85 | 43-61 |
| 2021-07-31 | @ St. Louis Cardinals | W 8-1 | 1460.61 | 1489.41 | 42.07% | 57.93% | +5.09 | 44-61 |
| 2021-08-01 | @ St. Louis Cardinals | L 3-7 | 1465.70 | 1484.33 | 43.50% | 56.50% | -2.89 | 44-62 |
| 2021-08-03 | @ Cincinnati Reds | W 7-5 | 1462.81 | 1508.47 | 39.72% | 60.28% | +2.83 | 45-62 |
| 2021-08-04 | @ Cincinnati Reds | L 5-6 | 1465.64 | 1505.64 | 40.51% | 59.49% | -1.35 | 45-63 |
| 2021-08-05 | @ Houston Astros | W 5-3 | 1464.29 | 1574.91 | 31.20% | 68.80% | +3.23 | 46-63 |
| 2021-08-06 | @ Houston Astros | W 5-4 | 1467.52 | 1571.68 | 32.00% | 68.00% | +1.60 | 47-63 |
| 2021-08-07 | @ Houston Astros | L 0-4 | 1469.12 | 1570.09 | 32.40% | 67.60% | -2.15 | 47-64 |
| 2021-08-08 | @ Houston Astros | W 7-5 | 1466.97 | 1572.24 | 31.86% | 68.14% | +3.20 | 48-64 |
| 2021-08-09 | Chicago White Sox | L 1-11 | 1470.17 | 1540.31 | 43.79% | 56.21% | -4.60 | 48-65 |
| 2021-08-10 | Chicago White Sox | W 4-3 | 1465.57 | 1544.90 | 42.49% | 57.51% | +1.91 | 49-65 |
| 2021-08-11 | Chicago White Sox | W 1-0 | 1467.48 | 1543.00 | 43.03% | 56.97% | +1.89 | 50-65 |
| 2021-08-13 | Tampa Bay Rays | L 4-10 | 1469.37 | 1574.58 | 38.90% | 61.10% | -3.16 | 50-66 |
| 2021-08-14 | Tampa Bay Rays | W 12-0 | 1466.21 | 1577.74 | 38.04% | 61.96% | +7.12 | 51-66 |
| 2021-08-15 | Tampa Bay Rays | W 5-4 | 1473.33 | 1570.62 | 39.99% | 60.01% | +2.00 | 52-66 |
| 2021-08-16 | Cleveland Indians | W 5-4 | 1475.33 | 1487.16 | 52.15% | 47.85% | +1.12 | 53-66 |
| 2021-08-17 | Cleveland Indians | L 1-3 | 1476.45 | 1486.03 | 52.47% | 47.53% | -2.46 | 53-67 |
| 2021-08-18 | Cleveland Indians | W 8-7 | 1473.99 | 1488.50 | 51.76% | 48.24% | +1.13 | 54-67 |
| 2021-08-19 | @ New York Yankees | L 5-7 | 1475.12 | 1538.48 | 37.31% | 62.69% | -1.75 | 54-68 |
| 2021-08-20 | @ New York Yankees | L 2-10 | 1473.37 | 1540.23 | 36.84% | 63.16% | -3.46 | 54-69 |
| 2021-08-21 | @ New York Yankees | L 1-7 | 1469.91 | 1543.69 | 35.92% | 64.08% | -2.92 | 54-70 |
| 2021-08-24 | @ Boston Red Sox | L 9-11 | 1466.99 | 1515.94 | 39.27% | 60.73% | -1.85 | 54-71 |
| 2021-08-25 | @ Boston Red Sox | W 9-6 | 1465.14 | 1517.78 | 38.77% | 61.23% | +2.49 | 55-71 |
| 2021-08-26 | @ Boston Red Sox | L 2-12 | 1467.63 | 1515.29 | 39.45% | 60.55% | -4.14 | 55-72 |
| 2021-08-27 | Milwaukee Brewers | W 2-0 | 1463.49 | 1555.80 | 40.68% | 59.32% | +2.79 | 56-72 |
| 2021-08-28 | Milwaukee Brewers | W 6-4 | 1466.28 | 1553.01 | 41.46% | 58.54% | +2.74 | 57-72 |
| 2021-08-29 | Milwaukee Brewers | L 2-6 | 1469.02 | 1550.26 | 42.23% | 57.77% | -2.80 | 57-73 |
| 2021-08-30 | @ Detroit Tigers | W 3-2 | 1466.22 | 1463.32 | 46.57% | 53.43% | +1.77 | 58-73 |
| 2021-08-31 | Chicago Cubs | L 1-3 | 1467.99 | 1444.03 | 57.25% | 42.75% | -2.68 | 58-74 |
| 2021-09-01 | Chicago Cubs | L 0-3 | 1465.31 | 1446.72 | 56.49% | 43.51% | -3.25 | 58-75 |
| 2021-09-03 | @ Tampa Bay Rays | L 3-5 | 1462.06 | 1588.99 | 29.22% | 70.78% | -1.37 | 58-76 |
| 2021-09-04 | @ Tampa Bay Rays | L 4-11 | 1460.69 | 1590.36 | 28.89% | 71.11% | -2.54 | 58-77 |
| 2021-09-05 | @ Tampa Bay Rays | W 6-5 | 1458.15 | 1592.90 | 28.30% | 71.70% | +2.38 | 59-77 |
| 2021-09-06 | @ Cleveland Indians | W 5-2 | 1460.53 | 1505.14 | 39.87% | 60.13% | +3.46 | 60-77 |
| 2021-09-07 | @ Cleveland Indians | W 3-0 | 1463.99 | 1501.68 | 40.83% | 59.17% | +3.40 | 61-77 |
| 2021-09-08 | @ Cleveland Indians | W 3-0 | 1467.39 | 1498.28 | 41.78% | 58.22% | +3.35 | 62-77 |
| 2021-09-09 | @ Cleveland Indians | L 1-4 | 1470.74 | 1494.93 | 42.72% | 57.28% | -2.46 | 62-78 |
| 2021-09-10 | Kansas City Royals | L 4-6 | 1468.28 | 1460.23 | 55.00% | 45.00% | -1.82 | 62-79 |
| 2021-09-11 | Kansas City Royals | W 9-2 | 1466.46 | 1462.06 | 54.48% | 45.52% | +3.99 | 63-79 |
| 2021-09-12 | Kansas City Royals | L 3-5 | 1470.45 | 1458.06 | 55.61% | 44.39% | -2.61 | 63-80 |
| 2021-09-13 | @ New York Yankees | L 5-6 | 1467.84 | 1529.05 | 37.60% | 62.40% | -0.88 | 63-81 |
| 2021-09-14 | Cleveland Indians | L 1-3 | 1466.96 | 1486.24 | 51.08% | 48.92% | -2.40 | 63-82 |
| 2021-09-14 | Cleveland Indians | W 6-3 | 1464.56 | 1488.63 | 50.39% | 49.61% | +2.85 | 64-82 |
| 2021-09-15 | Cleveland Indians | L 3-12 | 1467.41 | 1485.78 | 51.21% | 48.79% | -5.10 | 64-83 |
| 2021-09-17 | @ Toronto Blue Jays | W 7-3 | 1462.31 | 1572.52 | 31.25% | 68.75% | +4.57 | 65-83 |
| 2021-09-18 | @ Toronto Blue Jays | L 2-6 | 1466.88 | 1567.95 | 32.39% | 67.61% | -2.15 | 65-84 |
| 2021-09-19 | @ Toronto Blue Jays | L 3-5 | 1464.73 | 1570.10 | 31.85% | 68.15% | -1.50 | 65-85 |
| 2021-09-21 | @ Chicago Cubs | W 9-5 | 1463.23 | 1448.44 | 48.28% | 51.72% | +3.44 | 66-85 |
| 2021-09-22 | @ Chicago Cubs | W 5-4 | 1466.67 | 1445.01 | 49.26% | 50.74% | +1.68 | 67-85 |
| 2021-09-23 | Toronto Blue Jays | W 7-2 | 1468.35 | 1568.48 | 39.60% | 60.40% | +4.49 | 68-85 |
| 2021-09-24 | Toronto Blue Jays | W 3-1 | 1472.84 | 1563.99 | 40.84% | 59.16% | +2.77 | 69-85 |
| 2021-09-25 | Toronto Blue Jays | L 1-6 | 1475.61 | 1561.21 | 41.62% | 58.38% | -3.09 | 69-86 |
| 2021-09-26 | Toronto Blue Jays | L 2-5 | 1472.52 | 1564.30 | 40.75% | 59.25% | -2.34 | 69-87 |
| 2021-09-28 | Detroit Tigers | W 3-2 | 1470.18 | 1477.10 | 52.85% | 47.15% | +1.57 | 70-87 |
| 2021-09-29 | Detroit Tigers | W 5-2 | 1471.75 | 1475.54 | 53.30% | 46.70% | +2.68 | 71-87 |
| 2021-09-30 | Detroit Tigers | L 7-10 | 1474.43 | 1472.85 | 54.07% | 45.93% | -3.11 | 71-88 |
| 2021-10-01 | @ Kansas City Royals | L 6-11 | 1471.32 | 1461.48 | 47.56% | 52.44% | -3.53 | 71-89 |
| 2021-10-02 | @ Kansas City Royals | W 4-0 | 1467.79 | 1465.01 | 46.55% | 53.45% | +3.55 | 72-89 |
| 2021-10-03 | @ Kansas City Royals | W 7-3 | 1471.34 | 1461.46 | 47.57% | 52.43% | +3.48 | 73-89 |
| 2021-04-05 | @ Philadelphia Phillies | L 3-5 | 1499.32 | 1500.50 | 45.99% | 54.01% | -2.16 | 0-1 |
| 2021-04-06 | @ Philadelphia Phillies | W 8-4 | 1497.16 | 1502.66 | 45.37% | 54.63% | +3.63 | 1-1 |
| 2021-04-07 | @ Philadelphia Phillies | L 2-8 | 1500.79 | 1499.03 | 46.41% | 53.59% | -3.77 | 1-2 |
| 2021-04-08 | Miami Marlins | W 3-2 | 1497.02 | 1470.39 | 57.63% | 42.37% | +1.40 | 2-2 |
| 2021-04-10 | Miami Marlins | L 0-3 | 1498.42 | 1468.99 | 58.02% | 41.98% | -3.33 | 2-3 |
| 2021-04-13 | Philadelphia Phillies | W 4-3 | 1495.09 | 1499.51 | 53.21% | 46.79% | +1.10 | 3-3 |
| 2021-04-13 | Philadelphia Phillies | W 4-0 | 1496.19 | 1498.41 | 53.53% | 46.47% | +3.08 | 4-3 |
| 2021-04-14 | Philadelphia Phillies | W 5-1 | 1499.27 | 1495.32 | 54.41% | 45.59% | +3.03 | 5-3 |
| 2021-04-17 | @ Colorado Rockies | W 4-3 | 1502.30 | 1467.59 | 51.14% | 48.86% | +1.62 | 6-3 |
| 2021-04-17 | @ Colorado Rockies | L 2-7 | 1503.92 | 1465.97 | 51.61% | 48.39% | -3.83 | 6-4 |
| 2021-04-18 | @ Colorado Rockies | W 2-1 | 1500.09 | 1469.80 | 50.51% | 49.49% | +1.64 | 7-4 |
| 2021-04-20 | @ Chicago Cubs | L 1-3 | 1501.73 | 1491.81 | 47.58% | 52.42% | -2.23 | 7-5 |
| 2021-04-21 | @ Chicago Cubs | L 4-16 | 1499.50 | 1494.04 | 46.94% | 53.06% | -5.40 | 7-6 |
| 2021-04-22 | @ Chicago Cubs | L 3-4 | 1494.10 | 1499.44 | 45.39% | 54.61% | -1.06 | 7-7 |
| 2021-04-23 | Washington Nationals | W 6-0 | 1493.04 | 1499.48 | 52.92% | 47.08% | +3.82 | 8-7 |
| 2021-04-24 | Washington Nationals | L 1-7 | 1496.86 | 1495.66 | 54.02% | 45.98% | -4.39 | 8-8 |
| 2021-04-25 | Washington Nationals | W 4-0 | 1492.47 | 1500.05 | 52.76% | 47.24% | +3.14 | 9-8 |
| 2021-04-27 | Boston Red Sox | L 1-2 | 1495.61 | 1508.21 | 52.04% | 47.96% | -1.73 | 9-9 |
| 2021-04-28 | Boston Red Sox | L 0-1 | 1493.88 | 1509.94 | 51.54% | 48.46% | -1.71 | 9-10 |
| 2021-04-30 | @ Philadelphia Phillies | L 1-2 | 1492.17 | 1487.69 | 46.80% | 53.20% | -1.55 | 9-11 |
| 2021-05-01 | @ Philadelphia Phillies | W 5-4 | 1490.62 | 1489.24 | 46.35% | 53.65% | +1.78 | 10-11 |
| 2021-05-02 | @ Philadelphia Phillies | W 8-7 | 1492.40 | 1487.46 | 46.86% | 53.14% | +1.76 | 11-11 |
| 2021-05-03 | @ St. Louis Cardinals | L 5-6 | 1494.16 | 1519.19 | 42.60% | 57.40% | -1.41 | 11-12 |
| 2021-05-05 | @ St. Louis Cardinals | L 1-4 | 1492.75 | 1520.61 | 42.20% | 57.80% | -2.43 | 11-13 |
| 2021-05-05 | @ St. Louis Cardinals | W 7-2 | 1490.32 | 1523.03 | 41.52% | 58.48% | +4.34 | 12-13 |
| 2021-05-06 | @ St. Louis Cardinals | W 4-1 | 1494.66 | 1518.69 | 42.74% | 57.26% | +3.29 | 13-13 |
| 2021-05-07 | Arizona Diamondbacks | W 5-4 | 1497.95 | 1492.42 | 54.64% | 45.36% | +1.07 | 14-13 |
| 2021-05-08 | Arizona Diamondbacks | W 4-2 | 1499.02 | 1491.35 | 54.94% | 45.06% | +2.11 | 15-13 |
| 2021-05-09 | Arizona Diamondbacks | W 4-2 | 1501.13 | 1489.24 | 55.54% | 44.46% | +2.09 | 16-13 |
| 2021-05-11 | Baltimore Orioles | W 3-2 | 1503.22 | 1474.92 | 57.86% | 42.14% | +1.40 | 17-13 |
| 2021-05-12 | Baltimore Orioles | W 7-1 | 1504.62 | 1473.52 | 58.25% | 41.75% | +3.40 | 18-13 |
| 2021-05-14 | @ Tampa Bay Rays | L 2-3 | 1508.02 | 1530.53 | 42.95% | 57.05% | -1.43 | 18-14 |
| 2021-05-15 | @ Tampa Bay Rays | L 5-12 | 1506.59 | 1531.96 | 42.55% | 57.45% | -3.74 | 18-15 |
| 2021-05-16 | @ Tampa Bay Rays | L 1-7 | 1502.85 | 1535.70 | 41.50% | 58.50% | -3.37 | 18-16 |
| 2021-05-17 | @ Atlanta Braves | W 3-1 | 1499.48 | 1510.09 | 44.64% | 55.36% | +2.60 | 19-16 |
| 2021-05-18 | @ Atlanta Braves | W 4-3 | 1502.08 | 1507.49 | 45.38% | 54.62% | +1.81 | 20-16 |
| 2021-05-19 | @ Atlanta Braves | L 4-5 | 1503.89 | 1505.67 | 45.90% | 54.10% | -1.52 | 20-17 |
| 2021-05-21 | @ Miami Marlins | W 6-5 | 1502.37 | 1490.17 | 47.90% | 52.10% | +1.22 | 21-17 |
| 2021-05-22 | @ Miami Marlins | L 1-3 | 1503.59 | 1488.95 | 48.25% | 51.75% | -2.27 | 21-18 |
| 2021-05-23 | @ Miami Marlins | L 1-5 | 1501.32 | 1491.21 | 47.60% | 52.40% | -3.16 | 21-19 |
| 2021-05-24 | Colorado Rockies | L 2-3 | 1498.16 | 1464.63 | 58.59% | 41.41% | -1.94 | 21-20 |
| 2021-05-25 | Colorado Rockies | W 3-1 | 1496.22 | 1466.57 | 58.05% | 41.95% | +1.97 | 22-20 |
| 2021-05-27 | Colorado Rockies | W 1-0 | 1498.19 | 1464.60 | 58.60% | 41.40% | +1.37 | 23-20 |
| 2021-05-27 | Colorado Rockies | W 4-2 | 1499.56 | 1463.23 | 58.98% | 41.02% | +1.93 | 24-20 |
| 2021-05-29 | Atlanta Braves | W 13-2 | 1501.49 | 1516.03 | 51.76% | 48.24% | +5.31 | 25-20 |
| 2021-05-31 | @ Arizona Diamondbacks | W 6-2 | 1506.80 | 1461.71 | 52.63% | 47.37% | +3.14 | 26-20 |
| 2021-06-01 | @ Arizona Diamondbacks | L 5-6 | 1509.94 | 1458.57 | 53.53% | 46.47% | -1.25 | 26-21 |
| 2021-06-02 | @ Arizona Diamondbacks | W 7-6 | 1508.69 | 1459.83 | 53.17% | 46.83% | +1.55 | 27-21 |
| 2021-06-03 | @ San Diego Padres | L 3-4 | 1510.24 | 1541.18 | 41.77% | 58.23% | -1.38 | 27-22 |
| 2021-06-04 | @ San Diego Padres | L 0-2 | 1508.86 | 1542.57 | 41.38% | 58.62% | -1.95 | 27-23 |
| 2021-06-05 | @ San Diego Padres | W 4-0 | 1506.91 | 1544.51 | 40.84% | 59.16% | +3.93 | 28-23 |
| 2021-06-06 | @ San Diego Padres | W 6-2 | 1510.84 | 1540.58 | 41.94% | 58.06% | +3.86 | 29-23 |
| 2021-06-08 | @ Baltimore Orioles | L 3-10 | 1514.70 | 1449.64 | 55.49% | 44.51% | -4.88 | 29-24 |
| 2021-06-09 | @ Baltimore Orioles | W 14-1 | 1509.82 | 1454.51 | 54.10% | 45.90% | +5.50 | 30-24 |
| 2021-06-11 | San Diego Padres | W 3-2 | 1515.32 | 1532.87 | 51.33% | 48.67% | +1.61 | 31-24 |
| 2021-06-12 | San Diego Padres | W 4-1 | 1516.93 | 1531.25 | 51.79% | 48.21% | +2.77 | 32-24 |
| 2021-06-13 | San Diego Padres | L 3-7 | 1519.70 | 1528.48 | 52.59% | 47.41% | -3.49 | 32-25 |
| 2021-06-14 | Chicago Cubs | W 5-2 | 1516.21 | 1536.86 | 50.88% | 49.12% | +2.83 | 33-25 |
| 2021-06-15 | Chicago Cubs | W 3-2 | 1519.04 | 1534.04 | 51.69% | 48.31% | +1.60 | 34-25 |
| 2021-06-16 | Chicago Cubs | W 6-3 | 1520.64 | 1532.44 | 52.16% | 47.84% | +2.75 | 35-25 |
| 2021-06-17 | Chicago Cubs | L 0-2 | 1523.39 | 1529.68 | 52.95% | 47.05% | -2.48 | 35-26 |
| 2021-06-18 | @ Washington Nationals | L 0-1 | 1520.91 | 1495.94 | 49.74% | 50.26% | -1.65 | 35-27 |
| 2021-06-19 | @ Washington Nationals | W 5-1 | 1519.26 | 1497.59 | 49.26% | 50.74% | +3.36 | 36-27 |
| 2021-06-19 | @ Washington Nationals | L 2-6 | 1522.62 | 1494.22 | 50.23% | 49.77% | -3.33 | 36-28 |
| 2021-06-20 | @ Washington Nationals | L 2-5 | 1519.29 | 1497.55 | 49.27% | 50.73% | -2.84 | 36-29 |
| 2021-06-21 | Atlanta Braves | W 4-2 | 1516.45 | 1508.39 | 55.00% | 45.00% | +2.12 | 37-29 |
| 2021-06-21 | Atlanta Braves | L 0-1 | 1518.57 | 1506.28 | 55.60% | 44.40% | -1.85 | 37-30 |
| 2021-06-22 | Atlanta Braves | L 0-3 | 1516.72 | 1508.12 | 55.07% | 44.93% | -3.16 | 37-31 |
| 2021-06-23 | Atlanta Braves | W 7-3 | 1513.56 | 1511.29 | 54.17% | 45.83% | +3.04 | 38-31 |
| 2021-06-25 | Philadelphia Phillies | W 2-1 | 1516.60 | 1491.65 | 57.39% | 42.61% | +1.00 | 39-31 |
| 2021-06-25 | Philadelphia Phillies | L 1-2 | 1517.60 | 1490.65 | 57.67% | 42.33% | -1.36 | 39-32 |
| 2021-06-26 | Philadelphia Phillies | W 4-3 | 1516.24 | 1492.01 | 57.29% | 42.71% | +1.42 | 40-32 |
| 2021-06-27 | Philadelphia Phillies | L 2-4 | 1517.66 | 1490.59 | 57.69% | 42.31% | -2.71 | 40-33 |
| 2021-06-28 | @ Washington Nationals | L 4-8 | 1514.95 | 1504.20 | 47.69% | 52.31% | -3.16 | 40-34 |
| 2021-06-29 | @ Atlanta Braves | W 4-3 | 1511.79 | 1508.43 | 46.63% | 53.37% | +1.77 | 41-34 |
| 2021-06-30 | @ Atlanta Braves | L 2-20 | 1513.56 | 1506.66 | 47.14% | 52.86% | -6.64 | 41-35 |
| 2021-07-01 | @ Atlanta Braves | L 3-4 | 1506.92 | 1513.30 | 45.24% | 54.76% | -1.50 | 41-36 |
| 2021-07-03 | @ New York Yankees | W 8-3 | 1505.42 | 1512.87 | 45.09% | 54.91% | +4.07 | 42-36 |
| 2021-07-04 | @ New York Yankees | W 10-5 | 1509.49 | 1508.79 | 46.25% | 53.75% | +3.99 | 43-36 |
| 2021-07-04 | @ New York Yankees | L 2-4 | 1513.48 | 1504.80 | 47.40% | 52.60% | -2.22 | 43-37 |
| 2021-07-05 | Milwaukee Brewers | W 4-2 | 1511.26 | 1531.52 | 50.94% | 49.06% | +2.30 | 44-37 |
| 2021-07-07 | Milwaukee Brewers | W 4-3 | 1513.56 | 1529.22 | 51.60% | 48.40% | +1.14 | 45-37 |
| 2021-07-07 | Milwaukee Brewers | L 0-5 | 1514.70 | 1528.08 | 51.93% | 48.07% | -3.86 | 45-38 |
| 2021-07-09 | Pittsburgh Pirates | W 13-4 | 1510.84 | 1428.60 | 65.19% | 34.81% | +3.47 | 46-38 |
| 2021-07-10 | Pittsburgh Pirates | L 2-6 | 1514.31 | 1425.14 | 66.09% | 33.91% | -4.39 | 46-39 |
| 2021-07-10 | Pittsburgh Pirates | W 4-2 | 1509.92 | 1429.53 | 64.95% | 35.05% | +1.65 | 47-39 |
| 2021-07-11 | Pittsburgh Pirates | L 5-6 | 1511.57 | 1427.88 | 65.38% | 34.62% | -2.17 | 47-40 |
| 2021-07-16 | @ Pittsburgh Pirates | L 1-4 | 1509.40 | 1430.05 | 57.51% | 42.49% | -3.31 | 47-41 |
| 2021-07-17 | @ Pittsburgh Pirates | L 7-9 | 1506.09 | 1433.36 | 56.57% | 43.43% | -2.66 | 47-42 |
| 2021-07-18 | @ Pittsburgh Pirates | W 7-6 | 1503.43 | 1436.01 | 55.82% | 44.18% | +1.47 | 48-42 |
| 2021-07-19 | @ Cincinnati Reds | W 15-11 | 1504.90 | 1498.41 | 47.08% | 52.92% | +2.48 | 49-42 |
| 2021-07-20 | @ Cincinnati Reds | L 3-4 | 1507.38 | 1495.93 | 47.80% | 52.20% | -1.58 | 49-43 |
| 2021-07-21 | @ Cincinnati Reds | W 7-0 | 1505.80 | 1497.51 | 47.34% | 52.66% | +4.62 | 50-43 |
| 2021-07-23 | Toronto Blue Jays | W 3-0 | 1510.42 | 1531.53 | 50.82% | 49.18% | +2.83 | 51-43 |
| 2021-07-24 | Toronto Blue Jays | L 3-10 | 1513.25 | 1528.70 | 51.63% | 48.37% | -4.53 | 51-44 |
| 2021-07-25 | Toronto Blue Jays | W 5-4 | 1508.72 | 1533.23 | 50.33% | 49.67% | +1.64 | 52-44 |
| 2021-07-26 | Atlanta Braves | L 0-2 | 1510.36 | 1519.55 | 52.53% | 47.47% | -2.46 | 52-45 |
| 2021-07-26 | Atlanta Braves | W 1-0 | 1507.90 | 1522.01 | 51.82% | 48.18% | +1.60 | 53-45 |
| 2021-07-27 | Atlanta Braves | L 5-12 | 1509.50 | 1520.41 | 52.28% | 47.72% | -4.59 | 53-46 |
| 2021-07-28 | Atlanta Braves | W 2-1 | 1504.91 | 1525.01 | 50.96% | 49.04% | +1.62 | 54-46 |
| 2021-07-29 | Atlanta Braves | L 3-6 | 1506.53 | 1523.38 | 51.43% | 48.57% | -2.95 | 54-47 |
| 2021-07-30 | Cincinnati Reds | L 2-6 | 1503.58 | 1501.63 | 54.12% | 45.88% | -3.60 | 54-48 |
| 2021-07-31 | Cincinnati Reds | W 5-4 | 1499.98 | 1505.23 | 53.10% | 46.90% | +1.10 | 55-48 |
| 2021-08-01 | Cincinnati Reds | L 1-7 | 1501.08 | 1504.13 | 53.41% | 46.59% | -4.34 | 55-49 |
| 2021-08-02 | @ Miami Marlins | L 3-6 | 1496.74 | 1477.27 | 48.95% | 51.05% | -2.82 | 55-50 |
| 2021-08-03 | @ Miami Marlins | L 4-5 | 1493.92 | 1480.08 | 48.14% | 51.86% | -1.59 | 55-51 |
| 2021-08-04 | @ Miami Marlins | W 5-3 | 1492.33 | 1481.68 | 47.68% | 52.32% | +2.45 | 56-51 |
| 2021-08-05 | @ Miami Marlins | L 2-4 | 1494.78 | 1479.22 | 48.39% | 51.61% | -2.27 | 56-52 |
| 2021-08-06 | @ Philadelphia Phillies | L 2-4 | 1492.51 | 1502.09 | 44.79% | 55.21% | -2.10 | 56-53 |
| 2021-08-07 | @ Philadelphia Phillies | L 3-5 | 1490.41 | 1504.19 | 44.19% | 55.81% | -2.08 | 56-54 |
| 2021-08-08 | @ Philadelphia Phillies | L 0-3 | 1488.33 | 1506.27 | 43.60% | 56.40% | -2.50 | 56-55 |
| 2021-08-10 | Washington Nationals | W 8-7 | 1485.83 | 1480.69 | 54.58% | 45.42% | +1.50 | 57-55 |
| 2021-08-12 | Washington Nationals | W 4-1 | 1487.33 | 1479.18 | 55.01% | 44.99% | +2.59 | 58-55 |
| 2021-08-12 | Washington Nationals | W 5-4 | 1489.92 | 1476.60 | 55.75% | 44.25% | +1.47 | 59-55 |
| 2021-08-13 | Los Angeles Dodgers | L 5-6 | 1491.39 | 1596.61 | 38.90% | 61.10% | -0.91 | 59-56 |
| 2021-08-14 | Los Angeles Dodgers | L 1-2 | 1490.48 | 1597.52 | 38.65% | 61.35% | -0.91 | 59-57 |
| 2021-08-15 | Los Angeles Dodgers | L 4-14 | 1489.57 | 1598.43 | 38.40% | 61.60% | -4.03 | 59-58 |
| 2021-08-16 | @ San Francisco Giants | L 5-7 | 1485.54 | 1566.11 | 35.02% | 64.98% | -1.65 | 59-59 |
| 2021-08-17 | @ San Francisco Giants | L 2-3 | 1483.89 | 1567.76 | 34.59% | 65.41% | -1.14 | 59-60 |
| 2021-08-18 | @ San Francisco Giants | W 6-2 | 1482.75 | 1568.90 | 34.30% | 65.70% | +3.08 | 60-60 |
| 2021-08-19 | @ Los Angeles Dodgers | L 1-4 | 1485.83 | 1606.10 | 30.02% | 69.98% | -1.73 | 60-61 |
| 2021-08-20 | @ Los Angeles Dodgers | L 2-3 | 1484.10 | 1607.83 | 29.60% | 70.40% | -0.98 | 60-62 |
| 2021-08-21 | @ Los Angeles Dodgers | L 3-4 | 1483.12 | 1608.81 | 29.37% | 70.63% | -0.97 | 60-63 |
| 2021-08-22 | @ Los Angeles Dodgers | W 7-2 | 1482.15 | 1609.79 | 29.13% | 70.87% | +5.26 | 61-63 |
| 2021-08-24 | San Francisco Giants | L 0-8 | 1487.41 | 1566.33 | 42.55% | 57.45% | -4.00 | 61-64 |
| 2021-08-25 | San Francisco Giants | L 2-3 | 1483.41 | 1570.33 | 41.43% | 58.57% | -1.37 | 61-65 |
| 2021-08-26 | San Francisco Giants | L 2-3 | 1482.04 | 1571.70 | 41.05% | 58.95% | -1.37 | 61-66 |
| 2021-08-27 | Washington Nationals | L 1-2 | 1480.67 | 1474.23 | 54.77% | 45.23% | -1.81 | 61-67 |
| 2021-08-28 | Washington Nationals | W 5-3 | 1478.86 | 1476.05 | 54.25% | 45.75% | +2.14 | 62-67 |
| 2021-08-29 | Washington Nationals | W 9-4 | 1481.00 | 1473.90 | 54.86% | 45.14% | +3.35 | 63-67 |
| 2021-08-31 | Miami Marlins | W 6-5 | 1484.35 | 1463.32 | 56.84% | 43.16% | +1.44 | 64-67 |
| 2021-08-31 | Miami Marlins | W 3-1 | 1485.79 | 1461.89 | 57.24% | 42.76% | +2.01 | 65-67 |
| 2021-09-02 | Miami Marlins | W 4-3 | 1487.80 | 1459.88 | 57.81% | 42.19% | +1.40 | 66-67 |
| 2021-09-03 | @ Washington Nationals | W 6-2 | 1489.20 | 1462.07 | 50.05% | 49.95% | +2.34 | 67-67 |
| 2021-09-04 | @ Washington Nationals | W 11-9 | 1491.54 | 1459.73 | 50.72% | 49.28% | +1.64 | 68-67 |
| 2021-09-04 | @ Washington Nationals | L 3-4 | 1493.18 | 1458.09 | 51.20% | 48.80% | -1.70 | 68-68 |
| 2021-09-05 | @ Washington Nationals | W 13-6 | 1491.48 | 1459.79 | 50.71% | 49.29% | +4.33 | 69-68 |
| 2021-09-06 | @ Washington Nationals | L 3-4 | 1495.81 | 1455.46 | 51.95% | 48.05% | -1.73 | 69-69 |
| 2021-09-07 | @ Miami Marlins | W 9-4 | 1494.08 | 1463.69 | 50.52% | 49.48% | +3.68 | 70-69 |
| 2021-09-08 | @ Miami Marlins | L 1-2 | 1497.76 | 1460.02 | 51.58% | 48.42% | -1.22 | 70-70 |
| 2021-09-09 | @ Miami Marlins | L 2-3 | 1496.54 | 1461.23 | 51.23% | 48.77% | -1.70 | 70-71 |
| 2021-09-10 | New York Yankees | W 10-3 | 1494.84 | 1533.64 | 48.27% | 51.73% | +4.55 | 71-71 |
| 2021-09-11 | New York Yankees | L 7-8 | 1499.39 | 1529.09 | 49.58% | 50.42% | -1.65 | 71-72 |
| 2021-09-12 | New York Yankees | W 7-6 | 1497.74 | 1530.74 | 49.11% | 50.89% | +1.69 | 72-72 |
| 2021-09-13 | St. Louis Cardinals | L 0-7 | 1499.43 | 1497.45 | 54.13% | 45.87% | -4.75 | 72-73 |
| 2021-09-14 | St. Louis Cardinals | L 6-7 | 1494.68 | 1502.21 | 52.77% | 47.23% | -1.24 | 72-74 |
| 2021-09-15 | St. Louis Cardinals | L 4-11 | 1493.44 | 1503.45 | 52.41% | 47.59% | -4.61 | 72-75 |
| 2021-09-17 | Philadelphia Phillies | L 3-4 | 1488.83 | 1497.49 | 52.61% | 47.39% | -1.74 | 72-76 |
| 2021-09-18 | Philadelphia Phillies | L 3-5 | 1487.09 | 1499.23 | 52.11% | 47.89% | -2.45 | 72-77 |
| 2021-09-19 | Philadelphia Phillies | W 3-2 | 1484.64 | 1501.68 | 51.40% | 48.60% | +1.61 | 73-77 |
| 2021-09-21 | @ Boston Red Sox | L 3-6 | 1486.25 | 1527.92 | 40.28% | 59.72% | -2.31 | 73-78 |
| 2021-09-22 | @ Boston Red Sox | L 5-12 | 1483.94 | 1530.24 | 39.64% | 60.36% | -3.48 | 73-79 |
| 2021-09-24 | @ Milwaukee Brewers | L 1-5 | 1480.46 | 1546.75 | 36.92% | 63.08% | -2.45 | 73-80 |
| 2021-09-25 | @ Milwaukee Brewers | L 1-2 | 1478.01 | 1549.20 | 36.26% | 63.74% | -1.21 | 73-81 |
| 2021-09-26 | @ Milwaukee Brewers | L 4-8 | 1476.80 | 1550.41 | 35.94% | 64.06% | -2.38 | 73-82 |
| 2021-09-28 | Miami Marlins | W 5-2 | 1474.42 | 1447.76 | 57.63% | 42.37% | +2.43 | 74-82 |
| 2021-09-28 | Miami Marlins | W 2-1 | 1476.85 | 1445.33 | 58.31% | 41.69% | +0.98 | 75-82 |
| 2021-09-29 | Miami Marlins | L 2-3 | 1477.83 | 1444.35 | 58.59% | 41.41% | -1.94 | 75-83 |
| 2021-09-30 | Miami Marlins | W 12-3 | 1475.89 | 1446.29 | 58.04% | 41.96% | +4.17 | 76-83 |
| 2021-10-01 | @ Atlanta Braves | W 4-3 | 1480.06 | 1564.75 | 34.49% | 65.51% | +2.18 | 77-83 |
| 2021-10-02 | @ Atlanta Braves | L 5-6 | 1482.24 | 1562.58 | 35.05% | 64.95% | -1.16 | 77-84 |
| 2021-10-03 | @ Atlanta Braves | L 0-5 | 1481.08 | 1563.74 | 34.75% | 65.25% | -2.58 | 77-85 |
| 2021-04-01 | Toronto Blue Jays | L 2-3 | 1528.75 | 1493.89 | 58.78% | 41.22% | -1.38 | 0-1 |
| 2021-04-03 | Toronto Blue Jays | W 5-3 | 1527.37 | 1495.27 | 58.39% | 41.61% | +1.95 | 1-1 |
| 2021-04-04 | Toronto Blue Jays | L 1-3 | 1529.32 | 1493.32 | 58.94% | 41.06% | -2.77 | 1-2 |
| 2021-04-05 | Baltimore Orioles | W 7-0 | 1526.55 | 1488.07 | 59.28% | 40.72% | +3.58 | 2-2 |
| 2021-04-06 | Baltimore Orioles | W 7-2 | 1530.13 | 1484.49 | 60.27% | 39.73% | +2.95 | 3-2 |
| 2021-04-07 | Baltimore Orioles | L 3-4 | 1533.08 | 1481.54 | 61.08% | 38.92% | -1.44 | 3-3 |
| 2021-04-09 | @ Tampa Bay Rays | L 5-10 | 1531.64 | 1519.05 | 47.96% | 52.04% | -3.56 | 3-4 |
| 2021-04-10 | @ Tampa Bay Rays | L 0-4 | 1528.08 | 1522.61 | 46.94% | 53.06% | -3.11 | 3-5 |
| 2021-04-11 | @ Tampa Bay Rays | W 8-4 | 1524.97 | 1525.72 | 46.05% | 53.95% | +2.53 | 4-5 |
| 2021-04-12 | @ Toronto Blue Jays | W 3-1 | 1527.50 | 1495.20 | 54.63% | 45.37% | +2.13 | 5-5 |
| 2021-04-13 | @ Toronto Blue Jays | L 3-7 | 1529.63 | 1493.07 | 55.24% | 44.76% | -3.67 | 5-6 |
| 2021-04-14 | @ Toronto Blue Jays | L 4-5 | 1525.96 | 1496.74 | 54.20% | 45.80% | -1.80 | 5-7 |
| 2021-04-16 | Tampa Bay Rays | L 2-8 | 1524.16 | 1513.72 | 55.34% | 44.66% | -4.50 | 5-8 |
| 2021-04-17 | Tampa Bay Rays | L 3-6 | 1519.66 | 1518.22 | 54.05% | 45.95% | -3.10 | 5-9 |
| 2021-04-18 | Tampa Bay Rays | L 2-4 | 1516.56 | 1521.33 | 53.16% | 46.84% | -2.50 | 5-10 |
| 2021-04-20 | Atlanta Braves | W 3-1 | 1514.06 | 1520.33 | 52.95% | 47.05% | +2.21 | 6-10 |
| 2021-04-21 | Atlanta Braves | L 1-4 | 1516.27 | 1518.12 | 53.58% | 46.42% | -3.08 | 6-11 |
| 2021-04-22 | @ Cleveland Indians | W 6-3 | 1513.19 | 1508.49 | 46.83% | 53.17% | +3.05 | 7-11 |
| 2021-04-23 | @ Cleveland Indians | W 5-3 | 1516.24 | 1505.43 | 47.70% | 52.30% | +2.46 | 8-11 |
| 2021-04-24 | @ Cleveland Indians | W 2-1 | 1518.70 | 1502.97 | 48.41% | 51.59% | +1.71 | 9-11 |
| 2021-04-25 | @ Cleveland Indians | L 3-7 | 1520.41 | 1501.26 | 48.90% | 51.10% | -3.24 | 9-12 |
| 2021-04-26 | @ Baltimore Orioles | L 2-4 | 1517.17 | 1475.26 | 52.17% | 47.83% | -2.45 | 9-13 |
| 2021-04-27 | @ Baltimore Orioles | W 5-1 | 1514.72 | 1477.71 | 51.47% | 48.53% | +3.22 | 10-13 |
| 2021-04-28 | @ Baltimore Orioles | W 7-0 | 1517.94 | 1474.49 | 52.40% | 47.60% | +4.18 | 11-13 |
| 2021-04-29 | @ Baltimore Orioles | L 3-4 | 1522.12 | 1470.31 | 53.60% | 46.40% | -1.26 | 11-14 |
| 2021-04-30 | Detroit Tigers | W 10-0 | 1520.86 | 1433.72 | 65.83% | 34.17% | +3.59 | 12-14 |
| 2021-05-01 | Detroit Tigers | W 6-4 | 1524.45 | 1430.14 | 66.75% | 33.25% | +1.56 | 13-14 |
| 2021-05-02 | Detroit Tigers | W 2-0 | 1526.01 | 1428.58 | 67.15% | 32.85% | +1.54 | 14-14 |
| 2021-05-04 | Houston Astros | W 7-3 | 1527.55 | 1532.35 | 53.16% | 46.84% | +3.11 | 15-14 |
| 2021-05-05 | Houston Astros | W 6-3 | 1530.66 | 1529.24 | 54.05% | 45.95% | +2.64 | 16-14 |
| 2021-05-06 | Houston Astros | L 4-7 | 1533.30 | 1526.60 | 54.80% | 45.20% | -3.15 | 16-15 |
| 2021-05-07 | Washington Nationals | L 4-11 | 1530.15 | 1496.07 | 58.67% | 41.33% | -5.15 | 16-16 |
| 2021-05-08 | Washington Nationals | W 4-3 | 1525.00 | 1501.22 | 57.23% | 42.77% | +1.00 | 17-16 |
| 2021-05-09 | Washington Nationals | W 3-2 | 1526.00 | 1500.22 | 57.51% | 42.49% | +1.41 | 18-16 |
| 2021-05-11 | @ Tampa Bay Rays | W 3-1 | 1527.41 | 1530.45 | 45.72% | 54.28% | +2.55 | 19-16 |
| 2021-05-12 | @ Tampa Bay Rays | W 1-0 | 1529.96 | 1527.90 | 46.45% | 53.55% | +1.78 | 20-16 |
| 2021-05-13 | @ Tampa Bay Rays | L 1-9 | 1531.74 | 1526.12 | 46.96% | 53.04% | -4.41 | 20-17 |
| 2021-05-14 | @ Baltimore Orioles | W 5-4 | 1527.33 | 1470.13 | 54.37% | 45.63% | +1.52 | 21-17 |
| 2021-05-15 | @ Baltimore Orioles | W 8-2 | 1528.85 | 1468.61 | 54.80% | 45.20% | +3.67 | 22-17 |
| 2021-05-16 | @ Baltimore Orioles | L 6-10 | 1532.52 | 1464.94 | 55.85% | 44.15% | -3.71 | 22-18 |
| 2021-05-17 | @ Texas Rangers | L 2-5 | 1528.81 | 1464.86 | 55.33% | 44.67% | -3.18 | 22-19 |
| 2021-05-18 | @ Texas Rangers | W 7-4 | 1525.63 | 1468.04 | 54.42% | 45.58% | +2.62 | 23-19 |
| 2021-05-19 | @ Texas Rangers | W 2-0 | 1528.25 | 1465.42 | 55.17% | 44.83% | +2.11 | 24-19 |
| 2021-05-20 | @ Texas Rangers | W 2-0 | 1530.36 | 1463.31 | 55.77% | 44.23% | +2.08 | 25-19 |
| 2021-05-21 | Chicago White Sox | W 2-1 | 1532.44 | 1536.17 | 53.31% | 46.69% | +1.55 | 26-19 |
| 2021-05-22 | Chicago White Sox | W 7-0 | 1533.99 | 1534.62 | 53.76% | 46.24% | +4.06 | 27-19 |
| 2021-05-23 | Chicago White Sox | W 5-4 | 1538.05 | 1530.55 | 54.92% | 45.08% | +1.49 | 28-19 |
| 2021-05-25 | Toronto Blue Jays | L 2-6 | 1539.54 | 1513.25 | 57.58% | 42.42% | -3.82 | 28-20 |
| 2021-05-27 | Toronto Blue Jays | L 0-2 | 1535.72 | 1517.08 | 56.50% | 43.50% | -2.65 | 28-21 |
| 2021-05-27 | Toronto Blue Jays | W 5-3 | 1533.07 | 1519.73 | 55.75% | 44.25% | +2.08 | 29-21 |
| 2021-05-28 | @ Detroit Tigers | L 2-3 | 1535.15 | 1434.14 | 60.52% | 39.48% | -1.43 | 29-22 |
| 2021-05-29 | @ Detroit Tigers | L 1-6 | 1533.72 | 1435.56 | 60.13% | 39.87% | -4.46 | 29-23 |
| 2021-05-30 | @ Detroit Tigers | L 2-6 | 1529.26 | 1440.03 | 58.89% | 41.11% | -3.91 | 29-24 |
| 2021-05-31 | Tampa Bay Rays | L 1-3 | 1525.35 | 1562.70 | 48.48% | 51.52% | -2.28 | 29-25 |
| 2021-06-01 | Tampa Bay Rays | W 5-3 | 1523.07 | 1564.97 | 47.83% | 52.17% | +1.74 | 30-25 |
| 2021-06-02 | Tampa Bay Rays | W 4-3 | 1524.81 | 1563.24 | 48.32% | 51.68% | +1.71 | 31-25 |
| 2021-06-03 | Tampa Bay Rays | L 2-9 | 1526.52 | 1561.52 | 48.82% | 51.18% | -4.29 | 31-26 |
| 2021-06-04 | Boston Red Sox | L 2-5 | 1522.23 | 1521.47 | 53.96% | 46.04% | -3.10 | 31-27 |
| 2021-06-05 | Boston Red Sox | L 3-7 | 1519.13 | 1524.57 | 53.07% | 46.93% | -3.52 | 31-28 |
| 2021-06-06 | Boston Red Sox | L 5-6 | 1515.61 | 1528.09 | 52.06% | 47.94% | -1.22 | 31-29 |
| 2021-06-08 | @ Minnesota Twins | W 8-4 | 1514.39 | 1482.67 | 50.71% | 49.29% | +3.27 | 32-29 |
| 2021-06-09 | @ Minnesota Twins | W 9-6 | 1517.66 | 1479.39 | 51.65% | 48.35% | +2.78 | 33-29 |
| 2021-06-10 | @ Minnesota Twins | L 5-7 | 1520.44 | 1476.61 | 52.45% | 47.55% | -2.46 | 33-30 |
| 2021-06-12 | @ Philadelphia Phillies | L 7-8 | 1517.98 | 1490.20 | 50.14% | 49.86% | -1.18 | 33-31 |
| 2021-06-13 | @ Philadelphia Phillies | L 0-7 | 1516.80 | 1491.37 | 49.80% | 50.20% | -4.38 | 33-32 |
| 2021-06-15 | @ Toronto Blue Jays | W 6-5 | 1512.42 | 1528.51 | 43.86% | 56.14% | +1.87 | 34-32 |
| 2021-06-16 | @ Toronto Blue Jays | W 3-2 | 1514.29 | 1526.65 | 44.39% | 55.61% | +1.84 | 35-32 |
| 2021-06-17 | @ Toronto Blue Jays | W 8-4 | 1516.13 | 1524.80 | 44.92% | 55.08% | +3.66 | 36-32 |
| 2021-06-18 | Oakland Athletics | L 3-5 | 1519.79 | 1539.78 | 50.98% | 49.02% | -2.39 | 36-33 |
| 2021-06-19 | Oakland Athletics | W 7-5 | 1517.40 | 1542.17 | 50.29% | 49.71% | +2.33 | 37-33 |
| 2021-06-20 | Oakland Athletics | W 2-1 | 1519.73 | 1539.84 | 50.96% | 49.04% | +1.63 | 38-33 |
| 2021-06-22 | Kansas City Royals | L 5-6 | 1521.36 | 1461.61 | 62.20% | 37.80% | -2.07 | 38-34 |
| 2021-06-23 | Kansas City Royals | W 6-5 | 1519.29 | 1463.68 | 61.64% | 38.36% | +1.28 | 39-34 |
| 2021-06-24 | Kansas City Royals | W 8-1 | 1520.57 | 1462.40 | 61.99% | 38.01% | +3.34 | 40-34 |
| 2021-06-25 | @ Boston Red Sox | L 3-5 | 1523.91 | 1519.36 | 46.81% | 53.19% | -2.20 | 40-35 |
| 2021-06-26 | @ Boston Red Sox | L 2-4 | 1521.71 | 1521.55 | 46.18% | 53.82% | -2.17 | 40-36 |
| 2021-06-27 | @ Boston Red Sox | L 2-9 | 1519.54 | 1523.72 | 45.56% | 54.44% | -4.00 | 40-37 |
| 2021-06-28 | Los Angeles Angels | L 3-5 | 1515.54 | 1483.17 | 58.43% | 41.57% | -2.74 | 40-38 |
| 2021-06-29 | Los Angeles Angels | W 11-5 | 1512.80 | 1485.92 | 57.66% | 42.34% | +3.44 | 41-38 |
| 2021-06-30 | Los Angeles Angels | L 8-11 | 1516.24 | 1482.47 | 58.63% | 41.37% | -3.37 | 41-39 |
| 2021-07-03 | New York Mets | L 3-8 | 1512.87 | 1505.42 | 54.91% | 45.09% | -4.08 | 41-40 |
| 2021-07-04 | New York Mets | L 5-10 | 1508.79 | 1509.49 | 53.75% | 46.25% | -3.99 | 41-41 |
| 2021-07-04 | New York Mets | W 4-2 | 1504.80 | 1513.48 | 52.60% | 47.40% | +2.23 | 42-41 |
| 2021-07-06 | @ Seattle Mariners | W 12-1 | 1507.03 | 1483.45 | 49.54% | 50.46% | +5.55 | 43-41 |
| 2021-07-07 | @ Seattle Mariners | W 5-4 | 1512.58 | 1477.89 | 51.14% | 48.86% | +1.63 | 44-41 |
| 2021-07-08 | @ Seattle Mariners | L 0-4 | 1514.21 | 1476.27 | 51.61% | 48.39% | -3.43 | 44-42 |
| 2021-07-09 | @ Houston Astros | W 4-0 | 1510.78 | 1575.82 | 37.09% | 62.91% | +4.18 | 45-42 |
| 2021-07-10 | @ Houston Astros | W 1-0 | 1514.96 | 1571.64 | 38.21% | 61.79% | +2.05 | 46-42 |
| 2021-07-11 | @ Houston Astros | L 7-8 | 1517.01 | 1569.59 | 38.77% | 61.23% | -1.29 | 46-43 |
| 2021-07-16 | Boston Red Sox | L 0-4 | 1515.72 | 1531.13 | 51.64% | 48.36% | -3.43 | 46-44 |
| 2021-07-17 | Boston Red Sox | W 3-1 | 1512.29 | 1534.56 | 50.65% | 49.35% | +2.32 | 47-44 |
| 2021-07-18 | Boston Red Sox | W 9-1 | 1514.61 | 1532.24 | 51.32% | 48.68% | +4.57 | 48-44 |
| 2021-07-20 | Philadelphia Phillies | W 6-4 | 1519.18 | 1503.19 | 56.12% | 43.88% | +2.06 | 49-44 |
| 2021-07-21 | Philadelphia Phillies | W 6-5 | 1521.24 | 1501.13 | 56.71% | 43.29% | +1.02 | 50-44 |
| 2021-07-22 | @ Boston Red Sox | L 4-5 | 1522.26 | 1536.32 | 44.15% | 55.85% | -1.04 | 50-45 |
| 2021-07-23 | @ Boston Red Sox | L 2-6 | 1521.22 | 1537.36 | 43.86% | 56.14% | -2.91 | 50-46 |
| 2021-07-24 | @ Boston Red Sox | W 4-3 | 1518.31 | 1540.27 | 43.03% | 56.97% | +1.89 | 51-46 |
| 2021-07-25 | @ Boston Red Sox | L 4-5 | 1520.20 | 1538.38 | 43.57% | 56.43% | -1.45 | 51-47 |
| 2021-07-27 | @ Tampa Bay Rays | W 4-3 | 1518.75 | 1565.46 | 39.58% | 60.42% | +2.01 | 52-47 |
| 2021-07-28 | @ Tampa Bay Rays | W 3-1 | 1520.76 | 1563.45 | 40.13% | 59.87% | +1.99 | 53-47 |
| 2021-07-29 | @ Tampa Bay Rays | L 0-14 | 1522.75 | 1561.46 | 40.68% | 59.32% | -5.06 | 53-48 |
| 2021-07-30 | @ Miami Marlins | W 3-1 | 1517.69 | 1484.08 | 50.98% | 49.02% | +2.30 | 54-48 |
| 2021-07-31 | @ Miami Marlins | W 4-2 | 1519.99 | 1481.78 | 51.65% | 48.35% | +2.28 | 55-48 |
| 2021-08-01 | @ Miami Marlins | W 3-1 | 1522.27 | 1479.51 | 52.30% | 47.70% | +2.24 | 56-48 |
| 2021-08-02 | Baltimore Orioles | L 1-7 | 1524.51 | 1434.61 | 66.19% | 33.81% | -5.39 | 56-49 |
| 2021-08-03 | Baltimore Orioles | W 13-1 | 1519.12 | 1439.99 | 64.79% | 35.21% | +4.05 | 57-49 |
| 2021-08-04 | Baltimore Orioles | W 10-3 | 1523.17 | 1435.94 | 65.84% | 34.16% | +3.00 | 58-49 |
| 2021-08-05 | Seattle Mariners | W 5-3 | 1526.17 | 1489.59 | 59.02% | 40.98% | +1.93 | 59-49 |
| 2021-08-06 | Seattle Mariners | W 3-2 | 1528.10 | 1487.66 | 59.55% | 40.45% | +0.95 | 60-49 |
| 2021-08-07 | Seattle Mariners | W 5-4 | 1529.05 | 1486.72 | 59.82% | 40.18% | +1.33 | 61-49 |
| 2021-08-08 | Seattle Mariners | L 0-2 | 1530.38 | 1485.38 | 60.19% | 39.81% | -2.83 | 61-50 |
| 2021-08-09 | @ Kansas City Royals | W 8-6 | 1527.55 | 1446.05 | 57.81% | 42.19% | +1.41 | 62-50 |
| 2021-08-10 | @ Kansas City Royals | L 4-8 | 1528.96 | 1444.64 | 58.20% | 41.80% | -3.87 | 62-51 |
| 2021-08-11 | @ Kansas City Royals | W 5-2 | 1525.09 | 1448.51 | 57.12% | 42.88% | +2.47 | 63-51 |
| 2021-08-12 | @ Chicago White Sox | L 8-9 | 1527.56 | 1541.10 | 48.05% | 51.95% | -1.60 | 63-52 |
| 2021-08-14 | @ Chicago White Sox | W 7-5 | 1525.96 | 1542.70 | 43.77% | 56.23% | +1.87 | 64-52 |
| 2021-08-15 | @ Chicago White Sox | W 5-3 | 1527.83 | 1540.83 | 44.30% | 55.70% | +2.61 | 65-52 |
| 2021-08-16 | Los Angeles Angels | W 2-1 | 1530.44 | 1476.60 | 61.40% | 38.60% | +1.28 | 66-52 |
| 2021-08-17 | Boston Red Sox | W 5-3 | 1531.72 | 1525.49 | 54.74% | 45.26% | +2.13 | 67-52 |
| 2021-08-17 | Boston Red Sox | W 2-0 | 1533.85 | 1523.37 | 55.34% | 44.66% | +2.10 | 68-52 |
| 2021-08-18 | Boston Red Sox | W 5-2 | 1535.95 | 1521.27 | 55.94% | 44.06% | +2.53 | 69-52 |
| 2021-08-19 | Minnesota Twins | W 7-5 | 1538.48 | 1475.12 | 62.69% | 37.31% | +1.75 | 70-52 |
| 2021-08-20 | Minnesota Twins | W 10-2 | 1540.23 | 1473.37 | 63.16% | 36.84% | +3.46 | 71-52 |
| 2021-08-21 | Minnesota Twins | W 7-1 | 1543.69 | 1469.91 | 64.08% | 35.92% | +2.92 | 72-52 |
| 2021-08-23 | @ Atlanta Braves | W 5-1 | 1546.61 | 1555.34 | 44.91% | 55.09% | +3.66 | 73-52 |
| 2021-08-24 | @ Atlanta Braves | W 5-4 | 1550.27 | 1551.68 | 45.95% | 54.05% | +1.80 | 74-52 |
| 2021-08-26 | @ Oakland Athletics | W 7-6 | 1552.07 | 1533.41 | 48.83% | 51.17% | +1.69 | 75-52 |
| 2021-08-27 | @ Oakland Athletics | W 8-2 | 1553.76 | 1531.72 | 49.32% | 50.68% | +4.13 | 76-52 |
| 2021-08-28 | @ Oakland Athletics | L 2-3 | 1557.89 | 1527.59 | 50.51% | 49.49% | -1.68 | 76-53 |
| 2021-08-29 | @ Oakland Athletics | L 1-3 | 1556.21 | 1529.27 | 50.02% | 49.98% | -2.35 | 76-54 |
| 2021-08-30 | @ Los Angeles Angels | L 7-8 | 1553.86 | 1469.34 | 58.23% | 41.77% | -1.93 | 76-55 |
| 2021-08-31 | @ Los Angeles Angels | L 4-6 | 1551.93 | 1471.27 | 57.69% | 42.31% | -2.71 | 76-56 |
| 2021-09-01 | @ Los Angeles Angels | W 4-1 | 1549.22 | 1473.98 | 56.93% | 43.07% | +2.47 | 77-56 |
| 2021-09-03 | Baltimore Orioles | W 4-3 | 1551.69 | 1398.57 | 73.80% | 26.20% | +0.62 | 78-56 |
| 2021-09-04 | Baltimore Orioles | L 3-4 | 1552.31 | 1397.96 | 73.94% | 26.06% | -2.45 | 78-57 |
| 2021-09-05 | Baltimore Orioles | L 7-8 | 1549.86 | 1400.41 | 73.39% | 26.61% | -2.44 | 78-58 |
| 2021-09-06 | Toronto Blue Jays | L 0-8 | 1547.42 | 1549.62 | 53.53% | 46.47% | -5.03 | 78-59 |
| 2021-09-07 | Toronto Blue Jays | L 1-5 | 1542.39 | 1554.65 | 52.09% | 47.91% | -3.46 | 78-60 |
| 2021-09-08 | Toronto Blue Jays | L 3-6 | 1538.93 | 1558.11 | 51.09% | 48.91% | -2.93 | 78-61 |
| 2021-09-09 | Toronto Blue Jays | L 4-6 | 1536.00 | 1561.05 | 50.25% | 49.75% | -2.36 | 78-62 |
| 2021-09-10 | @ New York Mets | L 3-10 | 1533.64 | 1494.84 | 51.73% | 48.27% | -4.55 | 78-63 |
| 2021-09-11 | @ New York Mets | W 8-7 | 1529.09 | 1499.39 | 50.42% | 49.58% | +1.65 | 79-63 |
| 2021-09-12 | @ New York Mets | L 6-7 | 1530.74 | 1497.74 | 50.89% | 49.11% | -1.69 | 79-64 |
| 2021-09-13 | Minnesota Twins | W 6-5 | 1529.05 | 1467.84 | 62.40% | 37.60% | +0.88 | 80-64 |
| 2021-09-14 | @ Baltimore Orioles | W 7-2 | 1529.93 | 1398.53 | 64.62% | 35.38% | +2.63 | 81-64 |
| 2021-09-15 | @ Baltimore Orioles | W 4-3 | 1532.56 | 1395.90 | 65.31% | 34.69% | +1.15 | 82-64 |
| 2021-09-16 | @ Baltimore Orioles | L 2-3 | 1533.71 | 1394.75 | 65.61% | 34.39% | -1.54 | 82-65 |
| 2021-09-17 | Cleveland Indians | W 8-0 | 1532.17 | 1490.88 | 59.67% | 40.33% | +3.79 | 83-65 |
| 2021-09-18 | Cleveland Indians | L 3-11 | 1535.96 | 1487.09 | 60.72% | 39.28% | -5.70 | 83-66 |
| 2021-09-19 | Cleveland Indians | L 1-11 | 1530.26 | 1492.80 | 59.14% | 40.86% | -6.21 | 83-67 |
| 2021-09-20 | Texas Rangers | W 4-3 | 1524.05 | 1421.74 | 67.77% | 32.23% | +1.07 | 84-67 |
| 2021-09-21 | Texas Rangers | W 7-1 | 1525.12 | 1420.67 | 68.04% | 31.96% | +2.60 | 85-67 |
| 2021-09-22 | Texas Rangers | W 7-3 | 1527.72 | 1418.07 | 68.68% | 31.32% | +2.08 | 86-67 |
| 2021-09-24 | @ Boston Red Sox | W 8-3 | 1529.80 | 1533.72 | 45.59% | 54.41% | +4.03 | 87-67 |
| 2021-09-25 | @ Boston Red Sox | W 5-3 | 1533.83 | 1529.68 | 46.75% | 53.25% | +2.50 | 88-67 |
| 2021-09-26 | @ Boston Red Sox | W 6-3 | 1536.33 | 1527.18 | 47.47% | 52.53% | +3.03 | 89-67 |
| 2021-09-28 | @ Toronto Blue Jays | W 7-2 | 1539.36 | 1566.65 | 42.28% | 57.72% | +4.28 | 90-67 |
| 2021-09-29 | @ Toronto Blue Jays | L 5-6 | 1543.64 | 1562.36 | 43.49% | 56.51% | -1.44 | 90-68 |
| 2021-09-30 | @ Toronto Blue Jays | W 6-2 | 1542.20 | 1563.81 | 43.08% | 56.92% | +3.78 | 91-68 |
| 2021-10-01 | Tampa Bay Rays | L 3-4 | 1545.98 | 1591.42 | 47.32% | 52.68% | -1.58 | 91-69 |
| 2021-10-02 | Tampa Bay Rays | L 2-12 | 1544.40 | 1592.99 | 46.87% | 53.13% | -4.92 | 91-70 |
| 2021-10-03 | Tampa Bay Rays | W 1-0 | 1539.48 | 1597.91 | 45.46% | 54.54% | +1.82 | 92-70 |
| 2021-04-01 | Houston Astros | L 1-8 | 1520.32 | 1527.09 | 52.88% | 47.12% | -4.65 | 0-1 |
| 2021-04-02 | Houston Astros | L 5-9 | 1515.67 | 1531.73 | 51.54% | 48.46% | -3.42 | 0-2 |
| 2021-04-03 | Houston Astros | L 1-9 | 1512.25 | 1535.16 | 50.56% | 49.44% | -4.75 | 0-3 |
| 2021-04-04 | Houston Astros | L 2-9 | 1507.50 | 1539.90 | 49.19% | 50.81% | -4.32 | 0-4 |
| 2021-04-05 | Los Angeles Dodgers | L 3-10 | 1503.18 | 1563.85 | 45.14% | 54.86% | -3.96 | 0-5 |
| 2021-04-06 | Los Angeles Dodgers | L 1-5 | 1499.22 | 1567.82 | 44.01% | 55.99% | -2.93 | 0-6 |
| 2021-04-07 | Los Angeles Dodgers | W 4-3 | 1496.29 | 1570.74 | 43.18% | 56.82% | +1.34 | 1-6 |
| 2021-04-08 | @ Houston Astros | L 2-6 | 1497.63 | 1544.61 | 39.54% | 60.46% | -2.63 | 1-7 |
| 2021-04-09 | @ Houston Astros | W 6-2 | 1495.00 | 1547.23 | 38.82% | 61.18% | +4.06 | 2-7 |
| 2021-04-10 | @ Houston Astros | W 7-3 | 1499.06 | 1543.17 | 39.94% | 60.06% | +3.99 | 3-7 |
| 2021-04-12 | @ Arizona Diamondbacks | W 9-5 | 1503.05 | 1491.55 | 47.80% | 52.20% | +3.47 | 4-7 |
| 2021-04-13 | @ Arizona Diamondbacks | W 7-5 | 1506.52 | 1488.08 | 48.80% | 51.20% | +2.40 | 5-7 |
| 2021-04-15 | Detroit Tigers | W 8-4 | 1508.92 | 1455.74 | 61.31% | 38.69% | +2.57 | 6-7 |
| 2021-04-16 | Detroit Tigers | W 3-0 | 1511.49 | 1453.17 | 62.01% | 37.99% | +2.19 | 7-7 |
| 2021-04-17 | Detroit Tigers | W 7-0 | 1513.68 | 1450.99 | 62.60% | 37.40% | +3.28 | 8-7 |
| 2021-04-18 | Detroit Tigers | W 3-2 | 1516.96 | 1447.70 | 63.48% | 36.52% | +1.21 | 9-7 |
| 2021-04-20 | Minnesota Twins | W 7-0 | 1518.17 | 1515.72 | 54.20% | 45.80% | +4.03 | 10-7 |
| 2021-04-20 | Minnesota Twins | W 1-0 | 1522.20 | 1511.70 | 55.34% | 44.66% | +1.48 | 11-7 |
| 2021-04-21 | Minnesota Twins | W 13-12 | 1523.68 | 1510.22 | 55.77% | 44.23% | +1.04 | 12-7 |
| 2021-04-23 | @ Baltimore Orioles | W 3-1 | 1524.72 | 1476.09 | 53.14% | 46.86% | +2.20 | 13-7 |
| 2021-04-24 | @ Baltimore Orioles | W 7-2 | 1526.92 | 1473.89 | 53.77% | 46.23% | +3.43 | 14-7 |
| 2021-04-25 | @ Baltimore Orioles | L 1-8 | 1530.35 | 1470.46 | 54.75% | 45.25% | -4.81 | 14-8 |
| 2021-04-26 | @ Tampa Bay Rays | W 2-1 | 1525.54 | 1526.21 | 46.06% | 53.94% | +1.79 | 15-8 |
| 2021-04-27 | @ Tampa Bay Rays | L 3-4 | 1527.33 | 1524.42 | 46.57% | 53.43% | -1.54 | 15-9 |
| 2021-04-28 | @ Tampa Bay Rays | L 0-2 | 1525.79 | 1525.97 | 46.13% | 53.87% | -2.17 | 15-10 |
| 2021-04-29 | @ Tampa Bay Rays | W 3-2 | 1523.62 | 1528.13 | 45.51% | 54.49% | +1.81 | 16-10 |
| 2021-04-30 | Baltimore Orioles | L 2-3 | 1525.43 | 1471.57 | 61.40% | 38.60% | -2.04 | 16-11 |
| 2021-05-01 | Baltimore Orioles | L 4-8 | 1523.39 | 1473.61 | 60.84% | 39.16% | -4.04 | 16-12 |
| 2021-05-02 | Baltimore Orioles | W 7-5 | 1519.35 | 1477.65 | 59.73% | 40.27% | +1.89 | 17-12 |
| 2021-05-03 | Toronto Blue Jays | W 5-4 | 1521.24 | 1508.69 | 55.64% | 44.36% | +1.47 | 18-12 |
| 2021-05-04 | Toronto Blue Jays | W 4-1 | 1522.71 | 1507.22 | 56.05% | 43.95% | +2.53 | 19-12 |
| 2021-05-05 | Toronto Blue Jays | L 4-9 | 1525.24 | 1504.69 | 56.77% | 43.23% | -4.21 | 19-13 |
| 2021-05-06 | Toronto Blue Jays | L 4-10 | 1521.03 | 1508.91 | 55.57% | 44.43% | -4.52 | 19-14 |
| 2021-05-07 | Tampa Bay Rays | W 2-1 | 1516.51 | 1533.07 | 51.47% | 48.53% | +1.61 | 20-14 |
| 2021-05-08 | Tampa Bay Rays | W 6-3 | 1518.12 | 1531.46 | 51.93% | 48.07% | +2.76 | 21-14 |
| 2021-05-09 | Tampa Bay Rays | L 3-4 | 1520.88 | 1528.70 | 52.73% | 47.27% | -1.75 | 21-15 |
| 2021-05-11 | @ Boston Red Sox | W 3-2 | 1519.13 | 1515.38 | 46.69% | 53.31% | +1.77 | 22-15 |
| 2021-05-12 | @ Boston Red Sox | W 4-1 | 1520.90 | 1513.61 | 47.20% | 52.80% | +3.04 | 23-15 |
| 2021-05-13 | @ Boston Red Sox | L 1-8 | 1523.94 | 1510.58 | 48.07% | 51.93% | -4.22 | 23-16 |
| 2021-05-14 | @ Minnesota Twins | W 6-1 | 1519.72 | 1492.64 | 50.04% | 49.96% | +3.70 | 24-16 |
| 2021-05-15 | @ Minnesota Twins | L 4-5 | 1523.42 | 1488.93 | 51.11% | 48.89% | -1.69 | 24-17 |
| 2021-05-16 | @ Minnesota Twins | W 7-6 | 1521.73 | 1490.62 | 50.62% | 49.38% | +1.64 | 25-17 |
| 2021-05-18 | Houston Astros | W 6-5 | 1523.37 | 1543.62 | 50.94% | 49.06% | +1.63 | 26-17 |
| 2021-05-19 | Houston Astros | L 1-8 | 1525.00 | 1541.99 | 51.41% | 48.59% | -4.52 | 26-18 |
| 2021-05-20 | Houston Astros | L 4-8 | 1520.48 | 1546.50 | 50.11% | 49.89% | -3.33 | 26-19 |
| 2021-05-21 | @ Los Angeles Angels | W 8-4 | 1517.15 | 1469.01 | 53.07% | 46.93% | +3.12 | 27-19 |
| 2021-05-22 | @ Los Angeles Angels | W 6-2 | 1520.27 | 1465.89 | 53.96% | 46.04% | +3.06 | 28-19 |
| 2021-05-23 | @ Los Angeles Angels | L 5-6 | 1523.33 | 1462.84 | 54.84% | 45.16% | -1.82 | 28-20 |
| 2021-05-24 | Seattle Mariners | L 2-4 | 1521.51 | 1462.28 | 62.13% | 37.87% | -2.92 | 28-21 |
| 2021-05-25 | Seattle Mariners | L 3-4 | 1518.59 | 1465.19 | 61.34% | 38.66% | -2.04 | 28-22 |
| 2021-05-26 | Seattle Mariners | W 6-3 | 1516.55 | 1467.23 | 60.78% | 39.22% | +2.26 | 29-22 |
| 2021-05-27 | Los Angeles Angels | W 5-0 | 1518.81 | 1469.97 | 60.71% | 39.29% | +2.91 | 30-22 |
| 2021-05-28 | Los Angeles Angels | W 3-1 | 1521.72 | 1467.05 | 61.51% | 38.49% | +1.81 | 31-22 |
| 2021-05-29 | Los Angeles Angels | L 0-4 | 1523.53 | 1465.24 | 62.00% | 38.00% | -4.12 | 31-23 |
| 2021-05-30 | Los Angeles Angels | L 2-4 | 1519.41 | 1469.36 | 60.88% | 39.12% | -2.85 | 31-24 |
| 2021-05-31 | @ Seattle Mariners | L 5-6 | 1516.56 | 1473.42 | 52.35% | 47.65% | -1.23 | 31-25 |
| 2021-06-01 | @ Seattle Mariners | W 12-6 | 1515.33 | 1474.65 | 52.00% | 48.00% | +3.90 | 32-25 |
| 2021-06-02 | @ Seattle Mariners | W 6-0 | 1519.23 | 1470.74 | 53.12% | 46.88% | +3.81 | 33-25 |
| 2021-06-04 | @ Colorado Rockies | W 9-5 | 1523.04 | 1462.50 | 54.84% | 45.16% | +3.00 | 34-25 |
| 2021-06-05 | @ Colorado Rockies | W 6-3 | 1526.04 | 1459.51 | 55.70% | 44.30% | +2.55 | 35-25 |
| 2021-06-06 | @ Colorado Rockies | L 1-3 | 1528.59 | 1456.96 | 56.42% | 43.58% | -2.65 | 35-26 |
| 2021-06-08 | Arizona Diamondbacks | W 5-2 | 1525.94 | 1449.63 | 64.41% | 35.59% | +2.05 | 36-26 |
| 2021-06-09 | Arizona Diamondbacks | W 4-0 | 1527.99 | 1447.59 | 64.95% | 35.05% | +2.32 | 37-26 |
| 2021-06-10 | Kansas City Royals | L 1-6 | 1530.31 | 1470.49 | 62.21% | 37.79% | -4.62 | 37-27 |
| 2021-06-11 | Kansas City Royals | W 4-3 | 1525.69 | 1475.11 | 60.95% | 39.05% | +1.30 | 38-27 |
| 2021-06-12 | Kansas City Royals | W 11-2 | 1526.99 | 1473.81 | 61.31% | 38.69% | +3.85 | 39-27 |
| 2021-06-13 | Kansas City Royals | W 6-3 | 1530.84 | 1469.96 | 62.36% | 37.64% | +2.17 | 40-27 |
| 2021-06-14 | Los Angeles Angels | W 8-5 | 1533.01 | 1491.05 | 59.76% | 40.24% | +2.31 | 41-27 |
| 2021-06-15 | Los Angeles Angels | W 6-4 | 1535.32 | 1488.74 | 60.40% | 39.60% | +1.86 | 42-27 |
| 2021-06-16 | Los Angeles Angels | W 8-4 | 1537.18 | 1486.88 | 60.91% | 39.09% | +2.60 | 43-27 |
| 2021-06-18 | @ New York Yankees | W 5-3 | 1539.78 | 1519.79 | 49.02% | 50.98% | +2.39 | 44-27 |
| 2021-06-19 | @ New York Yankees | L 5-7 | 1542.17 | 1517.40 | 49.71% | 50.29% | -2.33 | 44-28 |
| 2021-06-20 | @ New York Yankees | L 1-2 | 1539.84 | 1519.73 | 49.04% | 50.96% | -1.63 | 44-29 |
| 2021-06-21 | @ Texas Rangers | L 3-8 | 1538.21 | 1437.68 | 60.46% | 39.54% | -4.49 | 44-30 |
| 2021-06-22 | @ Texas Rangers | W 13-6 | 1533.72 | 1442.17 | 59.21% | 40.79% | +3.58 | 45-30 |
| 2021-06-23 | @ Texas Rangers | L 3-5 | 1537.30 | 1438.59 | 60.21% | 39.79% | -2.82 | 45-31 |
| 2021-06-24 | @ Texas Rangers | W 5-1 | 1534.48 | 1441.41 | 59.42% | 40.58% | +2.69 | 46-31 |
| 2021-06-25 | @ San Francisco Giants | L 0-2 | 1537.17 | 1551.24 | 44.15% | 55.85% | -2.07 | 46-32 |
| 2021-06-26 | @ San Francisco Giants | L 5-6 | 1535.10 | 1553.31 | 43.56% | 56.44% | -1.02 | 46-33 |
| 2021-06-27 | @ San Francisco Giants | W 6-2 | 1534.08 | 1554.33 | 43.27% | 56.73% | +3.76 | 47-33 |
| 2021-06-29 | Texas Rangers | L 4-5 | 1537.84 | 1449.56 | 65.98% | 34.02% | -2.19 | 47-34 |
| 2021-06-30 | Texas Rangers | W 3-1 | 1535.65 | 1451.75 | 65.41% | 34.59% | +1.63 | 48-34 |
| 2021-07-01 | Texas Rangers | L 3-8 | 1537.28 | 1450.13 | 65.83% | 34.17% | -4.89 | 48-35 |
| 2021-07-02 | Boston Red Sox | L 2-3 | 1532.39 | 1536.56 | 53.25% | 46.75% | -1.25 | 48-36 |
| 2021-07-03 | Boston Red Sox | W 7-6 | 1531.14 | 1537.81 | 52.89% | 47.11% | +1.10 | 49-36 |
| 2021-07-04 | Boston Red Sox | L 0-1 | 1532.24 | 1536.71 | 53.21% | 46.79% | -1.76 | 49-37 |
| 2021-07-06 | @ Houston Astros | L 6-9 | 1530.48 | 1574.24 | 39.99% | 60.01% | -2.30 | 49-38 |
| 2021-07-07 | @ Houston Astros | L 3-4 | 1528.18 | 1576.54 | 39.35% | 60.65% | -1.31 | 49-39 |
| 2021-07-08 | @ Houston Astros | W 2-1 | 1526.87 | 1577.84 | 38.99% | 61.01% | +2.03 | 50-39 |
| 2021-07-09 | @ Texas Rangers | L 2-3 | 1528.90 | 1452.92 | 57.03% | 42.97% | -1.90 | 50-40 |
| 2021-07-10 | @ Texas Rangers | W 8-4 | 1527.00 | 1454.81 | 56.50% | 43.50% | +2.05 | 51-40 |
| 2021-07-11 | @ Texas Rangers | W 4-1 | 1529.05 | 1452.77 | 57.08% | 42.92% | +2.46 | 52-40 |
| 2021-07-16 | Cleveland Indians | W 5-4 | 1531.51 | 1491.79 | 59.46% | 40.54% | +1.35 | 53-40 |
| 2021-07-17 | Cleveland Indians | L 2-3 | 1532.86 | 1490.44 | 59.83% | 40.17% | -1.99 | 53-41 |
| 2021-07-18 | Cleveland Indians | L 2-4 | 1530.87 | 1492.43 | 59.28% | 40.72% | -2.78 | 53-42 |
| 2021-07-19 | Los Angeles Angels | W 4-1 | 1528.09 | 1490.56 | 59.15% | 40.85% | +2.35 | 54-42 |
| 2021-07-20 | Los Angeles Angels | W 6-0 | 1530.44 | 1488.21 | 59.80% | 40.20% | +3.27 | 55-42 |
| 2021-07-22 | @ Seattle Mariners | W 4-1 | 1533.71 | 1482.00 | 53.58% | 46.42% | +2.67 | 56-42 |
| 2021-07-23 | @ Seattle Mariners | L 3-4 | 1536.38 | 1479.33 | 54.34% | 45.66% | -1.81 | 56-43 |
| 2021-07-24 | @ Seattle Mariners | L 4-5 | 1534.57 | 1481.14 | 53.83% | 46.17% | -1.78 | 56-44 |
| 2021-07-25 | @ Seattle Mariners | L 3-4 | 1532.79 | 1482.92 | 53.32% | 46.68% | -1.77 | 56-45 |
| 2021-07-27 | @ San Diego Padres | L 4-7 | 1531.02 | 1538.57 | 45.07% | 54.93% | -2.60 | 56-46 |
| 2021-07-28 | @ San Diego Padres | W 10-4 | 1528.42 | 1541.17 | 44.34% | 55.66% | +4.53 | 57-46 |
| 2021-07-29 | @ Los Angeles Angels | W 4-0 | 1532.95 | 1488.63 | 52.52% | 47.48% | +3.15 | 58-46 |
| 2021-07-30 | @ Los Angeles Angels | W 2-0 | 1536.10 | 1485.47 | 53.43% | 46.57% | +2.19 | 59-46 |
| 2021-07-31 | @ Los Angeles Angels | L 0-1 | 1538.29 | 1483.29 | 54.05% | 45.95% | -1.79 | 59-47 |
| 2021-08-01 | @ Los Angeles Angels | W 8-3 | 1536.50 | 1485.08 | 53.54% | 46.46% | +3.45 | 60-47 |
| 2021-08-03 | San Diego Padres | L 1-8 | 1539.95 | 1534.29 | 54.65% | 45.35% | -4.81 | 60-48 |
| 2021-08-04 | San Diego Padres | W 5-4 | 1535.14 | 1539.09 | 53.28% | 46.72% | +1.10 | 61-48 |
| 2021-08-06 | Texas Rangers | W 4-1 | 1536.24 | 1418.32 | 69.70% | 30.30% | +1.23 | 62-48 |
| 2021-08-07 | Texas Rangers | W 12-3 | 1537.47 | 1417.09 | 70.00% | 30.00% | +2.99 | 63-48 |
| 2021-08-08 | Texas Rangers | W 6-3 | 1540.46 | 1414.10 | 70.71% | 29.29% | +1.69 | 64-48 |
| 2021-08-10 | @ Cleveland Indians | W 4-3 | 1542.15 | 1490.44 | 53.58% | 46.42% | +1.09 | 65-48 |
| 2021-08-11 | @ Cleveland Indians | W 6-3 | 1543.24 | 1489.35 | 53.89% | 46.11% | +2.65 | 66-48 |
| 2021-08-12 | @ Cleveland Indians | W 17-0 | 1545.89 | 1486.70 | 54.65% | 45.35% | +6.20 | 67-48 |
| 2021-08-13 | @ Texas Rangers | L 6-8 | 1552.09 | 1411.05 | 65.88% | 34.12% | -3.09 | 67-49 |
| 2021-08-14 | @ Texas Rangers | W 8-3 | 1549.00 | 1414.15 | 65.07% | 34.93% | +2.59 | 68-49 |
| 2021-08-15 | @ Texas Rangers | L 4-7 | 1551.59 | 1411.55 | 65.75% | 34.25% | -3.78 | 68-50 |
| 2021-08-16 | @ Chicago White Sox | L 2-5 | 1547.81 | 1538.22 | 47.53% | 52.47% | -2.73 | 68-51 |
| 2021-08-17 | @ Chicago White Sox | L 0-9 | 1545.08 | 1540.95 | 46.75% | 53.25% | -4.65 | 68-52 |
| 2021-08-18 | @ Chicago White Sox | L 2-3 | 1540.43 | 1545.61 | 45.41% | 54.59% | -1.51 | 68-53 |
| 2021-08-19 | @ Chicago White Sox | W 5-4 | 1538.92 | 1547.11 | 44.98% | 55.02% | +1.82 | 69-53 |
| 2021-08-20 | San Francisco Giants | W 4-1 | 1540.74 | 1565.82 | 50.25% | 49.75% | +2.87 | 70-53 |
| 2021-08-21 | San Francisco Giants | L 5-6 | 1543.61 | 1562.96 | 51.07% | 48.93% | -1.70 | 70-54 |
| 2021-08-22 | San Francisco Giants | L 1-2 | 1541.91 | 1564.65 | 50.58% | 49.42% | -1.68 | 70-55 |
| 2021-08-23 | Seattle Mariners | L 3-5 | 1540.23 | 1492.26 | 60.59% | 39.41% | -2.84 | 70-56 |
| 2021-08-24 | Seattle Mariners | L 1-5 | 1537.39 | 1495.11 | 59.81% | 40.19% | -3.98 | 70-57 |
| 2021-08-26 | New York Yankees | L 6-7 | 1533.41 | 1552.07 | 51.17% | 48.83% | -1.69 | 70-58 |
| 2021-08-27 | New York Yankees | L 2-8 | 1531.72 | 1553.76 | 50.68% | 49.32% | -4.13 | 70-59 |
| 2021-08-28 | New York Yankees | W 3-2 | 1527.59 | 1557.89 | 49.49% | 50.51% | +1.68 | 71-59 |
| 2021-08-29 | New York Yankees | W 3-1 | 1529.27 | 1556.21 | 49.98% | 50.02% | +2.35 | 72-59 |
| 2021-08-31 | @ Detroit Tigers | W 9-3 | 1531.62 | 1461.54 | 56.20% | 43.80% | +3.56 | 73-59 |
| 2021-09-01 | @ Detroit Tigers | L 6-8 | 1535.18 | 1457.98 | 57.21% | 42.79% | -2.68 | 73-60 |
| 2021-09-02 | @ Detroit Tigers | W 8-6 | 1532.50 | 1460.67 | 56.45% | 43.55% | +2.04 | 74-60 |
| 2021-09-03 | @ Toronto Blue Jays | L 10-11 | 1534.54 | 1541.89 | 45.10% | 54.90% | -1.50 | 74-61 |
| 2021-09-04 | @ Toronto Blue Jays | L 8-10 | 1533.04 | 1543.39 | 44.68% | 55.32% | -2.09 | 74-62 |
| 2021-09-05 | @ Toronto Blue Jays | L 0-8 | 1530.95 | 1545.48 | 44.08% | 55.92% | -4.14 | 74-63 |
| 2021-09-07 | Chicago White Sox | L 3-6 | 1526.81 | 1539.20 | 52.07% | 47.93% | -3.00 | 74-64 |
| 2021-09-08 | Chicago White Sox | W 5-1 | 1523.81 | 1542.20 | 51.21% | 48.79% | +3.24 | 75-64 |
| 2021-09-09 | Chicago White Sox | W 3-1 | 1527.05 | 1538.96 | 52.14% | 47.86% | +2.25 | 76-64 |
| 2021-09-10 | Texas Rangers | W 10-5 | 1529.30 | 1428.28 | 67.61% | 32.39% | +2.40 | 77-64 |
| 2021-09-11 | Texas Rangers | L 6-8 | 1531.70 | 1425.87 | 68.21% | 31.79% | -3.20 | 77-65 |
| 2021-09-12 | Texas Rangers | L 3-4 | 1528.50 | 1429.07 | 67.40% | 32.60% | -2.24 | 77-66 |
| 2021-09-14 | @ Kansas City Royals | L 7-10 | 1526.26 | 1460.67 | 55.56% | 44.44% | -3.19 | 77-67 |
| 2021-09-15 | @ Kansas City Royals | W 12-10 | 1523.07 | 1463.86 | 54.65% | 45.35% | +2.13 | 78-67 |
| 2021-09-16 | @ Kansas City Royals | W 7-2 | 1525.20 | 1461.73 | 55.26% | 44.74% | +3.32 | 79-67 |
| 2021-09-17 | @ Los Angeles Angels | W 5-4 | 1528.52 | 1471.87 | 54.29% | 45.71% | +1.52 | 80-67 |
| 2021-09-18 | @ Los Angeles Angels | W 3-1 | 1530.04 | 1470.35 | 54.72% | 45.28% | +2.12 | 81-67 |
| 2021-09-19 | @ Los Angeles Angels | W 3-2 | 1532.16 | 1468.23 | 55.33% | 44.67% | +1.05 | 82-67 |
| 2021-09-20 | Seattle Mariners | L 2-4 | 1533.21 | 1495.43 | 59.18% | 40.82% | -2.78 | 82-68 |
| 2021-09-21 | Seattle Mariners | L 2-5 | 1530.43 | 1498.21 | 58.41% | 41.59% | -3.36 | 82-69 |
| 2021-09-22 | Seattle Mariners | L 1-4 | 1527.07 | 1501.57 | 57.47% | 42.53% | -3.30 | 82-70 |
| 2021-09-23 | Seattle Mariners | L 5-6 | 1523.77 | 1504.88 | 56.54% | 43.46% | -1.88 | 82-71 |
| 2021-09-24 | Houston Astros | W 14-2 | 1521.89 | 1572.54 | 46.57% | 53.43% | +6.15 | 83-71 |
| 2021-09-25 | Houston Astros | W 2-1 | 1528.04 | 1566.40 | 48.33% | 51.67% | +1.71 | 84-71 |
| 2021-09-26 | Houston Astros | W 4-3 | 1529.75 | 1564.68 | 48.83% | 51.17% | +1.70 | 85-71 |
| 2021-09-27 | @ Seattle Mariners | L 4-13 | 1531.45 | 1505.17 | 49.93% | 50.07% | -4.97 | 85-72 |
| 2021-09-28 | @ Seattle Mariners | L 2-4 | 1526.48 | 1510.14 | 48.50% | 51.50% | -2.28 | 85-73 |
| 2021-09-29 | @ Seattle Mariners | L 2-4 | 1524.20 | 1512.42 | 47.84% | 52.16% | -2.25 | 85-74 |
| 2021-10-01 | @ Houston Astros | W 8-6 | 1521.95 | 1561.91 | 40.51% | 59.49% | +2.80 | 86-74 |
| 2021-10-02 | @ Houston Astros | L 4-10 | 1524.75 | 1559.11 | 41.29% | 58.71% | -3.36 | 86-75 |
| 2021-10-03 | @ Houston Astros | L 6-7 | 1521.39 | 1562.47 | 40.36% | 59.64% | -1.34 | 86-76 |
| 2021-04-01 | Atlanta Braves | W 3-2 | 1494.34 | 1525.35 | 49.39% | 50.61% | +1.18 | 1-0 |
| 2021-04-03 | Atlanta Braves | W 4-0 | 1495.52 | 1524.17 | 49.73% | 50.27% | +3.34 | 2-0 |
| 2021-04-04 | Atlanta Braves | W 2-1 | 1498.86 | 1520.83 | 50.69% | 49.31% | +1.64 | 3-0 |
| 2021-04-05 | New York Mets | W 5-3 | 1500.50 | 1499.32 | 54.01% | 45.99% | +2.16 | 4-0 |
| 2021-04-06 | New York Mets | L 4-8 | 1502.66 | 1497.16 | 54.63% | 45.37% | -3.63 | 4-1 |
| 2021-04-07 | New York Mets | W 8-2 | 1499.03 | 1500.79 | 53.59% | 46.41% | +3.77 | 5-1 |
| 2021-04-09 | @ Atlanta Braves | L 1-8 | 1502.80 | 1521.84 | 43.44% | 56.56% | -3.81 | 5-2 |
| 2021-04-10 | @ Atlanta Braves | L 4-5 | 1498.99 | 1525.65 | 42.37% | 57.63% | -1.41 | 5-3 |
| 2021-04-11 | @ Atlanta Braves | W 7-6 | 1497.58 | 1527.06 | 41.97% | 58.03% | +1.93 | 6-3 |
| 2021-04-13 | @ New York Mets | L 3-4 | 1499.51 | 1495.09 | 46.79% | 53.21% | -1.10 | 6-4 |
| 2021-04-13 | @ New York Mets | L 0-4 | 1498.41 | 1496.19 | 46.47% | 53.53% | -3.09 | 6-5 |
| 2021-04-14 | @ New York Mets | L 1-5 | 1495.32 | 1499.27 | 45.59% | 54.41% | -3.02 | 6-6 |
| 2021-04-16 | St. Louis Cardinals | W 9-2 | 1492.30 | 1504.93 | 52.04% | 47.96% | +4.21 | 7-6 |
| 2021-04-17 | St. Louis Cardinals | L 4-9 | 1496.51 | 1500.71 | 53.24% | 46.76% | -3.95 | 7-7 |
| 2021-04-18 | St. Louis Cardinals | W 2-0 | 1492.56 | 1504.67 | 52.11% | 47.89% | +2.25 | 8-7 |
| 2021-04-19 | San Francisco Giants | L 0-2 | 1494.81 | 1498.96 | 53.25% | 46.75% | -2.50 | 8-8 |
| 2021-04-20 | San Francisco Giants | L 7-10 | 1492.31 | 1501.46 | 52.53% | 47.47% | -3.03 | 8-9 |
| 2021-04-21 | San Francisco Giants | W 6-5 | 1489.28 | 1504.48 | 51.67% | 48.33% | +1.61 | 9-9 |
| 2021-04-23 | @ Colorado Rockies | L 4-5 | 1490.89 | 1474.78 | 48.46% | 51.54% | -1.61 | 9-10 |
| 2021-04-24 | @ Colorado Rockies | W 7-5 | 1489.28 | 1476.39 | 48.00% | 52.00% | +2.44 | 10-10 |
| 2021-04-25 | @ Colorado Rockies | L 2-12 | 1491.72 | 1473.95 | 48.70% | 51.30% | -5.11 | 10-11 |
| 2021-04-26 | @ St. Louis Cardinals | W 2-1 | 1486.61 | 1510.16 | 42.81% | 57.19% | +1.90 | 11-11 |
| 2021-04-27 | @ St. Louis Cardinals | L 2-5 | 1488.51 | 1508.26 | 43.34% | 56.66% | -2.50 | 11-12 |
| 2021-04-28 | @ St. Louis Cardinals | W 5-3 | 1486.01 | 1510.75 | 42.64% | 57.36% | +2.70 | 12-12 |
| 2021-04-29 | @ St. Louis Cardinals | L 3-4 | 1488.71 | 1508.06 | 43.40% | 56.60% | -1.02 | 12-13 |
| 2021-04-30 | New York Mets | W 2-1 | 1487.69 | 1492.17 | 53.20% | 46.80% | +1.55 | 13-13 |
| 2021-05-01 | New York Mets | L 4-5 | 1489.24 | 1490.62 | 53.65% | 46.35% | -1.78 | 13-14 |
| 2021-05-02 | New York Mets | L 7-8 | 1487.46 | 1492.40 | 53.14% | 46.86% | -1.76 | 13-15 |
| 2021-05-03 | Milwaukee Brewers | W 4-3 | 1485.70 | 1507.39 | 50.73% | 49.27% | +1.63 | 14-15 |
| 2021-05-04 | Milwaukee Brewers | W 6-5 | 1487.33 | 1505.75 | 51.20% | 48.80% | +1.62 | 15-15 |
| 2021-05-05 | Milwaukee Brewers | W 5-4 | 1488.95 | 1504.13 | 51.67% | 48.33% | +1.61 | 16-15 |
| 2021-05-06 | Milwaukee Brewers | W 2-0 | 1490.56 | 1502.53 | 52.13% | 47.87% | +2.25 | 17-15 |
| 2021-05-07 | @ Atlanta Braves | W 12-2 | 1492.81 | 1515.99 | 42.86% | 57.14% | +5.99 | 18-15 |
| 2021-05-08 | @ Atlanta Braves | L 7-8 | 1498.80 | 1510.00 | 44.56% | 55.44% | -1.04 | 18-16 |
| 2021-05-09 | @ Atlanta Braves | L 1-6 | 1497.76 | 1511.04 | 44.26% | 55.74% | -3.29 | 18-17 |
| 2021-05-11 | @ Washington Nationals | W 6-2 | 1494.47 | 1498.81 | 45.53% | 54.47% | +3.62 | 19-17 |
| 2021-05-12 | @ Washington Nationals | W 5-2 | 1498.09 | 1495.19 | 46.57% | 53.43% | +2.17 | 20-17 |
| 2021-05-13 | @ Washington Nationals | L 1-5 | 1500.26 | 1493.02 | 47.19% | 52.81% | -3.13 | 20-18 |
| 2021-05-14 | @ Toronto Blue Jays | W 5-1 | 1497.13 | 1520.26 | 46.68% | 53.32% | +3.54 | 21-18 |
| 2021-05-15 | @ Toronto Blue Jays | L 0-4 | 1500.67 | 1516.72 | 47.69% | 52.31% | -3.17 | 21-19 |
| 2021-05-16 | @ Toronto Blue Jays | L 8-10 | 1497.50 | 1519.89 | 46.78% | 53.22% | -2.19 | 21-20 |
| 2021-05-18 | Miami Marlins | W 8-3 | 1495.31 | 1486.37 | 55.12% | 44.88% | +3.33 | 22-20 |
| 2021-05-19 | Miami Marlins | L 1-3 | 1498.64 | 1483.04 | 56.07% | 43.93% | -2.64 | 22-21 |
| 2021-05-20 | Miami Marlins | L 0-6 | 1496.00 | 1485.67 | 55.32% | 44.68% | -4.49 | 22-22 |
| 2021-05-21 | Boston Red Sox | L 3-11 | 1491.51 | 1518.54 | 49.96% | 50.04% | -4.70 | 22-23 |
| 2021-05-22 | Boston Red Sox | L 3-4 | 1486.81 | 1523.23 | 48.61% | 51.39% | -1.61 | 22-24 |
| 2021-05-23 | Boston Red Sox | W 6-2 | 1485.20 | 1524.85 | 48.15% | 51.85% | +3.44 | 23-24 |
| 2021-05-24 | @ Miami Marlins | L 6-9 | 1488.64 | 1494.37 | 45.33% | 54.67% | -2.60 | 23-25 |
| 2021-05-25 | @ Miami Marlins | W 2-0 | 1486.04 | 1496.98 | 44.59% | 55.41% | +2.60 | 24-25 |
| 2021-05-26 | @ Miami Marlins | L 2-4 | 1488.64 | 1494.38 | 45.33% | 54.67% | -2.13 | 24-26 |
| 2021-05-27 | @ Miami Marlins | W 3-2 | 1486.51 | 1496.51 | 44.73% | 55.27% | +1.83 | 25-26 |
| 2021-05-29 | @ Tampa Bay Rays | L 3-5 | 1488.34 | 1558.60 | 36.39% | 63.61% | -1.70 | 25-27 |
| 2021-05-30 | @ Tampa Bay Rays | L 2-6 | 1486.64 | 1560.31 | 35.93% | 64.07% | -2.39 | 25-28 |
| 2021-05-31 | @ Cincinnati Reds | L 1-11 | 1484.25 | 1476.97 | 47.20% | 52.80% | -4.96 | 25-29 |
| 2021-06-01 | @ Cincinnati Reds | W 17-3 | 1479.29 | 1481.92 | 45.78% | 54.22% | +6.74 | 26-29 |
| 2021-06-04 | Washington Nationals | L 1-2 | 1486.03 | 1489.83 | 53.30% | 46.70% | -1.77 | 26-30 |
| 2021-06-05 | Washington Nationals | W 5-2 | 1484.26 | 1491.60 | 52.80% | 47.20% | +2.72 | 27-30 |
| 2021-06-06 | Washington Nationals | W 12-6 | 1486.98 | 1488.88 | 53.57% | 46.43% | +3.77 | 28-30 |
| 2021-06-08 | Atlanta Braves | L 5-9 | 1490.75 | 1511.22 | 50.91% | 49.09% | -3.38 | 28-31 |
| 2021-06-09 | Atlanta Braves | W 2-1 | 1487.37 | 1514.60 | 49.94% | 50.06% | +1.66 | 29-31 |
| 2021-06-10 | Atlanta Braves | W 4-3 | 1489.03 | 1512.94 | 50.41% | 49.59% | +1.17 | 30-31 |
| 2021-06-12 | New York Yankees | W 8-7 | 1490.20 | 1517.98 | 49.86% | 50.14% | +1.17 | 31-31 |
| 2021-06-13 | New York Yankees | W 7-0 | 1491.37 | 1516.80 | 50.20% | 49.80% | +4.38 | 32-31 |
| 2021-06-14 | @ Los Angeles Dodgers | L 1-3 | 1495.75 | 1579.55 | 34.60% | 65.40% | -1.63 | 32-32 |
| 2021-06-15 | @ Los Angeles Dodgers | L 3-5 | 1494.12 | 1581.18 | 34.18% | 65.82% | -1.60 | 32-33 |
| 2021-06-16 | @ Los Angeles Dodgers | W 2-0 | 1492.52 | 1582.78 | 33.77% | 66.23% | +3.11 | 33-33 |
| 2021-06-18 | @ San Francisco Giants | L 3-5 | 1495.63 | 1544.76 | 39.25% | 60.75% | -1.84 | 33-34 |
| 2021-06-19 | @ San Francisco Giants | W 13-6 | 1493.79 | 1546.60 | 38.74% | 61.26% | +5.38 | 34-34 |
| 2021-06-20 | @ San Francisco Giants | L 2-11 | 1499.17 | 1541.22 | 40.22% | 59.78% | -4.01 | 34-35 |
| 2021-06-22 | Washington Nationals | L 2-3 | 1495.16 | 1500.39 | 53.10% | 46.90% | -1.76 | 34-36 |
| 2021-06-23 | Washington Nationals | L 12-13 | 1493.40 | 1502.15 | 52.59% | 47.41% | -1.75 | 34-37 |
| 2021-06-25 | @ New York Mets | L 1-2 | 1491.65 | 1516.60 | 42.61% | 57.39% | -1.00 | 34-38 |
| 2021-06-25 | @ New York Mets | W 2-1 | 1490.65 | 1517.60 | 42.33% | 57.67% | +1.36 | 35-38 |
| 2021-06-26 | @ New York Mets | L 3-4 | 1492.01 | 1516.24 | 42.71% | 57.29% | -1.42 | 35-39 |
| 2021-06-27 | @ New York Mets | W 4-2 | 1490.59 | 1517.66 | 42.31% | 57.69% | +2.71 | 36-39 |
| 2021-06-28 | @ Cincinnati Reds | L 4-12 | 1493.30 | 1492.76 | 46.23% | 53.77% | -4.34 | 36-40 |
| 2021-06-29 | Miami Marlins | W 4-3 | 1488.96 | 1485.42 | 54.35% | 45.65% | +1.51 | 37-40 |
| 2021-06-30 | Miami Marlins | L 6-11 | 1490.47 | 1483.91 | 54.78% | 45.22% | -4.07 | 37-41 |
| 2021-07-02 | San Diego Padres | W 4-3 | 1486.40 | 1539.36 | 46.24% | 53.76% | +1.27 | 38-41 |
| 2021-07-03 | San Diego Padres | W 4-2 | 1487.67 | 1538.10 | 46.60% | 53.40% | +2.50 | 39-41 |
| 2021-07-04 | San Diego Padres | L 1-11 | 1490.17 | 1535.59 | 47.32% | 52.68% | -4.97 | 39-42 |
| 2021-07-05 | @ Chicago Cubs | W 13-3 | 1485.20 | 1503.76 | 43.51% | 56.49% | +5.94 | 40-42 |
| 2021-07-06 | @ Chicago Cubs | W 15-10 | 1491.14 | 1497.83 | 45.20% | 54.80% | +4.06 | 41-42 |
| 2021-07-07 | @ Chicago Cubs | L 3-8 | 1495.20 | 1493.76 | 46.36% | 53.64% | -3.44 | 41-43 |
| 2021-07-08 | @ Chicago Cubs | W 8-0 | 1491.76 | 1497.20 | 45.38% | 54.62% | +5.13 | 42-43 |
| 2021-07-09 | @ Boston Red Sox | L 5-11 | 1496.89 | 1535.77 | 40.66% | 59.34% | -3.31 | 42-44 |
| 2021-07-10 | @ Boston Red Sox | W 11-2 | 1493.58 | 1539.08 | 39.75% | 60.25% | +6.01 | 43-44 |
| 2021-07-11 | @ Boston Red Sox | W 5-4 | 1499.59 | 1533.08 | 41.41% | 58.59% | +1.94 | 44-44 |
| 2021-07-16 | Miami Marlins | W 5-2 | 1501.53 | 1488.91 | 55.65% | 44.35% | +2.55 | 45-44 |
| 2021-07-16 | Miami Marlins | L 0-7 | 1504.08 | 1486.36 | 56.37% | 43.63% | -4.95 | 45-45 |
| 2021-07-17 | Miami Marlins | W 4-2 | 1499.13 | 1491.31 | 54.96% | 45.04% | +1.50 | 46-45 |
| 2021-07-18 | Miami Marlins | W 7-4 | 1500.63 | 1489.81 | 55.39% | 44.61% | +2.56 | 47-45 |
| 2021-07-20 | @ New York Yankees | L 4-6 | 1503.19 | 1519.18 | 43.88% | 56.12% | -2.06 | 47-46 |
| 2021-07-21 | @ New York Yankees | L 5-6 | 1501.13 | 1521.24 | 43.29% | 56.71% | -1.02 | 47-47 |
| 2021-07-22 | Atlanta Braves | L 2-7 | 1500.11 | 1514.71 | 51.75% | 48.25% | -3.84 | 47-48 |
| 2021-07-23 | Atlanta Braves | W 5-1 | 1496.27 | 1518.55 | 50.65% | 49.35% | +3.28 | 48-48 |
| 2021-07-24 | Atlanta Braves | L 3-15 | 1499.55 | 1515.28 | 51.59% | 48.41% | -5.93 | 48-49 |
| 2021-07-25 | Atlanta Braves | W 2-1 | 1493.62 | 1521.21 | 49.88% | 50.12% | +1.66 | 49-49 |
| 2021-07-26 | Washington Nationals | W 6-5 | 1495.28 | 1491.30 | 54.42% | 45.58% | +1.51 | 50-49 |
| 2021-07-27 | Washington Nationals | L 4-6 | 1496.79 | 1489.79 | 54.85% | 45.15% | -2.57 | 50-50 |
| 2021-07-29 | Washington Nationals | L 1-3 | 1494.22 | 1492.36 | 54.11% | 45.89% | -2.54 | 50-51 |
| 2021-07-29 | Washington Nationals | W 11-8 | 1491.68 | 1494.90 | 53.38% | 46.62% | +2.68 | 51-51 |
| 2021-07-30 | @ Pittsburgh Pirates | L 0-7 | 1494.36 | 1423.32 | 56.33% | 43.67% | -4.95 | 51-52 |
| 2021-07-31 | @ Pittsburgh Pirates | L 2-3 | 1489.41 | 1428.27 | 54.93% | 45.07% | -1.82 | 51-53 |
| 2021-08-01 | @ Pittsburgh Pirates | W 15-4 | 1487.59 | 1430.10 | 54.41% | 45.59% | +5.02 | 52-53 |
| 2021-08-02 | @ Washington Nationals | W 7-5 | 1492.61 | 1491.98 | 46.24% | 53.76% | +2.52 | 53-53 |
| 2021-08-03 | @ Washington Nationals | W 5-4 | 1495.13 | 1489.45 | 46.97% | 53.03% | +1.76 | 54-53 |
| 2021-08-04 | @ Washington Nationals | W 9-5 | 1496.89 | 1487.69 | 47.47% | 52.53% | +3.49 | 55-53 |
| 2021-08-05 | @ Washington Nationals | W 7-6 | 1500.38 | 1484.21 | 48.47% | 51.53% | +1.71 | 56-53 |
| 2021-08-06 | New York Mets | W 4-2 | 1502.09 | 1492.51 | 55.21% | 44.79% | +2.10 | 57-53 |
| 2021-08-07 | New York Mets | W 5-3 | 1504.19 | 1490.41 | 55.81% | 44.19% | +2.08 | 58-53 |
| 2021-08-08 | New York Mets | W 3-0 | 1506.27 | 1488.33 | 56.40% | 43.60% | +2.50 | 59-53 |
| 2021-08-10 | Los Angeles Dodgers | L 0-5 | 1508.77 | 1592.14 | 41.93% | 58.07% | -3.11 | 59-54 |
| 2021-08-11 | Los Angeles Dodgers | L 2-8 | 1505.66 | 1595.25 | 41.06% | 58.94% | -3.34 | 59-55 |
| 2021-08-12 | Los Angeles Dodgers | W 2-1 | 1502.32 | 1598.59 | 40.13% | 59.87% | +1.99 | 60-55 |
| 2021-08-13 | Cincinnati Reds | L 1-6 | 1504.31 | 1515.64 | 52.22% | 47.78% | -3.88 | 60-56 |
| 2021-08-14 | Cincinnati Reds | W 6-1 | 1500.43 | 1519.52 | 51.11% | 48.89% | +3.63 | 61-56 |
| 2021-08-15 | Cincinnati Reds | L 4-7 | 1504.06 | 1515.89 | 52.15% | 47.85% | -3.00 | 61-57 |
| 2021-08-17 | @ Arizona Diamondbacks | L 2-3 | 1501.06 | 1423.50 | 57.26% | 42.74% | -1.90 | 61-58 |
| 2021-08-18 | @ Arizona Diamondbacks | L 2-4 | 1499.16 | 1425.40 | 56.72% | 43.28% | -2.66 | 61-59 |
| 2021-08-19 | @ Arizona Diamondbacks | L 2-6 | 1496.50 | 1428.06 | 55.97% | 44.03% | -3.72 | 61-60 |
| 2021-08-20 | @ San Diego Padres | W 4-3 | 1492.78 | 1517.52 | 42.64% | 57.36% | +1.91 | 62-60 |
| 2021-08-21 | @ San Diego Padres | L 3-4 | 1494.69 | 1515.62 | 43.18% | 56.82% | -1.02 | 62-61 |
| 2021-08-22 | @ San Diego Padres | W 7-4 | 1493.67 | 1516.63 | 42.89% | 57.11% | +3.29 | 63-61 |
| 2021-08-24 | Tampa Bay Rays | L 1-3 | 1496.96 | 1581.86 | 41.71% | 58.29% | -1.96 | 63-62 |
| 2021-08-25 | Tampa Bay Rays | L 4-7 | 1495.00 | 1583.82 | 41.17% | 58.83% | -2.37 | 63-63 |
| 2021-08-26 | Arizona Diamondbacks | L 7-8 | 1492.63 | 1429.95 | 62.60% | 37.40% | -2.08 | 63-64 |
| 2021-08-27 | Arizona Diamondbacks | W 7-6 | 1490.55 | 1432.03 | 62.04% | 37.96% | +0.90 | 64-64 |
| 2021-08-28 | Arizona Diamondbacks | W 7-0 | 1491.45 | 1431.14 | 62.28% | 37.72% | +3.31 | 65-64 |
| 2021-08-29 | Arizona Diamondbacks | W 7-4 | 1494.76 | 1427.83 | 63.17% | 36.83% | +2.12 | 66-64 |
| 2021-08-30 | @ Washington Nationals | W 7-4 | 1496.88 | 1470.55 | 49.93% | 50.07% | +2.88 | 67-64 |
| 2021-08-31 | @ Washington Nationals | W 12-6 | 1499.76 | 1467.67 | 50.76% | 49.24% | +4.00 | 68-64 |
| 2021-09-02 | @ Washington Nationals | W 7-6 | 1503.76 | 1463.67 | 51.91% | 48.09% | +1.60 | 69-64 |
| 2021-09-03 | @ Miami Marlins | L 3-10 | 1505.36 | 1458.48 | 52.89% | 47.11% | -4.65 | 69-65 |
| 2021-09-04 | @ Miami Marlins | L 2-3 | 1500.71 | 1463.13 | 51.55% | 48.45% | -1.71 | 69-66 |
| 2021-09-05 | @ Miami Marlins | W 4-3 | 1499.00 | 1464.84 | 51.06% | 48.94% | +1.15 | 70-66 |
| 2021-09-06 | @ Milwaukee Brewers | W 12-0 | 1500.15 | 1556.35 | 38.28% | 61.72% | +7.10 | 71-66 |
| 2021-09-07 | @ Milwaukee Brewers | L 0-10 | 1507.25 | 1549.25 | 40.23% | 59.77% | -4.23 | 71-67 |
| 2021-09-08 | @ Milwaukee Brewers | L 3-4 | 1503.02 | 1553.47 | 39.07% | 60.93% | -1.29 | 71-68 |
| 2021-09-09 | Colorado Rockies | L 3-4 | 1501.73 | 1475.60 | 57.56% | 42.44% | -1.91 | 71-69 |
| 2021-09-10 | Colorado Rockies | L 2-11 | 1499.82 | 1477.51 | 57.02% | 42.98% | -5.68 | 71-70 |
| 2021-09-11 | Colorado Rockies | W 6-1 | 1494.14 | 1483.19 | 55.41% | 44.59% | +3.31 | 72-70 |
| 2021-09-12 | Colorado Rockies | L 4-5 | 1497.45 | 1479.88 | 56.35% | 43.65% | -1.87 | 72-71 |
| 2021-09-14 | Chicago Cubs | L 3-6 | 1495.58 | 1450.28 | 60.23% | 39.77% | -3.47 | 72-72 |
| 2021-09-15 | Chicago Cubs | W 6-5 | 1492.11 | 1453.75 | 59.27% | 40.73% | +1.36 | 73-72 |
| 2021-09-16 | Chicago Cubs | W 17-8 | 1493.47 | 1452.40 | 59.64% | 40.36% | +4.02 | 74-72 |
| 2021-09-17 | @ New York Mets | W 4-3 | 1497.49 | 1488.83 | 47.39% | 52.61% | +1.74 | 75-72 |
| 2021-09-18 | @ New York Mets | W 5-3 | 1499.23 | 1487.09 | 47.89% | 52.11% | +2.45 | 76-72 |
| 2021-09-19 | @ New York Mets | L 2-3 | 1501.68 | 1484.64 | 48.60% | 51.40% | -1.62 | 76-73 |
| 2021-09-20 | Baltimore Orioles | L 0-2 | 1500.06 | 1390.23 | 68.71% | 31.29% | -3.22 | 76-74 |
| 2021-09-21 | Baltimore Orioles | W 3-2 | 1496.84 | 1393.46 | 67.90% | 32.10% | +0.75 | 77-74 |
| 2021-09-22 | Baltimore Orioles | W 4-3 | 1497.59 | 1392.70 | 68.09% | 31.91% | +1.06 | 78-74 |
| 2021-09-23 | Pittsburgh Pirates | W 12-6 | 1498.65 | 1416.05 | 65.24% | 34.76% | +2.83 | 79-74 |
| 2021-09-24 | Pittsburgh Pirates | W 8-6 | 1501.48 | 1413.22 | 65.98% | 34.02% | +1.60 | 80-74 |
| 2021-09-25 | Pittsburgh Pirates | W 3-0 | 1503.08 | 1411.63 | 66.39% | 33.61% | +1.93 | 81-74 |
| 2021-09-26 | Pittsburgh Pirates | L 0-6 | 1505.01 | 1409.69 | 66.88% | 33.12% | -5.44 | 81-75 |
| 2021-09-28 | @ Atlanta Braves | L 1-2 | 1499.57 | 1558.99 | 37.84% | 62.16% | -1.26 | 81-76 |
| 2021-09-29 | @ Atlanta Braves | L 2-7 | 1498.31 | 1560.24 | 37.50% | 62.50% | -2.78 | 81-77 |
| 2021-09-30 | @ Atlanta Braves | L 3-5 | 1495.53 | 1563.03 | 36.76% | 63.24% | -1.73 | 81-78 |
| 2021-10-01 | @ Miami Marlins | W 5-0 | 1493.80 | 1442.11 | 53.58% | 46.42% | +3.45 | 82-78 |
| 2021-10-02 | @ Miami Marlins | L 1-3 | 1497.25 | 1438.67 | 54.56% | 45.44% | -2.56 | 82-79 |
| 2021-10-03 | @ Miami Marlins | L 4-5 | 1494.69 | 1441.23 | 53.83% | 46.17% | -1.79 | 82-80 |
| 2021-04-01 | @ Chicago Cubs | W 5-3 | 1470.06 | 1508.27 | 40.76% | 59.24% | +2.79 | 1-0 |
| 2021-04-03 | @ Chicago Cubs | L 1-5 | 1472.85 | 1505.48 | 41.53% | 58.47% | -2.76 | 1-1 |
| 2021-04-04 | @ Chicago Cubs | L 3-4 | 1470.09 | 1508.24 | 40.76% | 59.24% | -1.35 | 1-2 |
| 2021-04-05 | @ Cincinnati Reds | L 3-5 | 1468.74 | 1501.12 | 41.57% | 58.43% | -1.96 | 1-3 |
| 2021-04-06 | @ Cincinnati Reds | L 1-14 | 1466.78 | 1503.07 | 41.02% | 58.98% | -4.91 | 1-4 |
| 2021-04-07 | @ Cincinnati Reds | L 4-11 | 1461.87 | 1507.98 | 39.66% | 60.34% | -3.48 | 1-5 |
| 2021-04-08 | Chicago Cubs | L 2-4 | 1458.39 | 1506.03 | 47.00% | 53.00% | -2.21 | 1-6 |
| 2021-04-10 | Chicago Cubs | W 8-2 | 1456.18 | 1508.23 | 46.37% | 53.63% | +4.36 | 2-6 |
| 2021-04-11 | Chicago Cubs | W 7-1 | 1460.54 | 1503.87 | 47.62% | 52.38% | +4.26 | 3-6 |
| 2021-04-12 | San Diego Padres | L 2-6 | 1464.80 | 1517.56 | 46.27% | 53.73% | -3.07 | 3-7 |
| 2021-04-13 | San Diego Padres | W 8-4 | 1461.73 | 1520.63 | 45.39% | 54.61% | +3.63 | 4-7 |
| 2021-04-14 | San Diego Padres | W 5-1 | 1465.36 | 1517.00 | 46.43% | 53.57% | +3.55 | 5-7 |
| 2021-04-15 | San Diego Padres | L 3-8 | 1468.91 | 1513.45 | 47.45% | 52.55% | -3.52 | 5-8 |
| 2021-04-16 | @ Milwaukee Brewers | W 6-1 | 1465.39 | 1507.48 | 40.22% | 59.78% | +4.44 | 6-8 |
| 2021-04-17 | @ Milwaukee Brewers | L 1-7 | 1469.83 | 1503.04 | 41.45% | 58.55% | -3.37 | 6-9 |
| 2021-04-18 | @ Milwaukee Brewers | W 6-5 | 1466.46 | 1506.41 | 40.51% | 59.49% | +1.40 | 7-9 |
| 2021-04-21 | @ Detroit Tigers | W 3-2 | 1467.86 | 1446.49 | 49.22% | 50.78% | +1.68 | 8-9 |
| 2021-04-21 | @ Detroit Tigers | L 2-5 | 1469.54 | 1444.80 | 49.71% | 50.29% | -2.86 | 8-10 |
| 2021-04-22 | @ Detroit Tigers | W 4-2 | 1466.68 | 1447.66 | 48.88% | 51.12% | +2.40 | 9-10 |
| 2021-04-23 | @ Minnesota Twins | L 0-2 | 1469.08 | 1509.18 | 40.49% | 59.51% | -1.90 | 9-11 |
| 2021-04-24 | @ Minnesota Twins | W 6-2 | 1467.18 | 1511.08 | 39.97% | 60.03% | +3.99 | 10-11 |
| 2021-04-25 | @ Minnesota Twins | W 6-2 | 1471.17 | 1507.09 | 41.07% | 58.93% | +3.91 | 11-11 |
| 2021-04-27 | Kansas City Royals | W 2-1 | 1475.08 | 1485.70 | 52.32% | 47.68% | +1.58 | 12-11 |
| 2021-04-28 | Kansas City Royals | L 6-9 | 1476.66 | 1484.11 | 52.78% | 47.22% | -3.03 | 12-12 |
| 2021-04-30 | St. Louis Cardinals | L 3-7 | 1473.63 | 1509.08 | 48.75% | 51.25% | -3.24 | 12-13 |
| 2021-05-01 | St. Louis Cardinals | L 5-12 | 1470.39 | 1512.31 | 47.82% | 52.18% | -4.20 | 12-14 |
| 2021-05-02 | St. Louis Cardinals | L 0-3 | 1466.19 | 1516.51 | 46.62% | 53.38% | -2.68 | 12-15 |
| 2021-05-03 | @ San Diego Padres | L 0-2 | 1463.51 | 1515.47 | 38.86% | 61.14% | -1.82 | 12-16 |
| 2021-05-04 | @ San Diego Padres | W 2-1 | 1461.69 | 1517.29 | 38.36% | 61.64% | +2.04 | 13-16 |
| 2021-05-05 | @ San Diego Padres | L 2-4 | 1463.73 | 1515.24 | 38.92% | 61.08% | -1.83 | 13-17 |
| 2021-05-07 | @ Chicago Cubs | L 2-3 | 1461.90 | 1502.07 | 40.48% | 59.52% | -1.34 | 13-18 |
| 2021-05-08 | @ Chicago Cubs | L 2-3 | 1460.56 | 1503.41 | 40.11% | 59.89% | -1.33 | 13-19 |
| 2021-05-09 | @ Chicago Cubs | W 6-5 | 1459.23 | 1504.74 | 39.74% | 60.26% | +2.00 | 14-19 |
| 2021-05-10 | Cincinnati Reds | L 1-14 | 1461.23 | 1490.93 | 49.58% | 50.42% | -5.94 | 14-20 |
| 2021-05-11 | Cincinnati Reds | W 7-2 | 1455.29 | 1496.86 | 47.87% | 52.13% | +3.87 | 15-20 |
| 2021-05-12 | Cincinnati Reds | L 1-5 | 1459.16 | 1492.99 | 48.99% | 51.01% | -2.30 | 15-21 |
| 2021-05-13 | San Francisco Giants | L 1-3 | 1456.86 | 1514.89 | 45.52% | 54.48% | -2.13 | 15-22 |
| 2021-05-14 | San Francisco Giants | W 3-2 | 1454.73 | 1517.03 | 44.91% | 55.09% | +1.29 | 16-22 |
| 2021-05-15 | San Francisco Giants | W 8-6 | 1456.02 | 1515.74 | 45.27% | 54.73% | +2.57 | 17-22 |
| 2021-05-16 | San Francisco Giants | L 1-4 | 1458.59 | 1513.17 | 46.01% | 53.99% | -2.65 | 17-23 |
| 2021-05-18 | @ St. Louis Cardinals | L 2-5 | 1455.94 | 1515.24 | 37.86% | 62.14% | -2.17 | 17-24 |
| 2021-05-19 | @ St. Louis Cardinals | L 5-8 | 1453.77 | 1517.41 | 37.27% | 62.73% | -2.15 | 17-25 |
| 2021-05-20 | @ Atlanta Braves | W 6-4 | 1451.62 | 1507.20 | 38.37% | 61.63% | +2.05 | 18-25 |
| 2021-05-21 | @ Atlanta Braves | L 1-20 | 1453.67 | 1505.15 | 38.92% | 61.08% | -5.63 | 18-26 |
| 2021-05-22 | @ Atlanta Braves | L 1-6 | 1448.04 | 1510.78 | 37.39% | 62.61% | -2.78 | 18-27 |
| 2021-05-23 | @ Atlanta Braves | L 1-7 | 1445.26 | 1513.56 | 36.65% | 63.35% | -2.98 | 18-28 |
| 2021-05-25 | Chicago Cubs | L 3-4 | 1442.28 | 1515.47 | 43.36% | 56.64% | -1.44 | 18-29 |
| 2021-05-26 | Chicago Cubs | L 1-4 | 1440.84 | 1516.91 | 42.95% | 57.05% | -2.47 | 18-30 |
| 2021-05-27 | Chicago Cubs | L 3-5 | 1438.37 | 1519.38 | 42.26% | 57.74% | -1.98 | 18-31 |
| 2021-05-29 | Colorado Rockies | W 7-0 | 1436.39 | 1461.30 | 50.27% | 49.73% | +4.37 | 19-31 |
| 2021-05-29 | Colorado Rockies | W 4-0 | 1440.76 | 1456.93 | 51.53% | 48.47% | +3.21 | 20-31 |
| 2021-05-30 | Colorado Rockies | L 3-4 | 1443.97 | 1453.71 | 52.45% | 47.55% | -1.74 | 20-32 |
| 2021-05-31 | @ Kansas City Royals | L 3-7 | 1442.23 | 1473.01 | 41.79% | 58.21% | -2.77 | 20-33 |
| 2021-06-01 | @ Kansas City Royals | L 5-10 | 1439.46 | 1475.79 | 41.02% | 58.98% | -3.05 | 20-34 |
| 2021-06-03 | Miami Marlins | W 5-3 | 1436.41 | 1486.20 | 46.69% | 53.31% | +2.51 | 21-34 |
| 2021-06-04 | Miami Marlins | W 9-2 | 1438.92 | 1483.69 | 47.41% | 52.59% | +4.62 | 22-34 |
| 2021-06-05 | Miami Marlins | W 8-7 | 1443.54 | 1479.07 | 48.74% | 51.26% | +1.20 | 23-34 |
| 2021-06-06 | Miami Marlins | L 1-3 | 1444.74 | 1477.87 | 49.09% | 50.91% | -2.31 | 23-35 |
| 2021-06-08 | Los Angeles Dodgers | L 3-5 | 1442.43 | 1579.05 | 34.70% | 65.30% | -1.63 | 23-36 |
| 2021-06-09 | Los Angeles Dodgers | L 1-2 | 1440.80 | 1580.68 | 34.28% | 65.72% | -1.13 | 23-37 |
| 2021-06-10 | Los Angeles Dodgers | L 3-6 | 1439.67 | 1581.82 | 33.98% | 66.02% | -1.39 | 23-38 |
| 2021-06-11 | @ Milwaukee Brewers | L 4-7 | 1438.28 | 1510.35 | 36.15% | 63.85% | -2.07 | 23-39 |
| 2021-06-12 | @ Milwaukee Brewers | L 4-7 | 1436.21 | 1512.43 | 35.60% | 64.40% | -2.05 | 23-40 |
| 2021-06-13 | @ Milwaukee Brewers | L 2-5 | 1434.16 | 1514.48 | 35.06% | 64.94% | -2.02 | 23-41 |
| 2021-06-14 | @ Washington Nationals | L 2-3 | 1432.14 | 1489.62 | 38.11% | 61.89% | -1.26 | 23-42 |
| 2021-06-15 | @ Washington Nationals | L 1-8 | 1430.88 | 1490.89 | 37.76% | 62.24% | -3.32 | 23-43 |
| 2021-06-16 | @ Washington Nationals | L 1-3 | 1427.56 | 1494.20 | 36.87% | 63.13% | -1.73 | 23-44 |
| 2021-06-18 | Cleveland Indians | W 11-10 | 1425.83 | 1512.61 | 41.45% | 58.55% | +1.94 | 24-44 |
| 2021-06-19 | Cleveland Indians | W 6-3 | 1427.77 | 1510.67 | 41.99% | 58.01% | +3.34 | 25-44 |
| 2021-06-20 | Cleveland Indians | L 1-2 | 1431.11 | 1507.34 | 42.93% | 57.07% | -1.43 | 25-45 |
| 2021-06-22 | Chicago White Sox | W 6-3 | 1429.68 | 1538.25 | 38.44% | 61.56% | +3.54 | 26-45 |
| 2021-06-23 | Chicago White Sox | L 3-4 | 1433.22 | 1534.71 | 39.41% | 60.59% | -1.30 | 26-46 |
| 2021-06-24 | @ St. Louis Cardinals | W 8-2 | 1431.92 | 1483.30 | 38.94% | 61.06% | +4.96 | 27-46 |
| 2021-06-25 | @ St. Louis Cardinals | W 5-4 | 1436.88 | 1478.34 | 40.30% | 59.70% | +1.98 | 28-46 |
| 2021-06-26 | @ St. Louis Cardinals | L 1-3 | 1438.86 | 1476.36 | 40.85% | 59.15% | -1.91 | 28-47 |
| 2021-06-27 | @ St. Louis Cardinals | W 7-2 | 1436.95 | 1478.27 | 40.32% | 59.68% | +4.43 | 29-47 |
| 2021-06-28 | @ Colorado Rockies | L 0-2 | 1441.38 | 1449.47 | 45.00% | 55.00% | -2.12 | 29-48 |
| 2021-06-29 | @ Colorado Rockies | L 0-8 | 1439.26 | 1451.58 | 44.40% | 55.60% | -4.17 | 29-49 |
| 2021-06-30 | @ Colorado Rockies | L 2-6 | 1435.09 | 1455.75 | 43.22% | 56.78% | -2.87 | 29-50 |
| 2021-07-01 | Milwaukee Brewers | L 2-7 | 1432.22 | 1524.57 | 40.67% | 59.33% | -3.02 | 29-51 |
| 2021-07-02 | Milwaukee Brewers | L 2-7 | 1429.20 | 1527.59 | 39.84% | 60.16% | -2.95 | 29-52 |
| 2021-07-03 | Milwaukee Brewers | L 2-11 | 1426.25 | 1530.55 | 39.03% | 60.97% | -3.89 | 29-53 |
| 2021-07-04 | Milwaukee Brewers | W 2-0 | 1422.36 | 1534.43 | 37.97% | 62.03% | +2.91 | 30-53 |
| 2021-07-05 | Atlanta Braves | W 11-1 | 1425.27 | 1515.28 | 41.00% | 59.00% | +6.20 | 31-53 |
| 2021-07-06 | Atlanta Braves | W 2-1 | 1431.47 | 1509.09 | 42.74% | 57.26% | +1.90 | 32-53 |
| 2021-07-07 | Atlanta Braves | L 3-14 | 1433.37 | 1507.18 | 43.27% | 56.73% | -4.77 | 32-54 |
| 2021-07-09 | @ New York Mets | L 4-13 | 1428.60 | 1510.84 | 34.81% | 65.19% | -3.46 | 32-55 |
| 2021-07-10 | @ New York Mets | W 6-2 | 1425.14 | 1514.31 | 33.91% | 66.09% | +4.39 | 33-55 |
| 2021-07-10 | @ New York Mets | L 2-4 | 1429.53 | 1509.92 | 35.05% | 64.95% | -1.65 | 33-56 |
| 2021-07-11 | @ New York Mets | W 6-5 | 1427.88 | 1511.57 | 34.62% | 65.38% | +2.17 | 34-56 |
| 2021-07-16 | New York Mets | W 4-1 | 1430.05 | 1509.40 | 42.49% | 57.51% | +3.31 | 35-56 |
| 2021-07-17 | New York Mets | W 9-7 | 1433.36 | 1506.09 | 43.43% | 56.57% | +2.65 | 36-56 |
| 2021-07-18 | New York Mets | L 6-7 | 1436.01 | 1503.43 | 44.18% | 55.82% | -1.46 | 36-57 |
| 2021-07-19 | @ Arizona Diamondbacks | L 2-4 | 1434.55 | 1414.27 | 49.06% | 50.94% | -2.31 | 36-58 |
| 2021-07-20 | @ Arizona Diamondbacks | L 6-11 | 1432.24 | 1416.58 | 48.40% | 51.60% | -3.59 | 36-59 |
| 2021-07-21 | @ Arizona Diamondbacks | L 4-6 | 1428.65 | 1420.17 | 47.37% | 52.63% | -2.22 | 36-60 |
| 2021-07-23 | @ San Francisco Giants | W 6-4 | 1426.43 | 1561.41 | 28.27% | 71.73% | +3.36 | 37-60 |
| 2021-07-24 | @ San Francisco Giants | W 10-2 | 1429.79 | 1558.04 | 29.06% | 70.94% | +6.67 | 38-60 |
| 2021-07-25 | @ San Francisco Giants | L 1-6 | 1436.46 | 1551.38 | 30.67% | 69.33% | -2.28 | 38-61 |
| 2021-07-27 | Milwaukee Brewers | L 0-9 | 1434.18 | 1534.24 | 39.61% | 60.39% | -3.95 | 38-62 |
| 2021-07-28 | Milwaukee Brewers | L 3-7 | 1430.23 | 1538.19 | 38.53% | 61.47% | -2.55 | 38-63 |
| 2021-07-29 | Milwaukee Brewers | L 0-12 | 1427.68 | 1540.75 | 37.83% | 62.17% | -4.36 | 38-64 |
| 2021-07-30 | Philadelphia Phillies | W 7-0 | 1423.32 | 1494.36 | 43.67% | 56.33% | +4.95 | 39-64 |
| 2021-07-31 | Philadelphia Phillies | W 3-2 | 1428.27 | 1489.41 | 45.07% | 54.93% | +1.83 | 40-64 |
| 2021-08-01 | Philadelphia Phillies | L 4-15 | 1430.10 | 1487.59 | 45.59% | 54.41% | -5.02 | 40-65 |
| 2021-08-02 | @ Milwaukee Brewers | L 2-6 | 1425.08 | 1545.83 | 29.96% | 70.04% | -1.99 | 40-66 |
| 2021-08-03 | @ Milwaukee Brewers | W 8-5 | 1423.09 | 1547.81 | 29.48% | 70.52% | +2.86 | 41-66 |
| 2021-08-04 | @ Milwaukee Brewers | L 2-4 | 1425.95 | 1544.95 | 30.17% | 69.83% | -1.41 | 41-67 |
| 2021-08-05 | @ Cincinnati Reds | L 4-7 | 1424.54 | 1506.98 | 34.78% | 65.22% | -2.00 | 41-68 |
| 2021-08-06 | @ Cincinnati Reds | L 0-10 | 1422.54 | 1508.98 | 34.26% | 65.74% | -3.60 | 41-69 |
| 2021-08-07 | @ Cincinnati Reds | L 3-11 | 1418.94 | 1512.58 | 33.33% | 66.67% | -3.13 | 41-70 |
| 2021-08-08 | @ Cincinnati Reds | L 2-3 | 1415.81 | 1515.71 | 32.54% | 67.46% | -1.08 | 41-71 |
| 2021-08-10 | St. Louis Cardinals | L 1-4 | 1414.73 | 1480.21 | 44.45% | 55.55% | -2.56 | 41-72 |
| 2021-08-11 | St. Louis Cardinals | L 0-4 | 1412.17 | 1482.76 | 43.73% | 56.27% | -2.90 | 41-73 |
| 2021-08-12 | St. Louis Cardinals | L 6-7 | 1409.27 | 1485.67 | 42.91% | 57.09% | -1.42 | 41-74 |
| 2021-08-14 | Milwaukee Brewers | W 14-4 | 1407.85 | 1557.36 | 33.04% | 66.96% | +7.03 | 42-74 |
| 2021-08-14 | Milwaukee Brewers | L 0-6 | 1414.88 | 1550.33 | 34.85% | 65.15% | -2.84 | 42-75 |
| 2021-08-15 | Milwaukee Brewers | L 1-2 | 1412.04 | 1553.16 | 34.11% | 65.89% | -1.13 | 42-76 |
| 2021-08-16 | @ Los Angeles Dodgers | L 1-2 | 1410.91 | 1602.46 | 22.15% | 77.85% | -0.74 | 42-77 |
| 2021-08-17 | @ Los Angeles Dodgers | L 3-4 | 1410.17 | 1603.19 | 22.01% | 77.99% | -0.73 | 42-78 |
| 2021-08-18 | @ Los Angeles Dodgers | L 0-9 | 1409.44 | 1603.92 | 21.86% | 78.14% | -2.17 | 42-79 |
| 2021-08-20 | @ St. Louis Cardinals | W 4-0 | 1407.27 | 1497.89 | 33.72% | 66.28% | +4.40 | 43-79 |
| 2021-08-21 | @ St. Louis Cardinals | W 5-4 | 1411.67 | 1493.49 | 34.86% | 65.14% | +2.16 | 44-79 |
| 2021-08-22 | @ St. Louis Cardinals | L 0-3 | 1413.83 | 1491.33 | 35.43% | 64.57% | -2.04 | 44-80 |
| 2021-08-23 | Arizona Diamondbacks | W 6-5 | 1411.79 | 1430.85 | 51.11% | 48.89% | +1.63 | 45-80 |
| 2021-08-24 | Arizona Diamondbacks | W 4-2 | 1413.42 | 1429.22 | 51.58% | 48.42% | +2.27 | 46-80 |
| 2021-08-25 | Arizona Diamondbacks | L 2-5 | 1415.69 | 1426.95 | 52.23% | 47.77% | -3.00 | 46-81 |
| 2021-08-26 | St. Louis Cardinals | W 11-7 | 1412.69 | 1492.43 | 42.44% | 57.56% | +3.82 | 47-81 |
| 2021-08-27 | St. Louis Cardinals | L 3-4 | 1416.51 | 1488.61 | 43.51% | 56.49% | -1.45 | 47-82 |
| 2021-08-28 | St. Louis Cardinals | L 0-13 | 1415.06 | 1490.05 | 43.11% | 56.89% | -5.16 | 47-83 |
| 2021-08-29 | St. Louis Cardinals | W 4-3 | 1409.90 | 1495.21 | 41.66% | 58.34% | +1.94 | 48-83 |
| 2021-08-31 | @ Chicago White Sox | L 2-4 | 1411.84 | 1543.00 | 28.72% | 71.28% | -1.35 | 48-84 |
| 2021-09-01 | @ Chicago White Sox | L 3-6 | 1410.49 | 1544.35 | 28.40% | 71.60% | -1.63 | 48-85 |
| 2021-09-02 | @ Chicago Cubs | L 5-6 | 1408.86 | 1449.97 | 40.35% | 59.65% | -0.95 | 48-86 |
| 2021-09-03 | @ Chicago Cubs | L 5-6 | 1407.91 | 1450.91 | 40.09% | 59.91% | -1.33 | 48-87 |
| 2021-09-04 | @ Chicago Cubs | L 6-7 | 1406.58 | 1452.24 | 39.72% | 60.28% | -1.32 | 48-88 |
| 2021-09-05 | @ Chicago Cubs | L 8-11 | 1405.26 | 1453.56 | 39.36% | 60.64% | -2.26 | 48-89 |
| 2021-09-06 | Detroit Tigers | W 6-3 | 1403.00 | 1466.46 | 44.74% | 55.26% | +3.18 | 49-89 |
| 2021-09-07 | Detroit Tigers | W 3-2 | 1406.18 | 1463.28 | 45.65% | 54.35% | +1.80 | 50-89 |
| 2021-09-08 | Detroit Tigers | L 1-5 | 1407.98 | 1461.48 | 46.16% | 53.84% | -3.06 | 50-90 |
| 2021-09-10 | Washington Nationals | W 4-3 | 1404.92 | 1457.62 | 46.28% | 53.72% | +1.78 | 51-90 |
| 2021-09-11 | Washington Nationals | W 10-7 | 1406.70 | 1455.84 | 46.79% | 53.21% | +3.06 | 52-90 |
| 2021-09-12 | Washington Nationals | L 2-6 | 1409.76 | 1452.78 | 47.66% | 52.34% | -3.17 | 52-91 |
| 2021-09-14 | Cincinnati Reds | W 6-5 | 1406.59 | 1508.29 | 39.38% | 60.62% | +2.02 | 53-91 |
| 2021-09-15 | Cincinnati Reds | W 5-4 | 1408.61 | 1506.27 | 39.94% | 60.06% | +1.99 | 54-91 |
| 2021-09-16 | Cincinnati Reds | L 0-1 | 1410.60 | 1504.28 | 40.49% | 59.51% | -1.34 | 54-92 |
| 2021-09-17 | @ Miami Marlins | W 2-1 | 1409.26 | 1463.80 | 38.51% | 61.49% | +2.04 | 55-92 |
| 2021-09-18 | @ Miami Marlins | W 6-3 | 1411.30 | 1461.76 | 39.06% | 60.94% | +3.50 | 56-92 |
| 2021-09-19 | @ Miami Marlins | L 5-6 | 1414.80 | 1458.26 | 40.03% | 59.97% | -0.94 | 56-93 |
| 2021-09-20 | @ Cincinnati Reds | L 5-9 | 1413.86 | 1503.81 | 33.81% | 66.19% | -2.24 | 56-94 |
| 2021-09-21 | @ Cincinnati Reds | W 6-2 | 1411.62 | 1506.05 | 33.23% | 66.77% | +4.43 | 57-94 |
| 2021-09-23 | @ Philadelphia Phillies | L 6-12 | 1416.05 | 1498.65 | 34.76% | 65.24% | -2.83 | 57-95 |
| 2021-09-24 | @ Philadelphia Phillies | L 6-8 | 1413.22 | 1501.48 | 34.02% | 65.98% | -1.59 | 57-96 |
| 2021-09-25 | @ Philadelphia Phillies | L 0-3 | 1411.63 | 1503.08 | 33.61% | 66.39% | -1.94 | 57-97 |
| 2021-09-26 | @ Philadelphia Phillies | W 6-0 | 1409.69 | 1505.01 | 33.12% | 66.88% | +5.44 | 58-97 |
| 2021-09-27 | @ Cincinnati Reds | L 1-13 | 1415.13 | 1505.41 | 33.76% | 66.24% | -3.88 | 58-98 |
| 2021-09-28 | Chicago Cubs | W 8-6 | 1411.25 | 1432.95 | 50.73% | 49.27% | +2.31 | 59-98 |
| 2021-09-29 | Chicago Cubs | L 2-3 | 1413.56 | 1430.64 | 51.40% | 48.60% | -1.70 | 59-99 |
| 2021-09-30 | Chicago Cubs | L 0-9 | 1411.86 | 1432.35 | 50.91% | 49.09% | -5.07 | 59-100 |
| 2021-10-01 | Cincinnati Reds | W 9-2 | 1406.79 | 1502.79 | 40.17% | 59.83% | +5.25 | 60-100 |
| 2021-10-02 | Cincinnati Reds | W 8-6 | 1412.04 | 1497.53 | 41.63% | 58.37% | +2.74 | 61-100 |
| 2021-10-03 | Cincinnati Reds | L 3-6 | 1414.78 | 1494.79 | 42.40% | 57.60% | -2.44 | 61-101 |
| 2021-04-01 | Arizona Diamondbacks | W 8-7 | 1506.32 | 1495.41 | 55.40% | 44.60% | +1.48 | 1-0 |
| 2021-04-02 | Arizona Diamondbacks | W 4-2 | 1507.80 | 1493.93 | 55.82% | 44.18% | +2.07 | 2-0 |
| 2021-04-03 | Arizona Diamondbacks | W 7-0 | 1509.87 | 1491.86 | 56.41% | 43.59% | +3.83 | 3-0 |
| 2021-04-04 | Arizona Diamondbacks | L 1-3 | 1513.70 | 1488.03 | 57.49% | 42.51% | -2.70 | 3-1 |
| 2021-04-05 | San Francisco Giants | L 2-3 | 1511.00 | 1492.43 | 56.49% | 43.51% | -1.87 | 3-2 |
| 2021-04-06 | San Francisco Giants | W 3-1 | 1509.13 | 1494.31 | 55.96% | 44.04% | +2.07 | 4-2 |
| 2021-04-07 | San Francisco Giants | L 2-3 | 1511.20 | 1492.24 | 56.54% | 43.46% | -1.33 | 4-3 |
| 2021-04-09 | @ Texas Rangers | W 3-0 | 1509.87 | 1470.68 | 51.79% | 48.21% | +2.77 | 5-3 |
| 2021-04-10 | @ Texas Rangers | W 7-4 | 1512.64 | 1467.90 | 52.58% | 47.42% | +2.73 | 6-3 |
| 2021-04-11 | @ Texas Rangers | W 2-0 | 1515.37 | 1465.18 | 53.36% | 46.64% | +2.19 | 7-3 |
| 2021-04-12 | @ Pittsburgh Pirates | W 6-2 | 1517.56 | 1464.80 | 53.73% | 46.27% | +3.07 | 8-3 |
| 2021-04-13 | @ Pittsburgh Pirates | L 4-8 | 1520.63 | 1461.73 | 54.61% | 45.39% | -3.63 | 8-4 |
| 2021-04-14 | @ Pittsburgh Pirates | L 1-5 | 1517.00 | 1465.36 | 53.57% | 46.43% | -3.55 | 8-5 |
| 2021-04-15 | @ Pittsburgh Pirates | W 8-3 | 1513.45 | 1468.91 | 52.55% | 47.45% | +3.52 | 9-5 |
| 2021-04-16 | Los Angeles Dodgers | L 6-11 | 1516.97 | 1581.00 | 44.66% | 55.34% | -2.35 | 9-6 |
| 2021-04-17 | Los Angeles Dodgers | L 0-2 | 1514.62 | 1583.34 | 43.99% | 56.01% | -2.06 | 9-7 |
| 2021-04-18 | Los Angeles Dodgers | W 5-2 | 1512.56 | 1585.41 | 43.41% | 56.59% | +3.25 | 10-7 |
| 2021-04-19 | Milwaukee Brewers | L 1-3 | 1515.81 | 1505.01 | 55.39% | 44.61% | -2.60 | 10-8 |
| 2021-04-20 | Milwaukee Brewers | L 0-6 | 1513.21 | 1507.61 | 54.65% | 45.35% | -4.44 | 10-9 |
| 2021-04-21 | Milwaukee Brewers | L 2-4 | 1508.77 | 1512.06 | 53.38% | 46.62% | -2.51 | 10-10 |
| 2021-04-22 | @ Los Angeles Dodgers | W 3-2 | 1506.26 | 1581.56 | 35.72% | 64.28% | +2.14 | 11-10 |
| 2021-04-23 | @ Los Angeles Dodgers | W 6-1 | 1508.40 | 1579.42 | 36.28% | 63.72% | +4.73 | 12-10 |
| 2021-04-24 | @ Los Angeles Dodgers | L 4-5 | 1513.13 | 1574.69 | 37.55% | 62.45% | -1.25 | 12-11 |
| 2021-04-25 | @ Los Angeles Dodgers | W 8-7 | 1511.88 | 1575.94 | 37.22% | 62.78% | +1.47 | 13-11 |
| 2021-04-27 | @ Arizona Diamondbacks | L 1-5 | 1513.35 | 1502.94 | 47.65% | 52.35% | -3.16 | 13-12 |
| 2021-04-28 | @ Arizona Diamondbacks | W 12-3 | 1510.19 | 1506.10 | 46.74% | 53.26% | +5.30 | 14-12 |
| 2021-04-30 | San Francisco Giants | W 3-2 | 1515.49 | 1511.13 | 54.47% | 45.53% | +1.52 | 15-12 |
| 2021-05-01 | San Francisco Giants | W 6-2 | 1517.01 | 1509.62 | 54.90% | 45.10% | +2.99 | 16-12 |
| 2021-05-02 | San Francisco Giants | L 1-7 | 1520.00 | 1506.63 | 55.75% | 44.25% | -4.53 | 16-13 |
| 2021-05-03 | Pittsburgh Pirates | W 2-0 | 1515.47 | 1463.51 | 61.14% | 38.86% | +1.82 | 17-13 |
| 2021-05-04 | Pittsburgh Pirates | L 1-2 | 1517.29 | 1461.69 | 61.64% | 38.36% | -2.05 | 17-14 |
| 2021-05-05 | Pittsburgh Pirates | W 4-2 | 1515.24 | 1463.73 | 61.08% | 38.92% | +1.83 | 18-14 |
| 2021-05-07 | @ San Francisco Giants | L 4-5 | 1517.07 | 1511.43 | 46.96% | 53.04% | -1.56 | 18-15 |
| 2021-05-08 | @ San Francisco Giants | L 1-7 | 1515.51 | 1512.99 | 46.51% | 53.49% | -3.78 | 18-16 |
| 2021-05-09 | @ San Francisco Giants | W 11-1 | 1511.73 | 1516.78 | 45.43% | 54.57% | +5.73 | 19-16 |
| 2021-05-11 | @ Colorado Rockies | W 8-1 | 1517.46 | 1464.69 | 53.73% | 46.27% | +4.06 | 20-16 |
| 2021-05-12 | @ Colorado Rockies | W 5-3 | 1521.52 | 1460.63 | 54.89% | 45.11% | +2.12 | 21-16 |
| 2021-05-12 | @ Colorado Rockies | L 2-3 | 1523.64 | 1458.51 | 55.50% | 44.50% | -1.30 | 21-17 |
| 2021-05-14 | St. Louis Cardinals | W 5-4 | 1522.34 | 1523.68 | 53.65% | 46.35% | +1.54 | 22-17 |
| 2021-05-15 | St. Louis Cardinals | W 13-3 | 1523.88 | 1522.15 | 54.09% | 45.91% | +4.82 | 23-17 |
| 2021-05-16 | St. Louis Cardinals | W 5-3 | 1528.70 | 1517.33 | 55.47% | 44.53% | +2.09 | 24-17 |
| 2021-05-17 | Colorado Rockies | W 7-0 | 1530.79 | 1463.64 | 63.20% | 36.80% | +3.23 | 25-17 |
| 2021-05-18 | Colorado Rockies | W 2-1 | 1534.02 | 1460.41 | 64.06% | 35.94% | +0.84 | 26-17 |
| 2021-05-19 | Colorado Rockies | W 3-0 | 1534.86 | 1459.57 | 64.28% | 35.72% | +2.06 | 27-17 |
| 2021-05-21 | Seattle Mariners | W 16-1 | 1536.92 | 1471.83 | 62.92% | 37.08% | +4.77 | 28-17 |
| 2021-05-22 | Seattle Mariners | W 6-4 | 1541.69 | 1467.06 | 64.19% | 35.81% | +1.68 | 29-17 |
| 2021-05-23 | Seattle Mariners | W 9-2 | 1543.37 | 1465.38 | 64.64% | 35.36% | +3.10 | 30-17 |
| 2021-05-24 | @ Milwaukee Brewers | L 3-5 | 1546.47 | 1491.83 | 54.00% | 46.00% | -2.53 | 30-18 |
| 2021-05-25 | @ Milwaukee Brewers | W 7-1 | 1543.94 | 1494.37 | 53.28% | 46.72% | +3.80 | 31-18 |
| 2021-05-26 | @ Milwaukee Brewers | W 2-1 | 1547.74 | 1490.57 | 54.36% | 45.64% | +1.07 | 32-18 |
| 2021-05-27 | @ Milwaukee Brewers | L 5-6 | 1548.81 | 1489.50 | 54.67% | 45.33% | -1.28 | 32-19 |
| 2021-05-28 | @ Houston Astros | W 10-3 | 1547.53 | 1541.51 | 47.01% | 52.99% | +3.29 | 33-19 |
| 2021-05-29 | @ Houston Astros | W 11-8 | 1550.82 | 1538.22 | 47.96% | 52.04% | +2.11 | 34-19 |
| 2021-05-30 | @ Houston Astros | L 4-7 | 1552.93 | 1536.11 | 48.57% | 51.43% | -2.79 | 34-20 |
| 2021-05-31 | @ Chicago Cubs | L 2-7 | 1550.14 | 1522.34 | 50.15% | 49.85% | -3.72 | 34-21 |
| 2021-06-01 | @ Chicago Cubs | L 3-4 | 1546.42 | 1526.07 | 49.07% | 50.93% | -1.63 | 34-22 |
| 2021-06-02 | @ Chicago Cubs | L 1-6 | 1544.79 | 1527.70 | 48.61% | 51.39% | -3.61 | 34-23 |
| 2021-06-03 | New York Mets | W 4-3 | 1541.18 | 1510.24 | 58.23% | 41.77% | +1.39 | 35-23 |
| 2021-06-04 | New York Mets | W 2-0 | 1542.57 | 1508.86 | 58.62% | 41.38% | +1.94 | 36-23 |
| 2021-06-05 | New York Mets | L 0-4 | 1544.51 | 1506.91 | 59.16% | 40.84% | -3.93 | 36-24 |
| 2021-06-06 | New York Mets | L 2-6 | 1540.58 | 1510.84 | 58.06% | 41.94% | -3.85 | 36-25 |
| 2021-06-07 | Chicago Cubs | W 9-4 | 1536.73 | 1525.72 | 55.42% | 44.58% | +3.31 | 37-25 |
| 2021-06-08 | Chicago Cubs | L 1-7 | 1540.04 | 1522.41 | 56.36% | 43.64% | -4.59 | 37-26 |
| 2021-06-09 | Chicago Cubs | L 1-3 | 1535.45 | 1526.99 | 55.05% | 44.95% | -2.58 | 37-27 |
| 2021-06-11 | @ New York Mets | L 2-3 | 1532.87 | 1515.32 | 48.67% | 51.33% | -1.62 | 37-28 |
| 2021-06-12 | @ New York Mets | L 1-4 | 1531.25 | 1516.93 | 48.21% | 51.79% | -2.77 | 37-29 |
| 2021-06-13 | @ New York Mets | W 7-3 | 1528.48 | 1519.70 | 47.41% | 52.59% | +3.49 | 38-29 |
| 2021-06-14 | @ Colorado Rockies | L 2-3 | 1531.97 | 1445.08 | 58.57% | 41.43% | -1.94 | 38-30 |
| 2021-06-15 | @ Colorado Rockies | L 4-8 | 1530.03 | 1447.02 | 58.02% | 41.98% | -3.86 | 38-31 |
| 2021-06-16 | @ Colorado Rockies | L 7-8 | 1526.17 | 1450.88 | 56.94% | 43.06% | -1.89 | 38-32 |
| 2021-06-17 | Cincinnati Reds | W 6-4 | 1524.28 | 1500.25 | 57.26% | 42.74% | +2.01 | 39-32 |
| 2021-06-18 | Cincinnati Reds | W 8-2 | 1526.29 | 1498.24 | 57.83% | 42.17% | +3.43 | 40-32 |
| 2021-06-19 | Cincinnati Reds | W 7-5 | 1529.72 | 1494.81 | 58.79% | 41.21% | +1.94 | 41-32 |
| 2021-06-20 | Cincinnati Reds | W 3-2 | 1531.66 | 1492.88 | 59.32% | 40.68% | +1.35 | 42-32 |
| 2021-06-21 | Los Angeles Dodgers | W 6-2 | 1533.01 | 1585.28 | 46.34% | 53.66% | +3.56 | 43-32 |
| 2021-06-22 | Los Angeles Dodgers | W 3-2 | 1536.57 | 1581.71 | 47.36% | 52.64% | +1.75 | 44-32 |
| 2021-06-23 | Los Angeles Dodgers | W 5-3 | 1538.32 | 1579.96 | 47.86% | 52.14% | +2.44 | 45-32 |
| 2021-06-25 | Arizona Diamondbacks | W 11-5 | 1540.76 | 1423.67 | 69.60% | 30.40% | +2.48 | 46-32 |
| 2021-06-26 | Arizona Diamondbacks | L 1-10 | 1543.24 | 1421.20 | 70.20% | 29.80% | -6.99 | 46-33 |
| 2021-06-27 | Arizona Diamondbacks | W 5-4 | 1536.25 | 1428.19 | 68.49% | 31.51% | +1.04 | 47-33 |
| 2021-06-29 | @ Cincinnati Reds | W 5-4 | 1537.29 | 1497.10 | 51.93% | 48.07% | +1.60 | 48-33 |
| 2021-06-30 | @ Cincinnati Reds | W 7-5 | 1538.89 | 1495.51 | 52.39% | 47.61% | +2.23 | 49-33 |
| 2021-07-01 | @ Cincinnati Reds | L 4-5 | 1541.12 | 1493.27 | 53.03% | 46.97% | -1.76 | 49-34 |
| 2021-07-02 | @ Philadelphia Phillies | L 3-4 | 1539.36 | 1486.40 | 53.76% | 46.24% | -1.26 | 49-35 |
| 2021-07-03 | @ Philadelphia Phillies | L 2-4 | 1538.10 | 1487.67 | 53.40% | 46.60% | -2.51 | 49-36 |
| 2021-07-04 | @ Philadelphia Phillies | W 11-1 | 1535.59 | 1490.17 | 52.68% | 47.32% | +4.97 | 50-36 |
| 2021-07-05 | Washington Nationals | L 5-7 | 1540.56 | 1503.69 | 59.06% | 40.94% | -2.77 | 50-37 |
| 2021-07-06 | Washington Nationals | W 7-4 | 1537.79 | 1506.47 | 58.28% | 41.72% | +2.40 | 51-37 |
| 2021-07-07 | Washington Nationals | L 5-15 | 1540.19 | 1504.07 | 58.95% | 41.05% | -6.19 | 51-38 |
| 2021-07-08 | Washington Nationals | W 9-8 | 1534.00 | 1510.26 | 57.22% | 42.78% | +1.42 | 52-38 |
| 2021-07-09 | Colorado Rockies | W 4-2 | 1535.42 | 1461.51 | 64.10% | 35.90% | +1.68 | 53-38 |
| 2021-07-10 | Colorado Rockies | L 0-3 | 1537.10 | 1459.83 | 64.54% | 35.46% | -3.71 | 53-39 |
| 2021-07-11 | Colorado Rockies | L 1-3 | 1533.39 | 1463.54 | 63.56% | 36.44% | -2.98 | 53-40 |
| 2021-07-16 | @ Washington Nationals | W 24-8 | 1530.41 | 1501.82 | 50.26% | 49.74% | +6.60 | 54-40 |
| 2021-07-17 | @ Washington Nationals | W 10-4 | 1537.01 | 1495.22 | 52.16% | 47.84% | +3.89 | 55-40 |
| 2021-07-18 | @ Washington Nationals | L 7-8 | 1540.90 | 1491.33 | 53.28% | 46.72% | -1.76 | 55-41 |
| 2021-07-20 | @ Atlanta Braves | L 1-2 | 1539.14 | 1516.45 | 49.41% | 50.59% | -1.64 | 55-42 |
| 2021-07-21 | @ Atlanta Braves | W 3-2 | 1537.50 | 1518.09 | 48.94% | 51.06% | +1.69 | 56-42 |
| 2021-07-21 | @ Atlanta Braves | W 6-5 | 1539.19 | 1516.39 | 49.43% | 50.57% | +1.68 | 57-42 |
| 2021-07-22 | @ Miami Marlins | W 3-2 | 1540.87 | 1480.44 | 54.83% | 45.17% | +1.50 | 58-42 |
| 2021-07-23 | @ Miami Marlins | W 5-2 | 1542.37 | 1478.94 | 55.26% | 44.74% | +2.57 | 59-42 |
| 2021-07-24 | @ Miami Marlins | L 2-3 | 1544.94 | 1476.36 | 55.99% | 44.01% | -1.86 | 59-43 |
| 2021-07-25 | @ Miami Marlins | L 3-9 | 1543.08 | 1478.22 | 55.46% | 44.54% | -4.51 | 59-44 |
| 2021-07-27 | Oakland Athletics | W 7-4 | 1538.57 | 1531.02 | 54.93% | 45.07% | +2.60 | 60-44 |
| 2021-07-28 | Oakland Athletics | L 4-10 | 1541.17 | 1528.42 | 55.66% | 44.34% | -4.53 | 60-45 |
| 2021-07-29 | Colorado Rockies | W 3-0 | 1536.64 | 1464.93 | 63.81% | 36.19% | +2.08 | 61-45 |
| 2021-07-30 | Colorado Rockies | L 4-9 | 1538.72 | 1462.85 | 64.36% | 35.64% | -4.78 | 61-46 |
| 2021-07-31 | Colorado Rockies | L 3-5 | 1533.94 | 1467.63 | 63.09% | 36.91% | -2.96 | 61-47 |
| 2021-08-01 | Colorado Rockies | W 8-1 | 1530.98 | 1470.59 | 62.29% | 37.71% | +3.31 | 62-47 |
| 2021-08-03 | @ Oakland Athletics | W 8-1 | 1534.29 | 1539.95 | 45.35% | 54.65% | +4.80 | 63-47 |
| 2021-08-04 | @ Oakland Athletics | L 4-5 | 1539.09 | 1535.14 | 46.72% | 53.28% | -1.09 | 63-48 |
| 2021-08-06 | Arizona Diamondbacks | L 5-8 | 1538.00 | 1415.34 | 70.27% | 29.73% | -4.04 | 63-49 |
| 2021-08-07 | Arizona Diamondbacks | W 6-2 | 1533.96 | 1419.38 | 69.29% | 30.71% | +2.03 | 64-49 |
| 2021-08-08 | Arizona Diamondbacks | W 2-0 | 1535.99 | 1417.34 | 69.79% | 30.21% | +1.42 | 65-49 |
| 2021-08-09 | Miami Marlins | W 8-3 | 1537.41 | 1470.01 | 63.23% | 36.77% | +2.73 | 66-49 |
| 2021-08-10 | Miami Marlins | W 6-5 | 1540.14 | 1467.28 | 63.96% | 36.04% | +1.20 | 67-49 |
| 2021-08-11 | Miami Marlins | L 0-7 | 1541.34 | 1466.08 | 64.28% | 35.72% | -5.65 | 67-50 |
| 2021-08-12 | @ Arizona Diamondbacks | L 3-12 | 1535.69 | 1413.03 | 63.46% | 36.54% | -6.32 | 67-51 |
| 2021-08-13 | @ Arizona Diamondbacks | L 2-3 | 1529.37 | 1419.35 | 61.76% | 38.24% | -2.05 | 67-52 |
| 2021-08-14 | @ Arizona Diamondbacks | L 0-7 | 1527.32 | 1421.40 | 61.20% | 38.80% | -5.37 | 67-53 |
| 2021-08-15 | @ Arizona Diamondbacks | W 8-2 | 1521.95 | 1426.77 | 59.72% | 40.28% | +3.27 | 68-53 |
| 2021-08-16 | @ Colorado Rockies | L 5-6 | 1525.22 | 1475.76 | 53.26% | 46.74% | -1.76 | 68-54 |
| 2021-08-17 | @ Colorado Rockies | L 3-7 | 1523.46 | 1477.52 | 52.75% | 47.25% | -3.51 | 68-55 |
| 2021-08-18 | @ Colorado Rockies | L 5-7 | 1519.95 | 1481.03 | 51.75% | 48.25% | -2.43 | 68-56 |
| 2021-08-20 | Philadelphia Phillies | L 3-4 | 1517.52 | 1492.78 | 57.36% | 42.64% | -1.90 | 68-57 |
| 2021-08-21 | Philadelphia Phillies | W 4-3 | 1515.62 | 1494.69 | 56.82% | 43.18% | +1.01 | 69-57 |
| 2021-08-22 | Philadelphia Phillies | L 4-7 | 1516.63 | 1493.67 | 57.11% | 42.89% | -3.28 | 69-58 |
| 2021-08-24 | Los Angeles Dodgers | L 2-5 | 1513.35 | 1604.52 | 40.84% | 59.16% | -2.35 | 69-59 |
| 2021-08-25 | Los Angeles Dodgers | L 3-5 | 1511.00 | 1606.87 | 40.19% | 59.81% | -1.33 | 69-60 |
| 2021-08-26 | Los Angeles Dodgers | L 0-4 | 1509.67 | 1608.21 | 39.82% | 60.18% | -2.65 | 69-61 |
| 2021-08-27 | @ Los Angeles Angels | W 5-0 | 1507.02 | 1467.96 | 51.77% | 48.23% | +3.58 | 70-61 |
| 2021-08-28 | @ Los Angeles Angels | L 2-10 | 1510.60 | 1464.38 | 52.79% | 47.21% | -4.96 | 70-62 |
| 2021-08-30 | @ Arizona Diamondbacks | W 7-5 | 1505.64 | 1425.71 | 57.59% | 42.41% | +2.00 | 71-62 |
| 2021-08-31 | @ Arizona Diamondbacks | W 3-0 | 1507.64 | 1423.72 | 58.15% | 41.85% | +2.40 | 72-62 |
| 2021-09-01 | @ Arizona Diamondbacks | L 3-8 | 1510.04 | 1421.31 | 58.82% | 41.18% | -4.36 | 72-63 |
| 2021-09-03 | Houston Astros | L 3-6 | 1505.68 | 1563.90 | 45.49% | 54.51% | -2.62 | 72-64 |
| 2021-09-04 | Houston Astros | W 10-2 | 1503.06 | 1566.52 | 44.74% | 55.26% | +5.19 | 73-64 |
| 2021-09-05 | Houston Astros | W 4-3 | 1508.25 | 1561.33 | 46.22% | 53.78% | +1.78 | 74-64 |
| 2021-09-07 | Los Angeles Angels | L 0-4 | 1510.03 | 1466.79 | 59.94% | 40.06% | -3.98 | 74-65 |
| 2021-09-08 | Los Angeles Angels | W 8-5 | 1506.05 | 1470.77 | 58.84% | 41.16% | +2.37 | 75-65 |
| 2021-09-10 | @ Los Angeles Dodgers | L 0-3 | 1508.42 | 1609.26 | 32.42% | 67.58% | -1.86 | 75-66 |
| 2021-09-11 | @ Los Angeles Dodgers | L 4-5 | 1506.56 | 1611.12 | 31.95% | 68.05% | -1.06 | 75-67 |
| 2021-09-12 | @ Los Angeles Dodgers | L 0-8 | 1505.50 | 1612.18 | 31.69% | 68.31% | -2.98 | 75-68 |
| 2021-09-13 | @ San Francisco Giants | L 1-9 | 1502.52 | 1581.68 | 35.21% | 64.79% | -3.31 | 75-69 |
| 2021-09-14 | @ San Francisco Giants | L 1-6 | 1499.21 | 1584.99 | 34.35% | 65.65% | -2.55 | 75-70 |
| 2021-09-15 | @ San Francisco Giants | W 9-6 | 1496.66 | 1587.54 | 33.69% | 66.31% | +3.82 | 76-70 |
| 2021-09-16 | @ San Francisco Giants | W 7-4 | 1500.48 | 1583.73 | 34.67% | 65.33% | +3.75 | 77-70 |
| 2021-09-17 | @ St. Louis Cardinals | L 2-8 | 1504.23 | 1508.05 | 45.61% | 54.39% | -3.70 | 77-71 |
| 2021-09-18 | @ St. Louis Cardinals | L 2-3 | 1500.53 | 1511.76 | 44.55% | 55.45% | -1.48 | 77-72 |
| 2021-09-19 | @ St. Louis Cardinals | L 7-8 | 1499.05 | 1513.24 | 44.13% | 55.87% | -1.47 | 77-73 |
| 2021-09-21 | San Francisco Giants | L 5-6 | 1497.58 | 1579.47 | 42.14% | 57.86% | -1.40 | 77-74 |
| 2021-09-22 | San Francisco Giants | L 6-8 | 1496.18 | 1580.86 | 41.74% | 58.26% | -1.96 | 77-75 |
| 2021-09-23 | San Francisco Giants | W 7-6 | 1494.22 | 1582.82 | 41.20% | 58.80% | +1.38 | 78-75 |
| 2021-09-24 | Atlanta Braves | L 0-4 | 1495.60 | 1553.00 | 45.60% | 54.40% | -3.03 | 78-76 |
| 2021-09-25 | Atlanta Braves | L 8-10 | 1492.57 | 1556.03 | 44.74% | 55.26% | -1.48 | 78-77 |
| 2021-09-26 | Atlanta Braves | L 3-4 | 1491.09 | 1557.52 | 44.32% | 55.68% | -1.47 | 78-78 |
| 2021-09-28 | @ Los Angeles Dodgers | L 1-2 | 1489.62 | 1615.33 | 29.36% | 70.64% | -0.98 | 78-79 |
| 2021-09-29 | @ Los Angeles Dodgers | L 9-11 | 1488.64 | 1616.31 | 29.13% | 70.87% | -1.36 | 78-80 |
| 2021-09-30 | @ Los Angeles Dodgers | L 3-8 | 1487.28 | 1617.68 | 28.81% | 71.19% | -2.14 | 78-81 |
| 2021-10-01 | @ San Francisco Giants | L 0-3 | 1485.14 | 1592.73 | 31.57% | 68.43% | -1.82 | 78-82 |
| 2021-10-02 | @ San Francisco Giants | W 3-2 | 1483.32 | 1594.54 | 31.12% | 68.88% | +1.62 | 79-82 |
| 2021-10-03 | @ San Francisco Giants | L 4-11 | 1484.94 | 1592.93 | 31.52% | 68.48% | -2.77 | 79-83 |
| 2021-04-01 | @ Seattle Mariners | L 7-8 | 1493.66 | 1486.16 | 47.23% | 52.77% | -1.11 | 0-1 |
| 2021-04-02 | @ Seattle Mariners | W 6-3 | 1492.55 | 1487.27 | 46.91% | 53.09% | +3.06 | 1-1 |
| 2021-04-03 | @ Seattle Mariners | L 0-4 | 1495.61 | 1484.22 | 47.79% | 52.21% | -3.18 | 1-2 |
| 2021-04-05 | @ San Diego Padres | W 3-2 | 1492.43 | 1511.00 | 43.51% | 56.49% | +1.88 | 2-2 |
| 2021-04-06 | @ San Diego Padres | L 1-3 | 1494.31 | 1509.13 | 44.04% | 55.96% | -2.07 | 2-3 |
| 2021-04-07 | @ San Diego Padres | W 3-2 | 1492.24 | 1511.20 | 43.46% | 56.54% | +1.33 | 3-3 |
| 2021-04-09 | Colorado Rockies | W 3-1 | 1493.57 | 1479.76 | 55.81% | 44.19% | +2.07 | 4-3 |
| 2021-04-10 | Colorado Rockies | W 4-3 | 1495.64 | 1477.69 | 56.40% | 43.60% | +1.45 | 5-3 |
| 2021-04-11 | Colorado Rockies | W 4-0 | 1497.09 | 1476.24 | 56.81% | 43.19% | +2.87 | 6-3 |
| 2021-04-12 | Cincinnati Reds | L 0-3 | 1499.96 | 1504.58 | 53.19% | 46.81% | -3.06 | 6-4 |
| 2021-04-13 | Cincinnati Reds | W 7-6 | 1496.90 | 1507.64 | 52.31% | 47.69% | +1.58 | 7-4 |
| 2021-04-14 | Cincinnati Reds | W 3-0 | 1498.48 | 1506.05 | 52.76% | 47.24% | +2.72 | 8-4 |
| 2021-04-16 | @ Miami Marlins | L 1-4 | 1501.20 | 1480.13 | 49.18% | 50.82% | -2.83 | 8-5 |
| 2021-04-17 | @ Miami Marlins | L 6-7 | 1498.37 | 1482.96 | 48.36% | 51.64% | -1.13 | 8-6 |
| 2021-04-18 | @ Miami Marlins | W 1-0 | 1497.24 | 1484.10 | 48.04% | 51.96% | +1.72 | 9-6 |
| 2021-04-19 | @ Philadelphia Phillies | W 2-0 | 1498.96 | 1494.81 | 46.75% | 53.25% | +2.50 | 10-6 |
| 2021-04-20 | @ Philadelphia Phillies | W 10-7 | 1501.46 | 1492.31 | 47.47% | 52.53% | +3.02 | 11-6 |
| 2021-04-21 | @ Philadelphia Phillies | L 5-6 | 1504.48 | 1489.28 | 48.33% | 51.67% | -1.60 | 11-7 |
| 2021-04-22 | Miami Marlins | W 3-0 | 1502.88 | 1482.45 | 56.75% | 43.25% | +2.49 | 12-7 |
| 2021-04-23 | Miami Marlins | W 5-3 | 1505.37 | 1479.96 | 57.45% | 42.55% | +1.99 | 13-7 |
| 2021-04-24 | Miami Marlins | L 2-5 | 1507.36 | 1477.96 | 58.02% | 41.98% | -3.33 | 13-8 |
| 2021-04-25 | Miami Marlins | W 4-3 | 1504.03 | 1481.30 | 57.08% | 42.92% | +1.42 | 14-8 |
| 2021-04-26 | Colorado Rockies | W 12-0 | 1505.45 | 1479.06 | 57.59% | 42.41% | +4.88 | 15-8 |
| 2021-04-27 | Colorado Rockies | L 5-7 | 1510.33 | 1474.18 | 58.96% | 41.04% | -1.96 | 15-9 |
| 2021-04-28 | Colorado Rockies | W 7-3 | 1508.37 | 1476.14 | 58.41% | 41.59% | +2.76 | 16-9 |
| 2021-04-30 | @ San Diego Padres | L 2-3 | 1511.13 | 1515.49 | 45.53% | 54.47% | -1.51 | 16-10 |
| 2021-05-01 | @ San Diego Padres | L 2-6 | 1509.62 | 1517.01 | 45.10% | 54.90% | -2.99 | 16-11 |
| 2021-05-02 | @ San Diego Padres | W 7-1 | 1506.63 | 1520.00 | 44.25% | 55.75% | +4.53 | 17-11 |
| 2021-05-04 | @ Colorado Rockies | W 12-4 | 1511.16 | 1471.04 | 51.92% | 48.08% | +4.52 | 18-11 |
| 2021-05-04 | @ Colorado Rockies | L 6-8 | 1515.68 | 1466.52 | 53.22% | 46.78% | -2.50 | 18-12 |
| 2021-05-05 | @ Colorado Rockies | L 5-6 | 1513.18 | 1469.02 | 52.50% | 47.50% | -1.75 | 18-13 |
| 2021-05-07 | San Diego Padres | W 5-4 | 1511.43 | 1517.07 | 53.04% | 46.96% | +1.56 | 19-13 |
| 2021-05-08 | San Diego Padres | W 7-1 | 1512.99 | 1515.51 | 53.49% | 46.51% | +3.79 | 20-13 |
| 2021-05-09 | San Diego Padres | L 1-11 | 1516.78 | 1511.73 | 54.57% | 45.43% | -5.73 | 20-14 |
| 2021-05-10 | Texas Rangers | W 3-1 | 1511.05 | 1476.17 | 58.78% | 41.22% | +1.93 | 21-14 |
| 2021-05-11 | Texas Rangers | W 4-2 | 1512.98 | 1474.24 | 59.32% | 40.68% | +1.91 | 22-14 |
| 2021-05-13 | @ Pittsburgh Pirates | W 3-1 | 1514.89 | 1456.86 | 54.48% | 45.52% | +2.14 | 23-14 |
| 2021-05-14 | @ Pittsburgh Pirates | L 2-3 | 1517.03 | 1454.73 | 55.09% | 44.91% | -1.29 | 23-15 |
| 2021-05-15 | @ Pittsburgh Pirates | L 6-8 | 1515.74 | 1456.02 | 54.73% | 45.27% | -2.57 | 23-16 |
| 2021-05-16 | @ Pittsburgh Pirates | W 4-1 | 1513.17 | 1458.59 | 53.99% | 46.01% | +2.64 | 24-16 |
| 2021-05-17 | @ Cincinnati Reds | W 6-3 | 1515.81 | 1491.46 | 49.65% | 50.35% | +2.90 | 25-16 |
| 2021-05-18 | @ Cincinnati Reds | W 4-2 | 1518.71 | 1488.57 | 50.48% | 49.52% | +2.32 | 26-16 |
| 2021-05-19 | @ Cincinnati Reds | W 4-0 | 1521.03 | 1486.24 | 51.15% | 48.85% | +3.25 | 27-16 |
| 2021-05-20 | @ Cincinnati Reds | W 19-4 | 1524.28 | 1483.00 | 52.08% | 47.92% | +6.16 | 28-16 |
| 2021-05-21 | Los Angeles Dodgers | L 1-2 | 1530.44 | 1575.40 | 47.39% | 52.61% | -1.58 | 28-17 |
| 2021-05-22 | Los Angeles Dodgers | L 3-6 | 1528.86 | 1576.98 | 46.93% | 53.07% | -2.69 | 28-18 |
| 2021-05-23 | Los Angeles Dodgers | L 5-11 | 1526.17 | 1579.67 | 46.16% | 53.84% | -3.76 | 28-19 |
| 2021-05-25 | @ Arizona Diamondbacks | W 8-0 | 1522.41 | 1468.63 | 53.88% | 46.12% | +4.33 | 29-19 |
| 2021-05-26 | @ Arizona Diamondbacks | W 5-4 | 1526.74 | 1464.30 | 55.11% | 44.89% | +1.49 | 30-19 |
| 2021-05-27 | @ Los Angeles Dodgers | L 3-4 | 1528.23 | 1584.58 | 38.26% | 61.74% | -1.27 | 30-20 |
| 2021-05-28 | @ Los Angeles Dodgers | W 8-5 | 1526.96 | 1585.85 | 37.91% | 62.09% | +2.53 | 31-20 |
| 2021-05-29 | @ Los Angeles Dodgers | W 11-6 | 1529.49 | 1583.33 | 38.60% | 61.40% | +4.55 | 32-20 |
| 2021-05-30 | @ Los Angeles Dodgers | W 5-4 | 1534.04 | 1578.77 | 39.85% | 60.15% | +2.00 | 33-20 |
| 2021-05-31 | Los Angeles Angels | W 6-1 | 1536.04 | 1472.22 | 62.75% | 37.25% | +2.77 | 34-20 |
| 2021-06-01 | Los Angeles Angels | L 1-8 | 1538.81 | 1469.45 | 63.49% | 36.51% | -5.58 | 34-21 |
| 2021-06-03 | Chicago Cubs | W 7-2 | 1533.23 | 1531.30 | 54.12% | 45.88% | +3.41 | 35-21 |
| 2021-06-04 | Chicago Cubs | W 8-5 | 1536.64 | 1527.90 | 55.09% | 44.91% | +2.58 | 36-21 |
| 2021-06-05 | Chicago Cubs | W 4-3 | 1539.22 | 1525.32 | 55.83% | 44.17% | +1.46 | 37-21 |
| 2021-06-06 | Chicago Cubs | L 3-4 | 1540.68 | 1523.85 | 56.24% | 43.76% | -1.86 | 37-22 |
| 2021-06-08 | @ Texas Rangers | W 9-4 | 1538.82 | 1444.50 | 59.60% | 40.40% | +3.00 | 38-22 |
| 2021-06-09 | @ Texas Rangers | L 3-4 | 1541.82 | 1441.50 | 60.43% | 39.57% | -1.42 | 38-23 |
| 2021-06-11 | @ Washington Nationals | W 1-0 | 1540.40 | 1485.67 | 54.01% | 45.99% | +1.52 | 39-23 |
| 2021-06-12 | @ Washington Nationals | L 0-2 | 1541.92 | 1484.14 | 54.45% | 45.55% | -2.55 | 39-24 |
| 2021-06-12 | @ Washington Nationals | W 2-1 | 1539.37 | 1486.70 | 53.72% | 46.28% | +1.08 | 40-24 |
| 2021-06-13 | @ Washington Nationals | L 0-5 | 1540.45 | 1485.61 | 54.03% | 45.97% | -4.01 | 40-25 |
| 2021-06-14 | Arizona Diamondbacks | W 5-2 | 1536.44 | 1438.37 | 67.23% | 32.77% | +1.89 | 41-25 |
| 2021-06-15 | Arizona Diamondbacks | W 9-8 | 1538.33 | 1436.48 | 67.71% | 32.29% | +1.07 | 42-25 |
| 2021-06-16 | Arizona Diamondbacks | W 13-7 | 1539.40 | 1435.41 | 67.98% | 32.02% | +2.60 | 43-25 |
| 2021-06-17 | Arizona Diamondbacks | W 10-3 | 1542.00 | 1432.80 | 68.63% | 31.37% | +2.76 | 44-25 |
| 2021-06-18 | Philadelphia Phillies | W 5-3 | 1544.76 | 1495.63 | 60.75% | 39.25% | +1.84 | 45-25 |
| 2021-06-19 | Philadelphia Phillies | L 6-13 | 1546.60 | 1493.79 | 61.26% | 38.74% | -5.38 | 45-26 |
| 2021-06-20 | Philadelphia Phillies | W 11-2 | 1541.22 | 1499.17 | 59.78% | 40.22% | +4.01 | 46-26 |
| 2021-06-22 | @ Los Angeles Angels | W 5-0 | 1545.23 | 1490.92 | 53.95% | 46.05% | +3.42 | 47-26 |
| 2021-06-23 | @ Los Angeles Angels | W 9-3 | 1548.65 | 1487.51 | 54.93% | 45.07% | +2.59 | 48-26 |
| 2021-06-25 | Oakland Athletics | W 2-0 | 1551.24 | 1537.17 | 55.85% | 44.15% | +2.07 | 49-26 |
| 2021-06-26 | Oakland Athletics | W 6-5 | 1553.31 | 1535.10 | 56.44% | 43.56% | +1.02 | 50-26 |
| 2021-06-27 | Oakland Athletics | L 2-6 | 1554.33 | 1534.08 | 56.73% | 43.27% | -3.76 | 50-27 |
| 2021-06-28 | @ Los Angeles Dodgers | L 2-3 | 1550.57 | 1580.46 | 41.92% | 58.08% | -1.39 | 50-28 |
| 2021-06-29 | @ Los Angeles Dodgers | L 1-3 | 1549.18 | 1581.85 | 41.53% | 58.47% | -1.95 | 50-29 |
| 2021-07-01 | @ Arizona Diamondbacks | L 3-5 | 1547.23 | 1420.44 | 64.01% | 35.99% | -3.01 | 50-30 |
| 2021-07-02 | @ Arizona Diamondbacks | W 11-4 | 1544.22 | 1423.44 | 63.21% | 36.79% | +3.23 | 51-30 |
| 2021-07-03 | @ Arizona Diamondbacks | W 6-5 | 1547.45 | 1420.21 | 64.07% | 35.93% | +1.19 | 52-30 |
| 2021-07-04 | @ Arizona Diamondbacks | W 5-2 | 1548.64 | 1419.02 | 64.38% | 35.62% | +2.05 | 53-30 |
| 2021-07-05 | St. Louis Cardinals | L 3-5 | 1550.69 | 1477.42 | 64.01% | 35.99% | -3.00 | 53-31 |
| 2021-07-06 | St. Louis Cardinals | L 5-6 | 1547.69 | 1480.43 | 63.21% | 36.79% | -2.10 | 53-32 |
| 2021-07-07 | St. Louis Cardinals | W 5-2 | 1545.59 | 1482.52 | 62.65% | 37.35% | +2.15 | 54-32 |
| 2021-07-09 | Washington Nationals | W 5-3 | 1547.74 | 1508.84 | 59.34% | 40.66% | +1.91 | 55-32 |
| 2021-07-10 | Washington Nationals | W 10-4 | 1549.65 | 1506.93 | 59.87% | 40.13% | +3.26 | 56-32 |
| 2021-07-11 | Washington Nationals | W 3-1 | 1552.91 | 1503.66 | 60.77% | 39.23% | +1.84 | 57-32 |
| 2021-07-16 | @ St. Louis Cardinals | W 7-2 | 1554.75 | 1481.66 | 56.62% | 43.38% | +3.22 | 58-32 |
| 2021-07-17 | @ St. Louis Cardinals | L 1-3 | 1557.97 | 1478.44 | 57.53% | 42.47% | -2.70 | 58-33 |
| 2021-07-18 | @ St. Louis Cardinals | L 1-2 | 1555.27 | 1481.15 | 56.77% | 43.23% | -1.88 | 58-34 |
| 2021-07-19 | @ Los Angeles Dodgers | W 7-2 | 1553.39 | 1596.07 | 40.13% | 59.87% | +4.44 | 59-34 |
| 2021-07-20 | @ Los Angeles Dodgers | L 6-8 | 1557.83 | 1591.62 | 41.37% | 58.63% | -1.94 | 59-35 |
| 2021-07-21 | @ Los Angeles Dodgers | W 4-2 | 1555.89 | 1593.57 | 40.83% | 59.17% | +2.78 | 60-35 |
| 2021-07-22 | @ Los Angeles Dodgers | W 5-3 | 1558.67 | 1590.79 | 41.60% | 58.40% | +2.74 | 61-35 |
| 2021-07-23 | Pittsburgh Pirates | L 4-6 | 1561.41 | 1426.43 | 71.73% | 28.27% | -3.37 | 61-36 |
| 2021-07-24 | Pittsburgh Pirates | L 2-10 | 1558.04 | 1429.79 | 70.94% | 29.06% | -6.66 | 61-37 |
| 2021-07-25 | Pittsburgh Pirates | W 6-1 | 1551.38 | 1436.46 | 69.33% | 30.67% | +2.27 | 62-37 |
| 2021-07-27 | Los Angeles Dodgers | W 2-1 | 1553.65 | 1587.16 | 49.03% | 50.97% | +1.70 | 63-37 |
| 2021-07-28 | Los Angeles Dodgers | L 0-8 | 1555.35 | 1585.47 | 49.52% | 50.48% | -4.65 | 63-38 |
| 2021-07-29 | Los Angeles Dodgers | W 5-0 | 1550.70 | 1590.12 | 48.18% | 51.82% | +3.84 | 64-38 |
| 2021-07-30 | Houston Astros | L 6-9 | 1554.54 | 1575.52 | 50.84% | 49.16% | -2.92 | 64-39 |
| 2021-07-31 | Houston Astros | W 8-6 | 1551.62 | 1578.44 | 49.99% | 50.01% | +2.35 | 65-39 |
| 2021-08-01 | Houston Astros | W 5-3 | 1553.97 | 1576.09 | 50.67% | 49.33% | +2.31 | 66-39 |
| 2021-08-02 | @ Arizona Diamondbacks | W 11-8 | 1556.28 | 1417.27 | 65.61% | 34.39% | +1.40 | 67-39 |
| 2021-08-03 | @ Arizona Diamondbacks | L 1-3 | 1557.68 | 1415.88 | 65.97% | 34.03% | -3.10 | 67-40 |
| 2021-08-04 | @ Arizona Diamondbacks | W 7-1 | 1554.58 | 1418.97 | 65.17% | 34.83% | +2.84 | 68-40 |
| 2021-08-05 | @ Arizona Diamondbacks | W 5-4 | 1557.42 | 1416.14 | 65.91% | 34.09% | +0.80 | 69-40 |
| 2021-08-06 | @ Milwaukee Brewers | L 1-2 | 1558.22 | 1546.36 | 47.85% | 52.15% | -1.13 | 69-41 |
| 2021-08-07 | @ Milwaukee Brewers | W 9-6 | 1557.09 | 1547.49 | 47.53% | 52.47% | +2.14 | 70-41 |
| 2021-08-08 | @ Milwaukee Brewers | W 5-4 | 1559.23 | 1545.35 | 48.14% | 51.86% | +1.72 | 71-41 |
| 2021-08-10 | Arizona Diamondbacks | W 8-7 | 1560.95 | 1415.92 | 72.89% | 27.11% | +0.90 | 72-41 |
| 2021-08-11 | Arizona Diamondbacks | W 7-2 | 1561.85 | 1415.02 | 73.09% | 26.91% | +2.00 | 73-41 |
| 2021-08-12 | Colorado Rockies | W 7-0 | 1563.85 | 1478.02 | 65.66% | 34.34% | +3.01 | 74-41 |
| 2021-08-13 | Colorado Rockies | W 5-4 | 1566.86 | 1475.00 | 66.44% | 33.56% | +1.12 | 75-41 |
| 2021-08-14 | Colorado Rockies | L 1-4 | 1567.98 | 1473.89 | 66.72% | 33.28% | -3.84 | 75-42 |
| 2021-08-15 | Colorado Rockies | W 5-2 | 1564.14 | 1477.73 | 65.74% | 34.26% | +1.97 | 76-42 |
| 2021-08-16 | New York Mets | W 7-5 | 1566.11 | 1485.54 | 64.98% | 35.02% | +1.65 | 77-42 |
| 2021-08-17 | New York Mets | W 3-2 | 1567.76 | 1483.89 | 65.41% | 34.59% | +1.14 | 78-42 |
| 2021-08-18 | New York Mets | L 2-6 | 1568.90 | 1482.75 | 65.70% | 34.30% | -3.08 | 78-43 |
| 2021-08-20 | @ Oakland Athletics | L 1-4 | 1565.82 | 1540.74 | 49.75% | 50.25% | -2.86 | 78-44 |
| 2021-08-21 | @ Oakland Athletics | W 6-5 | 1562.96 | 1543.61 | 48.93% | 51.07% | +1.69 | 79-44 |
| 2021-08-22 | @ Oakland Athletics | W 2-1 | 1564.65 | 1541.91 | 49.42% | 50.58% | +1.68 | 80-44 |
| 2021-08-24 | @ New York Mets | W 8-0 | 1566.33 | 1487.41 | 57.45% | 42.55% | +4.00 | 81-44 |
| 2021-08-25 | @ New York Mets | W 3-2 | 1570.33 | 1483.41 | 58.57% | 41.43% | +1.37 | 82-44 |
| 2021-08-26 | @ New York Mets | W 3-2 | 1571.70 | 1482.04 | 58.95% | 41.05% | +1.37 | 83-44 |
| 2021-08-27 | @ Atlanta Braves | L 5-6 | 1573.07 | 1549.88 | 49.48% | 50.52% | -1.65 | 83-45 |
| 2021-08-28 | @ Atlanta Braves | W 5-0 | 1571.42 | 1551.53 | 49.01% | 50.99% | +3.79 | 84-45 |
| 2021-08-29 | @ Atlanta Braves | L 0-9 | 1575.21 | 1547.74 | 50.10% | 49.90% | -4.99 | 84-46 |
| 2021-08-30 | Milwaukee Brewers | L 1-3 | 1570.22 | 1553.07 | 56.29% | 43.71% | -2.64 | 84-47 |
| 2021-08-31 | Milwaukee Brewers | L 2-6 | 1567.58 | 1555.71 | 55.54% | 44.46% | -3.69 | 84-48 |
| 2021-09-01 | Milwaukee Brewers | L 2-5 | 1563.89 | 1559.40 | 54.49% | 45.51% | -3.13 | 84-49 |
| 2021-09-02 | Milwaukee Brewers | W 5-1 | 1560.76 | 1562.53 | 53.59% | 46.41% | +3.08 | 85-49 |
| 2021-09-03 | Los Angeles Dodgers | W 3-2 | 1563.84 | 1608.34 | 47.45% | 52.55% | +1.23 | 86-49 |
| 2021-09-04 | Los Angeles Dodgers | L 1-6 | 1565.07 | 1607.10 | 47.81% | 52.19% | -3.55 | 86-50 |
| 2021-09-05 | Los Angeles Dodgers | W 6-4 | 1561.52 | 1610.65 | 46.79% | 53.21% | +2.50 | 87-50 |
| 2021-09-06 | @ Colorado Rockies | W 10-5 | 1564.02 | 1485.24 | 57.43% | 42.57% | +3.16 | 88-50 |
| 2021-09-07 | @ Colorado Rockies | W 12-3 | 1567.18 | 1482.08 | 58.31% | 41.69% | +4.15 | 89-50 |
| 2021-09-08 | @ Colorado Rockies | W 7-4 | 1571.33 | 1477.93 | 59.47% | 40.53% | +2.33 | 90-50 |
| 2021-09-10 | @ Chicago Cubs | W 6-1 | 1573.66 | 1458.30 | 62.48% | 37.52% | +2.79 | 91-50 |
| 2021-09-11 | @ Chicago Cubs | W 15-4 | 1576.45 | 1455.52 | 63.23% | 36.77% | +4.05 | 92-50 |
| 2021-09-12 | @ Chicago Cubs | W 6-5 | 1580.50 | 1451.47 | 64.30% | 35.70% | +1.18 | 93-50 |
| 2021-09-13 | San Diego Padres | W 9-1 | 1581.68 | 1502.52 | 64.79% | 35.21% | +3.31 | 94-50 |
| 2021-09-14 | San Diego Padres | W 6-1 | 1584.99 | 1499.21 | 65.65% | 34.35% | +2.55 | 95-50 |
| 2021-09-15 | San Diego Padres | L 6-9 | 1587.54 | 1496.66 | 66.31% | 33.69% | -3.81 | 95-51 |
| 2021-09-16 | San Diego Padres | L 4-7 | 1583.73 | 1500.48 | 65.33% | 34.67% | -3.76 | 95-52 |
| 2021-09-17 | Atlanta Braves | W 6-5 | 1579.97 | 1546.96 | 58.52% | 41.48% | +0.97 | 96-52 |
| 2021-09-18 | Atlanta Braves | W 2-0 | 1580.94 | 1545.99 | 58.79% | 41.21% | +1.94 | 97-52 |
| 2021-09-19 | Atlanta Braves | L 0-3 | 1582.88 | 1544.05 | 59.33% | 40.67% | -3.41 | 97-53 |
| 2021-09-21 | @ San Diego Padres | W 6-5 | 1579.47 | 1497.58 | 57.86% | 42.14% | +1.39 | 98-53 |
| 2021-09-22 | @ San Diego Padres | W 8-6 | 1580.86 | 1496.18 | 58.26% | 41.74% | +1.96 | 99-53 |
| 2021-09-23 | @ San Diego Padres | L 6-7 | 1582.82 | 1494.22 | 58.80% | 41.20% | -1.38 | 99-54 |
| 2021-09-24 | @ Colorado Rockies | W 7-2 | 1581.44 | 1490.74 | 59.10% | 40.90% | +3.04 | 100-54 |
| 2021-09-25 | @ Colorado Rockies | W 7-2 | 1584.48 | 1487.71 | 59.94% | 40.06% | +2.97 | 101-54 |
| 2021-09-26 | @ Colorado Rockies | W 6-2 | 1587.45 | 1484.73 | 60.76% | 39.24% | +2.61 | 102-54 |
| 2021-09-28 | Arizona Diamondbacks | W 6-4 | 1590.06 | 1413.86 | 76.29% | 23.71% | +1.11 | 103-54 |
| 2021-09-29 | Arizona Diamondbacks | W 1-0 | 1591.17 | 1412.75 | 76.52% | 23.48% | +0.78 | 104-54 |
| 2021-09-30 | Arizona Diamondbacks | W 5-4 | 1591.95 | 1411.97 | 76.68% | 23.32% | +0.78 | 105-54 |
| 2021-10-01 | San Diego Padres | W 3-0 | 1592.73 | 1485.14 | 68.43% | 31.57% | +1.81 | 106-54 |
| 2021-10-02 | San Diego Padres | L 2-3 | 1594.54 | 1483.32 | 68.88% | 31.12% | -1.61 | 106-55 |
| 2021-10-03 | San Diego Padres | W 11-4 | 1592.93 | 1484.94 | 68.48% | 31.52% | +2.77 | 107-55 |
| 2021-04-01 | San Francisco Giants | W 8-7 | 1486.16 | 1493.66 | 52.77% | 47.23% | +1.11 | 1-0 |
| 2021-04-02 | San Francisco Giants | L 3-6 | 1487.27 | 1492.55 | 53.09% | 46.91% | -3.05 | 1-1 |
| 2021-04-03 | San Francisco Giants | W 4-0 | 1484.22 | 1495.61 | 52.21% | 47.79% | +3.17 | 2-1 |
| 2021-04-05 | Chicago White Sox | L 0-6 | 1487.39 | 1498.52 | 52.25% | 47.75% | -4.25 | 2-2 |
| 2021-04-06 | Chicago White Sox | L 4-10 | 1483.14 | 1502.77 | 51.03% | 48.97% | -4.15 | 2-3 |
| 2021-04-07 | Chicago White Sox | W 8-4 | 1478.99 | 1506.92 | 49.84% | 50.16% | +3.33 | 3-3 |
| 2021-04-08 | @ Minnesota Twins | L 2-10 | 1482.32 | 1528.01 | 43.46% | 56.54% | -4.08 | 3-4 |
| 2021-04-10 | @ Minnesota Twins | W 4-3 | 1478.24 | 1532.10 | 38.60% | 61.40% | +1.44 | 4-4 |
| 2021-04-11 | @ Minnesota Twins | W 8-6 | 1479.68 | 1530.65 | 38.99% | 61.01% | +2.87 | 5-4 |
| 2021-04-13 | @ Baltimore Orioles | W 4-3 | 1482.55 | 1474.07 | 47.37% | 52.63% | +1.23 | 6-4 |
| 2021-04-13 | @ Baltimore Orioles | L 6-7 | 1483.78 | 1472.84 | 47.72% | 52.28% | -1.58 | 6-5 |
| 2021-04-15 | @ Baltimore Orioles | W 4-2 | 1482.20 | 1474.42 | 47.27% | 52.73% | +2.47 | 7-5 |
| 2021-04-15 | @ Baltimore Orioles | W 2-1 | 1484.67 | 1471.94 | 47.98% | 52.02% | +1.73 | 8-5 |
| 2021-04-16 | Houston Astros | W 6-5 | 1486.40 | 1526.35 | 48.11% | 51.89% | +1.72 | 9-5 |
| 2021-04-17 | Houston Astros | L 0-1 | 1488.12 | 1524.63 | 48.60% | 51.40% | -1.61 | 9-6 |
| 2021-04-18 | Houston Astros | W 7-2 | 1486.51 | 1526.24 | 48.14% | 51.86% | +3.85 | 10-6 |
| 2021-04-19 | Los Angeles Dodgers | W 4-3 | 1490.36 | 1582.15 | 40.75% | 59.25% | +1.97 | 11-6 |
| 2021-04-20 | Los Angeles Dodgers | L 0-1 | 1492.33 | 1580.19 | 41.30% | 58.70% | -1.37 | 11-7 |
| 2021-04-22 | @ Boston Red Sox | W 7-3 | 1490.96 | 1511.91 | 43.17% | 56.83% | +2.66 | 12-7 |
| 2021-04-23 | @ Boston Red Sox | L 5-6 | 1493.62 | 1509.24 | 43.93% | 56.07% | -1.45 | 12-8 |
| 2021-04-24 | @ Boston Red Sox | W 8-2 | 1492.17 | 1510.70 | 43.52% | 56.48% | +4.59 | 13-8 |
| 2021-04-25 | @ Boston Red Sox | L 3-5 | 1496.76 | 1506.11 | 44.82% | 55.18% | -2.10 | 13-9 |
| 2021-04-26 | @ Houston Astros | L 2-5 | 1494.66 | 1522.45 | 42.21% | 57.79% | -2.43 | 13-10 |
| 2021-04-27 | @ Houston Astros | L 0-2 | 1492.23 | 1524.87 | 41.53% | 58.47% | -1.95 | 13-11 |
| 2021-04-28 | @ Houston Astros | L 5-7 | 1490.28 | 1526.82 | 40.99% | 59.01% | -1.93 | 13-12 |
| 2021-04-29 | @ Houston Astros | W 1-0 | 1488.35 | 1528.75 | 40.45% | 59.55% | +1.98 | 14-12 |
| 2021-04-30 | Los Angeles Angels | W 7-4 | 1490.33 | 1483.77 | 54.78% | 45.22% | +2.60 | 15-12 |
| 2021-05-01 | Los Angeles Angels | L 5-10 | 1492.93 | 1481.17 | 55.52% | 44.48% | -4.12 | 15-13 |
| 2021-05-02 | Los Angeles Angels | W 2-0 | 1488.81 | 1485.29 | 54.35% | 45.65% | +2.14 | 16-13 |
| 2021-05-03 | Baltimore Orioles | L 3-5 | 1490.95 | 1475.76 | 56.01% | 43.99% | -2.63 | 16-14 |
| 2021-05-04 | Baltimore Orioles | W 5-2 | 1488.32 | 1478.39 | 55.26% | 44.74% | +2.57 | 17-14 |
| 2021-05-05 | Baltimore Orioles | L 0-6 | 1490.89 | 1475.81 | 56.00% | 44.00% | -4.55 | 17-15 |
| 2021-05-07 | @ Texas Rangers | W 5-4 | 1486.34 | 1471.74 | 48.25% | 51.75% | +1.72 | 18-15 |
| 2021-05-08 | @ Texas Rangers | L 8-9 | 1488.06 | 1470.02 | 48.74% | 51.26% | -1.62 | 18-16 |
| 2021-05-09 | @ Texas Rangers | L 2-10 | 1486.44 | 1471.64 | 48.28% | 51.72% | -4.53 | 18-17 |
| 2021-05-11 | @ Los Angeles Dodgers | L 4-6 | 1481.91 | 1560.49 | 35.29% | 64.71% | -1.66 | 18-18 |
| 2021-05-12 | @ Los Angeles Dodgers | L 1-7 | 1480.25 | 1562.14 | 34.85% | 65.15% | -2.83 | 18-19 |
| 2021-05-13 | Cleveland Indians | L 2-4 | 1477.42 | 1520.75 | 47.62% | 52.38% | -2.24 | 18-20 |
| 2021-05-14 | Cleveland Indians | W 7-3 | 1475.18 | 1522.98 | 46.98% | 53.02% | +3.52 | 19-20 |
| 2021-05-15 | Cleveland Indians | W 7-3 | 1478.70 | 1519.46 | 47.99% | 52.01% | +3.45 | 20-20 |
| 2021-05-16 | Cleveland Indians | W 3-2 | 1482.15 | 1516.01 | 48.98% | 51.02% | +1.70 | 21-20 |
| 2021-05-17 | Detroit Tigers | L 1-4 | 1483.85 | 1427.40 | 61.75% | 38.25% | -3.55 | 21-21 |
| 2021-05-18 | Detroit Tigers | L 0-5 | 1480.30 | 1430.95 | 60.78% | 39.22% | -4.51 | 21-22 |
| 2021-05-19 | Detroit Tigers | L 2-6 | 1475.79 | 1435.47 | 59.54% | 40.46% | -3.96 | 21-23 |
| 2021-05-21 | @ San Diego Padres | L 1-16 | 1471.83 | 1536.92 | 37.08% | 62.92% | -4.77 | 21-24 |
| 2021-05-22 | @ San Diego Padres | L 4-6 | 1467.06 | 1541.69 | 35.81% | 64.19% | -1.68 | 21-25 |
| 2021-05-23 | @ San Diego Padres | L 2-9 | 1465.38 | 1543.37 | 35.36% | 64.64% | -3.10 | 21-26 |
| 2021-05-24 | @ Oakland Athletics | W 4-2 | 1462.28 | 1521.51 | 37.87% | 62.13% | +2.91 | 22-26 |
| 2021-05-25 | @ Oakland Athletics | W 4-3 | 1465.19 | 1518.59 | 38.66% | 61.34% | +2.04 | 23-26 |
| 2021-05-26 | @ Oakland Athletics | L 3-6 | 1467.23 | 1516.55 | 39.22% | 60.78% | -2.26 | 23-27 |
| 2021-05-27 | Texas Rangers | W 5-0 | 1464.97 | 1463.09 | 54.12% | 45.88% | +3.41 | 24-27 |
| 2021-05-28 | Texas Rangers | W 3-2 | 1468.38 | 1459.68 | 55.09% | 44.91% | +1.49 | 25-27 |
| 2021-05-29 | Texas Rangers | W 3-2 | 1469.87 | 1458.19 | 55.51% | 44.49% | +1.48 | 26-27 |
| 2021-05-30 | Texas Rangers | W 4-2 | 1471.35 | 1456.71 | 55.93% | 44.07% | +2.07 | 27-27 |
| 2021-05-31 | Oakland Athletics | W 6-5 | 1473.42 | 1516.56 | 47.65% | 52.35% | +1.23 | 28-27 |
| 2021-06-01 | Oakland Athletics | L 6-12 | 1474.65 | 1515.33 | 48.00% | 52.00% | -3.91 | 28-28 |
| 2021-06-02 | Oakland Athletics | L 0-6 | 1470.74 | 1519.23 | 46.88% | 53.12% | -3.81 | 28-29 |
| 2021-06-03 | @ Los Angeles Angels | W 6-2 | 1466.93 | 1475.03 | 45.00% | 55.00% | +3.65 | 29-29 |
| 2021-06-04 | @ Los Angeles Angels | L 2-3 | 1470.58 | 1471.38 | 46.04% | 53.96% | -1.53 | 29-30 |
| 2021-06-05 | @ Los Angeles Angels | L 5-12 | 1469.05 | 1472.91 | 45.60% | 54.40% | -4.00 | 29-31 |
| 2021-06-06 | @ Los Angeles Angels | W 9-5 | 1465.05 | 1476.91 | 44.46% | 55.54% | +3.69 | 30-31 |
| 2021-06-08 | @ Detroit Tigers | L 3-5 | 1468.74 | 1443.84 | 49.73% | 50.27% | -2.34 | 30-32 |
| 2021-06-09 | @ Detroit Tigers | W 9-6 | 1466.40 | 1446.18 | 49.06% | 50.94% | +2.07 | 31-32 |
| 2021-06-10 | @ Detroit Tigers | L 3-8 | 1468.47 | 1444.11 | 49.65% | 50.35% | -3.68 | 31-33 |
| 2021-06-11 | @ Cleveland Indians | L 0-7 | 1464.79 | 1503.69 | 40.66% | 59.34% | -3.57 | 31-34 |
| 2021-06-12 | @ Cleveland Indians | L 4-5 | 1461.22 | 1507.26 | 39.67% | 60.33% | -0.94 | 31-35 |
| 2021-06-13 | @ Cleveland Indians | W 6-2 | 1460.28 | 1508.19 | 39.41% | 60.59% | +4.03 | 32-35 |
| 2021-06-14 | Minnesota Twins | W 4-3 | 1464.31 | 1475.56 | 52.23% | 47.77% | +1.58 | 33-35 |
| 2021-06-15 | Minnesota Twins | W 10-0 | 1465.89 | 1473.97 | 52.69% | 47.31% | +4.97 | 34-35 |
| 2021-06-16 | Minnesota Twins | L 2-7 | 1470.86 | 1469.01 | 54.11% | 45.89% | -4.02 | 34-36 |
| 2021-06-17 | Tampa Bay Rays | W 6-5 | 1466.84 | 1571.99 | 38.91% | 61.09% | +2.03 | 35-36 |
| 2021-06-18 | Tampa Bay Rays | W 5-1 | 1468.87 | 1569.96 | 39.47% | 60.53% | +4.02 | 36-36 |
| 2021-06-19 | Tampa Bay Rays | W 6-5 | 1472.89 | 1565.94 | 40.58% | 59.42% | +1.40 | 37-36 |
| 2021-06-20 | Tampa Bay Rays | W 6-2 | 1474.29 | 1564.55 | 40.96% | 59.04% | +2.77 | 38-36 |
| 2021-06-22 | Colorado Rockies | W 2-1 | 1477.06 | 1454.48 | 57.06% | 42.94% | +1.42 | 39-36 |
| 2021-06-23 | Colorado Rockies | L 2-5 | 1478.48 | 1453.05 | 57.46% | 42.54% | -3.30 | 39-37 |
| 2021-06-25 | @ Chicago White Sox | W 9-3 | 1475.18 | 1536.02 | 37.65% | 62.35% | +5.07 | 40-37 |
| 2021-06-26 | @ Chicago White Sox | W 3-2 | 1480.25 | 1530.95 | 39.03% | 60.97% | +2.02 | 41-37 |
| 2021-06-27 | @ Chicago White Sox | L 5-7 | 1482.27 | 1528.93 | 39.59% | 60.41% | -1.85 | 41-38 |
| 2021-06-29 | @ Toronto Blue Jays | L 3-9 | 1480.42 | 1531.74 | 38.95% | 61.05% | -3.17 | 41-39 |
| 2021-06-30 | @ Toronto Blue Jays | W 9-7 | 1477.25 | 1534.90 | 38.08% | 61.92% | +2.05 | 42-39 |
| 2021-07-01 | @ Toronto Blue Jays | W 7-2 | 1479.30 | 1532.85 | 38.64% | 61.36% | +4.56 | 43-39 |
| 2021-07-02 | Texas Rangers | W 5-4 | 1483.86 | 1455.01 | 57.94% | 42.06% | +0.99 | 44-39 |
| 2021-07-03 | Texas Rangers | L 3-7 | 1484.85 | 1454.03 | 58.21% | 41.79% | -3.87 | 44-40 |
| 2021-07-04 | Texas Rangers | W 4-1 | 1480.98 | 1457.89 | 57.13% | 42.87% | +2.47 | 45-40 |
| 2021-07-06 | New York Yankees | L 1-12 | 1483.45 | 1507.03 | 50.46% | 49.54% | -5.56 | 45-41 |
| 2021-07-07 | New York Yankees | L 4-5 | 1477.89 | 1512.58 | 48.86% | 51.14% | -1.62 | 45-42 |
| 2021-07-08 | New York Yankees | W 4-0 | 1476.27 | 1514.21 | 48.39% | 51.61% | +3.42 | 46-42 |
| 2021-07-09 | Los Angeles Angels | W 7-3 | 1479.69 | 1493.34 | 51.89% | 48.11% | +3.20 | 47-42 |
| 2021-07-10 | Los Angeles Angels | W 2-0 | 1482.89 | 1490.14 | 52.81% | 47.19% | +2.21 | 48-42 |
| 2021-07-11 | Los Angeles Angels | L 1-7 | 1485.10 | 1487.93 | 53.44% | 46.56% | -4.34 | 48-43 |
| 2021-07-16 | @ Los Angeles Angels | W 6-5 | 1480.76 | 1492.28 | 44.51% | 55.49% | +1.84 | 49-43 |
| 2021-07-17 | @ Los Angeles Angels | L 4-9 | 1482.60 | 1490.43 | 45.04% | 54.96% | -3.34 | 49-44 |
| 2021-07-18 | @ Los Angeles Angels | W 7-4 | 1479.26 | 1493.78 | 44.08% | 55.92% | +3.21 | 50-44 |
| 2021-07-20 | @ Colorado Rockies | W 6-4 | 1482.47 | 1462.00 | 49.09% | 50.91% | +2.39 | 51-44 |
| 2021-07-21 | @ Colorado Rockies | L 3-6 | 1484.86 | 1459.61 | 49.78% | 50.22% | -2.86 | 51-45 |
| 2021-07-22 | Oakland Athletics | L 1-4 | 1482.00 | 1533.71 | 46.42% | 53.58% | -2.67 | 51-46 |
| 2021-07-23 | Oakland Athletics | W 4-3 | 1479.33 | 1536.38 | 45.66% | 54.34% | +1.81 | 52-46 |
| 2021-07-24 | Oakland Athletics | W 5-4 | 1481.14 | 1534.57 | 46.17% | 53.83% | +1.78 | 53-46 |
| 2021-07-25 | Oakland Athletics | W 4-3 | 1482.92 | 1532.79 | 46.68% | 53.32% | +1.77 | 54-46 |
| 2021-07-26 | Houston Astros | W 11-8 | 1484.69 | 1573.26 | 41.20% | 58.80% | +3.38 | 55-46 |
| 2021-07-27 | Houston Astros | L 6-8 | 1488.07 | 1569.88 | 42.15% | 57.85% | -1.97 | 55-47 |
| 2021-07-28 | Houston Astros | L 4-11 | 1486.10 | 1571.86 | 41.59% | 58.41% | -3.66 | 55-48 |
| 2021-07-30 | @ Texas Rangers | W 9-5 | 1482.44 | 1424.29 | 54.50% | 45.50% | +3.02 | 56-48 |
| 2021-07-31 | @ Texas Rangers | L 4-5 | 1485.46 | 1421.27 | 55.36% | 44.64% | -1.30 | 56-49 |
| 2021-08-01 | @ Texas Rangers | L 3-4 | 1484.16 | 1422.57 | 54.99% | 45.01% | -1.82 | 56-50 |
| 2021-08-02 | @ Tampa Bay Rays | W 8-2 | 1482.34 | 1573.32 | 33.67% | 66.33% | +5.39 | 57-50 |
| 2021-08-03 | @ Tampa Bay Rays | W 4-2 | 1487.73 | 1567.93 | 35.07% | 64.93% | +3.05 | 58-50 |
| 2021-08-04 | @ Tampa Bay Rays | L 3-4 | 1490.78 | 1564.88 | 35.88% | 64.12% | -1.19 | 58-51 |
| 2021-08-05 | @ New York Yankees | L 3-5 | 1489.59 | 1526.17 | 40.98% | 59.02% | -1.93 | 58-52 |
| 2021-08-06 | @ New York Yankees | L 2-3 | 1487.66 | 1528.10 | 40.45% | 59.55% | -0.94 | 58-53 |
| 2021-08-07 | @ New York Yankees | L 4-5 | 1486.72 | 1529.05 | 40.18% | 59.82% | -1.34 | 58-54 |
| 2021-08-08 | @ New York Yankees | W 2-0 | 1485.38 | 1530.38 | 39.81% | 60.19% | +2.83 | 59-54 |
| 2021-08-10 | Texas Rangers | L 4-5 | 1488.21 | 1412.42 | 64.35% | 35.65% | -1.51 | 59-55 |
| 2021-08-11 | Texas Rangers | W 2-1 | 1486.70 | 1413.93 | 63.95% | 36.05% | +1.19 | 60-55 |
| 2021-08-12 | Texas Rangers | W 3-1 | 1487.89 | 1412.73 | 64.26% | 35.74% | +1.68 | 61-55 |
| 2021-08-13 | Toronto Blue Jays | W 3-2 | 1489.57 | 1558.64 | 43.94% | 56.06% | +1.86 | 62-55 |
| 2021-08-14 | Toronto Blue Jays | W 9-3 | 1491.43 | 1556.77 | 44.47% | 55.53% | +4.52 | 63-55 |
| 2021-08-15 | Toronto Blue Jays | L 3-8 | 1495.95 | 1552.26 | 45.76% | 54.24% | -3.40 | 63-56 |
| 2021-08-17 | @ Texas Rangers | W 3-1 | 1492.55 | 1415.34 | 57.21% | 42.79% | +2.01 | 64-56 |
| 2021-08-18 | @ Texas Rangers | W 3-1 | 1494.56 | 1413.33 | 57.77% | 42.23% | +1.98 | 65-56 |
| 2021-08-19 | @ Texas Rangers | W 9-8 | 1496.54 | 1411.34 | 58.33% | 41.67% | +0.98 | 66-56 |
| 2021-08-20 | @ Houston Astros | L 3-12 | 1497.52 | 1570.57 | 36.02% | 63.98% | -3.59 | 66-57 |
| 2021-08-21 | @ Houston Astros | L 1-15 | 1493.93 | 1574.15 | 35.07% | 64.93% | -4.35 | 66-58 |
| 2021-08-22 | @ Houston Astros | W 6-3 | 1489.58 | 1578.51 | 33.94% | 66.06% | +2.68 | 67-58 |
| 2021-08-23 | @ Oakland Athletics | W 5-3 | 1492.26 | 1540.23 | 39.41% | 60.59% | +2.85 | 68-58 |
| 2021-08-24 | @ Oakland Athletics | W 5-1 | 1495.11 | 1537.39 | 40.19% | 59.81% | +3.97 | 69-58 |
| 2021-08-26 | Kansas City Royals | L 4-6 | 1499.08 | 1455.40 | 60.00% | 40.00% | -2.82 | 69-59 |
| 2021-08-27 | Kansas City Royals | L 7-8 | 1496.26 | 1458.22 | 59.22% | 40.78% | -1.39 | 69-60 |
| 2021-08-28 | Kansas City Royals | L 2-4 | 1494.87 | 1459.61 | 58.83% | 41.17% | -2.76 | 69-61 |
| 2021-08-29 | Kansas City Royals | W 4-3 | 1492.11 | 1462.37 | 58.06% | 41.94% | +1.39 | 70-61 |
| 2021-08-30 | Houston Astros | L 3-4 | 1493.50 | 1568.14 | 43.16% | 56.84% | -1.43 | 70-62 |
| 2021-08-31 | Houston Astros | W 4-0 | 1492.07 | 1569.57 | 42.75% | 57.25% | +3.80 | 71-62 |
| 2021-09-01 | Houston Astros | W 1-0 | 1495.87 | 1565.77 | 43.83% | 56.17% | +1.87 | 72-62 |
| 2021-09-03 | @ Arizona Diamondbacks | W 6-5 | 1497.74 | 1425.68 | 56.48% | 43.52% | +1.02 | 73-62 |
| 2021-09-04 | @ Arizona Diamondbacks | W 8-5 | 1498.76 | 1424.66 | 56.77% | 43.23% | +2.48 | 74-62 |
| 2021-09-05 | @ Arizona Diamondbacks | W 10-4 | 1501.24 | 1422.17 | 57.47% | 42.53% | +2.45 | 75-62 |
| 2021-09-06 | @ Houston Astros | L 2-11 | 1503.69 | 1559.54 | 38.33% | 61.67% | -3.82 | 75-63 |
| 2021-09-07 | @ Houston Astros | L 4-5 | 1499.87 | 1563.36 | 37.29% | 62.71% | -0.87 | 75-64 |
| 2021-09-08 | @ Houston Astros | W 8-5 | 1499.00 | 1564.24 | 37.06% | 62.94% | +3.62 | 76-64 |
| 2021-09-10 | Arizona Diamondbacks | W 5-4 | 1502.62 | 1414.19 | 66.00% | 34.00% | +1.12 | 77-64 |
| 2021-09-11 | Arizona Diamondbacks | L 3-7 | 1503.74 | 1413.06 | 66.29% | 33.71% | -4.40 | 77-65 |
| 2021-09-12 | Arizona Diamondbacks | L 4-5 | 1499.34 | 1417.46 | 65.15% | 34.85% | -2.16 | 77-66 |
| 2021-09-13 | Boston Red Sox | W 5-4 | 1497.18 | 1517.43 | 50.94% | 49.06% | +1.63 | 78-66 |
| 2021-09-14 | Boston Red Sox | L 4-8 | 1498.81 | 1515.80 | 51.41% | 48.59% | -3.42 | 78-67 |
| 2021-09-15 | Boston Red Sox | L 4-9 | 1495.39 | 1519.21 | 50.43% | 49.57% | -2.64 | 78-68 |
| 2021-09-17 | @ Kansas City Royals | W 6-2 | 1492.75 | 1458.41 | 51.09% | 48.91% | +3.25 | 79-68 |
| 2021-09-18 | @ Kansas City Royals | L 1-8 | 1496.00 | 1455.17 | 52.02% | 47.98% | -4.57 | 79-69 |
| 2021-09-19 | @ Kansas City Royals | W 7-1 | 1491.43 | 1459.73 | 50.71% | 49.29% | +4.00 | 80-69 |
| 2021-09-20 | @ Oakland Athletics | W 4-2 | 1495.43 | 1533.21 | 40.82% | 59.18% | +2.78 | 81-69 |
| 2021-09-21 | @ Oakland Athletics | W 5-2 | 1498.21 | 1530.43 | 41.59% | 58.41% | +3.36 | 82-69 |
| 2021-09-22 | @ Oakland Athletics | W 4-1 | 1501.57 | 1527.07 | 42.53% | 57.47% | +3.31 | 83-69 |
| 2021-09-23 | @ Oakland Athletics | W 6-5 | 1504.88 | 1523.77 | 43.46% | 56.54% | +1.87 | 84-69 |
| 2021-09-24 | @ Los Angeles Angels | W 6-5 | 1506.75 | 1460.43 | 52.81% | 47.19% | +1.57 | 85-69 |
| 2021-09-25 | @ Los Angeles Angels | L 1-14 | 1508.32 | 1458.86 | 53.26% | 46.74% | -6.37 | 85-70 |
| 2021-09-26 | @ Los Angeles Angels | W 5-1 | 1501.95 | 1465.24 | 51.43% | 48.57% | +3.22 | 86-70 |
| 2021-09-27 | Oakland Athletics | W 13-4 | 1505.17 | 1531.45 | 50.07% | 49.93% | +4.97 | 87-70 |
| 2021-09-28 | Oakland Athletics | W 4-2 | 1510.14 | 1526.48 | 51.50% | 48.50% | +2.28 | 88-70 |
| 2021-09-29 | Oakland Athletics | W 4-2 | 1512.42 | 1524.20 | 52.16% | 47.84% | +2.25 | 89-70 |
| 2021-10-01 | Los Angeles Angels | L 1-2 | 1514.67 | 1460.82 | 61.40% | 38.60% | -2.04 | 89-71 |
| 2021-10-02 | Los Angeles Angels | W 6-4 | 1512.63 | 1462.86 | 60.84% | 39.16% | +1.84 | 90-71 |
| 2021-10-03 | Los Angeles Angels | L 3-7 | 1514.47 | 1461.02 | 61.34% | 38.66% | -4.08 | 90-72 |
| 2021-04-01 | @ Cincinnati Reds | W 11-6 | 1508.47 | 1496.88 | 47.81% | 52.19% | +3.87 | 1-0 |
| 2021-04-03 | @ Cincinnati Reds | L 6-9 | 1512.34 | 1493.01 | 48.93% | 51.07% | -2.81 | 1-1 |
| 2021-04-04 | @ Cincinnati Reds | L 1-12 | 1509.53 | 1495.82 | 48.12% | 51.88% | -5.30 | 1-2 |
| 2021-04-05 | @ Miami Marlins | W 4-1 | 1504.23 | 1479.90 | 49.65% | 50.35% | +2.90 | 2-2 |
| 2021-04-06 | @ Miami Marlins | W 4-2 | 1507.13 | 1477.01 | 50.48% | 49.52% | +2.32 | 3-2 |
| 2021-04-07 | @ Miami Marlins | W 7-0 | 1509.45 | 1474.68 | 51.15% | 48.85% | +4.29 | 4-2 |
| 2021-04-08 | Milwaukee Brewers | W 3-1 | 1513.74 | 1496.41 | 56.31% | 43.69% | +2.06 | 5-2 |
| 2021-04-10 | Milwaukee Brewers | L 5-9 | 1515.80 | 1494.36 | 56.89% | 43.11% | -3.78 | 5-3 |
| 2021-04-11 | Milwaukee Brewers | L 3-9 | 1512.02 | 1498.14 | 55.82% | 44.18% | -4.54 | 5-4 |
| 2021-04-12 | Washington Nationals | L 2-5 | 1507.48 | 1501.51 | 54.70% | 45.30% | -3.15 | 5-5 |
| 2021-04-13 | Washington Nationals | W 14-3 | 1504.33 | 1504.65 | 53.80% | 46.20% | +5.09 | 6-5 |
| 2021-04-14 | Washington Nationals | L 0-6 | 1509.42 | 1499.57 | 55.25% | 44.75% | -4.49 | 6-6 |
| 2021-04-16 | @ Philadelphia Phillies | L 2-9 | 1504.93 | 1492.30 | 47.96% | 52.04% | -4.22 | 6-7 |
| 2021-04-17 | @ Philadelphia Phillies | W 9-4 | 1500.71 | 1496.51 | 46.76% | 53.24% | +3.96 | 7-7 |
| 2021-04-18 | @ Philadelphia Phillies | L 0-2 | 1504.67 | 1492.56 | 47.89% | 52.11% | -2.25 | 7-8 |
| 2021-04-19 | @ Washington Nationals | W 12-5 | 1502.42 | 1501.04 | 46.35% | 53.65% | +4.71 | 8-8 |
| 2021-04-20 | @ Washington Nationals | L 2-3 | 1507.13 | 1496.33 | 47.70% | 52.30% | -1.58 | 8-9 |
| 2021-04-21 | @ Washington Nationals | L 0-1 | 1505.55 | 1497.92 | 47.25% | 52.75% | -1.57 | 8-10 |
| 2021-04-23 | Cincinnati Reds | W 5-4 | 1503.98 | 1499.14 | 54.54% | 45.46% | +1.51 | 9-10 |
| 2021-04-24 | Cincinnati Reds | W 2-0 | 1505.49 | 1497.63 | 54.97% | 45.03% | +2.11 | 10-10 |
| 2021-04-25 | Cincinnati Reds | W 5-2 | 1507.60 | 1495.52 | 55.57% | 44.43% | +2.56 | 11-10 |
| 2021-04-26 | Philadelphia Phillies | L 1-2 | 1510.16 | 1486.61 | 57.19% | 42.81% | -1.90 | 11-11 |
| 2021-04-27 | Philadelphia Phillies | W 5-2 | 1508.26 | 1488.51 | 56.66% | 43.34% | +2.49 | 12-11 |
| 2021-04-28 | Philadelphia Phillies | L 3-5 | 1510.75 | 1486.01 | 57.36% | 42.64% | -2.69 | 12-12 |
| 2021-04-29 | Philadelphia Phillies | W 4-3 | 1508.06 | 1488.71 | 56.60% | 43.40% | +1.02 | 13-12 |
| 2021-04-30 | @ Pittsburgh Pirates | W 7-3 | 1509.08 | 1473.63 | 51.25% | 48.75% | +3.23 | 14-12 |
| 2021-05-01 | @ Pittsburgh Pirates | W 12-5 | 1512.31 | 1470.39 | 52.18% | 47.82% | +4.20 | 15-12 |
| 2021-05-02 | @ Pittsburgh Pirates | W 3-0 | 1516.51 | 1466.19 | 53.38% | 46.62% | +2.68 | 16-12 |
| 2021-05-03 | New York Mets | W 6-5 | 1519.19 | 1494.16 | 57.40% | 42.60% | +1.42 | 17-12 |
| 2021-05-05 | New York Mets | W 4-1 | 1520.61 | 1492.75 | 57.80% | 42.20% | +2.42 | 18-12 |
| 2021-05-05 | New York Mets | L 2-7 | 1523.03 | 1490.32 | 58.48% | 41.52% | -4.34 | 18-13 |
| 2021-05-06 | New York Mets | L 1-4 | 1518.69 | 1494.66 | 57.26% | 42.74% | -3.29 | 18-14 |
| 2021-05-07 | Colorado Rockies | W 5-0 | 1515.40 | 1470.77 | 60.14% | 39.86% | +2.96 | 19-14 |
| 2021-05-08 | Colorado Rockies | W 9-8 | 1518.36 | 1467.81 | 60.95% | 39.05% | +1.30 | 20-14 |
| 2021-05-09 | Colorado Rockies | W 2-0 | 1519.66 | 1466.51 | 61.30% | 38.70% | +1.81 | 21-14 |
| 2021-05-11 | @ Milwaukee Brewers | W 6-1 | 1521.47 | 1501.57 | 49.01% | 50.99% | +2.68 | 22-14 |
| 2021-05-12 | @ Milwaukee Brewers | L 1-4 | 1524.15 | 1498.89 | 49.78% | 50.22% | -2.86 | 22-15 |
| 2021-05-13 | @ Milwaukee Brewers | W 2-0 | 1521.29 | 1501.75 | 48.96% | 51.04% | +2.39 | 23-15 |
| 2021-05-14 | @ San Diego Padres | L 4-5 | 1523.68 | 1522.34 | 46.35% | 53.65% | -1.53 | 23-16 |
| 2021-05-15 | @ San Diego Padres | L 3-13 | 1522.15 | 1523.88 | 45.91% | 54.09% | -4.82 | 23-17 |
| 2021-05-16 | @ San Diego Padres | L 3-5 | 1517.33 | 1528.70 | 44.53% | 55.47% | -2.09 | 23-18 |
| 2021-05-18 | Pittsburgh Pirates | W 5-2 | 1515.24 | 1455.94 | 62.14% | 37.86% | +2.17 | 24-18 |
| 2021-05-19 | Pittsburgh Pirates | W 8-5 | 1517.41 | 1453.77 | 62.73% | 37.27% | +2.15 | 25-18 |
| 2021-05-21 | Chicago Cubs | L 3-12 | 1519.56 | 1510.25 | 55.18% | 44.82% | -5.50 | 25-19 |
| 2021-05-22 | Chicago Cubs | W 2-1 | 1514.06 | 1515.74 | 53.61% | 46.39% | +1.54 | 26-19 |
| 2021-05-23 | Chicago Cubs | L 1-2 | 1515.60 | 1514.20 | 54.05% | 45.95% | -1.27 | 26-20 |
| 2021-05-24 | @ Chicago White Sox | L 1-5 | 1514.33 | 1529.06 | 44.06% | 55.94% | -2.92 | 26-21 |
| 2021-05-25 | @ Chicago White Sox | L 3-8 | 1511.41 | 1531.98 | 43.23% | 56.77% | -3.21 | 26-22 |
| 2021-05-26 | @ Chicago White Sox | W 4-0 | 1508.20 | 1535.19 | 42.32% | 57.68% | +3.83 | 27-22 |
| 2021-05-27 | @ Arizona Diamondbacks | W 5-4 | 1512.03 | 1462.81 | 53.23% | 46.77% | +1.10 | 28-22 |
| 2021-05-28 | @ Arizona Diamondbacks | W 8-6 | 1513.13 | 1461.71 | 53.54% | 46.46% | +2.18 | 29-22 |
| 2021-05-29 | @ Arizona Diamondbacks | W 7-4 | 1515.31 | 1459.53 | 54.16% | 45.84% | +2.63 | 30-22 |
| 2021-05-30 | @ Arizona Diamondbacks | L 2-9 | 1517.94 | 1456.89 | 54.92% | 45.08% | -4.82 | 30-23 |
| 2021-05-31 | @ Los Angeles Dodgers | L 4-9 | 1513.12 | 1576.77 | 37.27% | 62.73% | -2.77 | 30-24 |
| 2021-06-01 | @ Los Angeles Dodgers | W 3-2 | 1510.35 | 1579.54 | 36.53% | 63.47% | +2.11 | 31-24 |
| 2021-06-02 | @ Los Angeles Dodgers | L 3-14 | 1512.46 | 1577.43 | 37.09% | 62.91% | -4.09 | 31-25 |
| 2021-06-03 | Cincinnati Reds | L 2-4 | 1508.37 | 1475.19 | 58.55% | 41.45% | -2.74 | 31-26 |
| 2021-06-04 | Cincinnati Reds | L 4-6 | 1505.63 | 1477.94 | 57.78% | 42.22% | -2.72 | 31-27 |
| 2021-06-05 | Cincinnati Reds | L 2-5 | 1502.91 | 1480.65 | 57.01% | 42.99% | -3.28 | 31-28 |
| 2021-06-06 | Cincinnati Reds | L 7-8 | 1499.63 | 1483.93 | 56.08% | 43.92% | -1.86 | 31-29 |
| 2021-06-08 | Cleveland Indians | L 1-10 | 1497.77 | 1502.32 | 53.19% | 46.81% | -5.30 | 31-30 |
| 2021-06-09 | Cleveland Indians | W 8-2 | 1492.47 | 1507.62 | 51.67% | 48.33% | +3.93 | 32-30 |
| 2021-06-11 | @ Chicago Cubs | L 5-8 | 1496.40 | 1529.58 | 41.46% | 58.54% | -2.38 | 32-31 |
| 2021-06-12 | @ Chicago Cubs | L 2-7 | 1494.02 | 1531.96 | 40.79% | 59.21% | -3.03 | 32-32 |
| 2021-06-13 | @ Chicago Cubs | L 0-2 | 1490.99 | 1534.99 | 39.95% | 60.05% | -1.87 | 32-33 |
| 2021-06-14 | Miami Marlins | W 4-2 | 1489.12 | 1484.73 | 54.47% | 45.53% | +2.13 | 33-33 |
| 2021-06-15 | Miami Marlins | W 2-1 | 1491.25 | 1482.59 | 55.08% | 44.92% | +1.50 | 34-33 |
| 2021-06-16 | Miami Marlins | W 1-0 | 1492.75 | 1481.10 | 55.51% | 44.49% | +1.47 | 35-33 |
| 2021-06-17 | @ Atlanta Braves | L 0-4 | 1494.22 | 1505.25 | 44.58% | 55.42% | -2.96 | 35-34 |
| 2021-06-18 | @ Atlanta Braves | L 1-9 | 1491.26 | 1508.21 | 43.74% | 56.26% | -4.11 | 35-35 |
| 2021-06-20 | @ Atlanta Braves | W 9-1 | 1487.15 | 1512.32 | 42.58% | 57.42% | +5.40 | 36-35 |
| 2021-06-20 | @ Atlanta Braves | L 0-1 | 1492.55 | 1506.92 | 44.10% | 55.90% | -1.47 | 36-36 |
| 2021-06-22 | @ Detroit Tigers | L 2-8 | 1491.08 | 1441.94 | 53.21% | 46.79% | -4.33 | 36-37 |
| 2021-06-23 | @ Detroit Tigers | L 2-6 | 1486.75 | 1446.27 | 51.97% | 48.03% | -3.45 | 36-38 |
| 2021-06-24 | Pittsburgh Pirates | L 2-8 | 1483.30 | 1431.92 | 61.06% | 38.94% | -4.96 | 36-39 |
| 2021-06-25 | Pittsburgh Pirates | L 4-5 | 1478.34 | 1436.88 | 59.70% | 40.30% | -1.98 | 36-40 |
| 2021-06-26 | Pittsburgh Pirates | W 3-1 | 1476.36 | 1438.86 | 59.15% | 40.85% | +1.91 | 37-40 |
| 2021-06-27 | Pittsburgh Pirates | L 2-7 | 1478.27 | 1436.95 | 59.68% | 40.32% | -4.43 | 37-41 |
| 2021-06-28 | Arizona Diamondbacks | W 7-1 | 1473.84 | 1427.15 | 60.42% | 39.58% | +3.22 | 38-41 |
| 2021-06-29 | Arizona Diamondbacks | W 3-2 | 1477.06 | 1423.93 | 61.30% | 38.70% | +1.29 | 39-41 |
| 2021-06-30 | Arizona Diamondbacks | W 7-4 | 1478.35 | 1422.64 | 61.65% | 38.35% | +2.20 | 40-41 |
| 2021-07-01 | @ Colorado Rockies | L 2-5 | 1480.55 | 1458.62 | 49.30% | 50.70% | -2.83 | 40-42 |
| 2021-07-02 | @ Colorado Rockies | W 9-3 | 1477.72 | 1461.45 | 48.49% | 51.51% | +2.96 | 41-42 |
| 2021-07-03 | @ Colorado Rockies | L 2-3 | 1480.68 | 1458.49 | 49.34% | 50.66% | -1.64 | 41-43 |
| 2021-07-04 | @ Colorado Rockies | L 2-3 | 1479.04 | 1460.13 | 48.87% | 51.13% | -1.62 | 41-44 |
| 2021-07-05 | @ San Francisco Giants | W 5-3 | 1477.42 | 1550.69 | 35.99% | 64.01% | +3.01 | 42-44 |
| 2021-07-06 | @ San Francisco Giants | W 6-5 | 1480.43 | 1547.69 | 36.79% | 63.21% | +2.09 | 43-44 |
| 2021-07-07 | @ San Francisco Giants | L 2-5 | 1482.52 | 1545.59 | 37.35% | 62.65% | -2.14 | 43-45 |
| 2021-07-09 | @ Chicago Cubs | L 5-10 | 1480.38 | 1492.07 | 44.49% | 55.51% | -3.31 | 43-46 |
| 2021-07-10 | @ Chicago Cubs | W 6-0 | 1477.07 | 1495.38 | 43.55% | 56.45% | +4.59 | 44-46 |
| 2021-07-16 | San Francisco Giants | L 2-7 | 1481.66 | 1554.75 | 43.38% | 56.62% | -3.22 | 44-47 |
| 2021-07-17 | San Francisco Giants | W 3-1 | 1478.44 | 1557.97 | 42.47% | 57.53% | +2.71 | 45-47 |
| 2021-07-18 | San Francisco Giants | W 2-1 | 1481.15 | 1555.27 | 43.23% | 56.77% | +1.88 | 46-47 |
| 2021-07-19 | Chicago Cubs | W 8-3 | 1483.03 | 1492.91 | 52.43% | 47.57% | +3.53 | 47-47 |
| 2021-07-20 | Chicago Cubs | L 6-7 | 1486.56 | 1489.38 | 53.44% | 46.56% | -1.77 | 47-48 |
| 2021-07-21 | Chicago Cubs | W 3-2 | 1484.79 | 1491.16 | 52.93% | 47.07% | +1.10 | 48-48 |
| 2021-07-22 | Chicago Cubs | W 3-2 | 1485.89 | 1490.05 | 53.25% | 46.75% | +1.55 | 49-48 |
| 2021-07-23 | @ Cincinnati Reds | L 5-6 | 1487.44 | 1492.89 | 45.38% | 54.62% | -1.50 | 49-49 |
| 2021-07-24 | @ Cincinnati Reds | L 3-5 | 1485.94 | 1494.39 | 44.95% | 55.05% | -2.11 | 49-50 |
| 2021-07-25 | @ Cincinnati Reds | W 10-6 | 1483.83 | 1496.50 | 44.35% | 55.65% | +3.69 | 50-50 |
| 2021-07-27 | @ Cleveland Indians | W 4-2 | 1487.52 | 1487.34 | 46.18% | 53.82% | +2.53 | 51-50 |
| 2021-07-28 | @ Cleveland Indians | L 2-7 | 1490.05 | 1484.82 | 46.90% | 53.10% | -3.48 | 51-51 |
| 2021-07-30 | Minnesota Twins | W 5-1 | 1486.57 | 1463.46 | 57.13% | 42.87% | +2.84 | 52-51 |
| 2021-07-31 | Minnesota Twins | L 1-8 | 1489.41 | 1460.61 | 57.93% | 42.07% | -5.08 | 52-52 |
| 2021-08-01 | Minnesota Twins | W 7-3 | 1484.33 | 1465.70 | 56.50% | 43.50% | +2.88 | 53-52 |
| 2021-08-03 | Atlanta Braves | L 1-6 | 1487.21 | 1525.61 | 48.33% | 51.67% | -3.58 | 53-53 |
| 2021-08-04 | Atlanta Braves | L 4-7 | 1483.63 | 1529.20 | 47.30% | 52.70% | -2.72 | 53-54 |
| 2021-08-05 | Atlanta Braves | L 4-8 | 1480.91 | 1531.92 | 46.52% | 53.48% | -3.09 | 53-55 |
| 2021-08-06 | Kansas City Royals | W 4-2 | 1477.82 | 1448.43 | 58.01% | 41.99% | +1.97 | 54-55 |
| 2021-08-07 | Kansas City Royals | W 5-2 | 1479.79 | 1446.46 | 58.56% | 41.44% | +2.38 | 55-55 |
| 2021-08-08 | Kansas City Royals | L 5-6 | 1482.17 | 1444.08 | 59.23% | 40.77% | -1.96 | 55-56 |
| 2021-08-10 | @ Pittsburgh Pirates | W 4-1 | 1480.21 | 1414.73 | 55.55% | 44.45% | +2.55 | 56-56 |
| 2021-08-11 | @ Pittsburgh Pirates | W 4-0 | 1482.76 | 1412.17 | 56.27% | 43.73% | +2.91 | 57-56 |
| 2021-08-12 | @ Pittsburgh Pirates | W 7-6 | 1485.67 | 1409.27 | 57.09% | 42.91% | +1.42 | 58-56 |
| 2021-08-13 | @ Kansas City Royals | W 6-0 | 1487.09 | 1446.04 | 52.05% | 47.95% | +3.90 | 59-56 |
| 2021-08-14 | @ Kansas City Royals | W 9-4 | 1490.99 | 1442.14 | 53.17% | 46.83% | +3.48 | 60-56 |
| 2021-08-15 | @ Kansas City Royals | W 7-2 | 1494.47 | 1438.67 | 54.17% | 45.83% | +3.40 | 61-56 |
| 2021-08-17 | Milwaukee Brewers | L 0-2 | 1497.87 | 1554.30 | 45.74% | 54.26% | -2.15 | 61-57 |
| 2021-08-18 | Milwaukee Brewers | L 4-6 | 1495.72 | 1556.45 | 45.13% | 54.87% | -1.50 | 61-58 |
| 2021-08-19 | Milwaukee Brewers | W 8-4 | 1494.22 | 1557.94 | 44.70% | 55.30% | +3.67 | 62-58 |
| 2021-08-20 | Pittsburgh Pirates | L 0-4 | 1497.89 | 1407.27 | 66.28% | 33.72% | -4.40 | 62-59 |
| 2021-08-21 | Pittsburgh Pirates | L 4-5 | 1493.49 | 1411.67 | 65.14% | 34.86% | -2.16 | 62-60 |
| 2021-08-22 | Pittsburgh Pirates | W 3-0 | 1491.33 | 1413.83 | 64.57% | 35.43% | +2.04 | 63-60 |
| 2021-08-24 | Detroit Tigers | L 3-4 | 1493.37 | 1462.92 | 58.16% | 41.84% | -1.93 | 63-61 |
| 2021-08-25 | Detroit Tigers | W 3-2 | 1491.44 | 1464.85 | 57.62% | 42.38% | +0.99 | 64-61 |
| 2021-08-26 | @ Pittsburgh Pirates | L 7-11 | 1492.43 | 1412.69 | 57.56% | 42.44% | -3.82 | 64-62 |
| 2021-08-27 | @ Pittsburgh Pirates | W 4-3 | 1488.61 | 1416.51 | 56.49% | 43.51% | +1.44 | 65-62 |
| 2021-08-28 | @ Pittsburgh Pirates | W 13-0 | 1490.05 | 1415.06 | 56.89% | 43.11% | +5.16 | 66-62 |
| 2021-08-29 | @ Pittsburgh Pirates | L 3-4 | 1495.21 | 1409.90 | 58.34% | 41.66% | -1.93 | 66-63 |
| 2021-08-30 | @ Cincinnati Reds | W 3-1 | 1493.28 | 1520.78 | 42.25% | 57.75% | +2.71 | 67-63 |
| 2021-09-01 | @ Cincinnati Reds | W 5-4 | 1495.99 | 1518.07 | 43.01% | 56.99% | +1.89 | 68-63 |
| 2021-09-01 | @ Cincinnati Reds | L 2-12 | 1497.88 | 1516.17 | 43.55% | 56.45% | -4.57 | 68-64 |
| 2021-09-03 | @ Milwaukee Brewers | W 15-4 | 1493.31 | 1559.45 | 36.94% | 63.06% | +6.94 | 69-64 |
| 2021-09-04 | @ Milwaukee Brewers | L 0-4 | 1500.25 | 1552.51 | 38.82% | 61.18% | -2.58 | 69-65 |
| 2021-09-05 | @ Milwaukee Brewers | L 5-6 | 1497.67 | 1555.08 | 38.12% | 61.88% | -1.26 | 69-66 |
| 2021-09-06 | Los Angeles Dodgers | L 1-5 | 1496.41 | 1608.15 | 38.01% | 61.99% | -2.53 | 69-67 |
| 2021-09-07 | Los Angeles Dodgers | L 2-7 | 1493.88 | 1610.68 | 37.33% | 62.67% | -2.77 | 69-68 |
| 2021-09-08 | Los Angeles Dodgers | W 5-4 | 1491.11 | 1613.45 | 36.59% | 63.41% | +2.11 | 70-68 |
| 2021-09-09 | Los Angeles Dodgers | W 2-1 | 1493.22 | 1611.34 | 37.15% | 62.85% | +2.09 | 71-68 |
| 2021-09-10 | Cincinnati Reds | L 2-4 | 1495.31 | 1510.43 | 51.68% | 48.32% | -2.43 | 71-69 |
| 2021-09-11 | Cincinnati Reds | W 6-4 | 1492.88 | 1512.86 | 50.98% | 49.02% | +2.30 | 72-69 |
| 2021-09-12 | Cincinnati Reds | W 2-0 | 1495.18 | 1510.56 | 51.64% | 48.36% | +2.27 | 73-69 |
| 2021-09-13 | @ New York Mets | W 7-0 | 1497.45 | 1499.43 | 45.87% | 54.13% | +4.76 | 74-69 |
| 2021-09-14 | @ New York Mets | W 7-6 | 1502.21 | 1494.68 | 47.23% | 52.77% | +1.24 | 75-69 |
| 2021-09-15 | @ New York Mets | W 11-4 | 1503.45 | 1493.44 | 47.59% | 52.41% | +4.60 | 76-69 |
| 2021-09-17 | San Diego Padres | W 8-2 | 1508.05 | 1504.23 | 54.39% | 45.61% | +3.71 | 77-69 |
| 2021-09-18 | San Diego Padres | W 3-2 | 1511.76 | 1500.53 | 55.45% | 44.55% | +1.48 | 78-69 |
| 2021-09-19 | San Diego Padres | W 8-7 | 1513.24 | 1499.05 | 55.87% | 44.13% | +1.46 | 79-69 |
| 2021-09-20 | @ Milwaukee Brewers | W 5-2 | 1514.70 | 1561.02 | 39.63% | 60.37% | +3.47 | 80-69 |
| 2021-09-21 | @ Milwaukee Brewers | W 2-1 | 1518.17 | 1557.55 | 40.59% | 59.41% | +1.98 | 81-69 |
| 2021-09-22 | @ Milwaukee Brewers | W 10-2 | 1520.15 | 1555.58 | 41.14% | 58.86% | +5.52 | 82-69 |
| 2021-09-23 | @ Milwaukee Brewers | W 8-5 | 1525.67 | 1550.05 | 42.69% | 57.31% | +3.30 | 83-69 |
| 2021-09-24 | @ Chicago Cubs | W 8-5 | 1528.97 | 1443.32 | 58.39% | 41.61% | +2.39 | 84-69 |
| 2021-09-24 | @ Chicago Cubs | W 12-4 | 1531.36 | 1440.93 | 59.06% | 40.94% | +3.85 | 85-69 |
| 2021-09-25 | @ Chicago Cubs | W 8-5 | 1535.21 | 1437.09 | 60.12% | 39.88% | +2.29 | 86-69 |
| 2021-09-26 | @ Chicago Cubs | W 4-2 | 1537.50 | 1434.79 | 60.76% | 39.24% | +1.84 | 87-69 |
| 2021-09-28 | Milwaukee Brewers | W 6-2 | 1539.34 | 1552.79 | 51.92% | 48.08% | +3.19 | 88-69 |
| 2021-09-29 | Milwaukee Brewers | L 0-4 | 1542.53 | 1549.60 | 52.83% | 47.17% | -3.50 | 88-70 |
| 2021-09-30 | Milwaukee Brewers | W 4-3 | 1539.03 | 1553.11 | 51.83% | 48.17% | +1.60 | 89-70 |
| 2021-10-01 | Chicago Cubs | W 4-3 | 1540.63 | 1437.42 | 67.88% | 32.12% | +1.06 | 90-70 |
| 2021-10-02 | Chicago Cubs | L 5-6 | 1541.69 | 1436.35 | 68.15% | 31.85% | -2.26 | 90-71 |
| 2021-10-03 | Chicago Cubs | L 2-3 | 1539.43 | 1438.61 | 67.58% | 32.42% | -2.24 | 90-72 |
| 2021-04-01 | @ Miami Marlins | W 1-0 | 1530.30 | 1479.57 | 53.44% | 46.56% | +1.54 | 1-0 |
| 2021-04-02 | @ Miami Marlins | W 6-4 | 1531.84 | 1478.02 | 53.88% | 46.12% | +2.17 | 2-0 |
| 2021-04-03 | @ Miami Marlins | L 7-12 | 1534.01 | 1475.86 | 54.50% | 45.50% | -4.05 | 2-1 |
| 2021-04-05 | @ Boston Red Sox | L 2-11 | 1529.96 | 1484.50 | 52.69% | 47.31% | -5.25 | 2-2 |
| 2021-04-06 | @ Boston Red Sox | L 5-6 | 1524.71 | 1489.74 | 51.18% | 48.82% | -1.20 | 2-3 |
| 2021-04-07 | @ Boston Red Sox | L 2-9 | 1523.51 | 1490.94 | 50.83% | 49.17% | -4.46 | 2-4 |
| 2021-04-09 | New York Yankees | W 10-5 | 1519.05 | 1531.64 | 52.04% | 47.96% | +3.56 | 3-4 |
| 2021-04-10 | New York Yankees | W 4-0 | 1522.61 | 1528.08 | 53.06% | 46.94% | +3.11 | 4-4 |
| 2021-04-11 | New York Yankees | L 4-8 | 1525.72 | 1524.97 | 53.95% | 46.05% | -2.53 | 4-5 |
| 2021-04-12 | Texas Rangers | W 1-0 | 1523.19 | 1462.99 | 62.26% | 37.74% | +1.25 | 5-5 |
| 2021-04-13 | Texas Rangers | L 3-8 | 1524.44 | 1461.73 | 62.60% | 37.40% | -4.64 | 5-6 |
| 2021-04-14 | Texas Rangers | L 1-5 | 1519.80 | 1466.38 | 61.34% | 38.66% | -4.08 | 5-7 |
| 2021-04-15 | Texas Rangers | L 4-6 | 1515.72 | 1470.45 | 60.22% | 39.78% | -2.00 | 5-8 |
| 2021-04-16 | @ New York Yankees | W 8-2 | 1513.72 | 1524.16 | 44.66% | 55.34% | +4.50 | 6-8 |
| 2021-04-17 | @ New York Yankees | W 6-3 | 1518.22 | 1519.66 | 45.95% | 54.05% | +3.11 | 7-8 |
| 2021-04-18 | @ New York Yankees | W 4-2 | 1521.33 | 1516.56 | 46.84% | 53.16% | +2.50 | 8-8 |
| 2021-04-19 | @ Kansas City Royals | W 4-1 | 1523.83 | 1481.12 | 52.29% | 47.71% | +2.74 | 9-8 |
| 2021-04-20 | @ Kansas City Royals | W 14-7 | 1526.57 | 1478.37 | 53.08% | 46.92% | +4.12 | 10-8 |
| 2021-04-21 | @ Kansas City Royals | L 8-9 | 1530.69 | 1474.25 | 54.26% | 45.74% | -1.80 | 10-9 |
| 2021-04-23 | Toronto Blue Jays | L 3-5 | 1528.89 | 1496.95 | 58.37% | 41.63% | -2.74 | 10-10 |
| 2021-04-24 | Toronto Blue Jays | W 5-3 | 1526.15 | 1499.69 | 57.60% | 42.40% | +1.99 | 11-10 |
| 2021-04-25 | Toronto Blue Jays | L 0-1 | 1528.14 | 1497.70 | 58.16% | 41.84% | -1.93 | 11-11 |
| 2021-04-26 | Oakland Athletics | L 1-2 | 1526.21 | 1525.54 | 53.94% | 46.06% | -1.79 | 11-12 |
| 2021-04-27 | Oakland Athletics | W 4-3 | 1524.42 | 1527.33 | 53.43% | 46.57% | +1.55 | 12-12 |
| 2021-04-28 | Oakland Athletics | W 2-0 | 1525.97 | 1525.79 | 53.87% | 46.13% | +2.16 | 13-12 |
| 2021-04-29 | Oakland Athletics | L 2-3 | 1528.13 | 1523.62 | 54.49% | 45.51% | -1.81 | 13-13 |
| 2021-04-30 | Houston Astros | L 2-9 | 1526.32 | 1526.77 | 53.78% | 46.22% | -4.72 | 13-14 |
| 2021-05-01 | Houston Astros | L 1-3 | 1521.60 | 1531.49 | 52.43% | 47.57% | -2.46 | 13-15 |
| 2021-05-02 | Houston Astros | W 5-4 | 1519.14 | 1533.96 | 51.72% | 48.28% | +1.60 | 14-15 |
| 2021-05-03 | @ Los Angeles Angels | W 7-3 | 1520.74 | 1483.15 | 51.56% | 48.44% | +3.22 | 15-15 |
| 2021-05-04 | @ Los Angeles Angels | W 8-3 | 1523.96 | 1479.93 | 52.48% | 47.52% | +3.52 | 16-15 |
| 2021-05-05 | @ Los Angeles Angels | W 3-1 | 1527.48 | 1476.40 | 53.49% | 46.51% | +2.19 | 17-15 |
| 2021-05-06 | @ Los Angeles Angels | W 8-3 | 1529.67 | 1474.22 | 54.12% | 45.88% | +3.40 | 18-15 |
| 2021-05-07 | @ Oakland Athletics | L 1-2 | 1533.07 | 1516.51 | 48.53% | 51.47% | -1.61 | 18-16 |
| 2021-05-08 | @ Oakland Athletics | L 3-6 | 1531.46 | 1518.12 | 48.07% | 51.93% | -2.76 | 18-17 |
| 2021-05-09 | @ Oakland Athletics | W 4-3 | 1528.70 | 1520.88 | 47.27% | 52.73% | +1.75 | 19-17 |
| 2021-05-11 | New York Yankees | L 1-3 | 1530.45 | 1527.41 | 54.28% | 45.72% | -2.55 | 19-18 |
| 2021-05-12 | New York Yankees | L 0-1 | 1527.90 | 1529.96 | 53.55% | 46.45% | -1.78 | 19-19 |
| 2021-05-13 | New York Yankees | W 9-1 | 1526.12 | 1531.74 | 53.04% | 46.96% | +4.41 | 20-19 |
| 2021-05-14 | New York Mets | W 3-2 | 1530.53 | 1508.02 | 57.05% | 42.95% | +1.43 | 21-19 |
| 2021-05-15 | New York Mets | W 12-5 | 1531.96 | 1506.59 | 57.45% | 42.55% | +3.74 | 22-19 |
| 2021-05-16 | New York Mets | W 7-1 | 1535.70 | 1502.85 | 58.50% | 41.50% | +3.37 | 23-19 |
| 2021-05-18 | @ Baltimore Orioles | W 13-6 | 1539.07 | 1468.64 | 56.25% | 43.75% | +3.85 | 24-19 |
| 2021-05-19 | @ Baltimore Orioles | W 9-7 | 1542.92 | 1464.80 | 57.33% | 42.67% | +2.00 | 25-19 |
| 2021-05-20 | @ Baltimore Orioles | W 10-1 | 1544.92 | 1462.80 | 57.90% | 42.10% | +4.19 | 26-19 |
| 2021-05-21 | @ Toronto Blue Jays | W 9-7 | 1549.11 | 1521.59 | 53.95% | 46.05% | +1.53 | 27-19 |
| 2021-05-22 | @ Toronto Blue Jays | W 3-1 | 1550.64 | 1520.06 | 54.39% | 45.61% | +2.14 | 28-19 |
| 2021-05-23 | @ Toronto Blue Jays | W 6-4 | 1552.78 | 1517.92 | 55.00% | 45.00% | +2.11 | 29-19 |
| 2021-05-24 | @ Toronto Blue Jays | W 14-8 | 1554.89 | 1515.81 | 55.60% | 44.40% | +2.56 | 30-19 |
| 2021-05-25 | Kansas City Royals | L 1-2 | 1557.45 | 1468.00 | 66.13% | 33.87% | -2.20 | 30-20 |
| 2021-05-26 | Kansas City Royals | W 2-1 | 1555.25 | 1470.19 | 65.56% | 34.44% | +0.81 | 31-20 |
| 2021-05-27 | Kansas City Royals | W 7-2 | 1556.06 | 1469.39 | 65.77% | 34.23% | +2.54 | 32-20 |
| 2021-05-29 | Philadelphia Phillies | W 5-3 | 1558.60 | 1488.34 | 63.61% | 36.39% | +1.71 | 33-20 |
| 2021-05-30 | Philadelphia Phillies | W 6-2 | 1560.31 | 1486.64 | 64.07% | 35.93% | +2.39 | 34-20 |
| 2021-05-31 | @ New York Yankees | W 3-1 | 1562.70 | 1525.35 | 51.52% | 48.48% | +2.27 | 35-20 |
| 2021-06-01 | @ New York Yankees | L 3-5 | 1564.97 | 1523.07 | 52.17% | 47.83% | -1.73 | 35-21 |
| 2021-06-02 | @ New York Yankees | L 3-4 | 1563.24 | 1524.81 | 51.68% | 48.32% | -1.72 | 35-22 |
| 2021-06-03 | @ New York Yankees | W 9-2 | 1561.52 | 1526.52 | 51.18% | 48.82% | +4.29 | 36-22 |
| 2021-06-04 | @ Texas Rangers | L 4-5 | 1565.81 | 1447.59 | 62.86% | 37.14% | -2.08 | 36-23 |
| 2021-06-05 | @ Texas Rangers | W 3-0 | 1563.73 | 1449.68 | 62.30% | 37.70% | +2.16 | 37-23 |
| 2021-06-06 | @ Texas Rangers | W 7-1 | 1565.89 | 1447.51 | 62.89% | 37.11% | +3.02 | 38-23 |
| 2021-06-08 | Washington Nationals | W 3-1 | 1568.91 | 1485.11 | 65.40% | 34.60% | +1.63 | 39-23 |
| 2021-06-09 | Washington Nationals | L 7-9 | 1570.54 | 1483.48 | 65.82% | 34.18% | -2.19 | 39-24 |
| 2021-06-11 | Baltimore Orioles | W 4-2 | 1568.35 | 1449.02 | 69.87% | 30.13% | +1.42 | 40-24 |
| 2021-06-12 | Baltimore Orioles | W 5-4 | 1569.77 | 1447.60 | 70.21% | 29.79% | +0.98 | 41-24 |
| 2021-06-13 | Baltimore Orioles | W 7-1 | 1570.75 | 1446.61 | 70.45% | 29.55% | +2.41 | 42-24 |
| 2021-06-14 | @ Chicago White Sox | W 5-2 | 1573.16 | 1549.02 | 49.62% | 50.38% | +2.90 | 43-24 |
| 2021-06-15 | @ Chicago White Sox | L 0-3 | 1576.06 | 1546.12 | 50.45% | 49.55% | -2.91 | 43-25 |
| 2021-06-16 | @ Chicago White Sox | L 7-8 | 1573.15 | 1549.02 | 49.62% | 50.38% | -1.16 | 43-26 |
| 2021-06-17 | @ Seattle Mariners | L 5-6 | 1571.99 | 1466.84 | 61.09% | 38.91% | -2.03 | 43-27 |
| 2021-06-18 | @ Seattle Mariners | L 1-5 | 1569.96 | 1468.87 | 60.53% | 39.47% | -4.02 | 43-28 |
| 2021-06-19 | @ Seattle Mariners | L 5-6 | 1565.94 | 1472.89 | 59.42% | 40.58% | -1.39 | 43-29 |
| 2021-06-20 | @ Seattle Mariners | L 2-6 | 1564.55 | 1474.29 | 59.04% | 40.96% | -2.78 | 43-30 |
| 2021-06-22 | Boston Red Sox | L 5-9 | 1561.77 | 1521.25 | 59.57% | 40.43% | -2.79 | 43-31 |
| 2021-06-23 | Boston Red Sox | W 8-2 | 1558.98 | 1524.04 | 58.79% | 41.21% | +3.35 | 44-31 |
| 2021-06-24 | Boston Red Sox | W 1-0 | 1562.33 | 1520.69 | 59.72% | 40.28% | +1.34 | 45-31 |
| 2021-06-25 | Los Angeles Angels | W 4-3 | 1563.67 | 1484.91 | 64.74% | 35.26% | +1.17 | 46-31 |
| 2021-06-26 | Los Angeles Angels | W 13-3 | 1564.84 | 1483.74 | 65.04% | 34.96% | +3.67 | 47-31 |
| 2021-06-27 | Los Angeles Angels | L 4-6 | 1568.51 | 1480.07 | 66.00% | 34.00% | -3.10 | 47-32 |
| 2021-06-29 | @ Washington Nationals | L 3-4 | 1565.41 | 1507.37 | 54.49% | 45.51% | -1.81 | 47-33 |
| 2021-06-30 | @ Washington Nationals | L 6-15 | 1563.60 | 1509.18 | 53.97% | 46.03% | -5.38 | 47-34 |
| 2021-07-02 | @ Toronto Blue Jays | L 1-11 | 1558.22 | 1528.29 | 50.45% | 49.55% | -5.29 | 47-35 |
| 2021-07-03 | @ Toronto Blue Jays | L 3-6 | 1552.93 | 1533.59 | 48.93% | 51.07% | -2.82 | 47-36 |
| 2021-07-04 | @ Toronto Blue Jays | W 5-1 | 1550.11 | 1536.40 | 48.12% | 51.88% | +3.45 | 48-36 |
| 2021-07-05 | Cleveland Indians | W 9-8 | 1553.56 | 1491.51 | 62.51% | 37.49% | +1.24 | 49-36 |
| 2021-07-07 | Cleveland Indians | W 8-1 | 1554.80 | 1490.26 | 62.85% | 37.15% | +3.27 | 50-36 |
| 2021-07-07 | Cleveland Indians | W 4-0 | 1558.07 | 1487.00 | 63.72% | 36.28% | +2.41 | 51-36 |
| 2021-07-09 | Toronto Blue Jays | W 7-1 | 1560.48 | 1533.88 | 57.62% | 42.38% | +3.44 | 52-36 |
| 2021-07-10 | Toronto Blue Jays | W 5-2 | 1563.92 | 1530.43 | 58.59% | 41.41% | +2.38 | 53-36 |
| 2021-07-11 | Toronto Blue Jays | L 1-3 | 1566.30 | 1528.05 | 59.25% | 40.75% | -2.78 | 53-37 |
| 2021-07-16 | @ Atlanta Braves | W 7-6 | 1563.52 | 1514.47 | 53.20% | 46.80% | +1.10 | 54-37 |
| 2021-07-17 | @ Atlanta Braves | L 0-9 | 1564.62 | 1513.37 | 53.52% | 46.48% | -5.33 | 54-38 |
| 2021-07-18 | @ Atlanta Braves | W 7-5 | 1559.29 | 1518.70 | 51.99% | 48.01% | +2.25 | 55-38 |
| 2021-07-19 | Baltimore Orioles | L 1-6 | 1561.54 | 1425.62 | 71.84% | 28.16% | -5.33 | 55-39 |
| 2021-07-20 | Baltimore Orioles | W 9-3 | 1556.21 | 1430.96 | 70.58% | 29.42% | +2.39 | 56-39 |
| 2021-07-21 | Baltimore Orioles | W 5-4 | 1558.60 | 1428.56 | 71.15% | 28.85% | +0.96 | 57-39 |
| 2021-07-22 | @ Cleveland Indians | W 5-4 | 1559.56 | 1493.24 | 55.67% | 44.33% | +1.04 | 58-39 |
| 2021-07-23 | @ Cleveland Indians | W 10-5 | 1560.60 | 1492.20 | 55.96% | 44.04% | +3.27 | 59-39 |
| 2021-07-24 | @ Cleveland Indians | W 8-2 | 1563.87 | 1488.93 | 56.89% | 43.11% | +3.51 | 60-39 |
| 2021-07-25 | @ Cleveland Indians | L 2-3 | 1567.38 | 1485.42 | 57.87% | 42.13% | -1.92 | 60-40 |
| 2021-07-27 | New York Yankees | L 3-4 | 1565.46 | 1518.75 | 60.42% | 39.58% | -2.01 | 60-41 |
| 2021-07-28 | New York Yankees | L 1-3 | 1563.45 | 1520.76 | 59.87% | 40.13% | -1.99 | 60-42 |
| 2021-07-29 | New York Yankees | W 14-0 | 1561.46 | 1522.75 | 59.32% | 40.68% | +5.06 | 61-42 |
| 2021-07-30 | Boston Red Sox | W 7-3 | 1566.52 | 1534.38 | 58.40% | 41.60% | +2.76 | 62-42 |
| 2021-07-31 | Boston Red Sox | W 9-5 | 1569.28 | 1531.62 | 59.17% | 40.83% | +2.71 | 63-42 |
| 2021-08-01 | Boston Red Sox | W 3-2 | 1571.99 | 1528.91 | 59.92% | 40.08% | +1.33 | 64-42 |
| 2021-08-02 | Seattle Mariners | L 2-8 | 1573.32 | 1482.34 | 66.33% | 33.67% | -5.39 | 64-43 |
| 2021-08-03 | Seattle Mariners | L 2-4 | 1567.93 | 1487.73 | 64.93% | 35.07% | -3.05 | 64-44 |
| 2021-08-04 | Seattle Mariners | W 4-3 | 1564.88 | 1490.78 | 64.12% | 35.88% | +1.19 | 65-44 |
| 2021-08-06 | @ Baltimore Orioles | W 10-6 | 1566.07 | 1432.94 | 64.84% | 35.16% | +2.33 | 66-44 |
| 2021-08-07 | @ Baltimore Orioles | W 12-3 | 1568.40 | 1430.61 | 65.45% | 34.55% | +3.44 | 67-44 |
| 2021-08-08 | @ Baltimore Orioles | W 9-6 | 1571.84 | 1427.17 | 66.34% | 33.66% | +1.94 | 68-44 |
| 2021-08-10 | @ Boston Red Sox | W 8-4 | 1573.78 | 1517.43 | 54.24% | 45.76% | +3.04 | 69-44 |
| 2021-08-11 | @ Boston Red Sox | L 8-20 | 1576.82 | 1514.40 | 55.11% | 44.89% | -6.34 | 69-45 |
| 2021-08-12 | @ Boston Red Sox | W 8-1 | 1570.48 | 1520.73 | 53.30% | 46.70% | +4.10 | 70-45 |
| 2021-08-13 | @ Minnesota Twins | W 10-4 | 1574.58 | 1469.37 | 61.10% | 38.90% | +3.16 | 71-45 |
| 2021-08-14 | @ Minnesota Twins | L 0-12 | 1577.74 | 1466.21 | 61.96% | 38.04% | -7.12 | 71-46 |
| 2021-08-15 | @ Minnesota Twins | L 4-5 | 1570.62 | 1473.33 | 60.01% | 39.99% | -1.99 | 71-47 |
| 2021-08-16 | Baltimore Orioles | W 9-2 | 1568.63 | 1407.99 | 74.63% | 25.37% | +2.23 | 72-47 |
| 2021-08-17 | Baltimore Orioles | W 10-0 | 1570.86 | 1405.76 | 75.11% | 24.89% | +2.61 | 73-47 |
| 2021-08-18 | Baltimore Orioles | W 8-4 | 1573.47 | 1403.15 | 75.67% | 24.33% | +1.61 | 74-47 |
| 2021-08-19 | Baltimore Orioles | W 7-2 | 1575.08 | 1401.53 | 76.01% | 23.99% | +1.78 | 75-47 |
| 2021-08-20 | Chicago White Sox | L 5-7 | 1576.86 | 1545.29 | 58.32% | 41.68% | -1.93 | 75-48 |
| 2021-08-21 | Chicago White Sox | W 8-4 | 1574.93 | 1547.22 | 57.78% | 42.22% | +2.80 | 76-48 |
| 2021-08-22 | Chicago White Sox | W 9-0 | 1577.73 | 1544.42 | 58.56% | 41.44% | +4.13 | 77-48 |
| 2021-08-24 | @ Philadelphia Phillies | W 3-1 | 1581.86 | 1496.96 | 58.29% | 41.71% | +1.96 | 78-48 |
| 2021-08-25 | @ Philadelphia Phillies | W 7-4 | 1583.82 | 1495.00 | 58.83% | 41.17% | +2.37 | 79-48 |
| 2021-08-27 | @ Baltimore Orioles | W 6-3 | 1586.19 | 1402.32 | 71.18% | 28.82% | +1.65 | 80-48 |
| 2021-08-28 | @ Baltimore Orioles | W 4-3 | 1587.84 | 1400.67 | 71.57% | 28.43% | +0.95 | 81-48 |
| 2021-08-29 | @ Baltimore Orioles | W 12-8 | 1588.79 | 1399.72 | 71.79% | 28.21% | +1.87 | 82-48 |
| 2021-08-30 | Boston Red Sox | W 6-1 | 1590.66 | 1520.43 | 63.61% | 36.39% | +2.70 | 83-48 |
| 2021-08-31 | Boston Red Sox | W 8-5 | 1593.36 | 1517.73 | 64.33% | 35.67% | +2.05 | 84-48 |
| 2021-09-01 | Boston Red Sox | L 2-3 | 1595.41 | 1515.68 | 64.87% | 35.13% | -2.15 | 84-49 |
| 2021-09-02 | Boston Red Sox | L 0-4 | 1593.26 | 1517.83 | 64.30% | 35.70% | -4.27 | 84-50 |
| 2021-09-03 | Minnesota Twins | W 5-3 | 1588.99 | 1462.06 | 70.78% | 29.22% | +1.37 | 85-50 |
| 2021-09-04 | Minnesota Twins | W 11-4 | 1590.36 | 1460.69 | 71.11% | 28.89% | +2.54 | 86-50 |
| 2021-09-05 | Minnesota Twins | L 5-6 | 1592.90 | 1458.15 | 71.70% | 28.30% | -2.38 | 86-51 |
| 2021-09-06 | @ Boston Red Sox | W 11-10 | 1590.52 | 1521.36 | 56.07% | 43.93% | +1.03 | 87-51 |
| 2021-09-07 | @ Boston Red Sox | W 12-7 | 1591.55 | 1520.33 | 56.36% | 43.64% | +3.24 | 88-51 |
| 2021-09-08 | @ Boston Red Sox | L 1-2 | 1594.79 | 1517.09 | 57.28% | 42.72% | -1.90 | 88-52 |
| 2021-09-10 | @ Detroit Tigers | L 4-10 | 1592.89 | 1464.54 | 64.21% | 35.79% | -5.22 | 88-53 |
| 2021-09-11 | @ Detroit Tigers | W 7-2 | 1587.67 | 1469.76 | 62.82% | 37.18% | +2.76 | 89-53 |
| 2021-09-12 | @ Detroit Tigers | L 7-8 | 1590.43 | 1467.00 | 63.56% | 36.44% | -1.50 | 89-54 |
| 2021-09-13 | @ Toronto Blue Jays | L 1-8 | 1588.93 | 1567.84 | 49.18% | 50.82% | -4.32 | 89-55 |
| 2021-09-14 | @ Toronto Blue Jays | W 2-0 | 1584.61 | 1572.16 | 47.94% | 52.06% | +2.45 | 90-55 |
| 2021-09-15 | @ Toronto Blue Jays | L 3-6 | 1587.06 | 1569.72 | 48.64% | 51.36% | -2.80 | 90-56 |
| 2021-09-16 | Detroit Tigers | W 5-2 | 1584.26 | 1473.33 | 68.84% | 31.16% | +1.79 | 91-56 |
| 2021-09-17 | Detroit Tigers | W 7-4 | 1586.05 | 1471.54 | 69.28% | 30.72% | +1.25 | 92-56 |
| 2021-09-18 | Detroit Tigers | L 3-4 | 1587.30 | 1470.29 | 69.59% | 30.41% | -2.31 | 92-57 |
| 2021-09-19 | Detroit Tigers | L 0-2 | 1584.99 | 1472.60 | 69.02% | 30.98% | -3.24 | 92-58 |
| 2021-09-20 | Toronto Blue Jays | W 6-4 | 1581.75 | 1571.60 | 55.30% | 44.70% | +2.10 | 93-58 |
| 2021-09-21 | Toronto Blue Jays | L 2-4 | 1583.85 | 1569.50 | 55.89% | 44.11% | -2.62 | 93-59 |
| 2021-09-22 | Toronto Blue Jays | W 7-1 | 1581.23 | 1572.12 | 55.15% | 44.85% | +3.64 | 94-59 |
| 2021-09-24 | Miami Marlins | W 8-0 | 1584.87 | 1453.23 | 71.34% | 28.66% | +2.69 | 95-59 |
| 2021-09-25 | Miami Marlins | W 7-3 | 1587.56 | 1450.54 | 71.97% | 28.03% | +1.87 | 96-59 |
| 2021-09-26 | Miami Marlins | W 3-2 | 1589.43 | 1448.68 | 72.40% | 27.60% | +0.91 | 97-59 |
| 2021-09-28 | @ Houston Astros | L 3-4 | 1590.34 | 1562.98 | 50.08% | 49.92% | -1.66 | 97-60 |
| 2021-09-29 | @ Houston Astros | W 7-0 | 1588.68 | 1564.64 | 49.60% | 50.40% | +4.43 | 98-60 |
| 2021-09-30 | @ Houston Astros | L 2-3 | 1593.11 | 1560.22 | 50.88% | 49.12% | -1.69 | 98-61 |
| 2021-10-01 | @ New York Yankees | W 4-3 | 1591.42 | 1545.98 | 52.68% | 47.32% | +1.57 | 99-61 |
| 2021-10-02 | @ New York Yankees | W 12-2 | 1592.99 | 1544.40 | 53.13% | 46.87% | +4.92 | 100-61 |
| 2021-10-03 | @ New York Yankees | L 0-1 | 1597.91 | 1539.48 | 54.54% | 45.46% | -1.81 | 100-62 |
| 2021-04-01 | @ Kansas City Royals | L 10-14 | 1472.66 | 1475.20 | 45.79% | 54.21% | -3.04 | 0-1 |
| 2021-04-03 | @ Kansas City Royals | L 4-11 | 1469.62 | 1478.24 | 44.92% | 55.08% | -3.95 | 0-2 |
| 2021-04-04 | @ Kansas City Royals | W 7-3 | 1465.67 | 1482.19 | 43.80% | 56.20% | +3.73 | 1-2 |
| 2021-04-05 | Toronto Blue Jays | L 2-6 | 1469.40 | 1496.09 | 50.01% | 49.99% | -3.32 | 1-3 |
| 2021-04-06 | Toronto Blue Jays | W 7-4 | 1466.08 | 1499.41 | 49.06% | 50.94% | +2.93 | 2-3 |
| 2021-04-07 | Toronto Blue Jays | W 2-1 | 1469.01 | 1496.48 | 49.90% | 50.10% | +1.67 | 3-3 |
| 2021-04-09 | San Diego Padres | L 0-3 | 1470.68 | 1509.87 | 48.21% | 51.79% | -2.78 | 3-4 |
| 2021-04-10 | San Diego Padres | L 4-7 | 1467.90 | 1512.64 | 47.42% | 52.58% | -2.72 | 3-5 |
| 2021-04-11 | San Diego Padres | L 0-2 | 1465.18 | 1515.37 | 46.64% | 53.36% | -2.19 | 3-6 |
| 2021-04-12 | @ Tampa Bay Rays | L 0-1 | 1462.99 | 1523.19 | 37.74% | 62.26% | -1.26 | 3-7 |
| 2021-04-13 | @ Tampa Bay Rays | W 8-3 | 1461.73 | 1524.44 | 37.40% | 62.60% | +4.65 | 4-7 |
| 2021-04-14 | @ Tampa Bay Rays | W 5-1 | 1466.38 | 1519.80 | 38.66% | 61.34% | +4.07 | 5-7 |
| 2021-04-15 | @ Tampa Bay Rays | W 6-4 | 1470.45 | 1515.72 | 39.78% | 60.22% | +2.00 | 6-7 |
| 2021-04-16 | Baltimore Orioles | L 2-5 | 1472.45 | 1470.22 | 54.17% | 45.83% | -3.11 | 6-8 |
| 2021-04-17 | Baltimore Orioles | L 1-6 | 1469.34 | 1473.33 | 53.27% | 46.73% | -3.96 | 6-9 |
| 2021-04-18 | Baltimore Orioles | W 1-0 | 1465.38 | 1477.29 | 52.14% | 47.86% | +1.13 | 7-9 |
| 2021-04-19 | @ Los Angeles Angels | W 6-4 | 1466.51 | 1491.77 | 42.57% | 57.43% | +2.69 | 8-9 |
| 2021-04-20 | @ Los Angeles Angels | L 2-6 | 1469.20 | 1489.08 | 43.33% | 56.67% | -2.87 | 8-10 |
| 2021-04-21 | @ Los Angeles Angels | W 7-4 | 1466.33 | 1491.95 | 42.51% | 57.49% | +3.30 | 9-10 |
| 2021-04-23 | @ Chicago White Sox | L 7-9 | 1469.63 | 1509.39 | 40.54% | 59.46% | -1.90 | 9-11 |
| 2021-04-24 | @ Chicago White Sox | L 1-2 | 1467.73 | 1511.29 | 40.01% | 59.99% | -1.33 | 9-12 |
| 2021-04-25 | @ Chicago White Sox | L 4-8 | 1466.40 | 1512.62 | 39.65% | 60.35% | -2.63 | 9-13 |
| 2021-04-26 | Los Angeles Angels | L 4-9 | 1463.77 | 1481.97 | 51.23% | 48.77% | -3.81 | 9-14 |
| 2021-04-27 | Los Angeles Angels | W 6-1 | 1459.96 | 1485.77 | 50.14% | 49.86% | +3.71 | 10-14 |
| 2021-04-28 | Los Angeles Angels | L 3-4 | 1463.67 | 1482.07 | 51.21% | 48.79% | -1.70 | 10-15 |
| 2021-04-29 | Boston Red Sox | W 4-1 | 1461.97 | 1511.65 | 46.71% | 53.29% | +3.06 | 11-15 |
| 2021-04-30 | Boston Red Sox | L 1-6 | 1465.03 | 1508.59 | 47.59% | 52.41% | -3.53 | 11-16 |
| 2021-05-01 | Boston Red Sox | W 8-6 | 1461.50 | 1512.12 | 46.57% | 53.43% | +2.51 | 12-16 |
| 2021-05-02 | Boston Red Sox | W 5-3 | 1464.01 | 1509.61 | 47.29% | 52.71% | +2.47 | 13-16 |
| 2021-05-03 | @ Minnesota Twins | L 5-6 | 1466.48 | 1507.33 | 40.39% | 59.61% | -1.34 | 13-17 |
| 2021-05-04 | @ Minnesota Twins | W 6-3 | 1465.14 | 1508.67 | 40.02% | 59.98% | +2.44 | 14-17 |
| 2021-05-05 | @ Minnesota Twins | W 3-1 | 1467.58 | 1506.23 | 40.69% | 59.31% | +2.78 | 15-17 |
| 2021-05-06 | @ Minnesota Twins | W 4-3 | 1470.36 | 1503.44 | 41.47% | 58.53% | +1.38 | 16-17 |
| 2021-05-07 | Seattle Mariners | L 4-5 | 1471.74 | 1486.34 | 51.75% | 48.25% | -1.72 | 16-18 |
| 2021-05-08 | Seattle Mariners | W 9-8 | 1470.02 | 1488.06 | 51.26% | 48.74% | +1.62 | 17-18 |
| 2021-05-09 | Seattle Mariners | W 10-2 | 1471.64 | 1486.44 | 51.72% | 48.28% | +4.53 | 18-18 |
| 2021-05-10 | @ San Francisco Giants | L 1-3 | 1476.17 | 1511.05 | 41.22% | 58.78% | -1.93 | 18-19 |
| 2021-05-11 | @ San Francisco Giants | L 2-4 | 1474.24 | 1512.98 | 40.68% | 59.32% | -1.91 | 18-20 |
| 2021-05-13 | @ Houston Astros | L 3-4 | 1472.33 | 1536.15 | 37.25% | 62.75% | -0.88 | 18-21 |
| 2021-05-14 | @ Houston Astros | L 4-10 | 1471.45 | 1537.02 | 37.01% | 62.99% | -3.01 | 18-22 |
| 2021-05-15 | @ Houston Astros | L 5-6 | 1468.44 | 1540.03 | 36.21% | 63.79% | -1.20 | 18-23 |
| 2021-05-16 | @ Houston Astros | L 2-6 | 1467.24 | 1541.23 | 35.89% | 64.11% | -2.38 | 18-24 |
| 2021-05-17 | New York Yankees | W 5-2 | 1464.86 | 1528.81 | 44.67% | 55.33% | +3.18 | 19-24 |
| 2021-05-18 | New York Yankees | L 4-7 | 1468.04 | 1525.63 | 45.58% | 54.42% | -2.62 | 19-25 |
| 2021-05-19 | New York Yankees | L 0-2 | 1465.42 | 1528.25 | 44.83% | 55.17% | -2.11 | 19-26 |
| 2021-05-20 | New York Yankees | L 0-2 | 1463.31 | 1530.36 | 44.23% | 55.77% | -2.07 | 19-27 |
| 2021-05-21 | Houston Astros | W 7-5 | 1461.24 | 1549.83 | 41.20% | 58.80% | +1.95 | 20-27 |
| 2021-05-22 | Houston Astros | W 8-4 | 1463.19 | 1547.88 | 41.74% | 58.26% | +3.87 | 21-27 |
| 2021-05-23 | Houston Astros | W 3-2 | 1467.06 | 1544.01 | 42.83% | 57.17% | +1.34 | 22-27 |
| 2021-05-25 | @ Los Angeles Angels | L 5-11 | 1468.40 | 1464.66 | 46.69% | 53.31% | -3.80 | 22-28 |
| 2021-05-26 | @ Los Angeles Angels | L 8-9 | 1464.60 | 1468.45 | 45.60% | 54.40% | -1.51 | 22-29 |
| 2021-05-27 | @ Seattle Mariners | L 0-5 | 1463.09 | 1464.97 | 45.88% | 54.12% | -3.41 | 22-30 |
| 2021-05-28 | @ Seattle Mariners | L 2-3 | 1459.68 | 1468.38 | 44.91% | 55.09% | -1.49 | 22-31 |
| 2021-05-29 | @ Seattle Mariners | L 2-3 | 1458.19 | 1469.87 | 44.49% | 55.51% | -1.48 | 22-32 |
| 2021-05-30 | @ Seattle Mariners | L 2-4 | 1456.71 | 1471.35 | 44.07% | 55.93% | -2.07 | 22-33 |
| 2021-06-01 | @ Colorado Rockies | L 2-3 | 1454.64 | 1455.46 | 46.04% | 53.96% | -1.08 | 22-34 |
| 2021-06-02 | @ Colorado Rockies | L 3-6 | 1453.56 | 1456.54 | 45.73% | 54.27% | -2.63 | 22-35 |
| 2021-06-03 | @ Colorado Rockies | L 6-11 | 1450.93 | 1459.17 | 44.98% | 55.02% | -3.34 | 22-36 |
| 2021-06-04 | Tampa Bay Rays | W 5-4 | 1447.59 | 1565.81 | 37.14% | 62.86% | +2.09 | 23-36 |
| 2021-06-05 | Tampa Bay Rays | L 0-3 | 1449.68 | 1563.73 | 37.70% | 62.30% | -2.17 | 23-37 |
| 2021-06-06 | Tampa Bay Rays | L 1-7 | 1447.51 | 1565.89 | 37.11% | 62.89% | -3.01 | 23-38 |
| 2021-06-08 | San Francisco Giants | L 4-9 | 1444.50 | 1538.82 | 40.40% | 59.60% | -3.00 | 23-39 |
| 2021-06-09 | San Francisco Giants | W 4-3 | 1441.50 | 1541.82 | 39.57% | 60.43% | +1.41 | 24-39 |
| 2021-06-11 | @ Los Angeles Dodgers | L 1-12 | 1442.91 | 1583.20 | 27.65% | 72.35% | -3.04 | 24-40 |
| 2021-06-12 | @ Los Angeles Dodgers | W 12-1 | 1439.87 | 1586.24 | 26.96% | 73.04% | +8.04 | 25-40 |
| 2021-06-13 | @ Los Angeles Dodgers | L 3-5 | 1447.91 | 1578.20 | 28.82% | 71.18% | -1.35 | 25-41 |
| 2021-06-15 | @ Houston Astros | L 3-6 | 1446.56 | 1557.28 | 31.18% | 68.82% | -1.27 | 25-42 |
| 2021-06-16 | @ Houston Astros | L 4-8 | 1445.29 | 1558.55 | 30.87% | 69.13% | -2.05 | 25-43 |
| 2021-06-18 | Minnesota Twins | L 5-7 | 1443.24 | 1473.02 | 49.57% | 50.43% | -1.64 | 25-44 |
| 2021-06-19 | Minnesota Twins | L 2-3 | 1441.60 | 1474.67 | 49.09% | 50.91% | -1.63 | 25-45 |
| 2021-06-20 | Minnesota Twins | L 2-4 | 1439.97 | 1476.30 | 48.63% | 51.37% | -2.29 | 25-46 |
| 2021-06-21 | Oakland Athletics | W 8-3 | 1437.68 | 1538.21 | 39.54% | 60.46% | +4.49 | 26-46 |
| 2021-06-22 | Oakland Athletics | L 6-13 | 1442.17 | 1533.72 | 40.79% | 59.21% | -3.58 | 26-47 |
| 2021-06-23 | Oakland Athletics | W 5-3 | 1438.59 | 1537.30 | 39.79% | 60.21% | +2.82 | 27-47 |
| 2021-06-24 | Oakland Athletics | L 1-5 | 1441.41 | 1534.48 | 40.58% | 59.42% | -2.69 | 27-48 |
| 2021-06-25 | Kansas City Royals | W 9-4 | 1438.72 | 1459.06 | 50.93% | 49.07% | +3.64 | 28-48 |
| 2021-06-26 | Kansas City Royals | W 8-0 | 1442.36 | 1455.42 | 51.97% | 48.03% | +4.51 | 29-48 |
| 2021-06-27 | Kansas City Royals | W 4-1 | 1446.87 | 1450.91 | 53.27% | 46.73% | +2.69 | 30-48 |
| 2021-06-29 | @ Oakland Athletics | W 5-4 | 1449.56 | 1537.84 | 34.02% | 65.98% | +2.19 | 31-48 |
| 2021-06-30 | @ Oakland Athletics | L 1-3 | 1451.75 | 1535.65 | 34.59% | 65.41% | -1.62 | 31-49 |
| 2021-07-01 | @ Oakland Athletics | W 8-3 | 1450.13 | 1537.28 | 34.17% | 65.83% | +4.88 | 32-49 |
| 2021-07-02 | @ Seattle Mariners | L 4-5 | 1455.01 | 1483.86 | 42.06% | 57.94% | -0.98 | 32-50 |
| 2021-07-03 | @ Seattle Mariners | W 7-3 | 1454.03 | 1484.85 | 41.79% | 58.21% | +3.86 | 33-50 |
| 2021-07-04 | @ Seattle Mariners | L 1-4 | 1457.89 | 1480.98 | 42.87% | 57.13% | -2.46 | 33-51 |
| 2021-07-05 | Detroit Tigers | L 3-7 | 1455.43 | 1458.98 | 53.34% | 46.66% | -3.54 | 33-52 |
| 2021-07-06 | Detroit Tigers | W 10-5 | 1451.89 | 1462.52 | 52.32% | 47.68% | +3.54 | 34-52 |
| 2021-07-07 | Detroit Tigers | L 3-5 | 1455.43 | 1458.98 | 53.34% | 46.66% | -2.51 | 34-53 |
| 2021-07-09 | Oakland Athletics | W 3-2 | 1452.92 | 1528.90 | 42.97% | 57.03% | +1.89 | 35-53 |
| 2021-07-10 | Oakland Athletics | L 4-8 | 1454.81 | 1527.00 | 43.50% | 56.50% | -2.04 | 35-54 |
| 2021-07-11 | Oakland Athletics | L 1-4 | 1452.77 | 1529.05 | 42.92% | 57.08% | -2.47 | 35-55 |
| 2021-07-16 | @ Toronto Blue Jays | L 2-10 | 1450.30 | 1530.83 | 35.03% | 64.97% | -3.29 | 35-56 |
| 2021-07-18 | @ Toronto Blue Jays | L 0-5 | 1447.01 | 1534.12 | 34.17% | 65.83% | -2.53 | 35-57 |
| 2021-07-18 | @ Toronto Blue Jays | L 0-10 | 1444.48 | 1536.66 | 33.52% | 66.48% | -3.52 | 35-58 |
| 2021-07-19 | @ Detroit Tigers | L 0-14 | 1440.96 | 1459.32 | 43.54% | 56.46% | -5.41 | 35-59 |
| 2021-07-20 | @ Detroit Tigers | L 1-4 | 1435.55 | 1464.73 | 42.02% | 57.98% | -2.42 | 35-60 |
| 2021-07-21 | @ Detroit Tigers | L 2-4 | 1433.13 | 1467.15 | 41.34% | 58.66% | -1.94 | 35-61 |
| 2021-07-22 | @ Detroit Tigers | L 5-7 | 1431.19 | 1469.09 | 40.80% | 59.20% | -1.91 | 35-62 |
| 2021-07-23 | @ Houston Astros | L 3-7 | 1429.28 | 1568.58 | 27.77% | 72.23% | -1.85 | 35-63 |
| 2021-07-24 | @ Houston Astros | L 1-4 | 1427.43 | 1570.43 | 27.34% | 72.66% | -1.57 | 35-64 |
| 2021-07-25 | @ Houston Astros | L 1-3 | 1425.86 | 1572.00 | 26.98% | 73.02% | -1.27 | 35-65 |
| 2021-07-27 | Arizona Diamondbacks | W 5-4 | 1424.59 | 1421.41 | 54.30% | 45.70% | +1.52 | 36-65 |
| 2021-07-28 | Arizona Diamondbacks | L 2-3 | 1426.11 | 1419.89 | 54.74% | 45.26% | -1.82 | 36-66 |
| 2021-07-30 | Seattle Mariners | L 5-9 | 1424.29 | 1482.44 | 45.50% | 54.50% | -3.02 | 36-67 |
| 2021-07-31 | Seattle Mariners | W 5-4 | 1421.27 | 1485.46 | 44.64% | 55.36% | +1.30 | 37-67 |
| 2021-08-01 | Seattle Mariners | W 4-3 | 1422.57 | 1484.16 | 45.01% | 54.99% | +1.83 | 38-67 |
| 2021-08-02 | Los Angeles Angels | W 4-1 | 1424.40 | 1481.63 | 45.63% | 54.37% | +3.12 | 39-67 |
| 2021-08-03 | Los Angeles Angels | L 3-11 | 1427.52 | 1478.51 | 46.52% | 53.48% | -4.36 | 39-68 |
| 2021-08-04 | Los Angeles Angels | L 1-2 | 1423.16 | 1482.87 | 45.27% | 54.73% | -1.51 | 39-69 |
| 2021-08-05 | Los Angeles Angels | L 0-5 | 1421.65 | 1484.38 | 44.85% | 55.15% | -3.33 | 39-70 |
| 2021-08-06 | @ Oakland Athletics | L 1-4 | 1418.32 | 1536.24 | 30.30% | 69.70% | -1.23 | 39-71 |
| 2021-08-07 | @ Oakland Athletics | L 3-12 | 1417.09 | 1537.47 | 30.00% | 70.00% | -2.99 | 39-72 |
| 2021-08-08 | @ Oakland Athletics | L 3-6 | 1414.10 | 1540.46 | 29.29% | 70.71% | -1.68 | 39-73 |
| 2021-08-10 | @ Seattle Mariners | W 5-4 | 1412.42 | 1488.21 | 35.65% | 64.35% | +1.51 | 40-73 |
| 2021-08-11 | @ Seattle Mariners | L 1-2 | 1413.93 | 1486.70 | 36.05% | 63.95% | -1.20 | 40-74 |
| 2021-08-12 | @ Seattle Mariners | L 1-3 | 1412.73 | 1487.89 | 35.74% | 64.26% | -1.68 | 40-75 |
| 2021-08-13 | Oakland Athletics | W 8-6 | 1411.05 | 1552.09 | 34.12% | 65.88% | +3.10 | 41-75 |
| 2021-08-14 | Oakland Athletics | L 3-8 | 1414.15 | 1549.00 | 34.93% | 65.07% | -2.60 | 41-76 |
| 2021-08-15 | Oakland Athletics | W 7-4 | 1411.55 | 1551.59 | 34.25% | 65.75% | +3.79 | 42-76 |
| 2021-08-17 | Seattle Mariners | L 1-3 | 1415.34 | 1492.55 | 42.79% | 57.21% | -2.01 | 42-77 |
| 2021-08-18 | Seattle Mariners | L 1-3 | 1413.33 | 1494.56 | 42.23% | 57.77% | -1.99 | 42-78 |
| 2021-08-19 | Seattle Mariners | L 8-9 | 1411.34 | 1496.54 | 41.67% | 58.33% | -0.97 | 42-79 |
| 2021-08-20 | @ Boston Red Sox | L 0-6 | 1410.37 | 1518.74 | 31.48% | 68.52% | -2.56 | 42-80 |
| 2021-08-21 | @ Boston Red Sox | W 10-1 | 1407.81 | 1521.30 | 30.84% | 69.16% | +6.88 | 43-80 |
| 2021-08-23 | @ Boston Red Sox | L 4-8 | 1414.69 | 1514.41 | 32.56% | 67.44% | -1.53 | 43-81 |
| 2021-08-24 | @ Cleveland Indians | W 7-3 | 1413.16 | 1497.36 | 34.55% | 65.45% | +4.35 | 44-81 |
| 2021-08-25 | @ Cleveland Indians | L 2-7 | 1417.51 | 1493.02 | 35.69% | 64.31% | -2.65 | 44-82 |
| 2021-08-26 | @ Cleveland Indians | L 6-10 | 1414.86 | 1495.67 | 34.99% | 65.01% | -2.32 | 44-83 |
| 2021-08-27 | Houston Astros | L 4-5 | 1412.54 | 1572.88 | 31.67% | 68.33% | -1.05 | 44-84 |
| 2021-08-28 | Houston Astros | L 2-5 | 1411.49 | 1573.93 | 31.41% | 68.59% | -1.81 | 44-85 |
| 2021-08-29 | Houston Astros | W 13-2 | 1409.68 | 1575.74 | 30.97% | 69.03% | +7.60 | 45-85 |
| 2021-08-30 | Colorado Rockies | W 4-3 | 1417.28 | 1487.83 | 43.73% | 56.27% | +1.87 | 46-85 |
| 2021-08-31 | Colorado Rockies | W 4-3 | 1419.15 | 1485.97 | 44.26% | 55.74% | +1.85 | 47-85 |
| 2021-09-01 | Colorado Rockies | L 5-9 | 1421.00 | 1484.12 | 44.79% | 55.21% | -2.97 | 47-86 |
| 2021-09-03 | @ Los Angeles Angels | L 2-3 | 1418.03 | 1471.50 | 38.65% | 61.35% | -1.29 | 47-87 |
| 2021-09-04 | @ Los Angeles Angels | L 1-4 | 1416.74 | 1472.79 | 38.30% | 61.70% | -2.20 | 47-88 |
| 2021-09-05 | @ Los Angeles Angels | W 7-3 | 1414.54 | 1474.99 | 37.70% | 62.30% | +4.14 | 48-88 |
| 2021-09-06 | @ Los Angeles Angels | W 4-0 | 1418.68 | 1470.85 | 38.83% | 61.17% | +4.06 | 49-88 |
| 2021-09-07 | @ Arizona Diamondbacks | W 3-1 | 1422.74 | 1419.72 | 46.59% | 53.41% | +2.51 | 50-88 |
| 2021-09-08 | @ Arizona Diamondbacks | W 8-5 | 1425.25 | 1417.22 | 47.30% | 52.70% | +3.03 | 51-88 |
| 2021-09-10 | @ Oakland Athletics | L 5-10 | 1428.28 | 1529.30 | 32.39% | 67.61% | -2.41 | 51-89 |
| 2021-09-11 | @ Oakland Athletics | W 8-6 | 1425.87 | 1531.70 | 31.79% | 68.21% | +3.20 | 52-89 |
| 2021-09-12 | @ Oakland Athletics | W 4-3 | 1429.07 | 1528.50 | 32.60% | 67.40% | +2.24 | 53-89 |
| 2021-09-13 | Houston Astros | L 1-15 | 1431.31 | 1561.53 | 35.54% | 64.46% | -4.41 | 53-90 |
| 2021-09-14 | Houston Astros | W 8-1 | 1426.90 | 1565.95 | 34.38% | 65.62% | +5.76 | 54-90 |
| 2021-09-15 | Houston Astros | L 2-7 | 1432.66 | 1560.19 | 35.89% | 64.11% | -2.66 | 54-91 |
| 2021-09-16 | Houston Astros | L 1-12 | 1430.00 | 1562.85 | 35.19% | 64.81% | -3.88 | 54-92 |
| 2021-09-17 | Chicago White Sox | L 0-8 | 1426.12 | 1533.89 | 38.55% | 61.45% | -3.62 | 54-93 |
| 2021-09-18 | Chicago White Sox | W 2-1 | 1422.50 | 1537.51 | 37.57% | 62.43% | +2.07 | 55-93 |
| 2021-09-19 | Chicago White Sox | L 2-7 | 1424.57 | 1535.44 | 38.13% | 61.87% | -2.83 | 55-94 |
| 2021-09-20 | @ New York Yankees | L 3-4 | 1421.74 | 1524.05 | 32.23% | 67.77% | -1.07 | 55-95 |
| 2021-09-21 | @ New York Yankees | L 1-7 | 1420.67 | 1525.12 | 31.96% | 68.04% | -2.60 | 55-96 |
| 2021-09-22 | @ New York Yankees | L 3-7 | 1418.07 | 1527.72 | 31.32% | 68.68% | -2.08 | 55-97 |
| 2021-09-23 | @ Baltimore Orioles | L 0-3 | 1415.99 | 1391.64 | 49.65% | 50.35% | -2.85 | 55-98 |
| 2021-09-24 | @ Baltimore Orioles | W 8-5 | 1413.14 | 1394.50 | 48.83% | 51.17% | +2.94 | 56-98 |
| 2021-09-25 | @ Baltimore Orioles | L 2-3 | 1416.08 | 1391.56 | 49.68% | 50.32% | -1.65 | 56-99 |
| 2021-09-26 | @ Baltimore Orioles | W 7-4 | 1414.43 | 1393.20 | 49.20% | 50.80% | +2.92 | 57-99 |
| 2021-09-28 | Los Angeles Angels | W 5-2 | 1417.35 | 1462.01 | 47.43% | 52.57% | +3.03 | 58-99 |
| 2021-09-29 | Los Angeles Angels | L 2-7 | 1420.38 | 1458.99 | 48.30% | 51.70% | -3.59 | 58-100 |
| 2021-09-30 | Los Angeles Angels | W 7-6 | 1416.79 | 1462.57 | 47.27% | 52.73% | +1.75 | 59-100 |
| 2021-10-01 | Cleveland Indians | L 6-9 | 1418.54 | 1493.67 | 43.09% | 56.91% | -2.48 | 59-101 |
| 2021-10-02 | Cleveland Indians | W 7-2 | 1416.06 | 1496.15 | 42.39% | 57.61% | +4.28 | 60-101 |
| 2021-10-03 | Cleveland Indians | L 0-6 | 1420.34 | 1491.87 | 43.60% | 56.40% | -3.54 | 60-102 |
| 2021-04-01 | @ New York Yankees | W 3-2 | 1493.89 | 1528.75 | 41.22% | 58.78% | +1.38 | 1-0 |
| 2021-04-03 | @ New York Yankees | L 3-5 | 1495.27 | 1527.37 | 41.61% | 58.39% | -1.95 | 1-1 |
| 2021-04-04 | @ New York Yankees | W 3-1 | 1493.32 | 1529.32 | 41.06% | 58.94% | +2.77 | 2-1 |
| 2021-04-05 | @ Texas Rangers | W 6-2 | 1496.09 | 1469.40 | 49.99% | 50.01% | +3.32 | 3-1 |
| 2021-04-06 | @ Texas Rangers | L 4-7 | 1499.41 | 1466.08 | 50.94% | 49.06% | -2.93 | 3-2 |
| 2021-04-07 | @ Texas Rangers | L 1-2 | 1496.48 | 1469.01 | 50.10% | 49.90% | -1.66 | 3-3 |
| 2021-04-08 | Los Angeles Angels | L 5-7 | 1494.82 | 1488.32 | 54.77% | 45.23% | -1.82 | 3-4 |
| 2021-04-09 | Los Angeles Angels | L 1-7 | 1493.00 | 1490.13 | 50.41% | 49.59% | -4.10 | 3-5 |
| 2021-04-10 | Los Angeles Angels | W 15-1 | 1488.90 | 1494.23 | 49.23% | 50.77% | +6.30 | 4-5 |
| 2021-04-12 | New York Yankees | L 1-3 | 1495.20 | 1527.50 | 45.37% | 54.63% | -2.13 | 4-6 |
| 2021-04-13 | New York Yankees | W 7-3 | 1493.07 | 1529.63 | 44.76% | 55.24% | +3.67 | 5-6 |
| 2021-04-14 | New York Yankees | W 5-4 | 1496.74 | 1525.96 | 45.80% | 54.20% | +1.80 | 6-6 |
| 2021-04-15 | @ Kansas City Royals | L 5-7 | 1498.54 | 1478.30 | 49.06% | 50.94% | -2.30 | 6-7 |
| 2021-04-17 | @ Kansas City Royals | W 5-1 | 1496.24 | 1480.61 | 48.40% | 51.60% | +3.43 | 7-7 |
| 2021-04-17 | @ Kansas City Royals | L 2-3 | 1499.67 | 1477.18 | 49.38% | 50.62% | -1.64 | 7-8 |
| 2021-04-18 | @ Kansas City Royals | L 0-2 | 1498.03 | 1478.82 | 48.91% | 51.09% | -2.30 | 7-9 |
| 2021-04-20 | @ Boston Red Sox | L 2-4 | 1495.73 | 1513.13 | 43.68% | 56.32% | -2.05 | 7-10 |
| 2021-04-21 | @ Boston Red Sox | W 6-3 | 1493.68 | 1515.19 | 43.10% | 56.90% | +3.27 | 8-10 |
| 2021-04-23 | @ Tampa Bay Rays | W 5-3 | 1496.95 | 1528.89 | 41.63% | 58.37% | +2.74 | 9-10 |
| 2021-04-24 | @ Tampa Bay Rays | L 3-5 | 1499.69 | 1526.15 | 42.40% | 57.60% | -1.99 | 9-11 |
| 2021-04-25 | @ Tampa Bay Rays | W 1-0 | 1497.70 | 1528.14 | 41.84% | 58.16% | +1.93 | 10-11 |
| 2021-04-27 | Washington Nationals | W 9-5 | 1499.63 | 1496.91 | 50.39% | 49.61% | +3.30 | 11-11 |
| 2021-04-28 | Washington Nationals | L 2-8 | 1502.93 | 1493.62 | 51.34% | 48.66% | -4.18 | 11-12 |
| 2021-04-30 | Atlanta Braves | W 13-5 | 1498.75 | 1517.82 | 47.26% | 52.74% | +4.95 | 12-12 |
| 2021-05-01 | Atlanta Braves | W 6-5 | 1503.70 | 1512.87 | 48.68% | 51.32% | +1.21 | 13-12 |
| 2021-05-02 | Atlanta Braves | W 7-2 | 1504.91 | 1511.66 | 49.03% | 50.97% | +3.78 | 14-12 |
| 2021-05-03 | @ Oakland Athletics | L 4-5 | 1508.69 | 1521.24 | 44.36% | 55.64% | -1.47 | 14-13 |
| 2021-05-04 | @ Oakland Athletics | L 1-4 | 1507.22 | 1522.71 | 43.95% | 56.05% | -2.53 | 14-14 |
| 2021-05-05 | @ Oakland Athletics | W 9-4 | 1504.69 | 1525.24 | 43.23% | 56.77% | +4.22 | 15-14 |
| 2021-05-06 | @ Oakland Athletics | W 10-4 | 1508.91 | 1521.03 | 44.43% | 55.57% | +4.52 | 16-14 |
| 2021-05-07 | @ Houston Astros | L 4-10 | 1513.43 | 1529.75 | 43.83% | 56.17% | -3.57 | 16-15 |
| 2021-05-08 | @ Houston Astros | W 8-4 | 1509.86 | 1533.32 | 42.82% | 57.18% | +3.80 | 17-15 |
| 2021-05-09 | @ Houston Astros | L 4-7 | 1513.66 | 1529.52 | 43.89% | 56.11% | -2.53 | 17-16 |
| 2021-05-11 | @ Atlanta Braves | W 5-3 | 1511.13 | 1514.33 | 45.70% | 54.30% | +2.55 | 18-16 |
| 2021-05-12 | @ Atlanta Braves | W 4-1 | 1513.68 | 1511.78 | 46.43% | 53.57% | +3.08 | 19-16 |
| 2021-05-13 | @ Atlanta Braves | W 8-4 | 1516.76 | 1508.70 | 47.31% | 52.69% | +3.50 | 20-16 |
| 2021-05-14 | Philadelphia Phillies | L 1-5 | 1520.26 | 1497.13 | 53.32% | 46.68% | -3.54 | 20-17 |
| 2021-05-15 | Philadelphia Phillies | W 4-0 | 1516.72 | 1500.67 | 52.31% | 47.69% | +3.17 | 21-17 |
| 2021-05-16 | Philadelphia Phillies | W 10-8 | 1519.89 | 1497.50 | 53.22% | 46.78% | +2.20 | 22-17 |
| 2021-05-18 | Boston Red Sox | W 8-0 | 1522.09 | 1518.04 | 50.58% | 49.42% | +4.64 | 23-17 |
| 2021-05-19 | Boston Red Sox | L 3-7 | 1526.73 | 1513.40 | 51.92% | 48.08% | -3.45 | 23-18 |
| 2021-05-20 | Boston Red Sox | L 7-8 | 1523.28 | 1516.85 | 50.93% | 49.07% | -1.69 | 23-19 |
| 2021-05-21 | Tampa Bay Rays | L 7-9 | 1521.59 | 1549.11 | 46.05% | 53.95% | -1.53 | 23-20 |
| 2021-05-22 | Tampa Bay Rays | L 1-3 | 1520.06 | 1550.64 | 45.61% | 54.39% | -2.14 | 23-21 |
| 2021-05-23 | Tampa Bay Rays | L 4-6 | 1517.92 | 1552.78 | 45.00% | 55.00% | -2.11 | 23-22 |
| 2021-05-24 | Tampa Bay Rays | L 8-14 | 1515.81 | 1554.89 | 44.40% | 55.60% | -2.56 | 23-23 |
| 2021-05-25 | @ New York Yankees | W 6-2 | 1513.25 | 1539.54 | 42.42% | 57.58% | +3.83 | 24-23 |
| 2021-05-27 | @ New York Yankees | W 2-0 | 1517.08 | 1535.72 | 43.50% | 56.50% | +2.65 | 25-23 |
| 2021-05-27 | @ New York Yankees | L 3-5 | 1519.73 | 1533.07 | 44.25% | 55.75% | -2.08 | 25-24 |
| 2021-05-28 | @ Cleveland Indians | W 11-2 | 1517.65 | 1512.02 | 46.96% | 53.04% | +5.28 | 26-24 |
| 2021-05-30 | @ Cleveland Indians | W 4-1 | 1522.93 | 1506.74 | 48.48% | 51.52% | +2.97 | 27-24 |
| 2021-05-30 | @ Cleveland Indians | L 5-6 | 1525.90 | 1503.78 | 49.33% | 50.67% | -1.64 | 27-25 |
| 2021-06-01 | Miami Marlins | W 5-1 | 1524.26 | 1490.29 | 58.65% | 41.35% | +2.74 | 28-25 |
| 2021-06-02 | Miami Marlins | W 6-5 | 1527.00 | 1487.54 | 59.42% | 40.58% | +1.35 | 29-25 |
| 2021-06-04 | Houston Astros | L 1-13 | 1528.35 | 1543.73 | 51.64% | 48.36% | -5.94 | 29-26 |
| 2021-06-05 | Houston Astros | W 6-2 | 1522.41 | 1549.67 | 49.93% | 50.07% | +3.33 | 30-26 |
| 2021-06-06 | Houston Astros | L 3-6 | 1525.74 | 1546.34 | 50.89% | 49.11% | -2.93 | 30-27 |
| 2021-06-08 | @ Chicago White Sox | L 1-6 | 1522.81 | 1539.01 | 43.85% | 56.15% | -3.25 | 30-28 |
| 2021-06-09 | @ Chicago White Sox | W 6-2 | 1519.56 | 1542.26 | 42.93% | 57.07% | +3.78 | 31-28 |
| 2021-06-10 | @ Chicago White Sox | L 2-5 | 1523.34 | 1538.47 | 44.00% | 56.00% | -2.53 | 31-29 |
| 2021-06-11 | @ Boston Red Sox | L 5-6 | 1520.81 | 1526.66 | 45.32% | 54.68% | -1.50 | 31-30 |
| 2021-06-12 | @ Boston Red Sox | W 7-2 | 1519.31 | 1528.17 | 44.89% | 55.11% | +4.09 | 32-30 |
| 2021-06-13 | @ Boston Red Sox | W 18-4 | 1523.40 | 1524.08 | 46.06% | 53.94% | +6.70 | 33-30 |
| 2021-06-14 | @ Boston Red Sox | L 1-2 | 1530.10 | 1517.38 | 47.98% | 52.02% | -1.59 | 33-31 |
| 2021-06-15 | New York Yankees | L 5-6 | 1528.51 | 1512.42 | 56.14% | 43.86% | -1.86 | 33-32 |
| 2021-06-16 | New York Yankees | L 2-3 | 1526.65 | 1514.29 | 55.61% | 44.39% | -1.85 | 33-33 |
| 2021-06-17 | New York Yankees | L 4-8 | 1524.80 | 1516.13 | 55.08% | 44.92% | -3.66 | 33-34 |
| 2021-06-18 | @ Baltimore Orioles | L 1-7 | 1521.14 | 1435.77 | 58.35% | 41.65% | -4.74 | 33-35 |
| 2021-06-19 | @ Baltimore Orioles | W 10-7 | 1516.40 | 1440.51 | 57.02% | 42.98% | +2.47 | 34-35 |
| 2021-06-20 | @ Baltimore Orioles | W 7-4 | 1518.87 | 1438.04 | 57.72% | 42.28% | +2.43 | 35-35 |
| 2021-06-22 | @ Miami Marlins | W 2-1 | 1521.30 | 1489.66 | 50.70% | 49.30% | +1.64 | 36-35 |
| 2021-06-23 | @ Miami Marlins | W 3-1 | 1522.94 | 1488.02 | 51.17% | 48.83% | +2.29 | 37-35 |
| 2021-06-24 | Baltimore Orioles | W 9-0 | 1525.23 | 1426.77 | 67.28% | 32.72% | +3.26 | 38-35 |
| 2021-06-25 | Baltimore Orioles | L 5-6 | 1528.49 | 1423.51 | 68.10% | 31.90% | -1.60 | 38-36 |
| 2021-06-26 | Baltimore Orioles | W 12-4 | 1526.89 | 1425.11 | 67.70% | 32.30% | +3.03 | 39-36 |
| 2021-06-27 | Baltimore Orioles | W 5-2 | 1529.92 | 1422.07 | 68.46% | 31.54% | +1.82 | 40-36 |
| 2021-06-29 | Seattle Mariners | W 9-3 | 1531.74 | 1480.42 | 61.05% | 38.95% | +3.16 | 41-36 |
| 2021-06-30 | Seattle Mariners | L 7-9 | 1534.90 | 1477.25 | 61.92% | 38.08% | -2.05 | 41-37 |
| 2021-07-01 | Seattle Mariners | L 2-7 | 1532.85 | 1479.30 | 61.36% | 38.64% | -4.56 | 41-38 |
| 2021-07-02 | Tampa Bay Rays | W 11-1 | 1528.29 | 1558.22 | 49.55% | 50.45% | +5.30 | 42-38 |
| 2021-07-03 | Tampa Bay Rays | W 6-3 | 1533.59 | 1552.93 | 51.07% | 48.93% | +2.81 | 43-38 |
| 2021-07-04 | Tampa Bay Rays | L 1-5 | 1536.40 | 1550.11 | 51.88% | 48.12% | -3.44 | 43-39 |
| 2021-07-06 | @ Baltimore Orioles | L 5-7 | 1532.96 | 1430.88 | 60.67% | 39.33% | -2.85 | 43-40 |
| 2021-07-07 | @ Baltimore Orioles | W 10-2 | 1530.11 | 1433.73 | 59.88% | 40.12% | +3.77 | 44-40 |
| 2021-07-09 | @ Tampa Bay Rays | L 1-7 | 1533.88 | 1560.48 | 42.38% | 57.62% | -3.45 | 44-41 |
| 2021-07-10 | @ Tampa Bay Rays | L 2-5 | 1530.43 | 1563.92 | 41.41% | 58.59% | -2.38 | 44-42 |
| 2021-07-11 | @ Tampa Bay Rays | W 3-1 | 1528.05 | 1566.30 | 40.75% | 59.25% | +2.78 | 45-42 |
| 2021-07-16 | Texas Rangers | W 10-2 | 1530.83 | 1450.30 | 64.97% | 35.03% | +3.29 | 46-42 |
| 2021-07-18 | Texas Rangers | W 5-0 | 1534.12 | 1447.01 | 65.83% | 34.17% | +2.54 | 47-42 |
| 2021-07-18 | Texas Rangers | W 10-0 | 1536.66 | 1444.48 | 66.48% | 33.52% | +3.52 | 48-42 |
| 2021-07-19 | Boston Red Sox | L 4-13 | 1540.18 | 1527.67 | 55.63% | 44.37% | -5.54 | 48-43 |
| 2021-07-21 | Boston Red Sox | L 4-7 | 1534.64 | 1533.21 | 54.05% | 45.95% | -3.11 | 48-44 |
| 2021-07-23 | @ New York Mets | L 0-3 | 1531.53 | 1510.42 | 49.18% | 50.82% | -2.83 | 48-45 |
| 2021-07-24 | @ New York Mets | W 10-3 | 1528.70 | 1513.25 | 48.37% | 51.63% | +4.53 | 49-45 |
| 2021-07-25 | @ New York Mets | L 4-5 | 1533.23 | 1508.72 | 49.67% | 50.33% | -1.64 | 49-46 |
| 2021-07-26 | @ Boston Red Sox | L 4-5 | 1531.59 | 1539.82 | 44.98% | 55.02% | -1.50 | 49-47 |
| 2021-07-28 | @ Boston Red Sox | W 4-1 | 1530.09 | 1541.32 | 44.55% | 55.45% | +3.19 | 50-47 |
| 2021-07-28 | @ Boston Red Sox | L 1-4 | 1533.28 | 1538.13 | 45.46% | 54.54% | -2.61 | 50-48 |
| 2021-07-29 | @ Boston Red Sox | W 13-1 | 1530.67 | 1540.74 | 44.72% | 55.28% | +6.35 | 51-48 |
| 2021-07-30 | Kansas City Royals | W 6-4 | 1537.02 | 1448.61 | 66.00% | 34.00% | +1.60 | 52-48 |
| 2021-07-31 | Kansas City Royals | W 4-0 | 1538.62 | 1447.01 | 66.41% | 33.59% | +2.23 | 53-48 |
| 2021-08-01 | Kansas City Royals | W 5-1 | 1540.85 | 1444.78 | 66.98% | 33.02% | +2.19 | 54-48 |
| 2021-08-02 | Cleveland Indians | L 2-5 | 1543.04 | 1487.18 | 61.67% | 38.33% | -2.50 | 54-49 |
| 2021-08-03 | Cleveland Indians | W 7-2 | 1540.54 | 1489.68 | 60.99% | 39.01% | +2.89 | 55-49 |
| 2021-08-04 | Cleveland Indians | W 8-6 | 1543.43 | 1486.79 | 61.78% | 38.22% | +1.80 | 56-49 |
| 2021-08-05 | Cleveland Indians | W 3-0 | 1545.23 | 1484.99 | 62.27% | 37.73% | +2.17 | 57-49 |
| 2021-08-06 | Boston Red Sox | W 12-4 | 1547.40 | 1522.82 | 57.34% | 42.66% | +4.00 | 58-49 |
| 2021-08-07 | Boston Red Sox | W 1-0 | 1551.40 | 1518.81 | 58.46% | 41.54% | +1.38 | 59-49 |
| 2021-08-07 | Boston Red Sox | L 1-2 | 1552.78 | 1517.43 | 58.85% | 41.15% | -1.38 | 59-50 |
| 2021-08-08 | Boston Red Sox | W 9-8 | 1551.40 | 1518.81 | 58.46% | 41.54% | +1.38 | 60-50 |
| 2021-08-10 | @ Los Angeles Angels | W 6-3 | 1552.78 | 1485.13 | 59.61% | 40.39% | +2.32 | 61-50 |
| 2021-08-10 | @ Los Angeles Angels | W 4-0 | 1555.10 | 1482.81 | 56.51% | 43.49% | +2.89 | 62-50 |
| 2021-08-11 | @ Los Angeles Angels | W 10-2 | 1557.99 | 1479.92 | 57.33% | 42.67% | +4.01 | 63-50 |
| 2021-08-12 | @ Los Angeles Angels | L 3-6 | 1562.00 | 1475.92 | 58.45% | 41.55% | -3.36 | 63-51 |
| 2021-08-13 | @ Seattle Mariners | L 2-3 | 1558.64 | 1489.57 | 56.06% | 43.94% | -1.87 | 63-52 |
| 2021-08-14 | @ Seattle Mariners | L 3-9 | 1556.77 | 1491.43 | 55.53% | 44.47% | -4.51 | 63-53 |
| 2021-08-15 | @ Seattle Mariners | W 8-3 | 1552.26 | 1495.95 | 54.24% | 45.76% | +3.40 | 64-53 |
| 2021-08-17 | @ Washington Nationals | L 6-12 | 1555.66 | 1466.85 | 58.83% | 41.17% | -4.79 | 64-54 |
| 2021-08-18 | @ Washington Nationals | L 5-8 | 1550.87 | 1471.63 | 57.49% | 42.51% | -3.30 | 64-55 |
| 2021-08-20 | Detroit Tigers | L 1-4 | 1547.57 | 1460.06 | 65.88% | 34.12% | -2.68 | 64-56 |
| 2021-08-21 | Detroit Tigers | W 3-0 | 1544.89 | 1462.74 | 65.18% | 34.82% | +2.00 | 65-56 |
| 2021-08-22 | Detroit Tigers | L 3-5 | 1546.89 | 1460.73 | 65.70% | 34.30% | -2.18 | 65-57 |
| 2021-08-23 | Chicago White Sox | W 2-1 | 1544.71 | 1540.29 | 54.48% | 45.52% | +1.51 | 66-57 |
| 2021-08-24 | Chicago White Sox | L 2-5 | 1546.22 | 1538.78 | 54.91% | 45.09% | -3.16 | 66-58 |
| 2021-08-25 | Chicago White Sox | W 3-1 | 1543.06 | 1541.94 | 54.01% | 45.99% | +2.16 | 67-58 |
| 2021-08-26 | Chicago White Sox | L 7-10 | 1545.22 | 1539.78 | 54.62% | 45.38% | -3.14 | 67-59 |
| 2021-08-27 | @ Detroit Tigers | L 1-2 | 1542.08 | 1463.85 | 57.35% | 42.65% | -1.90 | 67-60 |
| 2021-08-28 | @ Detroit Tigers | W 3-2 | 1540.18 | 1465.76 | 56.81% | 43.19% | +1.01 | 68-60 |
| 2021-08-29 | @ Detroit Tigers | W 2-1 | 1541.19 | 1464.74 | 57.10% | 42.90% | +1.42 | 69-60 |
| 2021-08-30 | Baltimore Orioles | W 7-3 | 1542.61 | 1397.85 | 72.86% | 27.14% | +1.81 | 70-60 |
| 2021-08-31 | Baltimore Orioles | L 2-4 | 1544.42 | 1396.05 | 73.27% | 26.73% | -3.44 | 70-61 |
| 2021-09-01 | Baltimore Orioles | W 5-4 | 1540.98 | 1399.49 | 72.48% | 27.52% | +0.91 | 71-61 |
| 2021-09-03 | Oakland Athletics | W 11-10 | 1541.89 | 1534.54 | 54.90% | 45.10% | +1.50 | 72-61 |
| 2021-09-04 | Oakland Athletics | W 10-8 | 1543.39 | 1533.04 | 55.32% | 44.68% | +2.09 | 73-61 |
| 2021-09-05 | Oakland Athletics | W 8-0 | 1545.48 | 1530.95 | 55.92% | 44.08% | +4.14 | 74-61 |
| 2021-09-06 | @ New York Yankees | W 8-0 | 1549.62 | 1547.42 | 46.47% | 53.53% | +5.03 | 75-61 |
| 2021-09-07 | @ New York Yankees | W 5-1 | 1554.65 | 1542.39 | 47.91% | 52.09% | +3.46 | 76-61 |
| 2021-09-08 | @ New York Yankees | W 6-3 | 1558.11 | 1538.93 | 48.91% | 51.09% | +2.94 | 77-61 |
| 2021-09-09 | @ New York Yankees | W 6-4 | 1561.05 | 1536.00 | 49.75% | 50.25% | +2.36 | 78-61 |
| 2021-09-10 | @ Baltimore Orioles | L 3-6 | 1563.41 | 1402.97 | 68.34% | 31.66% | -3.93 | 78-62 |
| 2021-09-11 | @ Baltimore Orioles | W 11-10 | 1559.48 | 1406.90 | 67.35% | 32.65% | +1.08 | 79-62 |
| 2021-09-11 | @ Baltimore Orioles | W 11-2 | 1560.56 | 1405.81 | 67.63% | 32.37% | +3.23 | 80-62 |
| 2021-09-12 | @ Baltimore Orioles | W 22-7 | 1563.79 | 1402.59 | 68.43% | 31.57% | +4.05 | 81-62 |
| 2021-09-13 | Tampa Bay Rays | W 8-1 | 1567.84 | 1588.93 | 50.82% | 49.18% | +4.32 | 82-62 |
| 2021-09-14 | Tampa Bay Rays | L 0-2 | 1572.16 | 1584.61 | 52.06% | 47.94% | -2.44 | 82-63 |
| 2021-09-15 | Tampa Bay Rays | W 6-3 | 1569.72 | 1587.06 | 51.36% | 48.64% | +2.80 | 83-63 |
| 2021-09-17 | Minnesota Twins | L 3-7 | 1572.52 | 1462.31 | 68.75% | 31.25% | -4.57 | 83-64 |
| 2021-09-18 | Minnesota Twins | W 6-2 | 1567.95 | 1466.88 | 67.61% | 32.39% | +2.15 | 84-64 |
| 2021-09-19 | Minnesota Twins | W 5-3 | 1570.10 | 1464.73 | 68.15% | 31.85% | +1.50 | 85-64 |
| 2021-09-20 | @ Tampa Bay Rays | L 4-6 | 1571.60 | 1581.75 | 44.70% | 55.30% | -2.10 | 85-65 |
| 2021-09-21 | @ Tampa Bay Rays | W 4-2 | 1569.50 | 1583.85 | 44.11% | 55.89% | +2.62 | 86-65 |
| 2021-09-22 | @ Tampa Bay Rays | L 1-7 | 1572.12 | 1581.23 | 44.85% | 55.15% | -3.64 | 86-66 |
| 2021-09-23 | @ Minnesota Twins | L 2-7 | 1568.48 | 1468.35 | 60.40% | 39.60% | -4.49 | 86-67 |
| 2021-09-24 | @ Minnesota Twins | L 1-3 | 1563.99 | 1472.84 | 59.16% | 40.84% | -2.78 | 86-68 |
| 2021-09-25 | @ Minnesota Twins | W 6-1 | 1561.21 | 1475.61 | 58.38% | 41.62% | +3.09 | 87-68 |
| 2021-09-26 | @ Minnesota Twins | W 5-2 | 1564.30 | 1472.52 | 59.25% | 40.75% | +2.35 | 88-68 |
| 2021-09-28 | New York Yankees | L 2-7 | 1566.65 | 1539.36 | 57.72% | 42.28% | -4.29 | 88-69 |
| 2021-09-29 | New York Yankees | W 6-5 | 1562.36 | 1543.64 | 56.51% | 43.49% | +1.45 | 89-69 |
| 2021-09-30 | New York Yankees | L 2-6 | 1563.81 | 1542.20 | 56.92% | 43.08% | -3.78 | 89-70 |
| 2021-10-01 | Baltimore Orioles | W 6-4 | 1560.03 | 1394.73 | 75.13% | 24.87% | +1.16 | 90-70 |
| 2021-10-02 | Baltimore Orioles | W 10-1 | 1561.19 | 1393.56 | 75.38% | 24.62% | +2.46 | 91-70 |
| 2021-10-03 | Baltimore Orioles | W 12-4 | 1563.65 | 1391.11 | 75.90% | 24.10% | +2.26 | 92-70 |
| 2021-04-06 | Atlanta Braves | W 6-5 | 1509.96 | 1519.19 | 52.52% | 47.48% | +1.58 | 1-0 |
| 2021-04-07 | Atlanta Braves | L 6-7 | 1511.54 | 1517.62 | 52.98% | 47.02% | -1.76 | 1-1 |
| 2021-04-07 | Atlanta Braves | L 0-2 | 1509.78 | 1519.37 | 52.47% | 47.53% | -2.46 | 1-2 |
| 2021-04-09 | @ Los Angeles Dodgers | L 0-1 | 1507.32 | 1569.40 | 37.48% | 62.52% | -1.25 | 1-3 |
| 2021-04-10 | @ Los Angeles Dodgers | L 5-9 | 1506.07 | 1570.65 | 37.15% | 62.85% | -2.46 | 1-4 |
| 2021-04-11 | @ Los Angeles Dodgers | L 0-3 | 1503.61 | 1573.11 | 36.49% | 63.51% | -2.10 | 1-5 |
| 2021-04-12 | @ St. Louis Cardinals | W 5-2 | 1501.51 | 1507.48 | 45.30% | 54.70% | +3.14 | 2-5 |
| 2021-04-13 | @ St. Louis Cardinals | L 3-14 | 1504.65 | 1504.33 | 46.20% | 53.80% | -5.08 | 2-6 |
| 2021-04-14 | @ St. Louis Cardinals | W 6-0 | 1499.57 | 1509.42 | 44.75% | 55.25% | +4.49 | 3-6 |
| 2021-04-15 | Arizona Diamondbacks | L 6-11 | 1504.06 | 1485.68 | 56.46% | 43.54% | -4.19 | 3-7 |
| 2021-04-16 | Arizona Diamondbacks | W 1-0 | 1499.87 | 1489.87 | 55.27% | 44.73% | +1.48 | 4-7 |
| 2021-04-17 | Arizona Diamondbacks | W 6-2 | 1501.35 | 1488.38 | 55.70% | 44.30% | +2.95 | 5-7 |
| 2021-04-18 | Arizona Diamondbacks | L 2-5 | 1504.30 | 1485.44 | 56.53% | 43.47% | -3.26 | 5-8 |
| 2021-04-19 | St. Louis Cardinals | L 5-12 | 1501.04 | 1502.42 | 53.65% | 46.35% | -4.71 | 5-9 |
| 2021-04-20 | St. Louis Cardinals | W 3-2 | 1496.33 | 1507.13 | 52.30% | 47.70% | +1.59 | 6-9 |
| 2021-04-21 | St. Louis Cardinals | W 1-0 | 1497.92 | 1505.55 | 52.75% | 47.25% | +1.56 | 7-9 |
| 2021-04-23 | @ New York Mets | L 0-6 | 1499.48 | 1493.04 | 47.08% | 52.92% | -3.82 | 7-10 |
| 2021-04-24 | @ New York Mets | W 7-1 | 1495.66 | 1496.86 | 45.98% | 54.02% | +4.39 | 8-10 |
| 2021-04-25 | @ New York Mets | L 0-4 | 1500.05 | 1492.47 | 47.24% | 52.76% | -3.14 | 8-11 |
| 2021-04-27 | @ Toronto Blue Jays | L 5-9 | 1496.91 | 1499.63 | 49.61% | 50.39% | -3.29 | 8-12 |
| 2021-04-28 | @ Toronto Blue Jays | W 8-2 | 1493.62 | 1502.93 | 48.66% | 51.34% | +4.17 | 9-12 |
| 2021-04-30 | Miami Marlins | W 2-1 | 1497.79 | 1487.80 | 55.27% | 44.73% | +1.05 | 10-12 |
| 2021-05-01 | Miami Marlins | W 7-2 | 1498.84 | 1486.75 | 55.57% | 44.43% | +3.30 | 11-12 |
| 2021-05-02 | Miami Marlins | W 3-1 | 1502.14 | 1483.46 | 56.51% | 43.49% | +2.04 | 12-12 |
| 2021-05-04 | Atlanta Braves | L 1-6 | 1504.18 | 1507.88 | 53.32% | 46.68% | -3.95 | 12-13 |
| 2021-05-05 | Atlanta Braves | L 3-5 | 1500.23 | 1511.84 | 52.18% | 47.82% | -2.45 | 12-14 |
| 2021-05-06 | Atlanta Braves | L 2-3 | 1497.78 | 1514.29 | 51.48% | 48.52% | -1.71 | 12-15 |
| 2021-05-07 | @ New York Yankees | W 11-4 | 1496.07 | 1530.15 | 41.33% | 58.67% | +5.15 | 13-15 |
| 2021-05-08 | @ New York Yankees | L 3-4 | 1501.22 | 1525.00 | 42.77% | 57.23% | -1.00 | 13-16 |
| 2021-05-09 | @ New York Yankees | L 2-3 | 1500.22 | 1526.00 | 42.49% | 57.51% | -1.41 | 13-17 |
| 2021-05-11 | Philadelphia Phillies | L 2-6 | 1498.81 | 1494.47 | 54.47% | 45.53% | -3.62 | 13-18 |
| 2021-05-12 | Philadelphia Phillies | L 2-5 | 1495.19 | 1498.09 | 53.43% | 46.57% | -2.17 | 13-19 |
| 2021-05-13 | Philadelphia Phillies | W 5-1 | 1493.02 | 1500.26 | 52.81% | 47.19% | +3.13 | 14-19 |
| 2021-05-14 | @ Arizona Diamondbacks | W 17-2 | 1496.15 | 1488.67 | 47.23% | 52.77% | +6.79 | 15-19 |
| 2021-05-15 | @ Arizona Diamondbacks | L 4-11 | 1502.94 | 1481.88 | 49.18% | 50.82% | -4.32 | 15-20 |
| 2021-05-16 | @ Arizona Diamondbacks | W 3-0 | 1498.62 | 1486.20 | 47.93% | 52.07% | +2.99 | 16-20 |
| 2021-05-17 | @ Chicago Cubs | L 3-7 | 1501.61 | 1503.90 | 45.83% | 54.17% | -3.04 | 16-21 |
| 2021-05-18 | @ Chicago Cubs | L 3-6 | 1498.57 | 1506.94 | 44.96% | 55.04% | -2.59 | 16-22 |
| 2021-05-19 | @ Chicago Cubs | W 4-3 | 1495.98 | 1509.53 | 44.22% | 55.78% | +1.85 | 17-22 |
| 2021-05-20 | @ Chicago Cubs | L 2-5 | 1497.83 | 1507.67 | 44.75% | 55.25% | -2.57 | 17-23 |
| 2021-05-21 | Baltimore Orioles | W 4-2 | 1495.26 | 1458.60 | 59.03% | 40.97% | +1.92 | 18-23 |
| 2021-05-22 | Baltimore Orioles | W 12-9 | 1497.18 | 1456.68 | 59.56% | 40.44% | +2.33 | 19-23 |
| 2021-05-23 | Baltimore Orioles | W 6-5 | 1499.51 | 1454.36 | 60.21% | 39.79% | +1.32 | 20-23 |
| 2021-05-25 | Cincinnati Reds | L 1-2 | 1500.83 | 1474.74 | 57.55% | 42.45% | -1.91 | 20-24 |
| 2021-05-26 | Cincinnati Reds | W 5-3 | 1498.92 | 1476.65 | 57.01% | 42.99% | +2.02 | 21-24 |
| 2021-05-27 | Cincinnati Reds | L 0-3 | 1500.94 | 1474.64 | 57.58% | 42.42% | -3.31 | 21-25 |
| 2021-05-29 | Milwaukee Brewers | L 1-4 | 1497.63 | 1490.78 | 54.82% | 45.18% | -3.16 | 21-26 |
| 2021-05-29 | Milwaukee Brewers | L 2-6 | 1494.47 | 1493.93 | 53.92% | 46.08% | -3.58 | 21-27 |
| 2021-05-30 | Milwaukee Brewers | L 0-3 | 1490.89 | 1497.51 | 52.90% | 47.10% | -3.04 | 21-28 |
| 2021-05-31 | @ Atlanta Braves | L 3-5 | 1487.85 | 1510.72 | 42.90% | 57.10% | -2.01 | 21-29 |
| 2021-06-01 | @ Atlanta Braves | W 11-6 | 1485.84 | 1512.74 | 42.34% | 57.66% | +4.28 | 22-29 |
| 2021-06-02 | @ Atlanta Braves | W 5-3 | 1490.12 | 1508.46 | 43.54% | 56.46% | +2.65 | 23-29 |
| 2021-06-03 | @ Atlanta Braves | L 1-5 | 1492.77 | 1505.81 | 44.29% | 55.71% | -2.94 | 23-30 |
| 2021-06-04 | @ Philadelphia Phillies | W 2-1 | 1489.83 | 1486.03 | 46.70% | 53.30% | +1.77 | 24-30 |
| 2021-06-05 | @ Philadelphia Phillies | L 2-5 | 1491.60 | 1484.26 | 47.20% | 52.80% | -2.72 | 24-31 |
| 2021-06-06 | @ Philadelphia Phillies | L 6-12 | 1488.88 | 1486.98 | 46.43% | 53.57% | -3.77 | 24-32 |
| 2021-06-08 | @ Tampa Bay Rays | L 1-3 | 1485.11 | 1568.91 | 34.60% | 65.40% | -1.63 | 24-33 |
| 2021-06-09 | @ Tampa Bay Rays | W 9-7 | 1483.48 | 1570.54 | 34.18% | 65.82% | +2.19 | 25-33 |
| 2021-06-11 | San Francisco Giants | L 0-1 | 1485.67 | 1540.40 | 45.99% | 54.01% | -1.53 | 25-34 |
| 2021-06-12 | San Francisco Giants | W 2-0 | 1484.14 | 1541.92 | 45.55% | 54.45% | +2.56 | 26-34 |
| 2021-06-12 | San Francisco Giants | L 1-2 | 1486.70 | 1539.37 | 46.28% | 53.72% | -1.09 | 26-35 |
| 2021-06-13 | San Francisco Giants | W 5-0 | 1485.61 | 1540.45 | 45.97% | 54.03% | +4.01 | 27-35 |
| 2021-06-14 | Pittsburgh Pirates | W 3-2 | 1489.62 | 1432.14 | 61.89% | 38.11% | +1.27 | 28-35 |
| 2021-06-15 | Pittsburgh Pirates | W 8-1 | 1490.89 | 1430.88 | 62.24% | 37.76% | +3.31 | 29-35 |
| 2021-06-16 | Pittsburgh Pirates | W 3-1 | 1494.20 | 1427.56 | 63.13% | 36.87% | +1.74 | 30-35 |
| 2021-06-18 | New York Mets | W 1-0 | 1495.94 | 1520.91 | 50.26% | 49.74% | +1.65 | 31-35 |
| 2021-06-19 | New York Mets | L 1-5 | 1497.59 | 1519.26 | 50.74% | 49.26% | -3.37 | 31-36 |
| 2021-06-19 | New York Mets | W 6-2 | 1494.22 | 1522.62 | 49.77% | 50.23% | +3.33 | 32-36 |
| 2021-06-20 | New York Mets | W 5-2 | 1497.55 | 1519.29 | 50.73% | 49.27% | +2.84 | 33-36 |
| 2021-06-22 | @ Philadelphia Phillies | W 3-2 | 1500.39 | 1495.16 | 46.90% | 53.10% | +1.76 | 34-36 |
| 2021-06-23 | @ Philadelphia Phillies | W 13-12 | 1502.15 | 1493.40 | 47.41% | 52.59% | +1.75 | 35-36 |
| 2021-06-24 | @ Miami Marlins | W 7-3 | 1503.90 | 1485.73 | 48.76% | 51.24% | +3.40 | 36-36 |
| 2021-06-25 | @ Miami Marlins | L 2-11 | 1507.30 | 1482.33 | 49.74% | 50.26% | -4.96 | 36-37 |
| 2021-06-26 | @ Miami Marlins | L 2-3 | 1502.34 | 1487.28 | 48.31% | 51.69% | -1.60 | 36-38 |
| 2021-06-27 | @ Miami Marlins | W 5-1 | 1500.74 | 1488.88 | 47.85% | 52.15% | +3.46 | 37-38 |
| 2021-06-28 | New York Mets | W 8-4 | 1504.20 | 1514.95 | 52.31% | 47.69% | +3.17 | 38-38 |
| 2021-06-29 | Tampa Bay Rays | W 4-3 | 1507.37 | 1565.41 | 45.51% | 54.49% | +1.81 | 39-38 |
| 2021-06-30 | Tampa Bay Rays | W 15-6 | 1509.18 | 1563.60 | 46.03% | 53.97% | +5.37 | 40-38 |
| 2021-07-01 | Los Angeles Dodgers | L 2-6 | 1514.55 | 1583.80 | 43.92% | 56.08% | -2.91 | 40-39 |
| 2021-07-02 | Los Angeles Dodgers | L 5-10 | 1511.64 | 1586.72 | 43.09% | 56.91% | -3.20 | 40-40 |
| 2021-07-03 | Los Angeles Dodgers | L 3-5 | 1508.44 | 1589.92 | 42.19% | 57.81% | -1.98 | 40-41 |
| 2021-07-04 | Los Angeles Dodgers | L 1-5 | 1506.46 | 1591.90 | 41.64% | 58.36% | -2.77 | 40-42 |
| 2021-07-05 | @ San Diego Padres | W 7-5 | 1503.69 | 1540.56 | 40.94% | 59.06% | +2.78 | 41-42 |
| 2021-07-06 | @ San Diego Padres | L 4-7 | 1506.47 | 1537.79 | 41.72% | 58.28% | -2.40 | 41-43 |
| 2021-07-07 | @ San Diego Padres | W 15-5 | 1504.07 | 1540.19 | 41.05% | 58.95% | +6.19 | 42-43 |
| 2021-07-08 | @ San Diego Padres | L 8-9 | 1510.26 | 1534.00 | 42.78% | 57.22% | -1.42 | 42-44 |
| 2021-07-09 | @ San Francisco Giants | L 3-5 | 1508.84 | 1547.74 | 40.66% | 59.34% | -1.91 | 42-45 |
| 2021-07-10 | @ San Francisco Giants | L 4-10 | 1506.93 | 1549.65 | 40.13% | 59.87% | -3.27 | 42-46 |
| 2021-07-11 | @ San Francisco Giants | L 1-3 | 1503.66 | 1552.91 | 39.23% | 60.77% | -1.84 | 42-47 |
| 2021-07-16 | San Diego Padres | L 8-24 | 1501.82 | 1530.41 | 49.74% | 50.26% | -6.60 | 42-48 |
| 2021-07-17 | San Diego Padres | L 4-10 | 1495.22 | 1537.01 | 47.84% | 52.16% | -3.89 | 42-49 |
| 2021-07-18 | San Diego Padres | W 8-7 | 1491.33 | 1540.90 | 46.72% | 53.28% | +1.76 | 43-49 |
| 2021-07-19 | Miami Marlins | W 18-1 | 1493.09 | 1487.25 | 54.68% | 45.32% | +6.21 | 44-49 |
| 2021-07-20 | Miami Marlins | W 6-3 | 1499.30 | 1481.04 | 56.44% | 43.56% | +2.50 | 45-49 |
| 2021-07-21 | Miami Marlins | L 1-3 | 1501.80 | 1478.54 | 57.15% | 42.85% | -1.89 | 45-50 |
| 2021-07-23 | @ Baltimore Orioles | L 1-6 | 1499.91 | 1427.61 | 56.51% | 43.49% | -4.20 | 45-51 |
| 2021-07-24 | @ Baltimore Orioles | L 3-5 | 1495.71 | 1431.80 | 55.32% | 44.68% | -2.60 | 45-52 |
| 2021-07-25 | @ Baltimore Orioles | L 4-5 | 1493.11 | 1434.40 | 54.58% | 45.42% | -1.81 | 45-53 |
| 2021-07-26 | @ Philadelphia Phillies | L 5-6 | 1491.30 | 1495.28 | 45.58% | 54.42% | -1.51 | 45-54 |
| 2021-07-27 | @ Philadelphia Phillies | W 6-4 | 1489.79 | 1496.79 | 45.15% | 54.85% | +2.57 | 46-54 |
| 2021-07-29 | @ Philadelphia Phillies | W 3-1 | 1492.36 | 1494.22 | 45.89% | 54.11% | +2.54 | 47-54 |
| 2021-07-29 | @ Philadelphia Phillies | L 8-11 | 1494.90 | 1491.68 | 46.62% | 53.38% | -2.68 | 47-55 |
| 2021-07-30 | Chicago Cubs | W 4-3 | 1492.22 | 1480.66 | 55.50% | 44.50% | +1.48 | 48-55 |
| 2021-07-31 | Chicago Cubs | L 3-6 | 1493.70 | 1479.18 | 55.92% | 44.08% | -3.22 | 48-56 |
| 2021-08-01 | Chicago Cubs | W 6-5 | 1490.48 | 1482.40 | 55.00% | 45.00% | +1.50 | 49-56 |
| 2021-08-02 | Philadelphia Phillies | L 5-7 | 1491.98 | 1492.61 | 53.76% | 46.24% | -2.53 | 49-57 |
| 2021-08-03 | Philadelphia Phillies | L 4-5 | 1489.45 | 1495.13 | 53.03% | 46.97% | -1.76 | 49-58 |
| 2021-08-04 | Philadelphia Phillies | L 5-9 | 1487.69 | 1496.89 | 52.53% | 47.47% | -3.48 | 49-59 |
| 2021-08-05 | Philadelphia Phillies | L 6-7 | 1484.21 | 1500.38 | 51.53% | 48.47% | -1.71 | 49-60 |
| 2021-08-06 | @ Atlanta Braves | L 4-8 | 1482.50 | 1535.00 | 38.78% | 61.22% | -2.58 | 49-61 |
| 2021-08-07 | @ Atlanta Braves | W 3-2 | 1479.92 | 1537.58 | 38.08% | 61.92% | +2.06 | 50-61 |
| 2021-08-08 | @ Atlanta Braves | L 4-5 | 1481.98 | 1535.52 | 38.64% | 61.36% | -1.29 | 50-62 |
| 2021-08-10 | @ New York Mets | L 7-8 | 1480.69 | 1485.83 | 45.42% | 54.58% | -1.51 | 50-63 |
| 2021-08-12 | @ New York Mets | L 1-4 | 1479.18 | 1487.33 | 44.99% | 55.01% | -2.58 | 50-64 |
| 2021-08-12 | @ New York Mets | L 4-5 | 1476.60 | 1489.92 | 44.25% | 55.75% | -1.47 | 50-65 |
| 2021-08-13 | Atlanta Braves | L 2-4 | 1475.13 | 1533.85 | 45.42% | 54.58% | -2.13 | 50-66 |
| 2021-08-14 | Atlanta Braves | L 2-12 | 1473.00 | 1535.98 | 44.81% | 55.19% | -4.71 | 50-67 |
| 2021-08-15 | Atlanta Braves | L 5-6 | 1468.29 | 1540.68 | 43.47% | 56.53% | -1.44 | 50-68 |
| 2021-08-17 | Toronto Blue Jays | W 12-6 | 1466.85 | 1555.66 | 41.17% | 58.83% | +4.78 | 51-68 |
| 2021-08-18 | Toronto Blue Jays | W 8-5 | 1471.63 | 1550.87 | 42.51% | 57.49% | +3.31 | 52-68 |
| 2021-08-20 | @ Milwaukee Brewers | W 4-1 | 1474.94 | 1554.27 | 35.19% | 64.81% | +3.73 | 53-68 |
| 2021-08-21 | @ Milwaukee Brewers | L 6-9 | 1478.67 | 1550.54 | 36.17% | 63.83% | -2.08 | 53-69 |
| 2021-08-22 | @ Milwaukee Brewers | L 3-7 | 1476.59 | 1552.62 | 35.62% | 64.38% | -2.37 | 53-70 |
| 2021-08-24 | @ Miami Marlins | W 5-1 | 1474.22 | 1461.00 | 48.05% | 51.95% | +3.45 | 54-70 |
| 2021-08-25 | @ Miami Marlins | L 3-4 | 1477.67 | 1457.55 | 49.04% | 50.96% | -1.15 | 54-71 |
| 2021-08-26 | @ Miami Marlins | L 5-7 | 1476.52 | 1458.70 | 48.71% | 51.29% | -2.29 | 54-72 |
| 2021-08-27 | @ New York Mets | W 2-1 | 1474.23 | 1480.67 | 45.23% | 54.77% | +1.82 | 55-72 |
| 2021-08-28 | @ New York Mets | L 3-5 | 1476.05 | 1478.86 | 45.75% | 54.25% | -2.15 | 55-73 |
| 2021-08-29 | @ New York Mets | L 4-9 | 1473.90 | 1481.00 | 45.14% | 54.86% | -3.35 | 55-74 |
| 2021-08-30 | Philadelphia Phillies | L 4-7 | 1470.55 | 1496.88 | 50.07% | 49.93% | -2.88 | 55-75 |
| 2021-08-31 | Philadelphia Phillies | L 6-12 | 1467.67 | 1499.76 | 49.24% | 50.76% | -4.00 | 55-76 |
| 2021-09-02 | Philadelphia Phillies | L 6-7 | 1463.67 | 1503.76 | 48.09% | 51.91% | -1.60 | 55-77 |
| 2021-09-03 | New York Mets | L 2-6 | 1462.07 | 1489.20 | 49.95% | 50.05% | -2.34 | 55-78 |
| 2021-09-04 | New York Mets | L 9-11 | 1459.73 | 1491.54 | 49.28% | 50.72% | -1.64 | 55-79 |
| 2021-09-04 | New York Mets | W 4-3 | 1458.09 | 1493.18 | 48.80% | 51.20% | +1.70 | 56-79 |
| 2021-09-05 | New York Mets | L 6-13 | 1459.79 | 1491.48 | 49.29% | 50.71% | -4.33 | 56-80 |
| 2021-09-06 | New York Mets | W 4-3 | 1455.46 | 1495.81 | 48.05% | 51.95% | +1.72 | 57-80 |
| 2021-09-07 | @ Atlanta Braves | L 5-8 | 1457.18 | 1550.21 | 33.41% | 66.59% | -1.92 | 57-81 |
| 2021-09-08 | @ Atlanta Braves | W 4-2 | 1455.26 | 1552.13 | 32.92% | 67.08% | +3.15 | 58-81 |
| 2021-09-09 | @ Atlanta Braves | L 6-7 | 1458.41 | 1548.98 | 33.73% | 66.27% | -0.79 | 58-82 |
| 2021-09-10 | @ Pittsburgh Pirates | L 3-4 | 1457.62 | 1404.92 | 53.72% | 46.28% | -1.78 | 58-83 |
| 2021-09-11 | @ Pittsburgh Pirates | L 7-10 | 1455.84 | 1406.70 | 53.21% | 46.79% | -3.06 | 58-84 |
| 2021-09-12 | @ Pittsburgh Pirates | W 6-2 | 1452.78 | 1409.76 | 52.34% | 47.66% | +3.16 | 59-84 |
| 2021-09-13 | Miami Marlins | L 0-3 | 1455.94 | 1462.16 | 52.96% | 47.04% | -3.04 | 59-85 |
| 2021-09-14 | Miami Marlins | W 8-2 | 1452.90 | 1465.20 | 52.08% | 47.92% | +3.89 | 60-85 |
| 2021-09-15 | Miami Marlins | L 6-8 | 1456.79 | 1461.30 | 53.20% | 46.80% | -2.49 | 60-86 |
| 2021-09-17 | Colorado Rockies | L 8-9 | 1454.30 | 1485.33 | 49.39% | 50.61% | -1.64 | 60-87 |
| 2021-09-18 | Colorado Rockies | L 0-6 | 1452.66 | 1486.97 | 48.92% | 51.08% | -3.98 | 60-88 |
| 2021-09-19 | Colorado Rockies | W 3-0 | 1448.68 | 1490.95 | 47.77% | 52.23% | +3.00 | 61-88 |
| 2021-09-20 | @ Miami Marlins | L 7-8 | 1451.68 | 1459.20 | 45.08% | 54.92% | -1.06 | 61-89 |
| 2021-09-21 | @ Miami Marlins | W 7-1 | 1450.62 | 1460.25 | 44.78% | 55.22% | +4.49 | 62-89 |
| 2021-09-22 | @ Miami Marlins | W 7-5 | 1455.11 | 1455.76 | 46.06% | 53.94% | +2.54 | 63-89 |
| 2021-09-23 | @ Cincinnati Reds | W 3-2 | 1457.65 | 1501.62 | 39.96% | 60.04% | +1.99 | 64-89 |
| 2021-09-24 | @ Cincinnati Reds | L 7-8 | 1459.64 | 1499.62 | 40.51% | 59.49% | -0.95 | 64-90 |
| 2021-09-25 | @ Cincinnati Reds | L 6-7 | 1458.69 | 1500.57 | 40.24% | 59.76% | -1.34 | 64-91 |
| 2021-09-26 | @ Cincinnati Reds | L 2-9 | 1457.35 | 1501.91 | 39.88% | 60.12% | -3.50 | 64-92 |
| 2021-09-27 | @ Colorado Rockies | W 5-4 | 1453.85 | 1482.13 | 42.14% | 57.86% | +1.92 | 65-92 |
| 2021-09-28 | @ Colorado Rockies | L 1-3 | 1455.77 | 1480.21 | 42.68% | 57.32% | -2.00 | 65-93 |
| 2021-09-29 | @ Colorado Rockies | L 5-10 | 1453.77 | 1482.21 | 42.12% | 57.88% | -3.13 | 65-94 |
| 2021-10-01 | Boston Red Sox | L 2-4 | 1450.64 | 1519.72 | 43.94% | 56.06% | -2.06 | 65-95 |
| 2021-10-02 | Boston Red Sox | L 3-5 | 1448.58 | 1521.78 | 43.36% | 56.64% | -2.04 | 65-96 |
| 2021-10-03 | Boston Red Sox | L 5-7 | 1446.54 | 1523.81 | 42.78% | 57.22% | -2.01 | 65-97 |
Playoff Games
Every playoff game from each team's perspective, controlled by the team filter above. Sort any column by clicking its header. @ before an opponent name indicates an away game; the record column shows the team's running playoff W-L.
| Date | Opponent | Score | Pre Elo | Opp Elo | Win % | Loss % | Elo Δ | Record |
|---|---|---|---|---|---|---|---|---|
| 2021-10-08 | @ Milwaukee Brewers | L 1-2 | 1566.32 | 1543.99 | 49.36% | 50.64% | -1.64 | 0-1 |
| 2021-10-09 | @ Milwaukee Brewers | W 3-0 | 1564.68 | 1545.63 | 48.89% | 51.11% | +2.94 | 1-1 |
| 2021-10-11 | Milwaukee Brewers | W 3-0 | 1567.62 | 1542.69 | 57.39% | 42.61% | +2.45 | 2-1 |
| 2021-10-12 | Milwaukee Brewers | W 5-4 | 1570.07 | 1540.24 | 58.08% | 41.92% | +1.39 | 3-1 |
| 2021-10-16 | Los Angeles Dodgers | W 3-2 | 1571.46 | 1632.69 | 45.06% | 54.94% | +1.83 | 4-1 |
| 2021-10-17 | Los Angeles Dodgers | W 5-4 | 1573.29 | 1630.87 | 45.58% | 54.42% | +1.81 | 5-1 |
| 2021-10-19 | @ Los Angeles Dodgers | L 5-6 | 1575.10 | 1629.06 | 38.58% | 61.42% | -1.29 | 5-2 |
| 2021-10-20 | @ Los Angeles Dodgers | W 9-2 | 1573.81 | 1630.34 | 38.24% | 61.76% | +5.43 | 6-2 |
| 2021-10-21 | @ Los Angeles Dodgers | L 2-11 | 1579.24 | 1624.91 | 39.72% | 60.28% | -3.96 | 6-3 |
| 2021-10-23 | Los Angeles Dodgers | W 4-2 | 1575.28 | 1628.87 | 46.15% | 53.85% | +2.53 | 7-3 |
| 2021-10-26 | @ Houston Astros | W 6-2 | 1577.81 | 1575.63 | 46.47% | 53.53% | +3.56 | 8-3 |
| 2021-10-27 | @ Houston Astros | L 2-7 | 1581.37 | 1572.08 | 47.48% | 52.52% | -3.53 | 8-4 |
| 2021-10-29 | Houston Astros | W 2-0 | 1577.84 | 1575.60 | 54.17% | 45.83% | +2.15 | 9-4 |
| 2021-10-30 | Houston Astros | W 3-2 | 1579.99 | 1573.45 | 54.78% | 45.22% | +1.50 | 10-4 |
| 2021-10-31 | Houston Astros | L 5-9 | 1581.49 | 1571.95 | 55.21% | 44.79% | -3.66 | 10-5 |
| 2021-11-02 | @ Houston Astros | W 7-0 | 1577.83 | 1575.62 | 46.47% | 53.53% | +4.70 | 11-5 |
| 2021-10-05 | New York Yankees | W 6-2 | 1525.82 | 1541.30 | 51.63% | 48.37% | +3.22 | 1-0 |
| 2021-10-07 | @ Tampa Bay Rays | L 0-5 | 1529.04 | 1596.10 | 36.81% | 63.19% | -2.74 | 1-1 |
| 2021-10-08 | @ Tampa Bay Rays | W 14-6 | 1526.30 | 1598.83 | 36.09% | 63.91% | +6.00 | 2-1 |
| 2021-10-10 | Tampa Bay Rays | W 6-4 | 1532.30 | 1592.83 | 45.16% | 54.84% | +1.82 | 3-1 |
| 2021-10-11 | Tampa Bay Rays | W 6-5 | 1534.12 | 1591.01 | 45.68% | 54.32% | +1.81 | 4-1 |
| 2021-10-15 | @ Houston Astros | L 4-5 | 1535.93 | 1571.05 | 41.18% | 58.82% | -1.37 | 4-2 |
| 2021-10-16 | @ Houston Astros | W 9-5 | 1534.56 | 1572.42 | 40.80% | 59.20% | +3.93 | 5-2 |
| 2021-10-18 | Houston Astros | W 12-3 | 1538.49 | 1568.49 | 49.54% | 50.46% | +5.03 | 6-2 |
| 2021-10-19 | Houston Astros | L 2-9 | 1543.52 | 1563.46 | 50.98% | 49.02% | -4.48 | 6-3 |
| 2021-10-20 | Houston Astros | L 1-9 | 1539.04 | 1567.94 | 49.69% | 50.31% | -4.67 | 6-4 |
| 2021-10-22 | @ Houston Astros | L 0-5 | 1534.37 | 1572.61 | 40.75% | 59.25% | -3.02 | 6-5 |
| 2021-10-07 | @ Houston Astros | L 1-6 | 1543.82 | 1563.81 | 43.31% | 56.69% | -3.22 | 0-1 |
| 2021-10-08 | @ Houston Astros | L 4-9 | 1540.60 | 1567.03 | 42.40% | 57.60% | -3.14 | 0-2 |
| 2021-10-10 | Houston Astros | W 12-6 | 1537.46 | 1570.17 | 49.15% | 50.85% | +4.13 | 1-2 |
| 2021-10-12 | Houston Astros | L 1-10 | 1541.59 | 1566.04 | 50.34% | 49.66% | -5.01 | 1-3 |
| 2021-10-07 | Chicago White Sox | W 6-1 | 1563.81 | 1543.82 | 56.69% | 43.31% | +3.22 | 1-0 |
| 2021-10-08 | Chicago White Sox | W 9-4 | 1567.03 | 1540.60 | 57.60% | 42.40% | +3.14 | 2-0 |
| 2021-10-10 | @ Chicago White Sox | L 6-12 | 1570.17 | 1537.46 | 50.85% | 49.15% | -4.13 | 2-1 |
| 2021-10-12 | @ Chicago White Sox | W 10-1 | 1566.04 | 1541.59 | 49.66% | 50.34% | +5.01 | 3-1 |
| 2021-10-15 | Boston Red Sox | W 5-4 | 1571.05 | 1535.93 | 58.82% | 41.18% | +1.37 | 4-1 |
| 2021-10-16 | Boston Red Sox | L 5-9 | 1572.42 | 1534.56 | 59.20% | 40.80% | -3.93 | 4-2 |
| 2021-10-18 | @ Boston Red Sox | L 3-12 | 1568.49 | 1538.49 | 50.46% | 49.54% | -5.03 | 4-3 |
| 2021-10-19 | @ Boston Red Sox | W 9-2 | 1563.46 | 1543.52 | 49.02% | 50.98% | +4.48 | 5-3 |
| 2021-10-20 | @ Boston Red Sox | W 9-1 | 1567.94 | 1539.04 | 50.31% | 49.69% | +4.67 | 6-3 |
| 2021-10-22 | Boston Red Sox | W 5-0 | 1572.61 | 1534.37 | 59.25% | 40.75% | +3.02 | 7-3 |
| 2021-10-26 | Atlanta Braves | L 2-6 | 1575.63 | 1577.81 | 53.53% | 46.47% | -3.55 | 7-4 |
| 2021-10-27 | Atlanta Braves | W 7-2 | 1572.08 | 1581.37 | 52.52% | 47.48% | +3.52 | 8-4 |
| 2021-10-29 | @ Atlanta Braves | L 0-2 | 1575.60 | 1577.84 | 45.83% | 54.17% | -2.15 | 8-5 |
| 2021-10-30 | @ Atlanta Braves | L 2-3 | 1573.45 | 1579.99 | 45.22% | 54.78% | -1.50 | 8-6 |
| 2021-10-31 | @ Atlanta Braves | W 9-5 | 1571.95 | 1581.49 | 44.79% | 55.21% | +3.67 | 9-6 |
| 2021-11-02 | Atlanta Braves | L 0-7 | 1575.62 | 1577.83 | 53.53% | 46.47% | -4.71 | 9-7 |
| 2021-10-06 | St. Louis Cardinals | W 3-1 | 1627.34 | 1537.19 | 66.22% | 33.78% | +1.58 | 1-0 |
| 2021-10-08 | @ San Francisco Giants | L 0-4 | 1628.92 | 1595.70 | 50.93% | 49.07% | -3.38 | 1-1 |
| 2021-10-09 | @ San Francisco Giants | W 9-2 | 1625.54 | 1599.08 | 49.95% | 50.05% | +4.40 | 2-1 |
| 2021-10-11 | San Francisco Giants | L 0-1 | 1629.94 | 1594.68 | 58.83% | 41.17% | -1.96 | 2-2 |
| 2021-10-12 | San Francisco Giants | W 7-2 | 1627.98 | 1596.63 | 58.29% | 41.71% | +3.10 | 3-2 |
| 2021-10-14 | @ San Francisco Giants | W 2-1 | 1631.08 | 1593.54 | 51.55% | 48.45% | +1.61 | 4-2 |
| 2021-10-16 | @ Atlanta Braves | L 2-3 | 1632.69 | 1571.46 | 54.94% | 45.06% | -1.82 | 4-3 |
| 2021-10-17 | @ Atlanta Braves | L 4-5 | 1630.87 | 1573.29 | 54.42% | 45.58% | -1.81 | 4-4 |
| 2021-10-19 | Atlanta Braves | W 6-5 | 1629.06 | 1575.10 | 61.42% | 38.58% | +1.28 | 5-4 |
| 2021-10-20 | Atlanta Braves | L 2-9 | 1630.34 | 1573.81 | 61.76% | 38.24% | -5.43 | 5-5 |
| 2021-10-21 | Atlanta Braves | W 11-2 | 1624.91 | 1579.24 | 60.28% | 39.72% | +3.96 | 6-5 |
| 2021-10-23 | @ Atlanta Braves | L 2-4 | 1628.87 | 1575.28 | 53.85% | 46.15% | -2.53 | 6-6 |
| 2021-10-08 | Atlanta Braves | W 2-1 | 1543.99 | 1566.32 | 50.64% | 49.36% | +1.64 | 1-0 |
| 2021-10-09 | Atlanta Braves | L 0-3 | 1545.63 | 1564.68 | 51.11% | 48.89% | -2.94 | 1-1 |
| 2021-10-11 | @ Atlanta Braves | L 0-3 | 1542.69 | 1567.62 | 42.61% | 57.39% | -2.45 | 1-2 |
| 2021-10-12 | @ Atlanta Braves | L 4-5 | 1540.24 | 1570.07 | 41.92% | 58.08% | -1.40 | 1-3 |
| 2021-10-05 | @ Boston Red Sox | L 2-6 | 1541.30 | 1525.82 | 48.37% | 51.63% | -3.22 | 0-1 |
| 2021-10-08 | Los Angeles Dodgers | W 4-0 | 1595.70 | 1628.92 | 49.07% | 50.93% | +3.38 | 1-0 |
| 2021-10-09 | Los Angeles Dodgers | L 2-9 | 1599.08 | 1625.54 | 50.05% | 49.95% | -4.40 | 1-1 |
| 2021-10-11 | @ Los Angeles Dodgers | W 1-0 | 1594.68 | 1629.94 | 41.17% | 58.83% | +1.95 | 2-1 |
| 2021-10-12 | @ Los Angeles Dodgers | L 2-7 | 1596.63 | 1627.98 | 41.71% | 58.29% | -3.09 | 2-2 |
| 2021-10-14 | Los Angeles Dodgers | L 1-2 | 1593.54 | 1631.08 | 48.45% | 51.55% | -1.61 | 2-3 |
| 2021-10-06 | @ Los Angeles Dodgers | L 1-3 | 1537.19 | 1627.34 | 33.78% | 66.22% | -1.59 | 0-1 |
| 2021-10-07 | Boston Red Sox | W 5-0 | 1596.10 | 1529.04 | 63.19% | 36.81% | +2.73 | 1-0 |
| 2021-10-08 | Boston Red Sox | L 6-14 | 1598.83 | 1526.30 | 63.91% | 36.09% | -6.00 | 1-1 |
| 2021-10-10 | @ Boston Red Sox | L 4-6 | 1592.83 | 1532.30 | 54.84% | 45.16% | -1.82 | 1-2 |
| 2021-10-11 | @ Boston Red Sox | L 5-6 | 1591.01 | 1534.12 | 54.32% | 45.68% | -1.81 | 1-3 |
Biggest Upsets
The 25 games where the underdog won despite the lowest pregame win probability. Underdog Win % is the winner's pregame chance of winning the game (lower = bigger upset). @ before a team name indicates the away side. An asterisk (*) after the date marks a playoff game.
| # | Date | Underdog Win % | Winning Team | Losing Team | ||||
|---|---|---|---|---|---|---|---|---|
| Team | Elo | Score | Team | Elo | Score | |||
| 1 | 2021-07-09 | 23.99% | Arizona Diamondbacks | 1417.21 | 5 | @ Los Angeles Dodgers | 1590.74 | 2 |
| 2 | 2021-06-28 | 25.31% | Baltimore Orioles | 1420.26 | 9 | @ Houston Astros | 1581.46 | 7 |
| 3 | 2021-09-25 | 25.90% | @ Arizona Diamondbacks | 1409.92 | 7 | Los Angeles Dodgers | 1619.27 | 2 |
| 4 | 2021-09-04 | 26.06% | Baltimore Orioles | 1397.96 | 4 | @ New York Yankees | 1552.31 | 3 |
| 5 | 2021-06-29 | 26.08% | Baltimore Orioles | 1423.77 | 13 | @ Houston Astros | 1577.95 | 3 |
| 6 | 2021-09-18 | 26.30% | Arizona Diamondbacks | 1415.13 | 6 | @ Houston Astros | 1567.35 | 4 |
| 7 | 2021-09-05 | 26.61% | Baltimore Orioles | 1400.41 | 8 | @ New York Yankees | 1549.86 | 7 |
| 8 | 2021-08-31 | 26.73% | Baltimore Orioles | 1396.05 | 4 | @ Toronto Blue Jays | 1544.42 | 2 |
| 9 | 2021-06-12 | 26.96% | Texas Rangers | 1439.87 | 12 | @ Los Angeles Dodgers | 1586.24 | 1 |
| 10 | 2021-06-30 | 27.84% | Baltimore Orioles | 1431.53 | 5 | @ Houston Astros | 1570.19 | 2 |
| 11 | 2021-07-19 | 28.16% | Baltimore Orioles | 1425.62 | 6 | @ Tampa Bay Rays | 1561.54 | 1 |
| 12 | 2021-07-23 | 28.27% | Pittsburgh Pirates | 1426.43 | 6 | @ San Francisco Giants | 1561.41 | 4 |
| 13 | 2021-09-05 | 28.30% | Minnesota Twins | 1458.15 | 6 | @ Tampa Bay Rays | 1592.90 | 5 |
| 14 | 2021-08-27 | 28.87% | Colorado Rockies | 1480.95 | 4 | @ Los Angeles Dodgers | 1610.85 | 2 |
| 15 | 2021-07-24 | 29.06% | Pittsburgh Pirates | 1429.79 | 10 | @ San Francisco Giants | 1558.04 | 2 |
| 16 | 2021-08-22 | 29.13% | New York Mets | 1482.15 | 7 | @ Los Angeles Dodgers | 1609.79 | 2 |
| 17 | 2021-08-29 | 29.25% | Colorado Rockies | 1482.58 | 5 | @ Los Angeles Dodgers | 1609.22 | 0 |
| 18 | 2021-07-23 | 29.38% | Colorado Rockies | 1462.47 | 9 | @ Los Angeles Dodgers | 1588.05 | 6 |
| 19 | 2021-08-03 | 29.48% | Pittsburgh Pirates | 1423.09 | 8 | @ Milwaukee Brewers | 1547.81 | 5 |
| 20 | 2021-08-23 | 29.64% | Kansas City Royals | 1452.46 | 7 | @ Houston Astros | 1575.82 | 1 |
| 21 | 2021-08-06 | 29.73% | Arizona Diamondbacks | 1415.34 | 8 | @ San Diego Padres | 1538.00 | 5 |
| 22 | 2021-06-26 | 29.80% | Arizona Diamondbacks | 1421.20 | 10 | @ San Diego Padres | 1543.24 | 1 |
| 23 | 2021-09-19 | 30.15% | Chicago Cubs | 1445.16 | 6 | @ Milwaukee Brewers | 1564.30 | 4 |
| 24 | 2021-09-18 | 30.41% | Detroit Tigers | 1470.29 | 4 | @ Tampa Bay Rays | 1587.30 | 3 |
| 25 | 2021-08-21 | 30.84% | Texas Rangers | 1407.81 | 10 | @ Boston Red Sox | 1521.30 | 1 |
Biggest Elo Changes
The 25 games that moved the Elo needle the most. Elo Δ is the magnitude of the rating swing; both teams move by the same amount per game (one up, one down). The winning side is shown first. An asterisk (*) after the date marks a playoff game.
| # | Date | Elo Δ | Winning Team | Losing Team | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Team | Score | Elo | Win % | Team | Score | Elo | Win % | |||
| 1 | 2021-06-12 | 8.04 | Texas Rangers | 12 | 1439.87 | 26.96% | @ Los Angeles Dodgers | 1 | 1586.24 | 73.04% |
| 2 | 2021-06-29 | 7.76 | Baltimore Orioles | 13 | 1423.77 | 26.08% | @ Houston Astros | 3 | 1577.95 | 73.92% |
| 3 | 2021-08-29 | 7.60 | @ Texas Rangers | 13 | 1409.68 | 30.97% | Houston Astros | 2 | 1575.74 | 69.03% |
| 4 | 2021-08-14 | 7.12 | @ Minnesota Twins | 12 | 1466.21 | 38.04% | Tampa Bay Rays | 0 | 1577.74 | 61.96% |
| 5 | 2021-09-06 | 7.10 | Philadelphia Phillies | 12 | 1500.15 | 38.28% | @ Milwaukee Brewers | 0 | 1556.35 | 61.72% |
| 6 | 2021-08-14 | 7.03 | @ Pittsburgh Pirates | 14 | 1407.85 | 33.04% | Milwaukee Brewers | 4 | 1557.36 | 66.96% |
| 7 | 2021-06-26 | 6.99 | Arizona Diamondbacks | 10 | 1421.20 | 29.80% | @ San Diego Padres | 1 | 1543.24 | 70.20% |
| 8 | 2021-09-03 | 6.94 | St. Louis Cardinals | 15 | 1493.31 | 36.94% | @ Milwaukee Brewers | 4 | 1559.45 | 63.06% |
| 9 | 2021-08-21 | 6.89 | Texas Rangers | 10 | 1407.81 | 30.84% | @ Boston Red Sox | 1 | 1521.30 | 69.16% |
| 10 | 2021-05-14 | 6.79 | Washington Nationals | 17 | 1496.15 | 47.23% | @ Arizona Diamondbacks | 2 | 1488.67 | 52.77% |
| 11 | 2021-06-01 | 6.74 | Philadelphia Phillies | 17 | 1479.29 | 45.78% | @ Cincinnati Reds | 3 | 1481.92 | 54.22% |
| 12 | 2021-06-13 | 6.70 | Toronto Blue Jays | 18 | 1523.40 | 46.06% | @ Boston Red Sox | 4 | 1524.08 | 53.94% |
| 13 | 2021-07-24 | 6.67 | Pittsburgh Pirates | 10 | 1429.79 | 29.06% | @ San Francisco Giants | 2 | 1558.04 | 70.94% |
| 14 | 2021-06-06 | 6.66 | @ Baltimore Orioles | 18 | 1442.98 | 44.38% | Cleveland Indians | 5 | 1508.98 | 55.62% |
| 15 | 2021-06-30 | 6.64 | @ Atlanta Braves | 20 | 1506.66 | 52.86% | New York Mets | 2 | 1513.56 | 47.14% |
| 16 | 2021-08-26 | 6.61 | @ Baltimore Orioles | 13 | 1395.72 | 42.56% | Los Angeles Angels | 1 | 1474.57 | 57.44% |
| 17 | 2021-07-16 | 6.60 | San Diego Padres | 24 | 1530.41 | 50.26% | @ Washington Nationals | 8 | 1501.82 | 49.74% |
| 18 | 2021-09-03 | 6.57 | Detroit Tigers | 15 | 1458.62 | 37.48% | @ Cincinnati Reds | 5 | 1520.75 | 62.52% |
| 19 | 2021-09-25 | 6.38 | @ Los Angeles Angels | 14 | 1458.86 | 46.74% | Seattle Mariners | 1 | 1508.32 | 53.26% |
| 20 | 2021-07-29 | 6.36 | Toronto Blue Jays | 13 | 1530.67 | 44.72% | @ Boston Red Sox | 1 | 1540.74 | 55.28% |
| 21 | 2021-08-04 | 6.35 | Kansas City Royals | 9 | 1439.90 | 32.43% | @ Chicago White Sox | 1 | 1540.67 | 67.57% |
| 22 | 2021-08-11 | 6.34 | @ Boston Red Sox | 20 | 1514.40 | 44.89% | Tampa Bay Rays | 8 | 1576.82 | 55.11% |
| 23 | 2021-08-12 | 6.32 | @ Arizona Diamondbacks | 12 | 1413.03 | 36.54% | San Diego Padres | 3 | 1535.69 | 63.46% |
| 24 | 2021-04-10 | 6.30 | @ Toronto Blue Jays | 15 | 1488.90 | 49.23% | Los Angeles Angels | 1 | 1494.23 | 50.77% |
| 25 | 2021-06-19 | 6.26 | Miami Marlins | 11 | 1485.37 | 40.36% | @ Chicago Cubs | 1 | 1526.42 | 59.64% |